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Research

Research Group Mammalian Cell Cycle Control Mechanisms

Prof. Dr. Ingrid Hoffmann

Multipolar mitotic spindle
© dkfz.de

Initiation and propagation of cancer is not possible without cell division (mitosis) which depends on small cellular organelles known as centrosomes. Similar to DNA replication, the centrosome is duplicated only once within a normal cell cycle. Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of genomic instability, a hallmark of many cancer cells. Failure to properly duplicate centrosomes results in supernumerary centrosomes, which are frequently found in tumors. The research group Cell Cycle Control and Carcinogenesis is studying the molecular mechanisms underlying centrosome duplication. The aim is to identify and characterize proteins that regulate this process. Our focus is placed on the key regulator of centriole duplication, the polo-like kinase Plk4.

Other projects in the lab are aimed at (1) understanding how misorientation of the mitotic spindle contributes to cancer development (2) unraveling the mechanisms of drug resistance that imposes a major problem in cancer therapy.

Contact

Prof. Dr. Ingrid Hoffmann

Mammalian Cell Cycle Control Mechanisms (D345)

Deutsches Krebsforschungszentrum

Im Neuenheimer Feld 242

69120 Heidelberg

Contact Form

Selected Publications

Zhu, M., Settele, F., Kotak, S., Sanchez-Pulido, L., Ehret, L., Ponting, C, Gönczy, P. and Hoffmann, I. (2013) MISP is a novel Plk1 substrate required for proper spindle orientation and cell cycle progression. J. Cell Biol. 200, 773-787.
Brunk, K., Zhu, M., Bärenz, F., Kratz, AS., Haselmann-Weiss, U., Antony, C. and Hoffmann, I., (2016) Cep78 is a novel centriolar protein involved in Plk4-induced centriole overduplication, J. Cell Sci. 129, 2713-2718.
Kschonksak, Y. and Hoffmann, I. (2018) Activated Ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation, J Cell Sci, 131(10) jcs214544
Richter, K., Kschonsak, Y., Vodicska, B., and Hoffmann, I. (2020) FBXO45- MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation, Cell Death and Differentiation, 27, 758–772.