Publications with Co-authorships of Cellular Tools group
- Hai L., Hoffmann D. C., Wagener R. J., Azorin D. D., Hausmann D., Xie R., Huppertz M. C., Hiblot J., Sievers P., Heuer S., Ito J., Cebulla G., Kourtesakis A., Kaulen L. D., Ratliff M., Mandelbaum H., Jung E., Jabali A., Horschitz S., Ernst K. J., Reibold D., Warnken U., Venkataramani V., Will R., Suva M. L., Herold-Mende C., Sahm F., Winkler F., Schlesner M., Wick W., Kessler T., (2024) A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1. Nat Commun, 15:968
link to online source - Kramer C., Kilian M., Chih Y. C., Kourtesakis A., Hoffmann D. C., Boschert T., Koopmann P., Sanghvi K., De Roia A., Jung S., Jahne K., Day B., Shultz L. D., Ratliff M., Harbottle R., Green E. W., Will R., Wick W., Platten M., Bunse L., (2024) NLGN4X TCR transgenic T cells to treat gliomas. Neuro Oncol, 26:266-278
link to online source - Beumers L., Vlachavas E. I., Borgoni S., Schwarzmuller L., Penso-Dolfin L., Michels B. E., Sofyali E., Burmester S., Heiss D., Wilhelm H., Yarden Y., Helm D., Will R., Goncalves A., Wiemann S., (2023) Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets. NPJ Breast Cancer, 9:97
link to online source - Chen Z., Will R., Kim S. N., Busch M. A., Dunker N., Dammann P., Sure U., Zhu Y., (2023) Novel Function of Cancer Stem Cell Marker ALDH1A3 in Glioblastoma: Pro-Angiogenesis through Paracrine PAI-1 and IL-8. Cancers (Basel), 15:
link to online source - Hubers C., Abdul Pari A. A., Grieshober D., Petkov M., Schmidt A., Messmer T., Heyer C. M., Scholch S., Kapel S. S., Gengenbacher N., Singhal M., Schieb B., Fricke C., Will R., Remans K., Utikal J. S., Reissfelder C., Schlesner M., Hodivala-Dilke K. M., Kersten S., Goerdt S., Augustin H. G., Felcht M., (2023) Primary tumor-derived systemic nANGPTL4 inhibits metastasis. J Exp Med, 220:
link to online source - Kim M., Reidenbach S., Schlechter T., Rothmann A. C., Will R., Hofmann I., (2023) Plakophilin 1 deficiency in prostatic tumours is correlated with immune cell recruitment and controls the up-regulation of cytokine expression post-transcriptionally. FEBS J, 290:1907-1919
link to online source - Martija A. A., Krauss A., Bachle N., Doth L., Christians A., Krunic D., Schneider M., Helm D., Will R., Hartmann C., Herold-Mende C., von Deimling A., Pusch S., (2023) EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma. Acta Neuropathol Commun, 11:177
link to online source - Li X., Michels B. E., Tosun O. E., Jung J., Kappes J., Ibing S., Nataraj N. B., Sahay S., Schneider M., Worner A., Becki C., Ishaque N., Feuerbach L., Hessling B., Helm D., Will R., Yarden Y., Muller-Decker K., Wiemann S., Korner C., (2022) 5'isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1. J Exp Clin Cancer Res, 41:190
link to online source - Noronha A., Belugali Nataraj N., Lee J. S., Zhitomirsky B., Oren Y., Oster S., Lindzen M., Mukherjee S., Will R., Ghosh S., Simoni-Nieves A., Verma A., Chatterjee R., Borgoni S., Robinson W., Sinha S., Brandis A., Kerr D. L., Wu W., Sekar A., Giri S., Chung Y., Drago-Garcia D., Danysh B. P., Lauriola M., Fiorentino M., Ardizzoni A., Oren M., Blakely C. M., Ezike J., Wiemann S., Parida L., Bivona T. G., Aqeilan R. I., Brugge J. S., Regev A., Getz G., Ruppin E., Yarden Y., (2022) AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer. Cancer Discov, 12:2666-2683
link to online source - Will R., Bauer K., Kudla M., Montero-Vergara J., Wiemann S., Jendrossek V., Pena-Llopis S., Vega-Rubin-de-Celis S., (2022) A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux Assessment. Methods Mol Biol, 2445:75-98
link to online source - Bieg M., Moskalev E. A., Will R., Hebele S., Schwarzbach M., Schmeck S., Hohenberger P., Jakob J., Kasper B., Gaiser T., Strobel P., Wardelmann E., Kontny U., Braunschweig T., Sirbu H., Grutzmann R., Meidenbauer N., Ishaque N., Eils R., Wiemann S., Hartmann A., Agaimy A., Fritchie K., Giannini C., Haller F., (2021) Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants. Am J Pathol, 191:602-617
link to online source - Kuhn C., Menke M., Senger F., Mack C., Dierck F., Hille S., Schmidt I., Brunke G., Bunger P., Schmiedel N., Will R., Sossalla S., Frank D., Eschenhagen T., Carrier L., Lullmann-Rauch R., Rangrez A. Y., Frey N., (2021) FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo. JACC Basic Transl Sci, 6:365-380
