Next Generation Sequencing

Co-authorships of the NGS Core Facility group members are indicated in bold.

• An J. Y., Kurilov R., Peccerella T., Bergmann F., Edderkaoui M., Lim A., Zhou X., Pfütze K., Schulz A., Wolf S., Hu K., Springfeld C., Mughal S. S., Zezlina L., Fortunato F., Beyer G., Mayerle J., Roth S., Hulkkonen J., Merz D., Eii S., Mehrabi A., Loos M., Al-Saeedi M., Michalski C. W., Büchler M. W., Hackert T., Brors B., Pandol S. J., Bailey P., Neoptolemos J. P.: Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response. Transl Oncol 2024, 49:14.
• Zhou X., An J. Y., Kurilov R., Brors B., Hu K., Peccerella T., Roessler S., Pfuetze K., Schulz A., Wolf S., Hohmann N., Theile D., Sauter M., Burhenne J., Ei S., Heger U., Strobel O., Barry S. T., Springfeld C., Tjaden C., Bergmann F., Buechler M., Hackert T., Fortunato F., Neoptolemos J. P., Bailey P.: Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC. Nature Cancer 2023, 4:1362-+.
• Radke J., Ishaque N., Koll R., Gu Z. G., Schumann E., Sieverling L., Uhrig S., Hubschmann D., Toprak U. H., Lopez C., Hostench X. P., Borgoni S., Juraeva D., Pritsch F., Paramasivam N., Balasubramanian G. P., Schlesner M., Sahay S., Weniger M., Pehl D., Radbruch H., Osterloh A., Korfel A., Misch M., Onken J., Faust K., Vajkoczy P., Moskopp D., Wang Y. W., Jodicke A., Trumper L., Anagnostopoulos I., Lenze D., Kuppers R., Hummel M., Schmitt C. A., Wiestler O. D., Wolf S., Unterberg A., Eils R., Herold-Mende C., Brors B., Siebert R., Wiemann S., Heppner F. L., Consortium Icgc Mmml Seq: The genomic and transcriptional landscape of primary central nervous system lymphoma. Nature Communications 2022, 13:20.
• Pixberg C., Zapatka M., Hlevnjak M., Benedetto S., Suppelna J. P., Heil J., Smetanay K., Michel L., Fremd C., Körber V., Rübsam M., Buschhorn L., Heublein S., Schäfgen B., Golatta M., Gomez C., von Au A., Wallwiener M., Wolf S., Dikow N., Schaaf C., Gutjahr E., Allgäuer M., Stenzinger A., Pfütze K., Kirsten R., Hübschmann D., Sinn H. P., Jäger D., Trumpp A., Schlenk R., Höfer T., Thewes V., Schneeweiss A., Lichter P.: COGNITION: a prospective precision oncology trial for patients with early breast cancer at high risk following neoadjuvant chemotherapy. ESMO Open 2022, 7.
• Jahn A., Rump A., Widmann T. J., Heining C., Horak P., Hutter B., Paramasivam N., Uhrig S., Gieldon L., Drukewitz S., Kübler A., Bermudez M., Hackmann K., Porrmann J., Wagner J., Arlt M., Franke M., Fischer J., Kowalzyk Z., William D., Weth V., Oster S., Fröhlich M., Hüllein J., Valle González C., Kreutzfeldt S., Mock A., Heilig C. E., Lipka D. B., Möhrmann L., Hanf D., Oleś M., Teleanu V., Allgäuer M., Ruhnke L., Kutz O., Knurr A., Laßmann A., Endris V., Neumann O., Penzel R., Beck K., Richter D., Winter U., Wolf S., Pfütze K., Geörg C., Meißburger B., Buchhalter I., Augustin M., Aulitzky W. E., Hohenberger P., Kroiss M., Schirmacher P., Schlenk R. F., Keilholz U., Klauschen F., Folprecht G., Bauer S., Siveke J. T., Brandts C. H., Kindler T., Boerries M., Illert A. L., von Bubnoff N., Jost P. J., Metzeler K. H., Bitzer M., Schulze-Osthoff K., von Kalle C., Brors B., Stenzinger A., Weichert W., Hübschmann D., Fröhling S., Glimm H., Schröck E., Klink B.: Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers. Annals of Oncology 2022, 33:1186-1199.
