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• Damiescu R., Dawood M., Elbadawi M., Klauck S. M., Bringmann G., Efferth T., (2024) Identification of Cytisine Derivatives as Agonists of the Human Delta Opioid Receptor by Supercomputer-Based Virtual Drug Screening and Transcriptomics. ACS Chem Biol, 19:1963-1981
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• Damiescu R., Elbadawi M., Dawood M., Klauck S. M., Bringmann G., Efferth T., (2024) Aniquinazoline B, a Fungal Natural Product, Activates the mu-Opioid Receptor. ChemMedChem, 19:e202400213
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• Damiescu R., Yucer R., Klauck S. M., Bringmann G., Efferth T., Dawood M., (2024) Jozimine A(2), a Dimeric Naphthylisoquinoline (NIQ) Alkaloid, Shows In Vitro Cytotoxic Effects against Leukemia Cells through NF-kappaB Inhibition. Int J Mol Sci, 25:
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• Nabih H. K., Yucer R., Mahmoud N., Dawood M., Elbadawi M., Shahhamzehei N., Atia M. A. M., AbdelSadik A., Hussien T. A., Ibrahim M. A. A., Klauck S. M., Hegazy M. F., Efferth T., (2024) The cytotoxic activities of the major diterpene extracted from Salvia multicaulis (Bardakosh) are mediated by the regulation of heat-shock response and fatty acid metabolism pathways in human leukemia cells. Phytomedicine, 135:156023
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• Varol A., Boulos J. C., Jin C., Klauck S. M., Zhitkovich A., Efferth T., (2024) Inhibition of MSH6 augments the antineoplastic efficacy of cisplatin in non-small cell lung cancer as autophagy modulator. Chem Biol Interact, 402:111193
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• Varol A., Klauck S. M., Dantzer F., Efferth T., (2024) Enhancing cisplatin drug sensitivity through PARP3 inhibition: The influence on PDGF and G-coupled signal pathways in cancer. Chem Biol Interact, 398:111094
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• Yuan T., Edelmann D., Kather J. N., Fan Z., Tagscherer K. E., Roth W., Bewerunge-Hudler M., Brobeil A., Kloor M., Blaker H., Burwinkel B., Brenner H., Hoffmeister M., (2024) CpG-biomarkers in tumor tissue and prediction models for the survival of colorectal cancer: A systematic review and external validation study. Crit Rev Oncol Hematol, 193:104199
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• Yuan T., Wankhede D., Edelmann D., Kather J. N., Tagscherer K. E., Roth W., Bewerunge-Hudler M., Brobeil A., Kloor M., Blaker H., Brenner H., Hoffmeister M., (2024) Large-scale external validation and meta-analysis of gene methylation biomarkers in tumor tissue for colorectal cancer prognosis. EBioMedicine, 105:105223
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• Yucer R., Fayez S., Feineis D., Klauck S. M., Shan L., Bringmann G., Efferth T., Dawood M., (2024) Cytotoxicity of dioncophylline A and related naphthylisoquinolines in leukemia cells, mediated by NF-kappaB inhibition, angiogenesis suppression, G2/M cell cycle arrest, and autophagy induction. Phytomedicine, 126:155267
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• Boulos J. C., Omer E. A., Rigano D., Formisano C., Chatterjee M., Leich E., Klauck S. M., Shan L. T., Efferth T., (2023) Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma. Acta Pharmacol Sin, 44:2265-2281
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• Elbadawi M., Boulos J. C., Dawood M., Zhou M., Gul W., ElSohly M. A., Klauck S. M., Efferth T., (2023) The Novel Artemisinin Dimer Isoniazide ELI-XXIII-98-2 Induces c-MYC Inhibition, DNA Damage, and Autophagy in Leukemia Cells. Pharmaceutics, 15:
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• Zhou M., Boulos J. C., Klauck S. M., Efferth T., (2023) The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells. Cell Biol Toxicol, 39:2971-2997
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• Zhou M., Boulos J. C., Omer E. A., Klauck S. M., Efferth T., (2023) Modes of Action of a Novel c-MYC Inhibiting 1,2,4-Oxadiazole Derivative in Leukemia and Breast Cancer Cells. Molecules, 28:
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• Abdelfatah S., Nass J., Knorz C., Klauck S. M., Kupper J. H., Efferth T., (2022) Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells. Cell Biol Toxicol, 38:325-345
