Publications

Selected publications:

1. Glauner T. A., Truxa S., Cetin M., Schlüter K., Calafato D., Hartmann, F. J. (2024) Spatial quantification of cellular metabolism in tissues by metabolic regulome profiling. Revealing Unchartered Biology with Single Intact Cells, Chapter 4, Pages 71-98. https://doi.org/10.1016/B978-0-12-822213-3.00006-1
2. Cosgrove, J., Marçais, A., Hartmann, F. J., Bergthaler, A., Zanoni, I., Corrado, M., Perié, L., Cabezas-Wallscheid, N., Bousso, P., Alexandrov, T., Kielian, T., Martínez-Martín, N., Opitz, C. A., & Lyssiotis, C. A. (2024). A call for accessible tools to unlock single-cell immunometabolism research. Nature Metabolism. https://doi.org/10.1038/s42255-024-01031-w
3. Tanevski, J., Vulliard, L., Hartmann, F.J., & Saez-Rodriguez, J. (2024). Learning tissue representation by identification of persistent local patterns in spatial omics data. bioRxiv, 2024–03. https://doi.org/10.1101/2024.03.06.583691
4. Adamik, J., Munson, P. V., Maurer, D. M., Hartmann, F. J., Bendall, S. C., Argüello, R. J., & Butterfield, L. H. (2023). Immuno-metabolic dendritic cell vaccine signatures associate with overall survival in vaccinated melanoma patients. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42881-4
5. Mrdjen, D., Amouzgar, M., Cannon, B., Liu, C., Spence, A., McCaffrey, E., Bharadwaj, A., Tebaykin, D., Bukhari, S., Hartmann, F.J., Kagel, A., Vijayaragavan, K., Oliveria, J. P., Yakabi, K., Serrano, G., Corrada, M., Kawas, C. H., Fullaway, C., Bosse, M., Tibshirani, R., Beach, T., Angelo, M., Montine, T., & Bendall, S. (2023). Spatial proteomics reveals human microglial states shaped by anatomy and neuropathology. Research Square Platform LLC. http://dx.doi.org/10.21203/rs.3.rs-2987263/v1
6. Munson, P. V., Adamik, J., Hartmann, F. J., Favaro, P. M. B., Ho, D., Bendall, S. C., Combes, A. J., Krummel, M. F., Zhang, K., Kelley, R. K., & Butterfield, L. H. (2023). Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism. Cancer Research, 83(9), 1543–1557. https://doi.org/10.1158/0008-5472.can-22-3551
7. Robinson, M. L., Glass, D. R., Duran, V., Agudelo Rojas, O. L., Sanz, A. M., Consuegra, M., Sahoo, M. K., Hartmann, F. J., Bosse, M., Gelvez, R. M., Bueno, N., Pinsky, B. A., Montoya, J. G., Maecker, H., Estupiñan Cardenas, M. I., Villar Centeno, L. A., Garrido, E. M. R., Rosso, F., Bendall, S. C., & Einav, S. (2023). Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics. Science Advances, 9(12). https://doi.org/10.1126/sciadv.ade7702
8. Dellorusso, P. V., Proven, M. A., Calero-Nieto, F. J., Wang, X., Mitchell, C. A., Hartmann, F. J., Amouzgar, M., Favaro, P., DeVilbiss, A., Swann, J. W., Ho, T. T., Zhao, Z., Bendall, S. C., Morrison, S., Göttgens, B., & Passegué, E. (2023). Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells. bioRxiv. https://doi.org/10.1101/2023.08.17.553736
9. Adamik, J., Munson, P. V., Hartmann, F. J., Combes, A. J., Pierre, P., Krummel, M. F., Bendall, S. C., Argüello, R. J., & Butterfield, L. H. (2022). Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells. Nature Communications, 13(1), 5184. https://doi.org/10.1038/s41467-022-32849-1
10. Amouzgar, M., Glass, D. R., Baskar, R., Averbukh, I., Kimmey, S. C., Tsai, A. G., Hartmann, F. J., & Bendall, S. C. (2022). Supervised dimensionality reduction for exploration of single-cell data by HSS-LDA. Patterns, 3(8), 100536. https://doi.org/10.1016/j.patter.2022.100536
