Publications Antibodies Core Facility
Selected references: Antibodies produced by the Antibodies Core Facility
Kim M., Reidenbach S., Schlechter T., Rothmann AC., Will R., Hofmann I. Plakophilin 1-deficient cells up-regulate cytokine expression and this correlates with immune cell recruitment in prostatic tumors. (2023) FEBS Apr.290(7)1907-1919 PMID: 36380691
Nikitina E, Burk-Körner A, Wiesenfarth M, Alwers E, Heide D, Tessmer C, Ernst C, Krunic D, Schrotz-King P, Chang-Claude J, von Winterfeld M, Herpel E, Brobeil A, Brenner H, Heikenwalder M, Hoffmeister M, Kopp-Schneider A, Bund T. Bovine meat and milk factor protein expression in tumor-free mucosa of colorectal cancer patients coincides with macrophages and might interfere with patient survival. (2023) Mol Oncol. Feb 22. PMID: 36811271 doi: 10.1002/1878-0261.13390
Nikitina E., Alikhanyan K., Neßling M., Richter K., Kaden S., Ernst C., Seitz S., Chuprikova L., Häfele L., Gunst K., Rahbari N., Birgin E., Rasbach E. , Rahbari M., Brobeil A., Schenk M., Büchler M., de Villiers E., Bund T., Zur Hausen H. Structural expression of bovine milk and meat factors in tissues of colorectal, lung and pancreatic cancer patients. (2022) Int J Cancer Nov 28 ;153(1):173-182 PMID: 36444499
Phillips E., Balss J., Bethke F., Pusch S., Christen S., Hielscher T., Schnölzer M., Fletcher MNC., Habel A., Tessmer C., Brenner LM., Göttmann M., Capper D., Herold-Mende C., von Deimling A., Fendt SM., Goidts V. PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma. Oncogenesis. 2022 Sep 17;11(1):57 PMID: 36444499
Vit G, Hi A., Neugebauer N., Kraft BN., Sigismondo G., Cazzola, A., Tessmer C., Duro J., Krijgsveld J., Hofmann I., Berger M., Klüter H., Niehrs C., Nilsson J., Krämer A. Human SLFN5 and its Xenopus Laevis Ortholog regulate entry into mitosis and oocyte meiotic resumption. (2022) Cell Death Discov Dec 8;8(1):484 PMID: 36477080
Windhaber S., Xin Q., Uckeley ZM., Koch J., Obr M., Garnier C., Luengo-Guyonnot C., Duboeuf M., Schur FKM., Lozach PY. The Orthobunyavirus Germiston Enters Host Cells from Late Endosomes. (2022) J Virol. Mar 9; 96(5) PMID: 35019710
Yang D, Strobel TD, Bulkescher J, Tessmer C, Hofmann I, Hoppe-Seyler F, Hoppe-Seyler K. FAM57A (Family with Sequence Similarity 57 Member A) Is a Cell-Density-Regulated Protein and Promotes the Proliferation and Migration of Cervical Cancer Cells. Cells, 2022, 11(20), 3309 PMID: 36291175
Wohlfart D. P., Lou B., Middel C. S., Morgenstern J., Fleming T., Sticht C., Hausser I., Hell R., Hammes H. P., Szendrodi J., Nawroth P. P. and Kroll J. Accumulation of acetaldehyde in aldh2.1(-/-) zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biol, 2022, 50 102249 PMID: 35114580
Weissinger S. E., Zahn M., Marienfeld R., Tessmer C., Moldenhauer G. and Moller P. Combination of two monoclonal antibodies with SOCS1 N- and C-terminal binding sites to address SOCS1 status in B cells and B-cell lymphoma. Eur J Haematol, 2022, 108 (3):223-231 PMID: 34854137
Weisshaar N., Wu J., Ming Y., Madi A., Hotz-Wagenblatt A., Ma S., Mieg A., Hering M., Zettl F., Mohr K., Schlimbach T., Ten Bosch N., Hertel F., Muller L., Byren H., Wang M., Borgers H., Munz M., Schmitt L., van der Hoeven F., Kloz U., Carretero R., Schleussner N., Jackstadt R. F., Hofmann I. and Cui G. Rgs16 promotes antitumor CD8(+) T cell exhaustion. Sci Immunol, 2022, 7 (71):eabh1873 PMID: 35622904
Tessmer C., Plotzky C., Fees J., Welsch H., Eudenbach R., Faber M., Simon A., Angelova A., Rommelaere J., Hofmann I. and Nuesch J. P. F. Generation and Validation of Monoclonal Antibodies Suitable for Detecting and Monitoring Parvovirus Infections. Pathogens, 2022, 11 (2) PMID: 35215151
Cheung P. F., Yang J., Fang R., Borgers A., Krengel K., Stoffel A., Althoff K., Yip C. W., Siu E. H. L., Ng L. W. C., Lang K. S., Cham L. B., Engel D. R., Soun C., Cima I., Scheffler B., Striefler J. K., Sinn M., Bahra M., Pelzer U., Oettle H., Markus P., Smeets E. M. M., Aarntzen E., Savvatakis K., Liffers S. T., Lueong S. S., Neander C., Bazarna A., Zhang X., Paschen A., Crawford H. C., Chan A. W. H., Cheung S. T. and Siveke J. T. Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression. Nat Commun, 2022, 13 (1):156 PMID: 35013174
Varghese CS, Will R, Tessmer C, Hofmann I, Hessling B, Pawlita M, Höfler D. Biological activity characterization of the diagnostically relevant human papillomavirus 16 E1C RNA. (2021) Microbiology Research, 12(3), 539-552 doi: doi.org/10.3390/microbiolres12030038