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• Adeberg S., Knoll M., Koelsche C., Bernhardt D., Schrimpf D., Sahm F., Konig L., Harrabi S. B., Horner-Rieber J., Verma V., Bewerunge-Hudler M., Unterberg A., Sturm D., Jungk C., Herold-Mende C., Wick W., von Deimling A., Debus J., Rieken S., Abdollahi A., (2022) DNA-methylome-assisted classification of patients with poor prognostic subventricular zone associated IDH-wildtype glioblastoma. Acta Neuropathol, 144:129-142
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• Elbadawi M., Ammar R. M., Rabini S., Klauck S. M., Efferth T., (2022) Modulation of Intestinal Corticotropin-Releasing Hormone Signaling by the Herbal Preparation STW 5-II: Possible Mechanisms for Irritable Bowel Syndrome Management. Pharmaceuticals (Basel), 15:
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• Lu X., Blatt S., Dawood M., Klauck S. M., Fleischer E., Kammerer P. W., Efferth T., (2022) Novel artemisinin derivative FO8643 with anti-angiogenic activity inhibits growth and migration of cancer cells via VEGFR2 signaling. Eur J Pharmacol, 930:175158
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• Panossian A., Abdelfatah S., Efferth T., (2022) Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics. Pharmaceuticals (Basel), 15:
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• Saeed M. E. M., Boulos J. C., Mucklich S. B., Leich E., Chatterjee M., Klauck S. M., Efferth T., (2022) Disruption of Lipid Raft Microdomains, Regulation of CD38, TP53, and MYC Signaling, and Induction of Apoptosis by Lomitapide in Multiple Myeloma Cells. Cancer Genomics Proteomics, 19:540-555
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• Bauer S., Ratz L., Heckmann-Notzel D., Kaczorowski A., Hohenfellner M., Kristiansen G., Duensing S., Altevogt P., Klauck S. M., Sultmann H., (2021) miR-449a Repression Leads to Enhanced NOTCH Signaling in TMPRSS2:ERG Fusion Positive Prostate Cancer Cells. Cancers (Basel), 13:
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• Bieg M., Moskalev E. A., Will R., Hebele S., Schwarzbach M., Schmeck S., Hohenberger P., Jakob J., Kasper B., Gaiser T., Strobel P., Wardelmann E., Kontny U., Braunschweig T., Sirbu H., Grutzmann R., Meidenbauer N., Ishaque N., Eils R., Wiemann S., Hartmann A., Agaimy A., Fritchie K., Giannini C., Haller F., (2021) Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants. Am J Pathol, 191:602-617
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• Boulos J. C., Saeed M. E. M., Chatterjee M., Bulbul Y., Crudo F., Marko D., Munder M., Klauck S. M., Efferth T., (2021) Repurposing of the ALK Inhibitor Crizotinib for Acute Leukemia and Multiple Myeloma Cells. Pharmaceuticals (Basel), 14:
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• Dieter S. M., Siegl C., Codo P. L., Huerta M., Ostermann-Parucha A. L., Schulz E., Zowada M. K., Martin S., Laaber K., Nowrouzi A., Blatter M., Kreth S., Westermann F., Benner A., Uhrig U., Putzker K., Lewis J., Haegebarth A., Mumberg D., Holton S. J., Weiske J., Toepper L. M., Scheib U., Siemeister G., Ball C. R., Kuster B., Stoehr G., Hahne H., Johannes S., Lange M., Herbst F., Glimm H., (2021) Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep, 36:109394
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• Elbadawi M., Ammar R. M., Aziz-Kalbhenn H., Rabini S., Klauck S. M., Dawood M., Saeed M. E. M., Kampf C. J., Efferth T., (2021) Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids. Phytomedicine, 88:153589
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• Gao X., Zhang Y., Li X., Jansen L., Alwers E., Bewerunge-Hudler M., Schick M., Chang-Claude J., Hoffmeister M., Brenner H., (2021) DNA Methylation-Based Estimates of Circulating Leukocyte Composition for Predicting Colorectal Cancer Survival: A Prospective Cohort Study. Cancers (Basel), 13:
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• Haag D., Mack N., Benites Goncalves da Silva P., Statz B., Clark J., Tanabe K., Sharma T., Jager N., Jones D. T. W., Kawauchi D., Wernig M., Pfister S. M., (2021) H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model. Cancer Cell, 39:407-422 e13
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• Hegazy M. F., Dawood M., Mahmoud N., Elbadawi M., Sugimoto Y., Klauck S. M., Mohamed N., Efferth T., (2021) 2alpha-Hydroxyalantolactone from Pulicaria undulata: activity against multidrug-resistant tumor cells and modes of action. Phytomedicine, 81:153409
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• Herbst F., Lang T. J. L., Eckert E. S. P., Wunsche P., Wurm A. A., Kindinger T., Laaber K., Hemmati S., Hotz-Wagenblatt A., Zavidij O., Paruzynski A., Lu J., von Kalle C., Zenz T., Klein C., Schmidt M., Ball C. R., Glimm H., (2021) The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision. Leukemia, 35:2948-2963