11. Geeraerts, X., Fernández-Garcia, J., Hartmann, F. J., De Goede, K. E., Martens, L., Elkrim, Y., Debraekeleer, A., Stijlemans, B., Vandekeere, A., Rinaldi, G., De Rycke, R., Planque, M., Broekaert, D., Meinster, E., Clappaert, E., Bardet, P., Murgaski, A., Gysemans, C., Nana, F. A., ... Van Ginderachter, J. A. (2021). Macrophages are metabolically heterogeneous within the tumor microenvironment. Cell Reports, 37(13), 110171. https://doi.org/10.1016/j.celrep.2021.110171
12. Alspach, E., Chow, R. D., Demehri, S., Guerriero, J. L., Gujar, S., Hartmann, F. J., Helmink, B. A., Hudson, W. H., Ho, W. J., Ma, L., Maier, B. B., Maltez, V. I., Miller, B. C., Moran, A. E., Parry, E. M., Pillai, P. S., Rafiq, S., Reina-Campos, M., Rosato, P. C., ... Zappasodi, R. (2021). Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer Immunology Research, 9(11), 1245–1251. https://doi.org/10.1158/2326-6066.CIR-21-0519
13. Hartmann, F. J., Mrdjen, D., McCaffrey, E., Glass, D. R., Greenwald, N. F., Bharadwaj, A., Khair, Z., Verberk, S. G. S., Baranski, A., Baskar, R., Graf, W., Van Valen, D., Van den Bossche, J., Angelo, M., & Bendall, S. C. (2021). Single-cell metabolic profiling of human cytotoxic T cells. Nature Biotechnology, 39(2), 186–197. https://doi.org/10.1038/s41587-020-0651-8
14. Ackerman, S. E., Pearson, C. I., Gregorio, J. D., Gonzalez, J. C., Kenkel, J. A., Hartmann, F. J., Luo, A., Ho, P. Y., LeBlanc, H., Blum, L. K., Kimmey, S. C., Luo, A., Nguyen, M. L., Paik, J. C., Sheu, L. Y., Ackerman, B., Lee, A., Li, H., Melrose, J., ... Alonso, M. N. (2020). Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity. Nature Cancer, 2(1), 18–33. https://doi.org/10.1038/s43018-020-00136-x
15. Glass, D. R., Tsai, A. G., Oliveria, J. P., Hartmann, F. J., Kimmey, S. C., Calderon, A. A., Borges, L., Glass, M. C., Wagar, L. E., Davis, M. M., & Bendall, S. C. (2020). An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity. Immunity, 53(1), 217-232.e5. https://doi.org/10.1016/j.immuni.2020.06.013
16. Hartmann, F. J., & Bendall, S. C. (2020). Immune monitoring using mass cytometry and related high-dimensional imaging approaches. Nature Reviews Rheumatology, 16(2), 87–99. https://doi.org/10.1038/s41584-019-0338-z
17. Ackerman, S. E., Pearson, C. I., Gregorio, J. D., Gonzalez, J. C., Kenkel, J. A., Hartmann, F. J., Luo, A., Ho, P. Y., LeBlanc, H., Blum, L. K., Kimmey, S. C., Luo, A., Nguyen, M. L., Paik, J. C., Sheu, L. Y., Ackerman, B., Lee, A., Li, H., Melrose, J., Laura, R. P., Ramani, V. C., Henning, K. A., Jackson, D. Y., Safina, B. S., Yonehiro, G., Devens, B. H., Carmi, Y., Chapin, S. J., Bendall, S. C., Kowanetz, M., Dornan, D., Engleman, E. G., & Alonso, M. N. (2020). Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity. Nature Cancer, 2(1), 18–33. https://doi.org/10.1038/s43018-020-00136-x
18. Galli, E.*, Hartmann, F. J.*, Schreiner, B., Ingelfinger, F., Arvaniti, E., Diebold, M., Mrdjen, D., van der Meer, F., Krieg, C., Al Nimer, F., Sanderson, N., Stadelmann, C., Khademi, M., Piehl, F., Claassen, M., Derfuss, T., Olsson, T., & Becher, B. (2019). GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis. Nature Medicine, 25(8), 1290–1300. https://doi.org/10.1038/s41591-019-0521-4
19. Hartmann, F. J., Babdor, J., Gherardini, P. F., Amir, E.-A. D., Jones, K., Sahaf, B., Marquez, D. M., Krutzik, P., O'Donnell, E., Sigal, N., Maecker, H. T., Meyer, E., Spitzer, M. H., & Bendall, S. C. (2019). Comprehensive immune monitoring of clinical trials to advance human immunotherapy. Cell Reports, 28(3), 819-831.e4. https://doi.org/10.1016/j.celrep.2019.06.049
