Publications

2023

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice. Dev Cell. 58:2914-2929 e2917. Funk, M.C., J.G. Gleixner, F. Heigwer, D. Vonficht, E. Valentini, Z. Aydin, E. Tonin, S. Del Prete, S. Mahara, Y. Throm, J. Hetzer, D. Heide, O. Stegle, D.T. Odom, A. Feldmann, S. Haas, M. Heikenwalder, and M. Boutros. 2023.

Changes in PRC1 activity during interphase modulate lineage transition in pluripotent cells. Nat Commun. 14:180. Asenjo, H.G., M. Alcazar-Fabra, M. Espinosa-Martinez, L. Lopez-Onieva, A. Gallardo, E. Dimitrova, A. Feldmann, T. Pachano, J. Martorell-Marugan, P. Carmona-Saez, A. Sanchez-Pozo, A. Rada-Iglesias, R.J. Klose, and D. Landeira. 2023.

2022

Dimitrova, E., A. Feldmann, R.H. van der Weide, K.D. Flach, A. Lastuvkova, E. de Wit, and R.J. Klose. 2022. Distinct roles for CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction. Nat Struct Mol Biol. 29:1000-1010.

2020

A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity. Nat Commun. 11:2680. Ginno, P.A., D. Gaidatzis, A. Feldmann, L. Hoerner, D. Imanci, L. Burger, F. Zilbermann, A. Peters, F. Edenhofer, S.A. Smallwood, A.R. Krebs, and D. Schubeler. 2020.

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions. Nucleic Acids Res. 48:2942-2955. Feldmann, A., E. Dimitrova, A. Kenney, A. Lastuvkova, and R.J. Klose. 2020.

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells. Cell Rep. 30:820-835 e810. Rhodes, J.D.P., A. Feldmann, B. Hernandez-Rodriguez, N. Diaz, J.M. Brown, N.A. Fursova, N.P. Blackledge, P. Prathapan, P. Dobrinic, M.K. Huseyin, A. Szczurek, K. Kruse, K.A. Nasmyth, V.J. Buckle, J.M. Vaquerizas, and R.J. Klose. 2020.

PRC1 Catalytic Activity Is Central to Polycomb System Function. Mol Cell. 77:857-874 e859. Blackledge, N.P., N.A. Fursova, J.R. Kelley, M.K. Huseyin, A. Feldmann, and R.J. Klose. 2020.

2018

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment. Elife. 7. Dimitrova, E., T. Kondo, A. Feldmann, M. Nakayama, Y. Koseki, R. Konietzny, B.M. Kessler, H. Koseki, and R.J. Klose. 2018.

2017

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin. Cell Rep. 20:2313-2327. Brown, D.A., V. Di Cerbo, A. Feldmann, J. Ahn, S. Ito, N.P. Blackledge, M. Nakayama, M. McClellan, E. Dimitrova, A.H. Turberfield, H.K. Long, H.W. King, S. Kriaucionis, L. Schermelleh, T.G. Kutateladze, H. Koseki, and R.J. Klose. 2017.

2014

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription. Elife. 3:e01632. Di Cerbo, V., F. Mohn, D.P. Ryan, E. Montellier, S. Kacem, P. Tropberger, E. Kallis, M. Holzner, L. Hoerner, A. Feldmann, F.M. Richter, A.J. Bannister, G. Mittler, J. Michaelis, S. Khochbin, R. Feil, D. Schuebeler, T. Owen-Hughes, S. Daujat, and R. Schneider. 2014.

2013

Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions. PLoS Genet. 9:e1003994. Feldmann, A., R. Ivanek, R. Murr, D. Gaidatzis, L. Burger, and D. Schubeler. 2013.