Weissinger S. E., Zahn M., Marienfeld R., Tessmer C., Moldenhauer G. and Moller P. A new reliable and highly specific monoclonal antibody to detect the C-terminal region of silencer of cytokine signaling 1. Eur J Haematol, 2021, 107 (1):74-80 PMID: 33714214
Qi H., Schmohl F., Li X., Qian X., Tabler C. T., Bennewitz K., Sticht C., Morgenstern J., Fleming T., Volk N., Hausser I., Heidenreich E., Hell R., Nawroth P. P. and Kroll J. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Adv Sci (Weinh), 2021, 8 (18):e2101281 PMID: 34278746
Bund T., Nikitina E., Chakraborty D., Ernst C., Gunst K., Boneva B., Tessmer C., Volk N., Brobeil A., Weber A., Heikenwalder M., Zur Hausen H. and de Villiers E. M. Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions. Proc Natl Acad Sci U S A, 2021, 118 (12) PMID: 33723077
Woelfl F., Leger P., Oreshkova N., Pahmeier F., Windhaber S., Koch J., Stanifer M., Roman Sosa G., Uckeley Z. M., Rey F. A., Boulant S., Kortekaas J., Wichgers Schreur P. J. and Lozach P. Y. Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses. Viruses, 2020, 12 PMID: 32260371
Schmidt T. T., Sharma S., Reyes G. X., Kolodziejczak A., Wagner T., Luke B., Hofer A., Chabes A. and Hombauer H. Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio. Nucleic Acids Res, 2020, 48 (1):264-277 PMID: 31647103
Li X., Schmohl F., Qi H., Bennewitz K., Tabler C. T., Poschet G., Hell R., Volk N., Poth T., Hausser I., Morgenstern J., Fleming T., Nawroth P. P. and Kroll J. Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. Iscience, 2020, 23 (12):101763 PMID: 33251496
Kutscher L., Batora N., Okonechnikov K., Clark J., Vouri M., van Rijn S., Gearhart M., Orr B., Korshunov A., Kool M., Bardwell V., Pfister S. M., Northcott P. A. and Kawauchi D. Loss of the Transcriptional Co-Repressor Bcor Leads to Overexpression of the Growth Factor Igf2 and Shh Medulloblastoma Tumor Formation. Neuro Oncol, 2019, 21 107-107 PMCID:PMC6477224
Christians A., Poisel E., Hartmann C., von Deimling A. and Pusch S. Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation. Int J Cancer, 2019, 145 (2):461-473 PMID: 30614533
Oberacker T., Bajorat J., Ziola S., Schroeder A., Roth D., Kastl L., Edgar B. A., Wagner W., Gulow K. and Krammer P. H. Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging. FEBS Lett, 2018, 592 (13):2297-2307 PMID: 29897613
Barenz F., Kschonsak Y. T., Meyer A., Jafarpour A., Lorenz H. and Hoffmann I. Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry. Mol Biol Cell, 2018, mbcE18020115 PMID: 30354798
Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C. Stk33 is required for spermatid differentiation and male fertility in mice. Dev Biol. 2018 Jan 1; 433 (1):84-93 . doi: 10.1016/j.ydbio.2017.11.007. Epub 2017 Nov 16. PMID: 29155043
Savant S., La Porta S., Budnik A., Busch K., Hu J., Tisch N., Korn C., Valls A. F., Benest A. V., Terhardt D., Qu X., Adams R. H., Baldwin H. S., Ruiz de Almodovar C., Rodewald H. R. and Augustin H. G. The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep, 2015, 12 (11):1761-73 PMID: 26344773
Rode I., Martins V. C., Kublbeck G., Maltry N., Tessmer C., Rodewald H. R. Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus. (2015) J Immunol, 195 :5678-87 PMID: 26538393
Bar S., Rommelaere J. and Nuesch J. P. PKCeta/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis. PLoS Pathog, 2015, 11 (3):e1004703 PMID: 25742010
Schlecker E., Fiegler N., Arnold A., Altevogt P., Rose-John S., Moldenhauer G., Sucker A., Paschen A., von Strandmann E. P., Textor S. and Cerwenka A. Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30. Cancer Res, 2014, 74 (13):3429-40 PMID: 24780758
Reuss D. E., Habel A., Hagenlocher C., Mucha J., Ackermann U., Tessmer C., Meyer J., Capper D., Moldenhauer G., Mautner V., Frappart P. O., Schittenhelm J., Hartmann C., Hagel C., Katenkamp K., Petersen I., Mechtersheimer G. and von Deimling A. Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms. Acta Neuropathol, 2014, 127 (4):565-72 PMID: 24464231
Panjideh H., Muller G., Koch M., Wilde F., Scheu S., Moldenhauer G. and Lipp M. Immunotherapy of B-cell non-Hodgkin lymphoma by targeting the chemokine receptor CXCR5 in a preclinical mouse model. Int J Cancer, 2014, 135 (11):2623-32 PMID: 24729415
Hein Z., Uchtenhagen H., Abualrous E. T., Saini S. K., Janssen L., Van Hateren A., Wiek C., Hanenberg H., Momburg F., Achour A., Elliott T., Springer S. and Boulanger D. Peptide-independent stabilization of MHC class I molecules breaches cellular quality control. J Cell Sci, 2014, 127 (Pt 13):2885-97 PMID: 24806963