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• Kadioglu O., Klauck S. M., Fleischer E., Shan L., Efferth T., (2021) Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation. Arch Toxicol, 95:2485-2495
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• Koelsche C., Schrimpf D., Stichel D., Sill M., Sahm F., Reuss D. E., Blattner M., Worst B., Heilig C. E., Beck K., Horak P., Kreutzfeldt S., Paff E., Stark S., Johann P., Selt F., Ecker J., Sturm D., Pajtler K. W., Reinhardt A., Wefers A. K., Sievers P., Ebrahimi A., Suwala A., Fernandez-Klett F., Casalini B., Korshunov A., Hovestadt V., Kommoss F. K. F., Kriegsmann M., Schick M., Bewerunge-Hudler M., Milde T., Witt O., Kulozik A. E., Kool M., Romero-Perez L., Grunewald T. G. P., Kirchner T., Wick W., Platten M., Unterberg A., Uhl M., Abdollahi A., Debus J., Lehner B., Thomas C., Hasselblatt M., Paulus W., Hartmann C., Staszewski O., Prinz M., Hench J., Frank S., Versleijen-Jonkers Y. M. H., Weidema M. E., Mentzel T., Griewank K., de Alava E., Martin J. D., Gastearena M. A. I., Chang K. T., Low S. Y. Y., Cuevas-Bourdier A., Mittelbronn M., Mynarek M., Rutkowski S., Schuller U., Mautner V. F., Schittenhelm J., Serrano J., Snuderl M., Buttner R., Klingebiel T., Buslei R., Gessler M., Wesseling P., Dinjens W. N. M., Brandner S., Jaunmuktane Z., Lyskjaer I., Schirmacher P., Stenzinger A., Brors B., Glimm H., Heining C., Tirado O. M., Sainz-Jaspeado M., Mora J., Alonso J., Del Muro X. G., Moran S., Esteller M., Benhamida J. K., Ladanyi M., Wardelmann E., Antonescu C., Flanagan A., Dirksen U., Hohenberger P., Baumhoer D., Hartmann W., Vokuhl C., Flucke U., Petersen I., Mechtersheimer G., Capper D., Jones D. T. W., Frohling S., Pfister S. M., von Deimling A., (2021) Sarcoma classification by DNA methylation profiling. Nat Commun, 12:498
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• Kuhn C., Menke M., Senger F., Mack C., Dierck F., Hille S., Schmidt I., Brunke G., Bunger P., Schmiedel N., Will R., Sossalla S., Frank D., Eschenhagen T., Carrier L., Lullmann-Rauch R., Rangrez A. Y., Frey N., (2021) FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo. JACC Basic Transl Sci, 6:365-380
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• Lu X., Yan G., Dawood M., Klauck S. M., Sugimoto Y., Klinger A., Fleischer E., Shan L., Efferth T., (2021) A novel moniliformin derivative as pan-inhibitor of histone deacetylases triggering apoptosis of leukemia cells. Biochem Pharmacol, :114677
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• Lu X., Yan G., Klauck S. M., Fleischer E., Klinger A., Sugimoto Y., Shan L., Efferth T., (2021) Cytotoxicity of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide in multidrug-resistant cancer cells through activation of PERK/eIF2alpha/ATF4 pathway. Biochem Pharmacol, 193:114788
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• Maas S. L. N., Stichel D., Hielscher T., Sievers P., Berghoff A. S., Schrimpf D., Sill M., Euskirchen P., Blume C., Patel A., Dogan H., Reuss D., Dohmen H., Stein M., Reinhardt A., Suwala A. K., Wefers A. K., Baumgarten P., Ricklefs F., Rushing E. J., Bewerunge-Hudler M, Ketter R., Schittenhelm J., Jaunmuktane Z., Leu S., Greenway F. E. A., Bridges L. R., Jones T., Grady C., Serrano J., Golfinos J., Sen C., Mawrin C., Jungk C., Hanggi D., Westphal M., Lamszus K., Etminan N., Jungwirth G., Herold-Mende C., Unterberg A., Harter P. N., Wirsching H. G., Neidert M. C., Ratliff M., Platten M., Snuderl M., Aldape K. D., Brandner S., Hench J., Frank S., Pfister S. M., Jones D. T. W., Reifenberger G., Acker T., Wick W., Weller M., Preusser M., von Deimling A., Sahm F., German Consortium on Aggressive Meningiomas, (2021) Integrated Molecular-Morphologic Meningioma Classification: A Multicenter Retrospective Analysis, Retrospectively and Prospectively Validated. J Clin Oncol, :JCO2100784
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• Maia A., Gu Z., Koch A., Berdiel-Acer M., Will R, Schlesner M., Wiemann S., (2021) IFNbeta1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. Mol Oncol, 15:1308-1329
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• Panossian A., Abdelfatah S., Efferth T., (2021) Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations. Pharmaceuticals (Basel), 14:
