Publications
Research Articles:
2019
Peck Barrie, Schulze Almut*. Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment. Trends Cancer 2019, 5:693-703. Journal Article (Review Article)
2020
De Lira Maria Nathalia, Raman Sudha Janaki, Schulze Almut*, Schneider-Schaulies Sibylle, Avota Elita: Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation. Frontiers in molecular biosciences 2020, 7:217. Journal Article
Kaymak Irem, Maier Carina R*, Schmitz Werner, Campbell Andrew D, Dankworth Beatrice, Ade Carsten P, Walz Susanne, Paauwe, Madelon, Kalogirou Charis, Marouf Hecham, Rosenfeldt, Matthias T, Gay David M, McGregor Grace H, Sansom Owen J, Schulze Almut*: Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress. Cancer Res 2020, 80:189-203. Journal Article
Rajeeve Karthika, Vollmuth Nadine, Janaki-Raman Sudha, Wulff Thomas F, Baluapuri Apoorva, Dejure Francesca R, Huber Claudia, Fink Julian, Schmalhofer Maximilian, Schmitz Werner, Sivadasan Rajeeve, Wolf Elmar, Eisenreich Wolfgang, Schulze Almut*, Seibel Jürgen, Rudel Thomas: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. Nature microbiology 2020, 5:1390-1402. Journal Article
Schulze Almut*: Cancer metabolism - An update. Molecular metabolism 2020, 33:S2212877819309494. Journal Article (Editorial)
Snaebjornsson Marteinn Thor*, Janaki-Raman Sudha, Schulze Almut*: Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer. Cell metabolism 2020, 31:62-76. Journal Article (Review Article)
Triki Mouna, Rinaldi Gianmarco, Planque Melanie, Broekaert Dorien, Winkelkotte Alina M*, Maier Carina R*, Janaki Raman Sudha, Vandekeere Anke, Van Elsen Joke, Orth Martin F, Grünewald Thomas G P*, Schulze Almut*, Fendt Sarah-Maria: mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis. Cell reports 2020, 31:107806. Journal Article
2021
Hartmann Oliver, Reissland Michaela, Maier Carina R*, Fischer Thomas, Prieto-Garcia Cristian, Baluapuri Apoorva, Schwarz Jessica, Schmitz Werner, Garrido-Rodriguez Martin, Pahor Nikolett, Davies Clare C, Bassermann Florian, Orian Amir, Wolf Elmar, Schulze Almut*, Calzado Marco A, Rosenfeldt Mathias T, Diefenbacher Markus E: Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease. Frontiers in cell and developmental biology 2021, 9:641618. Journal Article
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson M T*, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Müller A, Spahn M, Seitz A K, Frank T, Marouf H, Büchel G, Eckstein M, Kübler H, Eilers M, Saar M, Junker K, Röhrig F, Kneitz B, Rosenfeldt M T, Schulze Almut*: MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Nature Communications 2021, 12:5066. Journal Article
Peixoto Joana, Janaki-Raman Sudha, Schlicker Lisa*, Schmitz Werner, Walz Susanne, Winkelkotte Alina*, Herold-Mende Christel, Soares Paula, Schulze Almut*, Lima Jorge: Integrated Metabolomics and Transcriptomics Analysis of Monolayer and Neurospheres from Established Glioblastoma Cell Lines. Cancers 2021, 13:1327. Journal Article
Rudalska Ramona, Harbig Jule, Snaebjornsson Marteinn T*, Klotz Sabrina, Zwirner Stefan, Taranets Liudmyla, Heinzmann Florian, Kronenberger Thales, Forster Michael, Cui Wei, D'Artista Luana, Einig Elias, Hinterleitner Martina, Schmitz Werner, Dylawerska Agata, Kang Tae-Won, Poso Antti, Rosenfeldt Mathias T, Malek Nisar P, Bitzer Michael, Laufer Stefan, Pichler Bernd J, Popov Nikita, Schulze Almut*, Zender Lars, Dauch Daniel. LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer. Nature Cancer 2021, 2:201-217. Journal Article
Ruiz-Pérez María Victoria, Sainero-Alcolado Lourdes, Oliynyk Ganna, Matuschek Isabell, Balboni Nicola, Ubhayasekera S J Kumari A, Snaebjornsson Marteinn Thor*, Makowski Kamil, Aaltonen Kristina, Bexell Daniel, Serra Dolors, Nilsson Roland, Bergquist Jonas, Schulze Almut*, Arsenian-Henriksson Marie: Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma. iScience 2021, 24:102128. Journal Article