Fogel M., Harari A., Muller-Holzner E., Zeimet A. G., Moldenhauer G. and Altevogt P. A standardized staining protocol for L1CAM on formalin-fixed, paraffin-embedded tissues using automated platforms. Int J Biol Markers, 2014, 29 (2):e180-3 PMID: 24242293
Doberstein K., Harter P. N., Haberkorn U., Bretz N. P., Arnold B., Carretero R., Moldenhauer G., Mittelbronn M. and Altevogt P. Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT. Int J Cancer, 2014 PMID: 25230579
Diebolder P., Keller A., Haase S., Schlegelmilch A., Kiefer J. D., Karimi T., Weber T., Moldenhauer G., Kehm R., Eis-Hubinger A. M., Jager D., Federspil P. A., Herold-Mende C., Dyckhoff G., Kontermann R. E., Arndt M. A. and Krauss J. Generation of "LYmph Node Derived Antibody Libraries" (LYNDAL) for selecting fully human antibody fragments with therapeutic potential. MAbs, 2014, 6 (1):130-42 PMID: 24256717
Bretz N. P., Salnikov A. V., Doberstein K., Garbi N., Kloess V., Joumaa S., Naumov I., Boon L., Moldenhauer G., Arber N. and Altevogt P. Lack of CD24 expression in mice reduces the number of leukocytes in the colon. Immunol Lett, 2014, 161 (1):140-8 PMID: 24956310
Bergmann F., Aulmann S., Sipos B., Kloor M., von Heydebreck A., Schweipert J., Harjung A., Mayer P., Hartwig W., Moldenhauer G., Capper D., Dyckhoff G., Freier K., Herpel E., Schleider A., Schirmacher P., Mechtersheimer G., Kloppel G. and Blaker H. Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases. Virchows Arch, 2014 PMID: 25298229
Zhu Z. L., Yan B. Y., Zhang Y., Yang Y. H., Wang M. W., Zentgraf H., Zhang X. H. and Sun X. F. Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma. Dis Markers, 2013, 35 (3):195-202 PMID: 24167366
Swiersy A., Wiek C., Zentgraf H. and Lindemann D. Characterization and manipulation of foamy virus membrane interactions. Cell Microbiol, 2013, 15 (2):227-36 PMID: 23051660
Momburg F., Watzl C. and Cerwenka A. NK cells--versatile tools for viral defense and cancer treatment. Eur J Immunol, 2013, 43 (4):860-3 PMID: 23592381
Maier B., Kirsch M., Anderhub S., Zentgraf H. and Kramer A. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle, 2013, 12 (9):1457-71 PMID: 23574715
Mahmutefendic H., Zagorac G. B., Tomas M. I., Groettrup M., Momburg F. and Lucin P. Endosomal trafficking of open Major Histocompatibility Class I conformers--implications for presentation of endocytosed antigens. Mol Immunol, 2013, 55 (2):149-52 PMID: 23200229
Kuhns S., Schmidt K. N., Reymann J., Gilbert D. F., Neuner A., Hub B., Carvalho R., Wiedemann P., Zentgraf H., Erfle H., Klingmuller U., Boutros M. and Pereira G. The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. J Cell Biol, 2013, 200 (4):505-22 PMID: 23400999
Heid H., Rickelt S., Zimbelmann R., Winter S., Schumacher H. and Dorflinger Y. Lipid droplets, perilipins and cytokeratins--unravelled liaisons in epithelium-derived cells. PLoS One, 2013, 8 (5):e63061 PMID: 23704888
Franke W. W., Heid H., Zimbelmann R., Kuhn C., Winter-Simanowski S., Dorflinger Y., Grund C. and Rickelt S. Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells. Cell Tissue Res, 2013, 353 (1):99-115 PMID: 23689684
Beutler N., Hauka S., Niepel A., Kowalewski D. J., Uhlmann J., Ghanem E., Erkelenz S., Wiek C., Hanenberg H., Schaal H., Stevanovic S., Springer S., Momburg F., Hengel H. and Halenius A. A natural tapasin isoform lacking exon 3 modifies peptide loading complex function. Eur J Immunol, 2013, 43 (6):1459-69 PMID: 23519916
Vulprecht J., David A., Tibelius A., Castiel A., Konotop G., Liu F., Bestvater F., Raab M. S., Zentgraf H., Izraeli S. and Kramer A. STIL is required for centriole duplication in human cells. J Cell Sci, 2012, 125 (Pt 5):1353-62 PMID: 22349705
Schmidt K. N., Kuhns S., Neuner A., Hub B., Zentgraf H. and Pereira G. Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis. J Cell Biol, 2012, 199 (7):1083-101 PMID: 23253480
Schmetzer O., Moldenhauer G., Nicolaou A., Schlag P., Riesenberg R. and Pezzutto A. Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms. Immunol Lett, 2012, 143 (2):184-92 PMID: 22387297
Schafer H., Geismann C., Heneweer C., Egberts J. H., Korniienko O., Kiefel H., Moldenhauer G., Bachem M. G., Kalthoff H., Altevogt P. and Sebens S. Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent. Carcinogenesis, 2012, 33 (1):84-93 PMID: 22095073
