Scientific Core Facilities and Services
Scientists at DKFZ and its partner sites have access to a broad portfolio of research infrastructures, including Core Facilities, as well as data management and IT-services. Core Facilities provide access to cutting-edge instrumentation, user support, and technology development. Data management and IT-ervices address IT infrastructure needs and offer tools for organizing and managing research data properly.
News from our Core Facilities
Dear User of the Light Microscopy Core Facility,
We are pleased to unveil our latest addition: the Leica LMD7 laser microdissection system!
The Leica LMD7 is an advanced laser microdissection system designed for precise isolation of specific cells or tissue regions from complex biological samples. It employs a high-precision UV laser to cut and separate selected microscopic areas without physical contact, minimizing contamination or damage to the surrounding tissue. The cut-out regions are then collected via gravity into a collection device for downstream molecular analysis, such as genomics (DNA/RNA), proteomics, or metabolomics.
The LMD7 is located in room S1.111a in TP4. Please contact Mahsa Shakouri for more information or to arrange a training session.
Kind regards,
Your LMCF
Below, the DKFZ Core Facilities are listed according to their area of specialty.
Genome, Transcriptome & Epigenome
The NGS Core Facility offers state-of-the-art DNA, RNA and bisulfite sequencing using Illumina MiSeq, NextSeq and NovaSeq technologies as well as Oxford Nanopore technologies.
More info about the Next Generation Sequencing Core Facility
The Microarray Core Facility provides state-of-the-art microarray technologies for Expression Profiling, Methylation Analysis, Genotyping/Copy-Number-Variation(CNV). High-throughput protein analysis utilizing cutting-edge Olink® technology, kinase activity profiling as well as assisted access to ddPCR and qPCR instruments and Ingenuity are also part of our service portfolio.
The Single-cell Open Lab provides an infrastructure for processing cells, preparing libraries for single-cell sequencing as well as spatial omics.
Proteome
The unit provides mass spectrometry based Proteomics. State-of-the-art hardware in combination with specialized workflows allows most sensitive and in-depth Proteome analysis.
The Single-cell Open Lab provides an infrastructure for processing cells, preparing libraries for single-cell sequencing as well as spatial omics.
The Microarray Core Facility provides state-of-the-art microarray technologies for Expression Profiling, Methylation Analysis, Genotyping/Copy-Number-Variation(CNV). High-throughput protein analysis utilizing cutting-edge Olink® technology, kinase activity profiling as well as assisted access to ddPCR and qPCR instruments and Ingenuity are also part of our service portfolio.
The Antibodies Core Facility offers the production of monoclonal (mouse/rat) antibodies using the hybridoma technology and the production of polyclonal (guinea pig) ABs. In addition the Antibodies Core Facility offers antibody sequencing, engineering and recombinant expression.
Metabolome
The Metabolomics Core Technology Platform (MCTP) is a core facility of Heidelberg University and officially collaborates with DKFZ. It is localized within the Centre for Organismal Studies. We offer a broad range of qualitative and quantitative metabolomics services from diverse sample matrices to all DKFZ groups as internal users.
Cellular and Preclinical Imaging
The Electron Microscopy Core Facility performs experiments in full service for ultrastructural studies by TEM as well as SEM.
The Light Microscopy Core Facility offers a variety of advanced imaging-related services at several locations on the campus. We provide consultation, hands-on training, technical support and open access (24/7) to cutting-edge instrumentation and a broad range of applications.
The Small Animal Imaging Center supports users in the application of numerous radiological methods such as ultrasound, optical imaging, µPET, µCT, µSPECT and MRT measurements to collect and quantify morphological and functional data in vivo.
The service Unit for Radiopharmaceuticals and Preclinical Studies provides consultation and support in imaging and irradiation design/irradiation for preclinical studies as well as in experimental design for animal studies.
More info about the Service Unit for Radiopharmaceuticals and Preclinical Studies
Cytometry and Screening
The Immune Monitoring Unit supports oncology studies (IITs or industry-sponsored studies) of all phases using various state-of-the-art immunological analysis techniques.
The Flow Cytometry Core Facility advises and supports scientists in the planning, execution and evaluation of flow cytometry analyses and cell sorting. Modern instruments (analytical instruments and cell sorters) as well as various software are available for this purpose.
More info about the Flow Cytometry Core Facility
The Chemical Biology Core Facility is a collaboration between DKFZ and the European Molecular Biology Laboratory (EMBL) in Heidelberg, and is located at EMBL. The aim of this core facility is to provide researchers with inhibitory molecules against their target of interest and enable them to answer essential questions in their research.
More info about the Chemical Biology Core Facility
Whole Tissue Analysis
The Immune Monitoring Unit supports oncology studies (IITs or industry-sponsored studies) of all phases using various state-of-the-art immunological analysis techniques.
The Light Microscopy Core Facility offers a variety of advanced imaging-related services at several locations on the campus. We provide consultation, hands-on training, technical support and open access (24/7) to cutting-edge instrumentation and a broad range of applications.
The Single-cell Open Lab provides an infrastructure for processing cells, preparing libraries for single-cell sequencing as well as spatial omics.
Reagents and Resources for Cancer Research
The Antibodies Core Facility offers the production of monoclonal (mouse/rat) antibodies using the hybridoma technology and the production of polyclonal (guinea pig) ABs. In addition the Antibodies Core Facility offers antibody sequencing, engineering and recombinant expression.
The Cellular Tools Core Facility offers standardized vector and clone resources as well as modular services for cell-based gain- and loss-of-function technologies.
The Dieter Morszeck Biorepository is a fully automated cold storage facility in which valuable liquid biospecimens can be stored.
More info about the Dieter Morszeck Biorepository
The service Unit for Radiopharmaceuticals and Preclinical Studies provides consultation and support in imaging and irradiation design/irradiation for preclinical studies as well as in experimental design for animal studies.
More info about the Service Unit for Radiopharmaceuticals and Preclinical Studies
Animal Services
The Center for Preclinical Research (ZPF) advises and assists researchers in the design and realization of their animal experiments. It consists of four subdivisions: Central Animal Laboratory, Tumor Models, Microbiological Diagnostics and Transgene Service.
Research Data Management
The Omics IT and Data Management Core Facility (ODCF) provides high-throughput computing, data management and basic bioinformatics services to groups at the DKFZ and their collaborating partners.
More info about the Omics IT and Data Management Core Facility
Library and IT Services
The Information Technology Core Facility (ITCF) is responsible for optimum usage of IT at DKFZ, for supporting staff of all departments in matters of choosing IT tools for their special needs as well as for providing central IT Services and support which are essential for everyone at DKFZ.
The Library provides among other things scientific literature and information needed by the scientists of the German Cancer Research Center.
Enabling Technology Department
The Enabling Technology Department is headed by the Chief Enabling Technology Officer Prof. Elisa May. She oversees the following Core Facilities: Antibodies, Cellular Tools, Chemical Biology (with EMBL), Dieter Morszeck Biorepository, Electron Microscopy, Flow Cytometry, Light Microscopy, Microarray, Next Generation Sequencing, Proteomics, Single Cell OpenLab, Small Animal Imaging, and the Scullery. The Department is also involved in two projects on biomage data management: the DFG project "Information Infrastructure for BioImage Data Management – I3D:bio", and the consortium "NFDI4BioImage" in the National Research Data Infrastructure NFDI, where Prof. May serves as a Co-Speaker.
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Dr. Christian Schmidt
Scientific Project Manager Research Data Management Microscopy
+49 6221 42 2657