Vogel Felix Christian Eduard*, Schulze Almut*: Fatty acid synthesis enables brain metastasis. Nature cancer 2021, 2:374 - 376. Journal Article (Editorial)
2022
Barayeu Uladzimir*, Schilling Danny*, Eid Mohammad*, Xavier da Silva Thamara Nishida, Schlicker Lisa*, Mitreska Nikolina, Zapp Christopher, Gräter Frauke, Miller Aubry*, Kappl Reinhard, Schulze Almut*, Friedmann Angeli José Pedro, Dick Tobias*: Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals. Nature chemical biology 2022, 19:28-37. Journal Article
Löhr Mario, Härtig Wolfgang, Schulze Almut*, Kroiß Matthias, Sbiera Silviu, Lapa Constantin, Mages Bianca, Strobel Sabrina, Hundt Jennifer Elisabeth, Bohnert Simone, Kircher Stefan, Janaki-Raman Sudha, Monoranu Camelia-Maria: SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma? International journal of molecular sciences 2022, 23:3726. Journal Article
Mainz Laura, Sarhan Mohamed A F E, Roth Sabine, Sauer Ursula, Kalogirou Charis, Eckstein Markus, Gerhard-Hartmann Elena, Seibert Helen-Desiree, Voelker Hans-Ulrich, Geppert Carol, Rosenwald Andreas, Eilers Martin, Schulze Almut*, Diefenbacher Markus, Rosenfeldt Mathias T: Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice. Autophagy 2022, 18:1-14. Journal Article
Miyazawa Hidenobu, Snaebjörnsson Marteinn Thor*, Prior Nicole, Kafkia Eleni, Hammarén Henrik M, Tsuchida-Straeten Nobuko, Patil Kiran R, Beck Martin, Aulehla Alexander: Glycolytic flux-signaling controls mouse embryo mesoderm development. eLife 2022, 11:e83299. Journal Article
Poeller Philipp*, Schulze Almut*: Akt protein boosts cancer metabolism through a two-pronged attack. Nature 2022, 608:43-44. Journal Article (Editorial)
Schwarz Jessica Denise, Lukassen Sören, Bhandare Pranjali, Eing Lorenz, Snaebjörnsson Marteinn Thor*, García Yiliam Cruz, Kisker Jan Philipp, Schulze Almut*, Wolf Elmar: The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis. Frontiers in cell and developmental biology 2022, 10:954358. Journal Article
Vollmuth Nadine, Schlicker Lisa*, Guo Yongxia, Hovhannisyan Pargev, Janaki-Raman Sudha, Kurmasheva Naziia, Schmitz Werner, Schulze Almut*, Stelzner Kathrin, Rajeeve Karthika, Rudel Thomas: c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis. eLife 2022, 11:e76721. Journal Article
2023
Chaves-Filho Adriano B*, Schulze Almut*. Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy. Cancer Cell, doi:10.1016/j.ccell.2023.05.013 (2023). Journal Article (Editorial)
Alborzinia Hamed*, Chen Zhiyi, Yildiz Umut*, Porto Freitas Florencio, Vogel Felix C E*, Varga Julianna P, Batani*, Jasmin, Bartenhagen Christoph, Schmitz Werner, Büchel Gabriele, Michalke Bernhard, Zheng Jashuo, Meierjohann Svenja, Girardi Enrico, Espinet Elisa, Flórez Andres F, dos Santos Ancely F, Aroua Nesrine*, Cheytan Tasneem*, Haenlin Julie*, Schlicker Lisa*, da Silva Thamara N X, Przybylla Adriana*, Zeisberger Petra*, Superti-Furga Giulio, Eilers Martin, Conrad Marcus, Fabiano Marietta, Schweizer Ulrich, Fischer Mathias, Schulze Almut*, Trumpp Andreas*, Friedmann Angeli J Pedro. LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. EMBO Mol med 2023, accepted in principle. Journal Article
Maier Carina R*, Hartmann Oliver, Prieto-Garcia Cristian, Al-Shami Kamal M*, Schlicker Lisa*, Vogel Felix C E*, Haid Silke*, Klann Kevin, Buck Victoria, Munch Christian, Schmitz Werner, Einig Elias, Krenz Bastian, Calzado Marco A, Eilers Martin, Popov Nikita, Rosenfeldt Mathias T, Diefenbacher Markus E, Schulze Almut*. USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer. Cell Death Differ 2023, published online 18. May. Journal Article
Winkelkotte, Alina M*, Schulze Almut*. Palmitate paves the way to lung metastasis. Trends Cancer 2023 9: 376-378. Journal Article (Editorial)
Book Chapters
Schulze, A., Bensaad, K. & Harris, A. L. Cancer Metabolism. Oxford Textbook of Cancer Biology (2019)
Brault, C. & Schulze, A. The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells. Recent Results Cancer Res 207, 1-22, doi:10.1007/978-3-319-42118-6_1