Salnikov A. V., Liu L., Platen M., Gladkich J., Salnikova O., Ryschich E., Mattern J., Moldenhauer G., Werner J., Schemmer P., Buchler M. W. and Herr I. Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential. PLoS One, 2012, 7 (9):e46391 PMID: 23050024
Rausch V., Liu L., Apel A., Rettig T., Gladkich J., Labsch S., Kallifatidis G., Kaczorowski A., Groth A., Gross W., Gebhard M. M., Schemmer P., Werner J., Salnikov A. V., Zentgraf H., Buchler M. W. and Herr I. Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. J Pathol, 2012, 227 (3):325-35 PMID: 22262369
Pieperhoff S., Rickelt S., Heid H., Claycomb W. C., Zimbelmann R., Kuhn C., Winter-Simanowski S., Kuhn C., Frey N. and Franke W. W. The plaque protein myozap identified as a novel major component of adhering junctions in endothelia of the blood and the lymph vascular systems. J Cell Mol Med, 2012, 16 (8):1709-19 PMID: 21992629
Ott M. G., Marme F., Moldenhauer G., Lindhofer H., Hennig M., Spannagl R., Essing M. M., Linke R. and Seimetz D. Humoral response to catumaxomab correlates with clinical outcome: results of the pivotal phase II/III study in patients with malignant ascites. Int J Cancer, 2012, 130 (9):2195-203 PMID: 21702044
Moldenhauer G., Salnikov A. V., Luttgau S., Herr I., Anderl J. and Faulstich H. Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma. J Natl Cancer Inst, 2012, 104 (8):622-34 PMID: 22457476
Marme F., Werft W., Walter A., Keller S., Wang X., Benner A., Burwinkel B., Sinn P., Hug S., Sohn C., Bretz N., Moldenhauer G., Rupp C., Rupp A. K., Biakhov M. Y., Bottini A., Friedrichs K., Khailenko V. A., Manikhas G. M., Ruiz A., Sanchez-Rovira P., Santoro A., Segui M. A., Villena C., Lichter P., Kristiansen G., Altevogt P. and Schneeweiss A. CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer. Breast Cancer Res Treat, 2012, 132 (3):819-31 PMID: 21960110
Herr I., Groth A., Salnikov A. V., Buchler M. W. and Moldenhauer G. Combining forces to hit cancer stem cells: TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody show efficacy against pancreatic cancer. Oncoimmunology, 2012, 1 (5):741-743 PMID: 22934267
Groth A., Salnikov A. V., Ottinger S., Gladkich J., Liu L., Kallifatidis G., Salnikova O., Ryschich E., Giese N., Giese T., Momburg F., Buchler M. W., Moldenhauer G. and Herr I. New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 Bispecific antibody for tumor targeting. Clin Cancer Res, 2012, 18 (4):1028-38 PMID: 22228630
Bretz N. P., Salnikov A. V., Perne C., Keller S., Wang X., Mierke C. T., Fogel M., Erbe-Hofmann N., Schlange T., Moldenhauer G. and Altevogt P. CD24 controls Src/STAT3 activity in human tumors. Cell Mol Life Sci, 2012, 69 (22):3863-79 PMID: 22760497
Bretz N., Noske A., Keller S., Erbe-Hofmann N., Schlange T., Salnikov A. V., Moldenhauer G., Kristiansen G. and Altevogt P. CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion. Clin Exp Metastasis, 2012, 29 (1):27-38 PMID: 21984372
Adelmann K., Frey D., Riedl E., Koeppel H., Pfister F., Peters V., Schmitt C. P., Sternik P., Hofmann S., Zentgraf H. W., Navis G., van den Born J., Bakker S. J., Kramer B. K., Yard B. A. and Hauske S. J. Different conformational forms of serum carnosinase detected by a newly developed sandwich ELISA for the measurements of carnosinase concentrations. Amino Acids, 2012, 43 (1):143-51 PMID: 22349764
Swiersy A., Wiek C., Reh J., Zentgraf H. and Lindemann D. Orthoretroviral-like prototype foamy virus Gag-Pol expression is compatible with viral replication. Retrovirology, 2011, 8 66 PMID: 21843316
Rupp A. K., Rupp C., Keller S., Brase J. C., Ehehalt R., Fogel M., Moldenhauer G., Marme F., Sultmann H. and Altevogt P. Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage. Gynecol Oncol, 2011, 122 (2):437-46 PMID: 21601258
Pietrosiuk A., Lenherr E. D., Falk S., Bonemann G., Kopp J., Zentgraf H., Sinning I. and Mogk A. Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion. J Biol Chem, 2011, 286 (34):30010-21 PMID: 21733841
Olins A. L., Langhans M., Monestier M., Schlotterer A., Robinson D. G., Viotti C., Zentgraf H., Zwerger M. and Olins D. E. An epichromatin epitope: persistence in the cell cycle and conservation in evolution. Nucleus, 2011, 2 (1):47-60 PMID: 21647299
Naumann P., Fortunato F., Zentgraf H., Buchler M. W., Herr I. and Werner J. Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer. Int J Oncol, 2011, 39 (1):101-9 PMID: 21537844
