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Research

HI-TRON Mainz Research Group Immunoproteomics

Prof. Dr. Stefan Tenzer

The Tenzer research group focuses on the development, optimization and application of mass spectrometry (MS)-based workflows for quantitative immunoproteomics to facilitate a detailed understanding of the interplay between tumor antigenicity, tumor microenvironment and the anti-tumor immune response. Currently, the research group harbours several high-resolution mass spectrometry instrument platforms, including three timsTOF Pro-2, one timsTOF SCP (Bruker) and two Orbitraps Exploris 480 (Thermo Scientific). With these high-performance instruments, the Tenzer research group investigates the contribution of proteases involved in MHC-I-restricted antigen processing and develops high sensitivity methods and workflows for the in-depth characterization of the immunopeptidome. This will enable high-throughput immuno-phenotyping of quantity-limited clinical samples to define biomarkers and neoantigen targets for individualized immunotherapies.

Contact

Prof. Dr. Stefan Tenzer

Immunoproteomics (D191)

Helmholtz Institute for Translational Oncology Mainz (HI-TRON Mainz) - A Helmholtz Institute by DKFZ
Obere Zahlbacherstr. 63
Building 911
55131 Mainz

E-Mail: Stefan.tenzer (at) dkfz-heidelberg.de