Immunogenomics Team

Only very recently have immunology questions begun to be addressed by systems biology approaches, generating enormous datasets that can be challenging to understand. The immunogenomics team is involved in implementing these cutting edge methods within the lab, and applying them to improve patient therapy.  Our interests include:

               Diagnostics (HLA typing from NGS data, TCR repertoire analysis)

               CRISPR (whole genome library screening)

               Therapy (cancer vaccine development and delivery)

               Model development (for lab based studies)

The Immunogenomics team welcomes applications from prospective PhD students or postdocs with a passion for personalised therapeutics, who have previous experience in either coding (R/Python), single cell analysis, high throughput screening (minimum 96 well based assays, ideally larger formats or pooled approaches), or T cell immunology.

• Edward Green, Phd - Team leader
• Chin Leng Tan, PhD - PostDoc
• Tamara Borschert, PhD - PostDoc
• Marie-Therese Neuhoff, M. Sc. - Phd Student
• Clàudia Maldonado Torres - Technical assistance
• Lucas Arnoldt, Student Assistent

• Tan CL, Lindner K, Boschert T, Meng Z, Rodriguez Ehrenfried A, De Roia A, Haltenhof G, Faenza A, Imperatore F, Bunse L, Lindner JM, Harbottle RP, Ratliff M, Offringa R, Poschke I, Platten M, Green EW. Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy. Nature Biotechnology. 2024
• Boschert T, Kromer K, Lerner T, Lindner K, Haltenhof G, Tan CL, Jähne K, Poschke I, Bunse L, Eisele P, Grassl N, Mildenberger I, Sahm K, Platten M, Lindner JM, Green EW H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a
  recovered patient. Science Advances. 2024
• Kyriacou CP, Dowse HB, Zhang L, Green EW. A Computational Error and Restricted Use of Time-series Analyses Underlie the Failure to Replicate period-Dependent Song Rhythms in Drosophila. Journal of Biological Rhythms. 2020
• Hilf N*, Kuttruff-Coqui S*, Frenzel K, Bukur V, Stevanovic S, Gouttefangeas C, Platten M, Tabatabai G, Dutoit V, van der Burg SH, thor Straten P, Martínez-Ricarte F, Ponsati B, Okada H, Lassen U, Admon A, Ottensmeier CH, Ulges A, Kreiter S, von Deimling A, Skardelly M, Migliorini D, Kroep JR, Idorn M, Rodon J, Piro J, Poulsen HS, Shraibman B, McCann K, Mendrzyk R, Löwer M, Stieglbauer M, Britten C, Capper D, Welters MJP, Sahuquillo J, Kiesel K, Derhovanessian E, Rusch E, Bunse L, Song C, Heesch S, Wagner C, Kemmer-Brueck A, Ludwig J, Castle JC, Schoor O, Tadmor A, Green E, Fritsche J, Meyer M, Pawlowski N, Dorner S, Hoffgaard F, Rössler B, Maurer D, Weinschenk T, Reinhardt S, Huber C, Rammensee HG, Singh H, Sahin U, Dietrich PY, Wick W. Actively personalized vaccination in newly diagnosed glioblastoma. Nature. 2019
• Green EW, Bunse L, Bozza M, Sanghvi K, Platten M. TCR validation toward gene therapy for cancer. Methods Enzymol. 2019
• Bunse L, Green EW, Platten M. High-throughput discovery of cancer-targeting TCRs. Methods Enzymol. 2019
• Bunse L*, Pusch S*, Bunse T*, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger M, Harter P, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende CM, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suva M, Niemeyer BA, von Deimling A, Wick W, Platten M. Suppression of antitumor T cell immunity by the oncometabolite R-2-hydroxyglutarate. Nat Med. 2018
• Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliviera AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat Commun. 2018 
• Green EW, Fedele G, Giorgini F, Kyriacou CP. A Drosophila RNAi collection is subject to dominant phenotypic effects. Nat Methods. 2014
• Fedele G, Green EW, Rosato E, Kyriacou CP. An electromagnetic field disrupts negative geotaxis in Drosophila via a CRY-dependent pathway. Nat Commun. 2014
• Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R, Kyriacou CP. Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. Nature. 2012
• Edgar RS*, Green EW*, Zhao Y*, van Ooijen G*, Olmedo M*, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O'Neill JS, Reddy AB. Peroxiredoxins are conserved markers of circadian rhythms. Nature. 2012 *Authors contributed equally.