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• Panossian A., Abdelfatah S., Efferth T., (2021) Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics. Pharmaceuticals (Basel), 14:
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• Pervaiz A., Zepp M., Georges R., Bergmann F., Mahmood S., Faiza S., Berger M. R., Adwan H., (2021) Antineoplastic effects of targeting CCR5 and its therapeutic potential for colorectal cancer liver metastasis. J Cancer Res Clin Oncol, 147:73-91
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• Platten M., Bunse L., Wick A., Bunse T., Le Cornet L., Harting I., Sahm F., Sanghvi K., Tan C. L., Poschke I., Green E., Justesen S., Behrens G. A., Breckwoldt M. O., Freitag A., Rother L. M., Schmitt A., Schnell O., Hense J., Misch M., Krex D., Stevanovic S., Tabatabai G., Steinbach J. P., Bendszus M., von Deimling A., Schmitt M., Wick W., (2021) A vaccine targeting mutant IDH1 in newly diagnosed glioma. Nature, 592:463-468
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• Schonung M., Meyer J., Nollke P., Olshen A. B., Hartmann M., Murakami N., Wakamatsu M., Okuno Y., Plass C., Loh M. L., Niemeyer C. M., Muramatsu H., Flotho C., Stieglitz E., Lipka D. B., (2021) International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia. Clin Cancer Res, 27:158-168
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• Tawk B., Wirkner U., Schwager C., Rein K., Zaoui K., Federspil P. A., Adeberg S., Linge A., Ganswindt U., Hess J., Unger K., Tinhofer I., Budach V., Lohaus F., Krause M., Guberina M., Stuschke M., Balermpas P., Rodel C., Grosu A. L., Schafer H., Zips D., Combs S. E., Pigorsch S., Zitzelsberger H., Baumeister P., Kirchner T., Bewerunge-Hudler M, Weichert W., Hess J., Herpel E., Belka C., Baumann M., Debus J., Abdollahi A., Dktk R. O. G., (2021) Tumor DNA-Methylome derived Epigenetic Fingerprint Identifies HPV-negative Head and Neck Patients at Risk for Locoregional Recurrence after Postoperative Radiochemotherapy. Int J Cancer, :
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• Touzart A., Mayakonda A., Smith C., Hey J., Toth R., Cieslak A., Andrieu G. P., Tran Quang C., Latiri M., Ghysdael J., Spicuglia S., Dombret H., Ifrah N., Macintyre E., Lutsik P., Boissel N., Plass C., Asnafi V., (2021) Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup. Sci Transl Med, 13:
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• van Tilburg C. M., Pfaff E., Pajtler K. W., Langenberg K. P. S., Fiesel P., Jones B. C., Balasubramanian G. P., Stark S., Johann P. D., Blattner-Johnson M., Schramm K., Dikow N., Hirsch S., Sutter C., Grund K., von Stackelberg A., Kulozik A. E., Lissat A., Borkhardt A., Meisel R., Reinhardt D., Klusmann J. H., Fleischhack G., Tippelt S., von Schweinitz D., Schmid I., Kramm C. M., von Bueren A. O., Calaminus G., Vorwerk P., Graf N., Westermann F., Fischer M., Eggert A., Burkhardt B., Wossmann W., Nathrath M., Hecker-Nolting S., Fruhwald M. C., Schneider D. T., Brecht I. B., Ketteler P., Fulda S., Koscielniak E., Meister M. T., Scheer M., Hettmer S., Schwab M., Tremmel R., Ora I., Hutter C., Gerber N. U., Lohi O., Kazanowska B., Kattamis A., Filippidou M., Goemans B., Zwaan C. M., Milde T., Jager N., Wolf S., Reuss D., Sahm F., von Deimling A., Dirksen U., Freitag A., Witt R., Lichter P., Kopp-Schneider A., Jones D. T. W., Molenaar J. J., Capper D., Pfister S. M., Witt O., (2021) The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. Cancer Discov, :
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• Abdul Pari A. A., Singhal M., Hubers C., Mogler C., Schieb B., Gampp A., Gengenbacher N., Reynolds L. E., Terhardt D., Geraud C., Utikal J., Thomas M., Goerdt S., Hodivala-Dilke K. M., Augustin H. G., Felcht M., (2020) Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma. Cancer Res, 80:2586-2598
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• Borgoni S., Sofyali E., Soleimani M., Wilhelm H., Muller-Decker K., Will R., Noronha A., Beumers L., Verschure P. J., Yarden Y., Magnani L., van Kampen A. H. C., Moerland P. D., Wiemann S., (2020) Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer. Cancers (Basel), 12:
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• Espinet E., Gu Z., Imbusch C. D., Giese N. A., Buscher M., Safavi M., Weisenburger S., Klein C., Vogel V., Falcone M., Insua-Rodriguez J., Reitberger M., Thiel V., Kossi S. O., Muckenhuber A., Sarai K., Lee A. Y., Backx E., Zarei S., Gaida M. M., Rodriguez-Paredes M., Donato E., Yen H. Y., Eils R., Schlesner M., Pfarr N., Hackert T., Plass C., Brors B., Steiger K., Weichenhan D., Arda H. E., Rooman I., Kopp J. L., Strobel O., Weichert W., Sprick M. R., Trumpp A., (2020) Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin. Cancer Discov, :
