In recent years a number of novel therapeutic strategies (kinase inhibitors, inhibitors of the anti-apoptotic molecule BCL2, monoclonal antibodies, CAR T cells, antibody-drug conjugates, and others) have been developed to treat malignant lymphoma. However – despite extensive characterization of the genome and transcriptome of lymphoma cells – predictive biomarkers have not been identified.
We aim at elucidating the signalling pathways that are actually active in the individual lymphoma patient by analyzing proteins and post-translational modifications from patient blood and lymphoma tissue. For validation of the identified pathways we use a broad spectrum of molecular biological and biochemical methods, with a focus on functional proteomics.
The concept of the Clinical Cooperation Unit is based on the idea of rapid forward and reverse translation between patient care and biomolecular research. Therefore, the group's PI is also in charge of lymphoma patients at the University Hospital Mannheim. This allows us on the one hand to analyze patient material first-hand. On the other hand, we can translate our findings back to the clinic and validate potential predictive biomarkers in lymphoma patients at first diagnosis and throughout the course of the disease.
Fabrice Lucien, Dakota Gustafson, Metka Lenassi, Bo Li, Jacob J. Teske, Eric Boilard, Katharina Clemm von Hohenberg, Juan Manual Falcón-Perez, Alice Gualerzi, Antonia Reale, Jennifer C. Jones, Cecilia Lässer, Charlotte Lawson, Irina Nazarenko, Lorraine O'Driscoll, Ryan Pink, Pia R-M Siljander, Carolina Soekmadji, An Hendrix, Joshua A Welsh, Kenneth W. Witwer, Rienk Nieuwland
Michael Dietachmayr, Abirami Rathakrishnan, Oleksandra Karpiuk, Felix von Zweydorf, Thomas Engleitner, Vanesa Fernandez-Sáiz, Petra Schenk, Marius Ueffing, Roland Rad, Martin Eilers, Christian Johannes Gloeckner, Katharina Clemm von Hohenberg* and Florian Bassermann* *equal contribution
Katharina Engel*, Martina Rudelius, Jolanta Slawska, Laura Jacobs, Behnaz Ahangarian Abhari, Bettina Altmann, Julia Kurutz, Abirami Rathakrishnan, Vanesa Fernández-Sáiz, Andrä Brunner, Bianca-Sabrin Targosu, Felicia Loewecke, Christian Johannes Gloeckner, Maris Ueffing, Simone Fulda, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Ulrich Keller, Philipp J. Jost, Andreas Rosenwald, Christian Peschl, Florian Bassermann *Katharina Engel is the maiden name of Katharina Clemm von Hohenberg