link to online source - Maia A., Gu Z., Koch A., Berdiel-Acer M., Will R., Schlesner M., Wiemann S., (2021) IFNbeta1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. Mol Oncol, 15:1308-1329
link to online source - Varghese Christy Susan, Will Rainer, Tessmer Claudia, Hofmann Ilse, Hessling Bernd, Pawlita Michael, Höfler Daniela, (2021) Biological Activity Characterization of the Diagnostically Relevant Human Papillomavirus 16 E1C RNA. Microbiology Research, 12:539-552
link to online source - Borgoni S., Sofyali E., Soleimani M., Wilhelm H., Muller-Decker K., Will R., Noronha A., Beumers L., Verschure P. J., Yarden Y., Magnani L., van Kampen A. H. C., Moerland P. D., Wiemann S., (2020) Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer. Cancers (Basel), 12:
link to online source - Hartmann L., Schroter P., Osen W., Baumann D., Offringa R., Moustafa M., Will R., Debus J., Brons S., Rieken S., Eichmuller S. B., (2020) Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines. Sci Rep, 10:21517
link to online source - Martin-Garcia D., Silva-Vilches C., Will R., Enk A. H., Lonsdorf A. S., (2020) Tumor-derived CCL20 affects B16 melanoma growth in mice. J Dermatol Sci, 97:57-65
link to online source - Haller F., Bieg M., Will R., Korner C., Weichenhan D., Bott A., Ishaque N., Lutsik P., Moskalev E. A., Mueller S. K., Bahr M., Woerner A., Kaiser B., Scherl C., Haderlein M., Kleinheinz K., Fietkau R., Iro H., Eils R., Hartmann A., Plass C., Wiemann S., Agaimy A., (2019) Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Nat Commun, 10:368
link to online source - Quandt J., Schlude C., Bartoschek M., Will R., Cid-Arregui A., Scholch S., Reissfelder C., Weitz J., Schneider M., Wiemann S., Momburg F., Beckhove P., (2018) Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses. Oncoimmunology, 7:e1500671
link to online source - Bott A., Erdem N., Lerrer S., Hotz-Wagenblatt A., Breunig C., Abnaof K., Worner A., Wilhelm H., Munstermann E., Ben-Baruch A., Wiemann S., (2017) miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget, :
link to online source - Breunig C., Pahl J., Kublbeck M., Miller M., Antonelli D., Erdem N., Wirth C., Will R., Bott A., Cerwenka A., Wiemann S., (2017) MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells. Cell Death Dis, 8:e2973
link to online source - Brocks D., Schmidt C. R., Daskalakis M., Jang H. S., Shah N. M., Li D., Li J., Zhang B., Hou Y., Laudato S., Lipka D. B., Schott J., Bierhoff H., Assenov Y., Helf M., Ressnerova A., Islam M. S., Lindroth A. M., Haas S., Essers M., Imbusch C. D., Brors B., Oehme I., Witt O., Lubbert M., Mallm J. P., Rippe K., Will R., Weichenhan D., Stoecklin G., Gerhauser C., Oakes C. C., Wang T., Plass C., (2017) Erratum: DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet, 49:1661
link to online sourcelink to online source - Brocks D., Schmidt C. R., Daskalakis M., Jang H. S., Shah N. M., Li D., Li J., Zhang B., Hou Y., Laudato S., Lipka D. B., Schott J., Bierhoff H., Assenov Y., Helf M., Ressnerova A., Islam M. S., Lindroth A. M., Haas S., Essers M., Imbusch C. D., Brors B., Oehme I., Witt O., Lubbert M., Mallm J. P., Rippe K., Will R., Weichenhan D., Stoecklin G., Gerhauser C., Oakes C. C., Wang T., Plass C., (2017) DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet, 49:1052-1060
link to online source - Eden M., Meder B., Volkers M., Poomvanicha M., Domes K., Branchereau M., Marck P., Will R., Bernt A., Rangrez A., Busch M., German Mouse Clinic Consortium, Hrabe de Angelis M., Heymes C., Rottbauer W., Most P., Hofmann F., Frey N., (2016) Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nat Commun, 7:11317
link to online source - Eden M., Meder B., Volkers M., Poomvanicha M., Domes K., Branchereau M., Marck P., Will R., Bernt A., Rangrez A., Busch M., Hrabe de Angelis M., Heymes C., Rottbauer W., Most P., Hofmann F., Frey N., (2016) Erratum: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nat Commun, 7:11835
link to online source - Goeppert B., Ernst C., Baer C., Roessler S., Renner M., Mehrabi A., Hafezi M., Pathil A., Warth A., Stenzinger A., Weichert W., Bahr M., Will R., Schirmacher P., Plass C., Weichenhan D., (2016) Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma. Epigenetics, 11:780-790