Mullers E., Uhlig T., Stirnnagel K., Fiebig U., Zentgraf H. and Lindemann D. Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis. J Virol, 2011, 85 (4):1452-63 PMID: 21106749
Merveille A. C., Davis E. E., Becker-Heck A., Legendre M., Amirav I., Bataille G., Belmont J., Beydon N., Billen F., Clement A., Clercx C., Coste A., Crosbie R., de Blic J., Deleuze S., Duquesnoy P., Escalier D., Escudier E., Fliegauf M., Horvath J., Hill K., Jorissen M., Just J., Kispert A., Lathrop M., Loges N. T., Marthin J. K., Momozawa Y., Montantin G., Nielsen K. G., Olbrich H., Papon J. F., Rayet I., Roger G., Schmidts M., Tenreiro H., Towbin J. A., Zelenika D., Zentgraf H., Georges M., Lequarre A. S., Katsanis N., Omran H. and Amselem S. CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nat Genet, 2011, 43 (1):72-8 PMID: 21131972
Meitinger F., Boehm M. E., Hofmann A., Hub B., Zentgraf H., Lehmann W. D. and Pereira G. Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis. Genes Dev, 2011, 25 (8):875-88 PMID: 21498574
Liebau M. C., Hopker K., Muller R. U., Schmedding I., Zank S., Schairer B., Fabretti F., Hohne M., Bartram M. P., Dafinger C., Hackl M., Burst V., Habbig S., Zentgraf H., Blaukat A., Walz G., Benzing T. and Schermer B. Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem, 2011, 286 (16):14237-45 PMID: 21357692
Kallifatidis G., Labsch S., Rausch V., Mattern J., Gladkich J., Moldenhauer G., Buchler M. W., Salnikov A. V. and Herr I. Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther, 2011, 19 (1):188-95 PMID: 20940707
Hoffmann S. C., Wabnitz G. H., Samstag Y., Moldenhauer G. and Ludwig T. Functional analysis of bispecific antibody (EpCAMxCD3)-mediated T-lymphocyte and cancer cell interaction by single-cell force spectroscopy. Int J Cancer, 2011, 128 (9):2096-104 PMID: 20635391
Dafinger C., Liebau M. C., Elsayed S. M., Hellenbroich Y., Boltshauser E., Korenke G. C., Fabretti F., Janecke A. R., Ebermann I., Nurnberg G., Nurnberg P., Zentgraf H., Koerber F., Addicks K., Elsobky E., Benzing T., Schermer B. and Bolz H. J. Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest, 2011, 121 (7):2662-7 PMID: 21633164
Capper D., Preusser M., Habel A., Sahm F., Ackermann U., Schindler G., Pusch S., Mechtersheimer G., Zentgraf H. and von Deimling A. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol, 2011, 122 (1):11-9 PMID: 21638088
Volkmann M., Luithle D., Zentgraf H., Schnolzer M., Fiedler S., Heid H., Schulze-Bergkamen A., Strassburg C. P., Gehrke S. G. and Manns M. P. SLA/LP/tRNP((Ser)Sec) antigen in autoimmune hepatitis: identification of the native protein in human hepatic cell extract. J Autoimmun, 2010, 34 (1):59-65 PMID: 19683415
Stirnnagel K., Luftenegger D., Stange A., Swiersy A., Mullers E., Reh J., Stanke N., Grosse A., Chiantia S., Keller H., Schwille P., Hanenberg H., Zentgraf H. and Lindemann D. Analysis of prototype foamy virus particle-host cell interaction with autofluorescent retroviral particles. Retrovirology, 2010, 7 45 PMID: 20478027
Riedl E., Koeppel H., Pfister F., Peters V., Sauerhoefer S., Sternik P., Brinkkoetter P., Zentgraf H., Navis G., Henning R. H., Van Den Born J., Bakker S. J., Janssen B., van der Woude F. J. and Yard B. A. N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia. Diabetes, 2010, 59 (8):1984-90 PMID: 20460427
Rickelt S., Rizzo S., Doerflinger Y., Zentgraf H., Basso C., Gerosa G., Thiene G., Moll R. and Franke W. W. A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. Mod Pathol, 2010, 23 (11):1429-37 PMID: 20693980
Reinartz A., Ehling J., Franz S., Simon V., Bravo I. G., Tessmer C., Zentgraf H., Lyer S., Schneider U., Koster J., Raupach K., Kammerer E., Klaus C., Tischendorf J. J., Kopitz J., Alonso A. and Gassler N. Small intestinal mucosa expression of putative chaperone fls485. BMC Gastroenterol, 2010, 10 27 PMID: 20205943
Mora R., Dokic I., Kees T., Huber C. M., Keitel D., Geibig R., Brugge B., Zentgraf H., Brady N. R. and Regnier-Vigouroux A. Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia, 2010, 58 (11):1364-83 PMID: 20607862
Meitinger F., Petrova B., Lombardi I. M., Bertazzi D. T., Hub B., Zentgraf H. and Pereira G. Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast. J Cell Sci, 2010, 123 (Pt 11):1851-61 PMID: 20442249
Koeberlein B., zur Hausen A., Bektas N., Zentgraf H., Chin R., Nguyen L. T., Kandolf R., Torresi J. and Bock C. T. Hepatitis B virus overexpresses suppressor of cytokine signaling-3 (SOCS3) thereby contributing to severity of inflammation in the liver. Virus Res, 2010, 148 (1-2):51-9 PMID: 20005910