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• Hartmann L., Schroter P., Osen W., Baumann D., Offringa R., Moustafa M., Will R., Debus J., Brons S., Rieken S., Eichmuller S. B., (2020) Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines. Sci Rep, 10:21517
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• Martin-Garcia D., Silva-Vilches C., Will R., Enk A. H., Lonsdorf A. S., (2020) Tumor-derived CCL20 affects B16 melanoma growth in mice. J Dermatol Sci, 97:57-65
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• Mederer T., Schmitteckert S., Volz J., Martinez C., Roth R., Thumberger T., Eckstein V., Scheuerer J., Thoni C., Lasitschka F., Carstensen L., Gunther P., Holland-Cunz S., Hofstra R., Brosens E., Rosenfeld J. A., Schaaf C. P., Schriemer D., Ceccherini I., Rusmini M., Tilghman J., Luzon-Toro B., Torroglosa A., Borrego S., Sze-Man Tang C., Garcia-Barcelo M., Tam P., Paramasivam N., Bewerunge-Hudler M., De La Torre C., Gretz N., Rappold G. A., Romero P., Niesler B., (2020) A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease. PLoS Genet, 16:e1009106
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• Pein M., Insua-Rodriguez J., Hongu T., Riedel A., Meier J., Wiedmann L., Decker K., Essers M. A. G., Sinn H. P., Spaich S., Sutterlin M., Schneeweiss A., Trumpp A., Oskarsson T., (2020) Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs. Nat Commun, 11:1494
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• Ronellenfitsch M. W., Harter P. N., Kirchner M., Heining C., Hutter B., Gieldon L., Schittenhelm J., Schuhmann M. U., Tatagiba M., Marquardt G., Wagner M., Endris V., Brandts C. H., Mautner V. F., Schrock E., Weichert W., Brors B., von Deimling A., Mittelbronn M., Steinbach J. P., Reuss D. E., Glimm H., Stenzinger A., Frohling S., (2020) Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors. J Clin Invest, 130:2488-2495
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• Sadik A., Somarribas Patterson L. F., Ozturk S., Mohapatra S. R., Panitz V., Secker P. F., Pfander P., Loth S., Salem H., Prentzell M. T., Berdel B., Iskar M., Faessler E., Reuter F., Kirst I., Kalter V., Foerster K. I., Jager E., Guevara C. R., Sobeh M., Hielscher T., Poschet G., Reinhardt A., Hassel J. C., Zapatka M., Hahn U., von Deimling A., Hopf C., Schlichting R., Escher B. I., Burhenne J., Haefeli W. E., Ishaque N., Bohme A., Schauble S., Thedieck K., Trump S., Seiffert M., Opitz C. A., (2020) IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell, 182:1252-1270 e34
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• Yan G., Dawood M., Bockers M., Klauck S. M., Fottner C., Weber M. M., Efferth T., (2020) Multiple modes of cell death in neuroendocrine tumors induced by artesunate. Phytomedicine, 79:153332
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• Zhang Y., Bewerunge-Hudler M., Schick M., Burwinkel B., Herpel E., Hoffmeister M., Brenner H., (2020) Blood-derived DNA methylation predictors of mortality discriminate tumor and healthy tissue in multiple organs. Mol Oncol, 14:2111-2123
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• Bermejo J. L., Huang G., Manoochehri M., Mesa K. G., Schick M., Silos R. G., Ko Y. D., Bruning T., Brauch H., Lo W. Y., Hoheisel J. D., Hamann U., (2019) Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer. Epigenomics, 11:81-93
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• Goeppert B., Truckenmueller F., Ori A., Fritz V., Albrecht T., Fraas A., Scherer D., Silos R. G., Sticht C., Gretz N., Mehrabi A., Bewerunge-Hudler M., Pusch S., Bermejo J. L., Dietrich P., Schirmacher P., Renner M., Roessler S., (2019) Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p. Sci Rep, 9:4796
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• Jia M., Zhang Y., Jansen L., Walter V., Edelmann D., Gundert M., Tagscherer K. E., Roth W., Bewerunge-Hudler M., Herpel E., Kloor M., Ulrich A., Burwinkel B., Blaker H., Chang-Claude J., Brenner H., Hoffmeister M., (2019) A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival. Clin Epigenetics, 11:109
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• Issa A., Gill J. W., Heideman M. R., Sahin O., Wiemann S., Dey J. H., Hynes N. E., (2013) Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. Breast Cancer Res, 15:R8
