Publications

• 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Gülcüler Balta GS, Monzel C, Kleber S, Beaudouin J, Balta E, Kaindl T, Chen S, Gao L, Thiemann M, Wirtz CR, Samstag Y,Tanaka M, Martin-Villalba A. 2019. Cell Reports. 29(8) 2295-2306. DOI: 10.1016/j.celrep.2019.10.054.
• Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. 2019. Cell. pii: S0092-8674(19)30103-5. DOI: 10.1016/j.cell.2019.01.040
• Onset of differentiation is post-transcriptionally controlled in adult neural stem cells. Baser A, Skabkin M, Kleber S, Dang Y, Gülcüler Balta G, Kalamakis G, Göpferich M, Carvajal Ibañez D, Schefzik R, Santos Lopez A, Llorens Bobadilla E, Schultz C, Fischer B and Martin-Villalba A. 2019. Nature 566:100-104. doi: 10.1038/s41586-019-0888-x.
• Cell-cell contact dictates life or death decisions following CD95 activation in cancer. Gulculer Balta GS, Monzel C, Kleber S, Beaudouin J, Kaindl T, Thiemann M, Wirtz CR, Tanaka M, Martin-Villalba A. 2018. bioRxiv. DOI: 10.1101/308346

• Cell-cell contact dictates life or death decisions following CD95 activation in cancer. Gulculer Balta GS, Monzel C, Kleber S, Beaudouin J, Kaindl T, Thiemann M, Wirtz CR, Tanaka M, Martin-Villalba A. 2018. bioRxiv. DOI: 10.1101/308346
• An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury. Sascha Dehler, Wilson Pak-Kin Lou, Liang Gao, Maxim Skabkin, Sabrina Dällenbach, Andreas Neumann and Ana Martin-Villalba. Front. Mol. Neurosci., DOI: 10.3389/fnmol.2018.00443
• Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1. Lou WP-K , Mateos A , Koch M , Klussman S, Yang C, Lu N, Kumar S, Limpert S, Göpferich M, Zschaetzsch M, Sliwinski C, Kenzelmann M, Seedorf M, Maillo C, Senis E, Grimm D, Puttagunta R, Mendez R, Liu K, Hassan BA and Martin-Villalba A. 2018, Journal: Frontiers in Molecular Neuroscience 10, Article 445. DOI: 10.3389/fnmol.2017.00445
• Revealing age-related changes of adult hippocampal neurogenesis using mathematical models. Ziebell F, Dehler S, Martin-Villalba A, Marciniak-Czochra A. 2018 Journal: Development 145(1):pii: dev153544. DOI: 10.1242/dev.153544.

• CNS Macrophages Control Neurovascular Development via CD95L. Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A. Cell Reports 19(7):1378-1393. 2017. DOI: 10.1016/j.celrep.2017.04.056.
• Neural Stem Cell Activation and the Role of Protein Synthesis. Avni Baser, Maxim Skabkin and Ana Martin-Villalba. Brain Plasticity 3, 27–41. DOI 10.3233/BPL-160038.

• Adult NSC diversity and plasticity: the role of the niche. Llorens-Bobadilla E, Martin-Villalba A. Current Opinion in Neurobiology 42:68-74. 2016. DOI: 10.1016/j.conb.2016.11.008.

• Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex. Bifari F *, Decimo I *, Pino A, Llorens-Bobadilla E, Zhao S, Lange C, Panuccio G, Boeckx B, Thienpont B, Vinckier S, Wyns S, Bouché A, Lambrechts D, Giugliano M, Dewerchin M, Martin-Villalba A, Carmeliet P †. Cell Stem Cell 20(3):360–373. 2016. DOI: 10.1016/j.stem.2016.10.020.

• Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas. Wollny D, Zhao S, Everlien I, Lun X, Brunken J, Brüne D, Ziebell F, Tabansky I, Weichert W, Marciniak-Czochra A, Martin-Villalba A. Developmental Cell 39(3). 2016. DOI: 10.1016/j.devcel.2016.10.002.

• RNA-seq library preparation from single pancreatic acinar cells. Wollny D, Zhao S, Martin-Villalba A. bioRxiv. 2016. DOI: 10.1101/085696.

• Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion. Gao L, Gülcüler GS, Golbach L, Block H, Zarbock A, Martin-Villalba A. eLife 5. 2016. DOI: 10.7554/eLife.18542.

• CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells. Drachsler M *, Kleber S *, Mateos A, Volk K, Mohr N, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz CR, Mueller W, Synowitz M, Martin-Villalba A. Cell Death & Disease 7, e2209. 2016. DOI: 10.1038/cddis.2016.102.

• Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury. Llorens-Bobadilla E, Zhao S, Baser A, Saiz-Castro G, Zwadlo K, Martin-Villalba A. Cell Stem Cell 17(3):329-40. 2015. DOI: 10.1016/j.stem.2015.07.002.

• Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice.Gao L, Brenner D, Llorens-Bobadilla E, Saiz-Castro G, Frank T, Wieghofer P, Hill O, Thiemann M, Karray S, Prinz M, Weishaupt JH, Martin-Villalba A.J Exp Med. 2015 Mar 16. pii: jem.20132423. [Epub ahead of print]

• CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.Teodorczyk M, Kleber S, Wollny D, Sefrin JP, Aykut B, Mateos A, Herhaus P, Sancho-Martinez I, Hill O, Gieffers C, Sykora J, Weichert W, Eisen C, Trumpp A, Sprick MR, Bergmann F, Welsch T, Martin-Villalba A.Cell Death Differ. 2015 Jan 23. doi: 10.1038/cdd.2014.217. [Epub ahead of print]

• Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.Mracsko E, Liesz A, Stojanovic A, Lou WP, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R.J Neurosci. 2014 Dec 10;34(50):16784-95. doi: 10.1523/JNEUROSCI.1867-14.2014.

• Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review.Seib DR, Martin-Villalba A.Gerontology. 2014 Nov 29.

• Inflammatory dysregulation of blood monocytes in Parkinson's disease patients.Grozdanov V, Bliederhaeuser C, Ruf WP, Roth V, Fundel-Clemens K, Zondler L, Brenner D, Martin-Villalba A, Hengerer B, Kassubek J, Ludolph AC, Weishaupt JH, Danzer KM.Acta Neuropathol. 2014 Nov;128(5):651-63. doi: 10.1007/s00401-014-1345-4. Epub 2014 Oct 5.

• In vivo interrogation of central nervous system translatome by polyribosome fractionation.Lou WP, Baser A, Klußmann S, Martin-Villalba A.J Vis Exp. 2014 Apr 30;(86). doi: 10.3791/51255.

• Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells. Ziebell F, Martin-Villalba A, Marciniak-Czochra A.J R Soc Interface. 2014 Mar 5;11(94):20140144. doi: 10.1098/rsif.2014.0144. Print 2014 May 6.

• CD95 in Cancer: Tool or Target? Martin-Villalba, Ana, Enric Llorens-Bobadilla, and Damian Wollny. Trends in Molecular Medicine (March 26, 2013).

• Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline. Seib, Désirée R M, Nina S Corsini, Kristina Ellwanger, Christian Plaas, Alvaro Mateos, Claudia Pitzer, Christof Niehrs, Tansu Celikel, and Ana Martin-Villalba. Cell Stem Cell 12, no. 2 (February 7, 2013): 204–214.

2011

• Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.Zhang M, Kleber S, Röhrich M, Timke C, Han N, Tuettenberg J, Martin-Villalba A, Debus J, Peschke P, Wirkner U, Lahn M, Huber PE.Cancer Res. 2011 Dec 1;71(23):7155-67. doi: 10.1158/0008-5472.CAN-11-1212. Epub 2011 Oct 17.

• A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.Milde T, Kleber S, Korshunov A, Witt H, Hielscher T, Koch P, Kopp HG, Jugold M, Deubzer HE, Oehme I, Lodrini M, Gröne HJ, Benner A, Brüstle O, Gilbertson RJ, von Deimling A, Kulozik AE, Pfister SM, Martin-Villalba A, Witt O.Acta Neuropathol. 2011 Nov;122(5):637-50. doi: 10.1007/s00401-011-0866-3. Epub 2011 Aug 24.

• Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis.Ribeiro D, Ellwanger K, Glagow D, Theofilopoulos S, Corsini NS, Martin-Villalba A, Niehrs C, Arenas E.PLoS One. 2011 Feb 11;6(2):e15786. doi: 10.1371/journal.pone.0015786.

• Integrin Alpha 6: Anchors Away for Glioma Stem Cells. Corsini NS, Martin-Villalba A. Cell Stem Cell. 2010 May 7;6(5):403-4.

• The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury. Pitzer C, Klussmann S, Krüger C, Letellier E, Plaas C, Dittgen T, Kirsch F, Stieltjes B, Weber D, Laage R, Martin-Villalba A, Schneider A. J Neurochem. 2010 May;113(4):930-42. Epub 2010 Feb 25.

• CD95-Ligand on Peripheral Myeloid Cells Activates Syk Kinase to Trigger Their Recruitment to the Inflammatory Site. Letellier E, Kumar S, Sancho-Martinez I, Krauth S, Funke-Kaiser A, Laudenklos S, Konecki K, Klussmann S, Corsini NS, Kleber S, Drost N, Neumann A, Lévi-Strauss M, Brors B, Gretz N, Edler L, Fischer C, Hill O, Thiemann M, Biglari B, Karray S, Martin-Villalba A. Immunity. 2010 Feb 26;32(2):240-252. Epub 2010 Feb 11.

• Teodorczyk M, Martin-Villalba A. Sensing invasion: cell surface receptors driving spreading of glioblastoma. J Cell Physiol. 2010 Jan;222(1):1-10.

• Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A. The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell. 2009 Aug 7;5(2):178-90.

