Redox Regulation

  • Cell and Tumor Biology
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Prof. Dr. Tobias Dick

We aim to understand how tumor cells adapt to oxidative stress.

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Our Research

Redox regulation is a process by which endogenous oxidants and reductants, derived from metabolism, dynamically modify proteins (including metabolic enzymes and transcription factors) to change their functional behavior in an adaptive manner. Research in recent years has started to reveal how tumor cells sense redox changes to trigger rapid adaptation and lasting cytoprotection. 

Our group aims to understand the relevant sensing and signaling pathways, as well as the mechanisms of stress tolerance. Based on mechanistic insight, we develop tools enabling the visualization and manipulation of redox regulation inside living cells and model organisms. We employ these tools to better understand stress adaptation in both healthy and malignant situations. We are interested in intervention strategies that selectively disrupt cytoprotective mechanisms in malignant cells.

Key Publications

2025 - Nature Chemistry
2024 - Nature Communications
2023 - Nature Metabolism
2023 - Nature Chemical Biology
2022 - Nature Chemical Biology
2020 - Nature Communications
2017 - Nature Chemical Biology
2016 - Nature Chemical Biology
2015 - Nature Chemical Biology
2014 - Nature Chemical Biology
2013 - Nature Chemical Biology
2008 - Nature Methods

Team

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    Prof. Dr. Tobias Dick

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    Ilona Braspenning-Wesch

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    Laura de Cubas Landaluce

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    Lukas Lang

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    Julia Langer

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    Alexander Pattberg

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    Danny Schilling

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    Nuriza Suleimenova

Open Positions

PhD and Postdoctoral Positions

Motivated candidates with a strong success record and solid background in biochemistry and/or cellular and molecular biology are encouraged to apply via email to Tobias Dick (t.dick@dkfz.de). 

Please send your CV with grades, a list of publications, a description of research interests, and the email addresses of two referees.

 

Master Thesis Positions

We are looking for a highly motivated student to work on a Master thesis in the field of free radical biology.

Get in touch with us

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Prof. Dr. Tobias Dick

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