• van Tilburg Cornelis M, Pfaff Elke, Pajtler Kristian W, Langenberg Karin P S, Fiesel Petra, Jones, Barbara C, Balasubramanian Gnana Prakash, Stark Sebastian, Johann Pascal D, Blattner-Johnson Mirjam, Schramm Kathrin, Dikow Nicola, Hirsch Steffen, Sutter Christian, Grund Kerstin, von Stackelberg Arend, Kulozik Andreas E, Lissat Andrej, Borkhardt Arndt, Meisel Roland, Reinhardt Dirk, Klusmann Jan-Henning, Fleischhack Gudrun, Tippelt Stephan, von Schweinitz Dietrich, Schmid Irene, Kramm Christof M, von Bueren Andre O, Calaminus Gabriele, Vorwerk Peter, Graf Norbert, Westermann Frank, Fischer Matthias, Eggert Angelika, Burkhardt Birgit, Wossmann Wilhelm, Nathrath Michaela, Hecker-Nolting Stefanie, Fruhwald Michael C, Schneider Dominik T, Brecht Ines B, Ketteler Petra, Fulda Simone, Koscielniak Ewa, Meister Michael T, Scheer Monika, Hettmer Simone, Schwab Matthias, Tremmel Roman, Ora Ingrid, Hutter Caroline, Gerber Nicolas U, Lohi Olli, Kazanowska Bernarda, Kattamis Antonis, Filippidou Maria, Goemans Bianca, Zwaan C Michel, Milde Till, Jäger Natalie, Wolf Stephan, Reuss David, Sahm Felix, von Deimling Andreas, Dirksen Uta, Freitag Angelika, Witt Ruth, Lichter Peter, Kopp-Schneider Annette, Jones David T W, Molenaar Jan J, Capper David, Pfister Stefan, Witt Olaf: The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets. Cancer Discovery 2021, 11:2764-2779.
• Reich M., Spomer L., Klindt C., Fuchs K., Stindt J., Deutschmann K., Hohne J., Liaskou E., Hov J. R., Karlsen T. H., Beuers U., Verheij J., Ferreira-Gonzalez S., Hirschfield G., Forbes S. J., Schramm C., Esposito I., Nierhoff D., Fickert P., Fuchs C. D., Trauner M., Garcia-Beccaria M., Gabernet G., Nahnsen S., Mallm J. P., Vogel M., Schoonjans K., Lautwein T., Kohrer K., Haussinger D., Luedde T., Heikenwalder M., Keitel V.: Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. Journal of Hepatology 2021, 75:634-646.
• Mikami Y., Philips R. L., Sciume G., Petermann F., Meylan F., Nagashima H., Yao C., Davis F. P., Brooks S. R., Sun H. W., Takahashi H., Poholek A. C., Shih H. Y., Afzali B., Muljo S. A., Hafner M., Kanno Y., O'Shea J. J.: MicroRNA-221 and-222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23. Immunity 2021, 54:514-+.
• Kayser S., Hills R. K., Langova R., Kramer M., Guijarro F., Sustkova Z., Estey E. H., Shaw C. M., Racil Z., Mayer J., Zak P., Baer M. R., Brunner A. M., Szotkowski T., Cetkovsky P., Grimwade D., Walter R. B., Burnett A. K., Ho A. D., Ehninger G., Muller-Tidow C., Platzbecker U., Thiede C., Rollig C., Schulz A., Warsow G., Brors B., Esteve J., Russell N. H., Schlenk R. F., Levis M. J.: Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study. British Journal of Haematology 2021, 192:832-842.
• Horak P., Heining C., Kreutzfeldt S., Hutter B., Mock A., Hullein J., Frohlich M., Uhrig S., Jahn A., Rump A., Gieldon L., Mohrmann L., Hanf D., Teleanu V., Heilig C. E., Lipka D. B., Allgauer M., Ruhnke L., Lassmann A., Endris V., Neumann O., Penzel R., Beck K., Richter D., Winter U., Wolf S., Pfutze K., Georg C., Meissburger B., Buchhalter I., Augustin M., Aulitzky W. E., Hohenberger P., Kroiss M., Schirmacher P., Schlenk R. F., Keilholz U., Klauschen F., Folprecht G., Bauer S., Siveke J. T., Brandts C. H., Kindler T., Boerries M., Illert A. L., Von Bubnoff N., Jost P. J., Spiekermann K., Bitzer M., Schulze-Osthoff K., Von Kalle C., Klink B., Brors B., Stenzinger A., Schrock E., Hubschmann D., Weichert W., Glimm H., Frohling S.: Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers. Cancer Discovery 2021, 11:2780-2795.
