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Research

Clinical Cooperation Unit Dermato-Oncology

Prof. Dr. Jochen Sven Utikal

Primary malignant melanoma
© dkfz.de

The Clinical Cooperation Unit Dermato-Oncology is engaged in the diagnosis and therapy of skin tumors. Research results obtained are transferred directly into clinical practice. The main focus is on malignant melanoma, a tumor that originates from the pigment cells of the skin. The Clinical Cooperation Unit Dermato-Oncology conducts several translational research projects, including different Phase I-IV clinical trials, with innovative melanoma therapies. (LINK: clinical trials)

Translational research focuses on cellular plasticity of melanoma cells, target identification to overcome resistance mechanisms, immunosuppression in melanoma, and prognostic and predictive melanoma biomarker.

Contact

Prof. Dr. Jochen Sven Utikal

Dermato-Oncology (A370)

Deutsches Krebsforschungszentrum

Im Neuenheimer Feld 280

69120 Heidelberg

Tel: +49 621 383 4461

E-Mail: j.utikal@dkfz-heidelberg.de

Selected Publications

Sahin U et al., (2020). An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma. Nature, 585(7823):107-112.
Bitsch R, et al. (2022). STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice. J Immunother Cancer; 10(3):e004384.
Arkhypov I et al. (2022). HSP90? induces immunosuppressive myeloid cells in melanoma via TLR4 signaling. J Immunother Cancer, 10(9):e005551.
Steinfass T, et al. (2023). Secretogranin II influences the assembly and function of MHC class I in melanoma. Exp Hematol Oncol. 12:29.