Hristov G., Kramer M., Li J., El-Andaloussi N., Mora R., Daeffler L., Zentgraf H., Rommelaere J. and Marchini A. Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species. J Virol, 2010, 84 (12):5909-22 PMID: 20375165
Gdynia G., Keith M., Kopitz J., Bergmann M., Fassl A., Weber A. N., George J., Kees T., Zentgraf H. W., Wiestler O. D., Schirmacher P. and Roth W. Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria. Cancer Res, 2010, 70 (21):8558-68 PMID: 20959471
Eck W., Nicholson A. I., Zentgraf H., Semmler W. and Bartling S. Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett, 2010, 10 (7):2318-22 PMID: 20496900
Chin R., Nachbur U., Earnest-Silveira L., Bankovacki A., Koeberlein B., Zentgraf H., Bock C. T., Silke J. and Torresi J. Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus. Virus Res, 2010, 147 (1):7-16 PMID: 19786052
Capper D., Weissert S., Balss J., Habel A., Meyer J., Jager D., Ackermann U., Tessmer C., Korshunov A., Zentgraf H., Hartmann C. and von Deimling A. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol, 2010, 20 (1):245-54 PMID: 19903171
Bock B. C., Tagscherer K. E., Fassl A., Kramer A., Oehme I., Zentgraf H. W., Keith M. and Roth W. The PEA-15 protein regulates autophagy via activation of JNK. J Biol Chem, 2010, 285 (28):21644-54 PMID: 20452983
Bentmann A., Kawelke N., Moss D., Zentgraf H., Bala Y., Berger I., Gasser J. A. and Nakchbandi I. A. Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function. J Bone Miner Res, 2010, 25 (4):706-15 PMID: 19821765
Andrulis M., Capper D., Meyer J., Penzel R., Hartmann C., Zentgraf H. and von Deimling A. IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as determined by a mutation specific antibody. Haematologica, 2010, 95 (10):1797-8 PMID: 20534697
Andrulis M., Capper D., Luft T., Hartmann C., Zentgraf H. and von Deimling A. Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation-specific antibody and direct sequencing. Leuk Res, 2010, 34 (8):1091-3 PMID: 20227112
Widegren E., Onnesjo S., Arbman G., Kayed H., Zentgraf H., Kleeff J., Zhang H. and Sun X. F. Expression of FXYD3 protein in relation to biological and clinicopathological variables in colorectal cancers. Chemotherapy, 2009, 55 (6):407-13 PMID: 19955746
Wang M. W., Gu P., Zhang Z. Y., Zhu Z. L., Geng Y., Kayed H., Zentgraf H. and Sun X. F. FXYD3 expression in gliomas and its clinicopathological significance. Oncol Res, 2009, 18 (4):133-9 PMID: 20112499
Olins A. L., Hoang T. V., Zwerger M., Herrmann H., Zentgraf H., Noegel A. A., Karakesisoglou I., Hodzic D. and Olins D. E. The LINC-less granulocyte nucleus. Eur J Cell Biol, 2009, 88 (4):203-14 PMID: 19019491
Mora R., Abschuetz A., Kees T., Dokic I., Joschko N., Kleber S., Geibig R., Mosconi E., Zentgraf H., Martin-Villalba A. and Regnier-Vigouroux A. TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia. Glia, 2009, 57 (5):561-81 PMID: 18942750
Ludwig S., Mannherz H. G., Schmitt S., Schaffer M., Zentgraf H. and Napirei M. Murine serum deoxyribonuclease 1 (Dnase1) activity partly originates from the liver. Int J Biochem Cell Biol, 2009, 41 (5):1079-93 PMID: 18973821
Loges N. T., Olbrich H., Becker-Heck A., Haffner K., Heer A., Reinhard C., Schmidts M., Kispert A., Zariwala M. A., Leigh M. W., Knowles M. R., Zentgraf H., Seithe H., Nurnberg G., Nurnberg P., Reinhardt R. and Omran H. Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. Am J Hum Genet, 2009, 85 (6):883-9 PMID: 19944400
Loftas P., Onnesjo S., Widegren E., Adell G., Kayed H., Kleeff J., Zentgraf H. and Sun X. F. Expression of FXYD-3 is an independent prognostic factor in rectal cancer patients with preoperative radiotherapy. Int J Radiat Oncol Biol Phys, 2009, 75 (1):137-42 PMID: 19289258
Kiessling F., Huppert J., Zhang C., Jayapaul J., Zwick S., Woenne E. C., Mueller M. M., Zentgraf H., Eisenhut M., Addadi Y., Neeman M. and Semmler W. RGD-labeled USPIO inhibits adhesion and endocytotic activity of alpha v beta3-integrin-expressing glioma cells and only accumulates in the vascular tumor compartment. Radiology, 2009, 253 (2):462-9 PMID: 19789239
Francis R. J., Chatterjee B., Loges N. T., Zentgraf H., Omran H. and Lo C. W. Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway. Am J Physiol Lung Cell Mol Physiol, 2009, 296 (6):L1067-75 PMID: 19346437
