We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential enable/disable

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name	Webedition CMS
Purpose	This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name	econda
Purpose	Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

Statistics enable/disable

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name	econda
Purpose	Statistics

External media enable/disable

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name	YouTube
Purpose	Show YouTube content
Name	Twitter
Purpose	activate Twitter Feeds

Research

Molecular principles in neural stem cells, neurogenesis and brain diseases

Coexpression of the stem cell specific transcription factor Sox2 (red) and the chromatin remodeler CHD7 in neural stem cells
© Haikun Liu, Ph.D.

We generated a series of mouse models and human organoid models that allow us to precisely manipulate gene expression in neural stem cells and brain tumor stem cells. In this project, we are dedicated to unravel how the dynamic transcriptional regulations are involved in regulating the identity, activity and fate of NSCs. We are systematically analyzing the role of essential transcription factors and chromatin regulators in neurogenesis in order to generalize the molecular principles of cell identity determination. In particular we are interested in studying transcription regulators like Nr2e1 and Chd7 which are mutated in human neurological disorders and brain cancers.