• Hlevnjak Mario, Schulze Markus, Elgaafary Shaymaa, Fremd Carlo, Michel Laura, Beck Katja, Pfütze Katrin, Richter Daniela, Wolf Stephan, Horak Peter, Kreutzfeldt Simon, Pixberg Constantin, Hutter Barbara, Ishaque Naveed, Hirsch Steffen, Gieldon Laura, Stenzinger Albrecht, Springfeld Christoph, Smetanay Katharina, Seitz Julia, Mavratzas Athanasios, Brors Benedikt, Kirsten Romy, Schuetz Florian, Fröhling Stefan, Sinn Hans-Peter, Jäger Dirk, Thewes Verena, Zapatka Marc, Lichter Peter, Schneeweiss Andreas: CATCH: A Prospective Precision Oncology Trial in Metastatic Breast Cancer. JCO precision oncology 2021, 5:676 - 686.
• Gutekunst J., Maiakovska O., Hanna K., Provataris P., Horn H., Wolf S., Skelton C. E., Dorn N. J., Lyko F.: Phylogeographic reconstruction of the marbled crayfish origin. Communications Biology 2021, 4:1096.
• Förster A., Brand F., Banan R., Huneburg R., Weber C. A. M., Ewert W., Kronenberg J., Previti C., Elyan N., Beyer U., Martens H., Hong B., Brasen J. H., Erbersdobler A., Krauss J. K., Stangel M., Samii A., Wolf S., Preller M., Aretz S., Wiese B., Hartmann C., Weber R. G.: Rare germline variants in the E-cadherin gene CDH1 are associated with the risk of brain tumors of neuroepithelial and epithelial origin. Acta Neuropathologica 2021, 142:191-210.
• Worst T. S., Previti C., Nitschke K., Diessl N., Gross J. C., Hoffmann L., Frey L., Thomas V., Kahlert C., Bieback K., Crigna A. T., Fricke F., Porubsky S., Westhoff N., von Hardenberg J., Nuhn P., Erben P., Michel M. S., Boutros M.: miR-10a-5p and miR-29b-3p as Extracellular Vesicle-Associated Prostate Cancer Detection Markers. Cancers 2020, 12:43.
• Li Constance H, Prokopec Stephenie D, Sun Ren X, […] Wolf Stephan, […]Veer L Van't, von Mering Christian: Sex differences in oncogenic mutational processes. Nature Communications 2020, 11:4330.
• Horak Peter, Heining Christoph, Mock Andreas, Kreutzfeldt Simon, Lassmann Andreas, Moehrmann Lino, Huellein Jennifer, Hanf Dorothea, Jahn Arne, Ruhnke Leo, Gieldon Laura, Heilig Christoph E., Teleanu Veronica, Froehlich Martina, Uhrig Sebastian, Beck Katja, Richter Daniela, Wolf Stephan, Pfuetze Katrin, Geoerg Christina, Meissburger Bettina, Klauschen Frederick, Keilholz Ulrich, Ochsenreither Sebastian, Folprecht Gunnar, Siveke Jens, Bauer Sebastian, Kindler Thomas, Brandts Christian, Boerries Melanie, Illert Anna L., von Bubnoff Nikolas, Spiekermann Karsten, Jost Philipp J., Schulze-Osthoff Klaus, Bitzer Michael, Schirmacher Peter, von Kalle Christof, Schlenk Richard F., Klink Barbara, Hutter Barbara, Huebschmann Daniel, Stenzinger Albrecht, Weichert Wilko, Schroeck Evelin, Brors Benedikt, Glimm Hanno, Froehling Stefan, German Canc Consortium Dktk: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium. In Cancer Research, vol. 80. pp. 821; 2020:821.
• Choukair D., Eberle B., Vick P., Hermanns P., Weiss B., Paramasivam N., Schlesner M., Lornsen K., Roeth R., Klutmann C., Kreis J., Hoffmann G. F., Pohlenz J., Rappold G. A., Bettendorf M.: Identification of Transient Receptor Potential Channel 4-Associated Proteinas a Novel Candidate Gene Causing Congenital Primary Hypothyroidism. Hormone Research in Paediatrics 2020, 93:16-29.
• Campbell Peter J., Getz Gad, Korbel Jan O., […] Wolf Stephan, […] Zhang Hongxin, Zhang Jiashan: Pan-cancer analysis of whole genomes. Nature 2020, 578:82-+.
• Bailey Matthew H, Meyerson William U, […] Wolf Stephan, […] , van de Vijver Marc J, Van't Veer L., von Mering Christian: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications 2020, 11:4748.