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• Kuner R., Falth M., Pressinotti N. C., Brase J. C., Puig S. B., Metzger J., Gade S., Schafer G., Bartsch G., Steiner E., Klocker H., Sultmann H., (2013) The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer. J Mol Med (Berl), 91:237-48
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• Renner M., Wolf T., Meyer H., Hartmann W., Penzel R., Ulrich A., Lehner B., Hovestadt V., Czwan E., Egerer G., Schmitt T., Alldinger I., Renker E. K., Ehemann V., Eils R., Wardelmann E., Buttner R., Lichter P., Brors B., Schirmacher P., Mechtersheimer G., (2013) Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas. Genome Biol, 14:r137
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• Ward A., Balwierz A., Zhang J. D., Kublbeck M., Pawitan Y., Hielscher T., Wiemann S., Sahin O., (2013) Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene, 32:1173-82
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• Zeisel A., Yitzhaky A., Koerner C., Lauriola M., Cohen-Dvashi H., Kostler W. J., Yarden Y., Wiemann S., Domany E., (2013) qCMA: a desktop application for quantitative collective cell migration analysis. J Biomol Screen, 18:356-60
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• Abba M., Laufs S., Aghajany M., Korn B., Benner A., Allgayer H., (2012) Look who's talking: deregulated signaling in colorectal cancer. Cancer Genomics Proteomics, 9:15-25
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• Campa D., Butterbach K., Slager S. L., Skibola C. F., de Sanjose S., Benavente Y., Becker N., Foretova L., Maynadie M., Cocco P., Staines A., Kaaks R., Boffetta P., Brennan P., Conde L., Bracci P. M., Caporaso N. E., Strom S. S., Camp N. J., Cerhan J. R., Consortium G., Canzian F., Nieters A., (2012) A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. Int J Cancer, 131:803-12
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• Dolnik A., Engelmann J. C., Scharfenberger-Schmeer M., Mauch J., Kelkenberg-Schade S., Haldemann B., Fries T., Kronke J., Kuhn M. W., Paschka P., Kayser S., Wolf S., Gaidzik V. I., Schlenk R. F., Rucker F. G., Dohner H., Lottaz C., Dohner K., Bullinger L., (2012) Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing. Blood, 120:e83-92
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• Jones D. T., Jager N., Kool M., Zichner T., Hutter B., Sultan M., Cho Y. J., Pugh T. J., Hovestadt V., Stutz A. M., Rausch T., Warnatz H. J., Ryzhova M., Bender S., Sturm D., Pleier S., Cin H., Pfaff E., Sieber L., Wittmann A., Remke M., Witt H., Hutter S., Tzaridis T., Weischenfeldt J., Raeder B., Avci M., Amstislavskiy V., Zapatka M., Weber U. D., Wang Q., Lasitschka B., Bartholomae C. C., Schmidt M., von Kalle C., Ast V., Lawerenz C., Eils J., Kabbe R., Benes V., van Sluis P., Koster J., Volckmann R., Shih D., Betts M. J., Russell R. B., Coco S., Tonini G. P., Schuller U., Hans V., Graf N., Kim Y. J., Monoranu C., Roggendorf W., Unterberg A., Herold-Mende C., Milde T., Kulozik A. E., von Deimling A., Witt O., Maass E., Rossler J., Ebinger M., Schuhmann M. U., Fruhwald M. C., Hasselblatt M., Jabado N., Rutkowski S., von Bueren A. O., Williamson D., Clifford S. C., McCabe M. G., Collins V. P., Wolf S., Wiemann S., Lehrach H., Brors B., Scheurlen W., Felsberg J., Reifenberger G., Northcott P. A., Taylor M. D., Meyerson M., Pomeroy S. L., Yaspo M. L., Korbel J. O., Korshunov A., Eils R., Pfister S. M., Lichter P., (2012) Dissecting the genomic complexity underlying medulloblastoma. Nature, 488:100-5
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• Jurmeister S., Baumann M., Balwierz A., Keklikoglou I., Ward A., Uhlmann S., Zhang J. D., Wiemann S., Sahin O., (2012) MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. Mol Cell Biol, 32:633-51
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• Keklikoglou I., Koerner C., Schmidt C., Zhang J. D., Heckmann D., Shavinskaya A., Allgayer H., Guckel B., Fehm T., Schneeweiss A., Sahin O., Wiemann S., Tschulena U., (2012) MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kappaB and TGF-beta signaling pathways. Oncogene, 31:4150-63
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• Koch C. M., Joussen S., Schellenberg A., Lin Q., Zenke M., Wagner W., (2012) Monitoring of cellular senescence by DNA-methylation at specific CpG sites. Aging Cell, 11:366-9
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• Koch C. M., Reck K., Shao K., Lin Q., Joussen S., Ziegler P., Walenda G., Drescher W., Opalka B., May T., Brummendorf T. H., Zenke M., Saric T., Wagner W., (2012) Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Res, 23:248-59