Capper D., Zentgraf H., Balss J., Hartmann C. and von Deimling A. Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol, 2009, 118 (5):599-601 PMID: 19798509
Bonemann G., Pietrosiuk A., Diemand A., Zentgraf H. and Mogk A. Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J, 2009, 28 (4):315-25 PMID: 19131969
Bar H., Sharma S., Kleiner H., Mucke N., Zentgraf H., Katus H. A., Aebi U. and Herrmann H. Interference of amino-terminal desmin fragments with desmin filament formation. Cell Motil Cytoskeleton, 2009, 66 (11):986-99 PMID: 19530175
Apel A., Zentgraf H., Buchler M. W. and Herr I. Autophagy-A double-edged sword in oncology. Int J Cancer, 2009, 125 (5):991-5 PMID: 19452527
Schermer B., Ghenoiu C., Bartram M., Muller R. U., Kotsis F., Hohne M., Kuhn W., Rapka M., Nitschke R., Zentgraf H., Fliegauf M., Omran H., Walz G. and Benzing T. The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol, 2006, 175 (4):547-54 PMID: 17101696
Muller M., Meyer M., Schilling T., Ulsperger E., Lehnert T., Zentgraf H., Stremmel W., Volkmann M. and Galle P. R. Testing for anti-p53 antibodies increases the diagnostic sensitivity of conventional tumor markers. Int J Oncol, 2006, 29 (4):973-80 PMID: 16964393
Michel A., Kopp-Schneider A., Zentgraf H., Gruber A. D. and de Villiers E. M. E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. J Virol, 2006, 80 (22):11153-64 PMID: 16971438
Knoess M., Kurz A. K., Goreva O., Bektas N., Breuhahn K., Odenthal M., Schirmacher P., Dienes H. P., Bock C. T., Zentgraf H. and zur Hausen A. Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases. World J Gastroenterol, 2006, 12 (36):5870-4 PMID: 17007055
Fliegauf M., Horvath J., von Schnakenburg C., Olbrich H., Muller D., Thumfart J., Schermer B., Pazour G. J., Neumann H. P., Zentgraf H., Benzing T. and Omran H. Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol, 2006, 17 (9):2424-33 PMID: 16885411
Schlieker C., Zentgraf H., Dersch P. and Mogk A. ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria. Biol Chem, 2005, 386 (11):1115-27 PMID: 16307477
Schermer B., Hopker K., Omran H., Ghenoiu C., Fliegauf M., Fekete A., Horvath J., Kottgen M., Hackl M., Zschiedrich S., Huber T. B., Kramer-Zucker A., Zentgraf H., Blaukat A., Walz G. and Benzing T. Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J, 2005, 24 (24):4415-24 PMID: 16308564
Gombert M., Dieu-Nosjean M. C., Winterberg F., Bunemann E., Kubitza R. C., Da Cunha L., Haahtela A., Lehtimaki S., Muller A., Rieker J., Meller S., Pivarcsi A., Koreck A., Fridman W. H., Zentgraf H. W., Pavenstadt H., Amara A., Caux C., Kemeny L., Alenius H., Lauerma A., Ruzicka T., Zlotnik A. and Homey B. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J Immunol, 2005, 174 (8):5082-91 PMID: 15814739
Gerke P., Sellin L., Kretz O., Petraschka D., Zentgraf H., Benzing T. and Walz G. NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol, 2005, 16 (6):1693-702 PMID: 15843475
Gareiss M., Eberhardt K., Kruger E., Kandert S., Bohm C., Zentgraf H., Muller C. R. and Dabauvalle M. C. Emerin expression in early development of Xenopus laevis. Eur J Cell Biol, 2005, 84 (2-3):295-309 PMID: 15819409
Publications Protein Interaction / Biomolecular Interaction Measurement
References: Protein Interaction / Biomolecular Interaction Measurement
Sicong Ma, Roger Sandhoff, Xiu Luo, Fuwei Shang, Qiaozhen Shi, Zhaolong Li, Jingxia Wu, Yanan Ming, Frank Schwarz, Alaa Madi, Nina Weisshaar, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Xin Yan, Kerstin Mohr, Nora Ten Bosch, Zhe Li, Gernot Poschet, Hans-Reimer Rodewald, Nina Papavasiliou, Xi Wang, Pu Gao, Guoliang Cui
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos
Sci Immunol. 2024 Apr 19;9(94):eadg8817. doi: 10.1126/sciimmunol.adg8817. Epub 2024 Apr 19. PMID:38640251
Ralph Klose, Caroline Berger, Iris Moll, M Gordian Adam, Frank Schwarz, Kerstin Mohr, Hellmut G Augustin, Andreas Fischer
Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis
Cardiovascular Research, Volume 107, Issue 1, 1 July 2015, Pages 153–163, Epub 2013 Mar 14. 10.1093.cvv151
Sonja Blasche, Mario Mörtl, Holger Steuber, Gabriella Siszler, Shahista Nisa, Frank Schwarz, Inna Lavrik, Thomas M A Gronewold, Klaus Maskos, Michael S Donnenberg, Dirk Ullmann, Peter Uetz, Manfred Kögl
The E. coli effector protein NleF is a caspase inhibitor
PLoS One . 2013;8(3):e58937. Epub 2013 Mar 14 PMID: 23516580
Blasche S, Arens S, Ceol A, Siszler G, Schmidt MA, Häuser R, Schwarz F, Wuchty S, Aloy P, Uetz P, Stradal T, Koegl M.