• Kayser S., Hills R. K., Langova R., Kramer M., Guijarro F., Sustkova Z., Estey E. H., Shaw C. M., Racil Z., Mayer J., Zak P., Baer M. R., Brunner A. M., Szotkowski T., Cetkovsky P., Grimwade D., Walter R. B., Burnett A. K., Ho A. D., Ehninger G., Muller-Tidow C., Platzbecker U., Thiede C., Rollig C., Schulz A, Warsow G., Brors B., Esteve J., Russell N. H., Schlenk R. F., Levis M. J., (2021) Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study. Br J Haematol, 192:832-842
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Co-authorships of the NGS Core Facility group members are indicated in bold.

• Erkek S., Johann P. D., Finetti M. A., Drosos Y., Chou H. C., Zapatka M., Sturm D., Jones D. T. W., Korshunov A., Rhyzova M., Wolf S., Mallm J. P., Beck K., Witt O., Kulozik A. E., Fruhwald M. C., Northcott P. A., Korbel J. O., Lichter P., Eils R., Gajjar A., Roberts C. W. M., Williamson D., Hasselblatt M., Chavez L., Pfister S. M., Kool M., (2019) Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell, 35:95-110 e8
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• Ott T., Kaufmann L., Granzow M., Hinderhofer K., Bartram C. R., Theiss S., Seitz A., Paramasivam N., Schulz A, Moog U., Blum M., Evers C. M., (2019) The Frog Xenopus as a Model to Study Joubert Syndrome: The Case of a Human Patient With Compound Heterozygous Variants in PIBF1. Front Physiol, 10:134
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• Chudasama P., Mughal S. S., Sanders M. A., Hubschmann D., Chung I., Deeg K. I., Wong S. H., Rabe S., Hlevnjak M., Zapatka M., Ernst A., Kleinheinz K., Schlesner M., Sieverling L., Klink B., Schrock E., Hoogenboezem R. M., Kasper B., Heilig C. E., Egerer G., Wolf S., von Kalle C., Eils R., Stenzinger A., Weichert W., Glimm H., Groschel S., Kopp H. G., Omlor G., Lehner B., Bauer S., Schimmack S., Ulrich A., Mechtersheimer G., Rippe K., Brors B., Hutter B., Renner M., Hohenberger P., Scholl C., Frohling S., (2018) Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun, 9:144
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• Dimitrov B., Himmelreich N., Hipgrave Ederveen A. L., Luchtenborg C., Okun J. G., Breuer M., Hutter A. M., Carl M., Guglielmi L., Hellwig A., Thiemann K. C., Jost M., Peters V., Staufner C., Hoffmann G. F., Hackenberg A., Paramasivam N., Wiemann S., Eils R., Schlesner M., Strahl S., Brugger B., Wuhrer M., Christoph Korenke G., Thiel C., (2018) Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab, 123:364-374
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• Grobner S. N., Worst B. C., Weischenfeldt J., Buchhalter I., Kleinheinz K., Rudneva V. A., Johann P. D., Balasubramanian G. P., Segura-Wang M., Brabetz S., Bender S., Hutter B., Sturm D., Pfaff E., Hubschmann D., Zipprich G., Heinold M., Eils J., Lawerenz C., Erkek S., Lambo S., Waszak S., Blattmann C., Borkhardt A., Kuhlen M., Eggert A., Fulda S., Gessler M., Wegert J., Kappler R., Baumhoer D., Burdach S., Kirschner-Schwabe R., Kontny U., Kulozik A. E., Lohmann D., Hettmer S., Eckert C., Bielack S., Nathrath M., Niemeyer C., Richter G. H., Schulte J., Siebert R., Westermann F., Molenaar J. J., Vassal G., Witt H., Icgc PedBrain-Seq Project, Icgc Mmml- Seq Project, Burkhardt B., Kratz C. P., Witt O., van Tilburg C. M., Kramm C. M., Fleischhack G., Dirksen U., Rutkowski S., Fruhwald M., von Hoff K., Wolf S, Klingebiel T., Koscielniak E., Landgraf P., Koster J., Resnick A. C., Zhang J., Liu Y., Zhou X., Waanders A. J., Zwijnenburg D. A., Raman P., Brors B., Weber U. D., Northcott P. A., Pajtler K. W., Kool M., Piro R. M., Korbel J. O., Schlesner M., Eils R., Jones D. T. W., Lichter P., Chavez L., Zapatka M., Pfister S. M., (2018) The landscape of genomic alterations across childhood cancers. Nature, :
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• Gutekunst J., Andriantsoa R., Falckenhayn C., Hanna K., Stein W., Rasamy J., Lyko F., (2018) Clonal genome evolution and rapid invasive spread of the marbled crayfish. Nat Ecol Evol, 2:567-573