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• Shamu C. E., Wiemann S., Boutros M., (2012) On target: a public repository for large-scale RNAi experiments. Nat Cell Biol, 14:115
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• Shao K., Koch C., Gupta M. K., Lin Q., Lenz M., Laufs S., Denecke B., Schmidt M., Linke M., Hennies H. C., Hescheler J., Zenke M., Zechner U., Saric T., Wagner W., (2012) Induced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-derived Differences in DNA Methylation Profiles. Mol Ther, 21:240-50
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• Simpson J. C., Joggerst B., Laketa V., Verissimo F., Cetin C., Erfle H., Bexiga M. G., Singan V. R., Heriche J. K., Neumann B., Mateos A., Blake J., Bechtel S., Benes V., Wiemann S., Ellenberg J., Pepperkok R., (2012) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol, 14:764-74
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• Spaich S., Will R. D., Just S., Spaich S., Kuhn C., Frank D., Berger I.M., Wiemann S., Korn B., Koegl M., Backs J., Katus H. A., Rottbauer W., Frey N., (2012) Fbxl22, A Cardiac-Enriched F-Box Protein, Regulates Sarcomeric Protein Turnover and is Essential for Maintenance of Contractile Function In Vivo. Circ Res, 111:Epub ahead of print
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• Sturm D., Witt H., Hovestadt V., Khuong-Quang D. A., Jones D. T., Konermann C., Pfaff E., Tonjes M., Sill M., Bender S., Kool M., Zapatka M., Becker N., Zucknick M., Hielscher T., Liu X. Y., Fontebasso A. M., Ryzhova M., Albrecht S., Jacob K., Wolter M., Ebinger M., Schuhmann M. U., van Meter T., Fruhwald M. C., Hauch H., Pekrun A., Radlwimmer B., Niehues T., von Komorowski G., Durken M., Kulozik A. E., Madden J., Donson A., Foreman N. K., Drissi R., Fouladi M., Scheurlen W., von Deimling A., Monoranu C., Roggendorf W., Herold-Mende C., Unterberg A., Kramm C. M., Felsberg J., Hartmann C., Wiestler B., Wick W., Milde T., Witt O., Lindroth A. M., Schwartzentruber J., Faury D., Fleming A., Zakrzewska M., Liberski P. P., Zakrzewski K., Hauser P., Garami M., Klekner A., Bognar L., Morrissy S., Cavalli F., Taylor M. D., van Sluis P., Koster J., Versteeg R., Volckmann R., Mikkelsen T., Aldape K., Reifenberger G., Collins V. P., Majewski J., Korshunov A., Lichter P., Plass C., Jabado N., Pfister S. M., (2012) Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell, 22:425-37
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• Uhlmann S., Mannsperger H., Zhang J. D., Horvat E. A., Schmidt C., Kublbeck M., Henjes F., Ward A., Tschulena U., Zweig K., Korf U., Wiemann S., Sahin O., (2012) Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol, 8:570
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• Winnefeld M., Brueckner B., Gronniger E., Stab F., Wenck H., Lyko F., (2012) Stable ethnic variations in DNA methylation patterns of human skin. J Invest Dermatol, 132:466-8
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• Amann P. M., Schadendorf D., Owen R. W., Korn B., Eichmuller S. B., Bazhin A. V., (2011) Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Exp Dermatol, 20:373-5
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• Bai S.W., Herrera-Abreu M.T., Rohn J., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J., (2011) A novel strategy to identify and characterize a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. BMC Biology, 9:54
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• Bartholomae C. C., Arens A., Balaggan K. S., Yanez-Munoz R. J., Montini E., Howe S. J., Paruzynski A., Korn B., Appelt J. U., Macneil A., Cesana D., Abel U., Glimm H., Naldini L., Ali R. R., Thrasher A. J., von Kalle C., Schmidt M., (2011) Lentiviral vector integration profiles differ in rodent postmitotic tissues. Mol Ther, 19:703-10
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• Bender C., Heyde S., Henjes F., Wiemann S., Korf U., Beissbarth T., (2011) Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'. BMC Bioinformatics, 12:291
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• Bocker M. T., Hellwig I., Breiling A., Eckstein V., Ho A. D., Lyko F., (2011) Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood, 117:e182-9
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• Breitling L. P., Yang R., Korn B., Burwinkel B., Brenner H., (2011) Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet, 88:450-7