• Sancho-Martinez I, Martin-Villalba A. Tyrosine phosphorylation and CD95: a FAScinating switch. Cell Cycle. 2009 Mar 15;8(6):838-42. Epub 2009 Mar 22. Review.

• Mora R, Abschuetz A, Kees T, Dokic I, Joschko N, Kleber S, Geibig R, Mosconi E, Zentgraf H, Martin-Villalba A, Régnier-Vigouroux A. TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia. Glia. 2009 Apr 1;57(5):561-81.

• Martin-Villalba A, Okuducu AF, von Deimling A. The Evolution of Our Understanding on Glioma. Brain Pathol. 2008 Mar 26

• Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Gröne HJ, Ganten TM, Sültmann H, Tüttenberg J, von Deimling A, Regnier-Vigouroux A, Herold-Mende C, Martin-Villalba A. Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell. 2008 Mar;13(3):235-48.

• Letellier E, Martin-Villalba A. Spinal cord injuries entering the Fas(t) lane. Neurosurgery. 2007 Jun;60(6):N6-7.

• Stieltjes B, Klussmann S, Bock M, Umathum R, Mangalathu J, Letellier E, Rittgen W, Edler L, Krammer PH, Kauczor HU, Martin-Villalba A, Essig M. Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice. Magn Reson Med. 2006 May;55(5):1124-31.

• Kuhn A, Herrmann M, Kleber S, Beckmann-Welle M, Fehsel K, Martin-Villalba A, Lehmann P, Ruzicka T, Krammer PH, Kolb-Bachofen V. Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum. 2006 Mar;54(3):939-50.

• Zuliani C, Kleber S, Klussmann S, Wenger T, Kenzelmann M, Schreglmann N, Martinez A, del Rio JA, Soriano E, Vodrazka P, Kuner R, Groene HJ, Herr I, Krammer PH, Martin-Villalba A. Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ. 2006 Jan;13(1):31-40.

• Jennemann R, Sandhoff R, Wang S, Kiss E, Gretz N, Zuliani C, Martin-Villalba A, Jager R, Schorle H, Kenzelmann M, Bonrouhi M, Wiegandt H, Grone HJ. Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12459-64. Epub 2005 Aug 18.

• Klussmann S, Martin-Villalba A. Molecular targets in spinal cord injury. J Mol Med. 2005 Sep;83(9):657-71. Epub 2005 Aug 2. Review.

• Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grunewald S, Kuner R, Weber D, Kruger C, Klaussner B, Gotz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M. Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4. J Neurochem. 2004 Mar;88(5):1114-26.

• Demjen D, Klussmann S, Kleber S, Zuliani C, Stieltjes B, Metzger C, Hirt UA, Walczak H, Falk W, Essig M, Edler L, Krammer PH, Martin-Villalba A. Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nat Med. 2004 Apr;10(4):389-95. Epub 2004 Mar 7.

• Winter C, Weiss C, Martin-Villalba A, Zimmermann M, Schenkel J. JunB and Bcl-2 overexpression results in protection against cell death of nigral neurons following axotomy. Brain Res Mol Brain Res. 2002 Aug 15;104(2):194-202.

• Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schutz G. Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May;31(1):47-54. Epub 2002 Apr 22.

• Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel J, Krammer PH. Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke. Cell Death Differ. 2001 Jul;8(7):679-86.

• Jeremias I, Kupatt C, Martin-Villalba A, Habazettl H, Schenkel J, Boekstegers P, Debatin KM. Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia. Circulation. 2000 Aug 22;102(8):915-20.

• Martin-Villalba A, Herr I, Jeremias I, Hahne M, Brandt R, Vogel J, Schenkel J, Herdegen T, Debatin KM. CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J Neurosci. 1999 May 15;19(10):3809-17.

• Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med. 1999 May;5(5):554-9.

• Herr I, Martin-Villalba A, Kurz E, Roncaioli P, Schenkel J, Cifone MG, Debatin KM. FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. Brain Res. 1999 May 1;826(2):210-9.

• Martin-Villalba A, Winter C, Brecht S, Buschmann T, Zimmermann M, Herdegen T. Rapid and long-lasting suppression of the ATF-2 transcription factor is a common response to neuronal injury. Brain Res Mol Brain Res. 1998 Nov 20;62(2):158-66.

• Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci. 1998 Jul 15;18(14):5124-35.

• Buschmann T, Martin-Villalba A, Kocsis JD, Waxman SG, Zimmermann M, Herdegen T. Expression of Jun, Fos, and ATF-2 proteins in axotomized explanted and cultured adult rat dorsal root ganglia. Neuroscience. 1998 May;84(1):163-76.

• Brecht S, Martin-Villalba A, Zuschratter W, Bravo R, Herdegen T. Transection of rat fimbria-fornix induces lasting expression of c-Jun protein in axotomized septal neurons immunonegative for choline acetyltransferase and nitric oxide synthase. Exp Neurol. 1995 Jul;134(1):112-25.