link to online source - Haller F., Knopf J., Ackermann A., Bieg M., Kleinheinz K., Schlesner M., Moskalev E. A., Will R., Satir A. A., Abdelmagid I. E., Giedl J., Carbon R., Rompel O., Hartmann A., Wiemann S., Metzler M., Agaimy A., (2016) Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol, 238:700-10
link to online source - Cohen-Dvashi H., Ben-Chetrit N., Russell R., Carvalho S., Lauriola M., Nisani S., Mancini M., Nataraj N., Kedmi M., Roth L., Kostler W., Zeisel A., Yitzhaky A., Zylberg J., Tarcic G., Eilam R., Wigelman Y., Will R., Lavi S., Porat Z., Wiemann S., Ricardo S., Schmitt F., Caldas C., Yarden Y., (2015) Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression. EMBO Mol Med, :
- Keklikoglou I., Hosaka K., Bender C., Bott A., Koerner C., Mitra D., Will R., Woerner A., Muenstermann E., Wilhelm H., Cao Y., Wiemann S., (2015) MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes. Oncogene, 34:4867-78
link to online source - Shukla K., Sharma A. K., Ward A., Will R., Hielscher T., Balwierz A., Breunig C., Munstermann E., Konig R., Keklikoglou I., Wiemann S., (2015) MicroRNA-30c-2-3p negatively regulates NF-kappaB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer. Mol Oncol, 9:1106-19
link to online source - Keklikoglou I., Hosaka K., Bender C., Bott A., Koerner C., Mitra D., Will R., Woerner A., Muenstermann E., Wilhelm H., Cao Y., Wiemann S., (2014) MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes. Oncogene, :
- Frank D., Gantenberg J., Boomgaarden I., Kuhn C., Will R., Jarr K. U., Eden M., Kramer K., Luedde M., Mairbaurl H., Katus H. A., Frey N., (2012) MicroRNA-20a inhibits stress-induced cardiomyocyte apoptosis involving its novel target Egln3/PHD3. , 52:711-7
- Kuhn C., Frank D., Dierck F., Oehl U., Krebs J., Will R., Lehmann L. H., Backs J., Katus H. A., Frey N., (2012) Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP). Basic Res Cardiol, 107:262
- Rosenberg M., Lutz M., Kuhl C., Will R., Eckstein V., Krebs J., Katus H. A., Frey N., (2012) Coculture with hematopoietic stem cells protects cardiomyocytes against apoptosis via paracrine activation of AKT. J Transl Med, 10:115
- Spaich S., Will R. D., Just S., Kuhn C., Frank D., Berger I. M., Wiemann S., Korn B., Koegl M., Backs J., Katus H. A., Rottbauer W., Frey N., (2012) F-box and leucine-rich repeat protein 22 is a cardiac-enriched f-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. Circ Res, 111:1504-16
link to online source - Luedde M., Spaich S., Hippe H. J., Busch S., Will R., Abu-Taha I., Klein T., Kuhn C., Frank D., Katus H. A., Frey N., (2011) Affixin (beta-parvin) promotes cardioprotective signaling via STAT3 activation. , 50:919-23
link to online source - Frank D., Frauen R., Hanselmann C., Kuhn C., Will R., Gantenberg J., Fuzesi L., Katus H. A., Frey N., (2010) Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo. , 49:673-82
- Luedde M., Ehlermann P., Weichenhan D., Will R., Zeller R., Rupp S., Muller A., Steen H., Ivandic B. T., Ulmer H. E., Kern M., Katus H. A., Frey N., (2010) Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation. Cardiovasc Res, 86:452-60
link to online source - Seeger T. S., Frank D., Rohr C., Will R., Just S., Grund C., Lyon R., Luedde M., Koegl M., Sheikh F., Rottbauer W., Franke W. W., Katus H. A., Olson E. N., Frey N., (2010) Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ Res, 106:880-90
- Will R. D., Eden M., Just S., Hansen A., Eder A., Frank D., Kuhn C., Seeger T. S., Oehl U., Wiemann S., Korn B., Koegl M., Rottbauer W., Eschenhagen T., Katus H. A., Frey N., (2010) Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Circ Res, 107:1253-64
- Kuhn C., Frank D., Will R., Jaschinski C., Frauen R., Katus H. A., Frey N., (2009) DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy. J Biol Chem, 284:17320-7
- Frey N., Frank D., Lippl S., Kuhn C., Kogler H., Barrientos T., Rohr C., Will R., Muller O. J., Weiler H., Bassel-Duby R., Katus H. A., Olson E. N., (2008) Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. J Clin Invest, 118:3598-608
- Frank D., Kuhn C., van Eickels M., Gehring D., Hanselmann C., Lippl S., Will R., Katus H. A., Frey N., (2007) Calsarcin-1 protects against angiotensin-II induced cardiac hypertrophy. Circulation, 116:2587-96
- Neubrand V. E., Will R. D., Mobius W., Poustka A., Wiemann S., Schu P., Dotti C. G., Pepperkok R., Simpson J. C., (2005) Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. EMBO J, 24:1122-33
last update:
23/01/2025