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• Campa D., Husing A., Stein A., Dostal L., Boeing H., Pischon T., Tjonneland A., Roswall N., Overvad K., Ostergaard J. N., Rodriguez L., Sala N., Sanchez M. J., Larranaga N., Huerta J. M., Barricarte A., Khaw K. T., Wareham N., Travis R. C., Allen N. E., Lagiou P., Trichopoulou A., Trichopoulos D., Palli D., Sieri S., Tumino R., Sacerdote C., van Kranen H., Bueno-de-Mesquita H. B., Hallmans G., Johansson M., Romieu I., Jenab M., Cox D. G., Siddiq A., Riboli E., Canzian F., Kaaks R., (2011) Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). PLoS One, 6:e16914
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• Chiocchetti A., Pakalapati G., Duketis E., Wiemann S., Poustka A., Poustka F., Klauck S. M., (2011) Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. Am J Med Genet A, 155A:1472-5
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• Feyerabend T. B., Weiser A., Tietz A., Stassen M., Harris N., Kopf M., Radermacher P., Moller P., Benoist C., Mathis D., Fehling H. J., Rodewald H. R., (2011) Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity, 35:832-44
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• Hagemann S., Heil O., Lyko F., Brueckner B., (2011) Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS One, 6:e17388
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• Meder B., Haas J., Keller A., Heid C., Just S., Borries A., Boisguerin V., Scharfenberger-Schmeer M., Stahler P., Beier M., Weichenhan D., Strom T. M., Pfeufer A., Korn B., Katus H. A., Rottbauer W., (2011) Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies. Circ Cardiovasc Genet, 4:110-22
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• Seibold P., Hein R., Schmezer P., Hall P., Liu J., Dahmen N., Flesch-Janys D., Popanda O., Chang-Claude J., (2011) Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk. Int J Cancer, 129:1467-76
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• Zhang J. D., Koerner C., Bechtel S., Bender C., Keklikoglou I., Schmidt C., Irsigler A., Ernst U., Sahin O., Wiemann S., Tschulena U., (2011) Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. PLoS One, 6:e22176
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• Bork S., Pfister S., Witt H., Horn P., Korn B., Ho A. D., Wagner W., (2010) DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell, 9:54-63
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• Bourbeillon J., Orchard S., Benhar I., Borrebaeck C., de Daruvar A., Dubel S., Frank R., Gibson F., Gloriam D., Haslam N., Hiltker T., Humphrey-Smith I., Hust M., Juncker D., Koegl M., Konthur Z., Korn B., Krobitsch S., Muyldermans S., Nygren P. A., Palcy S., Polic B., Rodriguez H., Sawyer A., Schlapshy M., Snyder M., Stoevesandt O., Taussig M. J., Templin M., Uhlen M., van der Maarel S., Wingren C., Hermjakob H., Sherman D., (2010) Minimum information about a protein affinity reagent (MIAPAR). Nat Biotechnol, 28:650-3
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• de Souza Rocha Simonini P., Breiling A., Gupta N., Malekpour M., Youns M., Omranipour R., Malekpour F., Volinia S., Croce C. M., Najmabadi H., Diederichs S., Sahin O., Mayer D., Lyko F., Hoheisel J. D., Riazalhosseini Y., (2010) Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. Cancer Res, 70:9175-84
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• Gloriam D. E., Orchard S., Bertinetti D., Bjorling E., Bongcam-Rudloff E., Borrebaeck C. A., Bourbeillon J., Bradbury A. R., de Daruvar A., Dubel S., Frank R., Gibson T. J., Gold L., Haslam N., Herberg F. W., Hiltke T., Hoheisel J. D., Kerrien S., Koegl M., Konthur Z., Korn B., Landegren U., Montecchi-Palazzi L., Palcy S., Rodriguez H., Schweinsberg S., Sievert V., Stoevesandt O., Taussig M. J., Ueffing M., Uhlen M., van der Maarel S., Wingren C., Woollard P., Sherman D. J., Hermjakob H., (2010) A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics, 9:1-10
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• Gronniger E., Weber B., Heil O, Peters N., Stab F., Wenck H., Korn B., Winnefeld M., Lyko F., (2010) Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet, 6:e1000971
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• Uhlmann S., Zhang J. D., Schwager A., Mannsperger H., Riazalhosseini Y., Burmester S., Ward A., Korf U., Wiemann S., Sahin O., (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene, 29:4297-306
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