Tumor Progression & Metastasis

Tumor progression and metastasis are often caused by an increased angiogenesis and/or lymphangiogenesis. In order to shed further light on the contribution of vascular important molecules in tumor-associated angiogenesis and lymphangiogenesis in vivo, we are pursuing our study in different tumor models using non-invasive bioluminescence and fluorescent imaging systems. The experiments include tumor models to understand fundamental mechanisms of tumor-associated blood and lymph vessels differentiation and the mechanisms of blood and lymph borne metastatic dissemination.

• Role and characterization of new vascular differentiation molecules associated with hematogenous and lymphatic metastasis routes in a syngeneic orthotopic mammary tumor model.
• The roles of these molecules in tumor versus vascular versus stroma compartment and their respective contribution to metastasis.
• Development and characterization of tumor metastasis models to identify differential gene expression profiles of tumor cells following haematogenous versus lymphatic metastasis routes.

Please contact Prof. Dr. Hellmut Augustin for further information:

=> CV of Prof. Dr. Hellmut Augustin