20. Hartmann, F. J., Simonds, E. F., Vivanco, N., Bruce, T., Borges, L., Nolan, G. P., Spitzer, M. H., & Bendall, S. C. (2019). Scalable conjugation and characterization of immunoglobulins with stable mass isotope reporters for single-cell mass cytometry analysis. In Methods in Molecular Biology (pp. 55–81). Springer New York. https://doi.org/10.1007/978-1-4939-9454-0_5
21. Hartmann, F. J., Simonds, E. F., & Bendall, S. C. (2018). A universal live cell barcoding-platform for multiplexed human single cell analysis. Scientific Reports, 8(1), 10770. https://doi.org/10.1038/s41598-018-28791-2
22. Krieg, C., Nowicka, M., Guglietta, S., Schindler, S., Hartmann, F. J., Weber, L. M., Dummer, R., Robinson, M. D., Levesque, M. P., & Becher, B. (2018). High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy. Nature Medicine, 24(2), 144–153. https://doi.org/10.1038/nm.4466
23. Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., Greter, M., & Becher, B. (2018). High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease. Immunity, 48(3), 599. https://doi.org/10.1016/j.immuni.2018.02.014
24. Nowicka, M., Krieg, C., Crowell, H. L., Weber, L. M., Hartmann, F. J., Guglietta, S., Becher, B., Levesque, M. P., & Robinson, M. D. (2017). CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets. F1000Research, 6, 748. https://doi.org/10.12688/f1000research.11622.2
25. Mrdjen, D., Hartmann, F. J., & Becher, B. (2017). High dimensional cytometry of central nervous system leukocytes during neuroinflammation. In Inflammation: Methods and Protocols (pp. 321–332). Springer New York. https://doi.org/10.1007/978-1-4939-6786-5_22
26. Hartmann, F. J., Bernard-Valnet, R., Quériault, C., Mrdjen, D., Weber, L. M., Galli, E., Krieg, C., Robinson, M. D., Nguyen, X. H., Dauvilliers, Y., Liblau, R. S., & Becher, B. (2016). High-dimensional single-cell analysis reveals the immune signature of narcolepsy. The Journal of Experimental Medicine, 213(12), 2621–2633. https://doi.org/10.1084/jem.20160897
27. Mair, F., Hartmann, F. J., Mrdjen, D., Tosevski, V., Krieg, C., & Becher, B. (2015). The end of gating? An introduction to automated analysis of high dimensional cytometry data. European Journal of Immunology, 46(1), 34–43. https://doi.org/10.1002/eji.201545774
28. Croxford, A. L., Lanzinger, M., Hartmann, F. J., Schreiner, B., Mair, F., Pelczar, P., Clausen, B. E., Jung, S., Greter, M., & Becher, B. (2015). The cytokine GM-CSF drives the inflammatory signature of CCR2+ monocytes and licenses autoimmunity. Immunity, 43(3), 502–514. https://doi.org/10.1016/j.immuni.2015.08.010
29. Hartmann, F. J., Khademi, M., Aram, J., Ammann, S., Kockum, I., Constantinescu, C., Gran, B., Piehl, F., Olsson, T., Codarri, L., & Becher, B. (2014). Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells. Nature Communications, 5, 5056. https://doi.org/10.1038/ncomms6056
30. Schmidt, H. H., Ge, Y., Hartmann, F. J., Conrad, H., Klug, F., Nittel, S., Bernhard, H., Domschke, C., Schuetz, F., Sohn, C., & Beckhove, P. (2013). HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients. OncoImmunology, 2(6), e24962. https://doi.org/10.4161/onci.24962
31. Parmentier, J., Hartmann, F. J., & Fricker, G. (2010). In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules. European Journal of Pharmaceutics and Biopharmaceutics, 76(3), 394–403. https://doi.org/10.1016/j.ejpb.2010.09.002