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• Mack S. C., Pajtler K. W., Chavez L., Okonechnikov K., Bertrand K. C., Wang X., Erkek S., Federation A., Song A., Lee C., Wang X., McDonald L., Morrow J. J., Saiakhova A., Sin-Chan P., Wu Q., Michaelraj K. A., Miller T. E., Hubert C. G., Ryzhova M., Garzia L., Donovan L., Dombrowski S., Factor D. C., Luu B., Valentim C. L. L., Gimple R. C., Morton A., Kim L., Prager B. C., Lee J. J. Y., Wu X., Zuccaro J., Thompson Y., Holgado B. L., Reimand J., Ke S. Q., Tropper A., Lai S., Vijayarajah S., Doan S., Mahadev V., Minan A. F., Grobner S. N., Lienhard M., Zapatka M., Huang Z., Aldape K. D., Carcaboso A. M., Houghton P. J., Keir S. T., Milde T., Witt H., Li Y., Li C. J., Bian X. W., Jones D. T. W., Scott I., Singh S. K., Huang A., Dirks P. B., Bouffet E., Bradner J. E., Ramaswamy V., Jabado N., Rutka J. T., Northcott P. A., Lupien M., Lichter P., Korshunov A., Scacheri P. C., Pfister S. M., Kool M., Taylor M. D., Rich J. N., (2018) Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature, 553:101-105
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• Mishra R. R., Belder N., Ansari S. A., Kayhan M., Bal H., Raza U., Ersan P. G., Tokat U. M., Eyupoglu E., Saatci O., Jandaghi P., Wiemann S., Uner A., Cekic C., Riazalhosseini Y., Sahin O., (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res, 24:1987-2001
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• Paramasivam N., Granzow M., Evers C., Hinderhofer K., Wiemann S., Bartram C.R., Eils R., Schlesner M., (2018) Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data. OBM Genetics, 2:1-1
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• Saatci O., Borgoni S., Akbulut O., Durmus S., Raza U., Eyupoglu E., Alkan C., Akyol A., Kutuk O., Wiemann S, Sahin O., (2018) Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer. Oncogene, 37:2251-2269
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• Simm F., Griesbeck A., Choukair D., Weiss B., Paramasivam N., Klammt J., Schlesner M., Wiemann S., Martinez C., Hoffmann G. F., Pfaffle R. W., Bettendorf M., Rappold G. A., (2018) Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency. Genet Med, 20:728-736
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• Agaimy A., Bieg M., Michal M., Geddert H., Markl B., Seitz J., Moskalev E. A., Schlesner M., Metzler M., Hartmann A., Wiemann S, Michal M., Mentzel T., Haller F., (2017) Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas. Am J Surg Pathol, 41:195-203
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• Delacher M., Imbusch C. D., Weichenhan D., Breiling A., Hotz-Wagenblatt A., Trager U., Hofer A. C., Kagebein D., Wang Q., Frauhammer F., Mallm J. P., Bauer K., Herrmann C., Lang P. A., Brors B., Plass C., Feuerer M., (2017) Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat Immunol, :
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• Evers C., Staufner C., Granzow M., Paramasivam N., Hinderhofer K., Kaufmann L., Fischer C., Thiel C., Opladen T., Kotzaeridou U., Wiemann S., Schlesner M., Eils R., Kolker S., Bartram C. R., Hoffmann G. F., Moog U., (2017) Impact of clinical exomes in neurodevelopmental and neurometabolic disorders. Mol Genet Metab, 121:297-307
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• Haderk F., Schulz R., Iskar M., Cid L. L., Worst T., Willmund K. V., Schulz A., Warnken U., Seiler J., Benner A., Nessling M., Zenz T., Gobel M., Durig J., Diederichs S., Paggetti J., Moussay E., Stilgenbauer S., Zapatka M., Lichter P., Seiffert M., (2017) Tumor-derived exosomes modulate PD-L1 expression in monocytes. Sci Immunol, 2:
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• Heilmann K., Toth R., Bossmann C., Klimo K., Plass C., Gerhauser C., (2017) Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer. Oncogene, 36:6446-6461