The EHEC-host interactome reveals novel targets for the translocated intimin receptor.
Sci Rep. 2014 Dec 18:4:7531.doi: 10.1038/srep07531. PMID: 25519916
-- A publication based on results from our groups contribution in the FP7 EU project AntiPathoGN --
Häuser R1, Ceol A, Rajagopala SV, Mosca R, Siszler G, Wermke N, Sikorski P, Schwarz F, Schick M, Wuchty S, Aloy P, Uetz P.
A Second-generation Protein-Protein Interaction Network of Helicobacter pylori.
Mol Cell Proteomics. 2014 Mar 14 PMID: 24627523
-- A publication based on results from our groups contribution in the FP7 EU project AntiPathoGN --
Rajagopala, S. V., Sikorski, P., Kumar, A., Mosca, R., Vlasblom, J., Arnold, R., Franca-Koh, J., Pakala, S. B., Phanse, S., Ceol, A., Häuser, R., Siszler, G., Wuchty, S., Emili, A., Babu, M., Aloy, P., Pieper, R., and Uetz, P. (2014)
The binary protein-protein interaction landscape of Escherichia coli.
Nat Biotechnol. 2014 Mar;32(3):285-90 PMID: 24561554
-- A publication with results from our groups contribution in the FP7 EU project AntiPathoGN --
Häuser, R., Pech, M., Kijek, J., Yamamoto, H., Titz, B., Naeve, F., Tovchigrechko, A., Yamamoto, K., Szaflarski, W., Takeuchi, N., Stellberger, T., Diefenbacher, M. E., Nierhaus, K. H., and Uetz, P
RsfA (YbeB) proteins are conserved ribosomal silencing factors
PLoS Genet 8, (2012) PMID: 22829778
Kerstin Mohr and Manfred Koegl
High-Throughput Yeast Two-Hybrid Screening of Complex cDNA Libraries
Methods Mol Biol. 2012;812:89-102. PMID: 22218855
Pfefferle S , Schöpf J, Kögl M, Friedel C, Müller M, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Kallies S, Niemeyer D, Vanessa Ditt V, Kuri T, Züst R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, Pöhlmann S, Haas J, Drosten Christian, von Brunn A
The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors
PLoS Pathog. 2011 Oct;7(10):e1002331. Epub 2011 Oct 27 PMID: 22046132
Koegl, M., and Uetz, P. (2008)
Improving yeast two hybrid screening systems.
Briefings in Functional Genomics and Proteomics, 6:302-12. (pdf)
Kremoser, C., Albers, M., Burris, T.P., Deuschle, U. Koegl, M. (2007)
Panning for SNuRMs: Using cofactor profiling for the rational discovery of selective nuclear receptor modulators.
Drug Discov. Today, 12:860-9. PMID: 17933688
Yan J, Kim YS, Yang XP, Albers M, Koegl M, Jetten AM. (2007)
Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor {alpha} Nucleic Acids Res. 35:1673-86. (pdf)
Albers M., Blume B., Schlueter T., Wright M.B., Kober I., Kremoser C., Deuschle U., Koegl M. (2006)
A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
J Biol Chem. 281:4920-4930. (pdf)
Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M. (2005)
Automated Yeast Two-hybrid Screening for Nuclear Receptor-interacting Proteins.
Mol. Cell. Proteomics 4:205-213. (pdf)
Albert, S., Gaudan, S., Knigge, H., Raetsch, A., Delgado, A., Huhse, B., Albers, M., Rebholz-Schuhmann and Koegl, M. (2003)
Computer-assisted generation of a protein-interaction database for nuclear receptors. Mol. Endo.17,1555-15567. (pdf)
Motz, M. Kober, I., Girardot, C., Loeser, E., Bauer, U., Albers, M., Moeckel, G., Minch, E., Voss, H., Kilger, C. and Koegl, M. (2002).
Elucidation of an archaeal replication protein network to generate enhanced PCR enzymes.
J. Biol. Chem. 277, 16179-16188. (pdf)