Immunoproteomics

Currently, the research group harbours several high-resolution mass spectrometry instrument platforms, including three timsTOF Pro-2, one timsTOF SCP (Bruker) and two Orbitraps Exploris 480 (Thermo Scientific). With these high-performance instruments, the Tenzer research group investigates the contribution of proteases involved in MHC-I-restricted antigen processing and develops high sensitivity methods and workflows for the in-depth characterization of the immunopeptidome. This will enable high-throughput immuno-phenotyping of quantity-limited clinical samples to define biomarkers and neoantigen targets for individualized immunotherapies.