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• Horak P., Klink B., Heining C., Groschel S., Hutter B., Frohlich M., Uhrig S., Hubschmann D., Schlesner M., Eils R., Richter D., Pfutze K., Georg C., Meissburger B., Wolf S., Schulz A., Penzel R., Herpel E., Kirchner M., Lier A., Endris V., Singer S., Schirmacher P., Weichert W., Stenzinger A., Schlenk R. F., Schrock E., Brors B., von Kalle C., Glimm H., Frohling S., (2017) Precision oncology based on omics data: The NCT Heidelberg experience. Int J Cancer, 141:877-886
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• Mamlouk S., Childs L. H., Aust D., Heim D., Melching F., Oliveira C., Wolf T., Durek P., Schumacher D., Blaker H., von Winterfeld M., Gastl B., Mohr K., Menne A., Zeugner S., Redmer T., Lenze D., Tierling S., Mobs M., Weichert W., Folprecht G., Blanc E., Beule D., Schafer R., Morkel M., Klauschen F., Leser U., Sers C., (2017) DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer. Nat Commun, 8:14093
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• Northcott P. A., Buchhalter I., Morrissy A. S., Hovestadt V., Weischenfeldt J., Ehrenberger T., Grobner S., Segura-Wang M., Zichner T., Rudneva V. A., Warnatz H. J., Sidiropoulos N., Phillips A. H., Schumacher S., Kleinheinz K., Waszak S. M., Erkek S., Jones D. T. W., Worst B. C., Kool M., Zapatka M., Jager N., Chavez L., Hutter B., Bieg M., Paramasivam N., Heinold M., Gu Z., Ishaque N., Jager-Schmidt C., Imbusch C. D., Jugold A., Hubschmann D., Risch T., Amstislavskiy V., Gonzalez F. G. R., Weber U. D., Wolf S., Robinson G. W., Zhou X., Wu G., Finkelstein D., Liu Y., Cavalli F. M. G., Luu B., Ramaswamy V., Wu X., Koster J., Ryzhova M., Cho Y. J., Pomeroy S. L., Herold-Mende C., Schuhmann M., Ebinger M., Liau L. M., Mora J., McLendon R. E., Jabado N., Kumabe T., Chuah E., Ma Y., Moore R. A., Mungall A. J., Mungall K. L., Thiessen N., Tse K., Wong T., Jones S. J. M., Witt O., Milde T., Von Deimling A., Capper D., Korshunov A., Yaspo M. L., Kriwacki R., Gajjar A., Zhang J., Beroukhim R., Fraenkel E., Korbel J. O., Brors B., Schlesner M., Eils R., Marra M. A., Pfister S. M., Taylor M. D., Lichter P., (2017) The whole-genome landscape of medulloblastoma subtypes. Nature, 547:311-317
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• Pei W., Feyerabend T. B., Rossler J., Wang X., Postrach D., Busch K., Rode I., Klapproth K., Dietlein N., Quedenau C., Chen W., Sauer S., Wolf S., Hofer T., Rodewald H. R., (2017) Polylox barcoding reveals haematopoietic stem cell fates realized in vivo. Nature, 548:456-460
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• Rafiullah R., Long A. B., Ivanova A. A., Ali H., Berkel S., Mustafa G., Paramasivam N., Schlesner M., Wiemann S., Wade R. C., Bolthauser E., Blum M., Kahn R. A., Caspary T., Rappold G. A., (2017) A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity. Eur J Hum Genet, 25:1324-1334
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• Ratnaparkhe M., Hlevnjak M., Kolb T., Jauch A., Maass K. K., Devens F., Rode A., Hovestadt V., Korshunov A., Pastorczak A., Mlynarski W., Sungalee S., Korbel J., Hoell J., Fischer U., Milde T., Kramm C., Nathrath M., Chrzanowska K., Tausch E., Takagi M., Taga T., Constantini S., Loeffen J., Meijerink J., Zielen S., Gohring G., Schlegelberger B., Maass E., Siebert R., Kunz J., Kulozik A. E., Worst B., Jones D. T., Pfister S. M., Zapatka M., Lichter P., Ernst A., (2017) Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis. Leukemia, :
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• Haller F., Knopf J., Ackermann A., Bieg M., Kleinheinz K., Schlesner M., Moskalev E. A., Will R., Satir A. A., Abdelmagid I. E., Giedl J., Carbon R., Rompel O., Hartmann A., Wiemann S., Metzler M., Agaimy A., (2016) Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol, 238:700-10
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