Publications
Original Articles
1. Benabdallah NS, Dalal V, Sotiriou A, Scott RW, Kommoss FKF, Pejkovska A, Gaspar L, Wagner L, Sánchez-Rivera FJ, Ta M, Thornton S, Nielsen TO, Underhill TM, Banito A. An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma. (2022) bioRxiv preprint.
2. Li X, Huang C, Sánchez-Rivera FJ, Kennedy MJ, Tschaharganeh DF, Morris IV JP, Montinaro A, O'Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, WalczakH, Lowe SW. A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. PNAS (2022) 119(17).
3. Gatzweiler C, Ridinger J, Herter S, Gerloff X, ElHarouni D, Berker Y, Imle R, Schmitt L, Kreth S, Stainczyk S, Ayhan S, Najafi S, Krunic D, Frese K, Meder B, Reuss D, Fiesel P, Schramm K, Blattner-Johnson M, Jones DTW, Banito A, Westermann F, Oppermann S, Milde T, Peterziel H, Witt O, Oehme I. Functional therapeutical target validation using Pediatric Zebrafish Xenograft Models. Cancers (2022), 14(3):849
4. Cidre-Aranaz F, Li J, Hölting TLB, Orth MF, Imle R, Kutschmann S, Ammirati G, Ceranski K, Carreño-Gonzalez MJ, Kasan M, Marchetto A, Funk CM, Bestvater F,Bersini S, Arrigoni C, Moretti M, Thiel U, Baumhoer D, Sahm F, Pfister SM, Hartmann W,Dirksen U, Romero-Pérez L, Banito A, Shunya Ohmura, Julian Musa, Thomas Kirchner, Maximilian M. L. Knott, Thomas G. P. Grünewald. Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma. Molecular Cancer (2022), 21, article 1.
5. Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott M, Hölting T, Stein S, Funk CM, Sastre A, Alonso J, Romero-Pérez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F, Grünewald TG. Therapeutic targeting of the PLK1-PRC1-axis triggers death in genomically silent childhood cancer. Nat Commun (2021) Sep 16;12(1):5356.
6. Revia S, Seretny A, Wendler L, Banito A, Eckert C, Breuer K, Mayakonda A, Lutsik P, Evert M, Ribback S, Gallage S, Bakri IC, Breuhahn K, Schirmacher P, Heinrich S, Gaida MM, Heikenwälder M, Calvisi DF, Plass C, Lowe SW, Tschaharganeh DF. Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signaling in cancer. Gut (2021), Sep 11; gutjnl-2021-325405.
7. Li J, Mulvihill TS, Li L, Barrott JJ, Nelson ML, Wagner L, Lock IC, Pozner A, Lambert SL, Ozenberger BB, Ward MB, Grossmann AH, Liu T, Banito A, Cairns BR and Jones KB. A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction. Cancer Discov. (2021), Jun 2. doi: 10.1158/2159-8290.CD-20-1219.
8. Kommoss FKF, Chang KTE, Stichel D, Banito A, Jones DTW, Heilig CE, Frohling S et al. Endometrial stromal sarcomas with BCOR-rearrangement harbor MDM2 amplifications. J Patho Clin Res (2020) Jul;6(3):178.184.
9. Loizou E, Banito A, Livshits G, Ho YJ, Koche RP, Sánchez-Rivera FJ, Mayle A, Chen CC, Kinalis S, Bagger FO, Kastenhuber ER, Durham BH, Lowe SW. A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1. Cancer Discov. (2019) Jul;9(7):962-979.
10. Banito A, Li X, Laporte A, Roe JS, Huang CH, Dancsok A, Tschaharganeh DF, Tasdemir N, Ladanyi M, Jones KB, Capecchi MR, Vakoc CR, Torsten N, Lowe SW. SS18-SSX oncoprotein hijacks KDM2B-PRC1.1 to drive synovial sarcoma. Cancer Cell. (2018) March; 33 (3): 527-541.
11. Aarts M, Beolchi P, Banito A, Carroll T, Kulisic M, Kaemena D, Dharmalingam G, Martin N, Reik W, Zuber J, Chandra T and Gil J. Coupling shRNA screens with single-cell RNA-Seq identifies mechanisms regulating senescence during reprogramming. Genes Dev. (2017) Oct 15;31(20):2085-2098.
12. Tordella L, Khan S, Hohmeyer A, Banito A, Klotz S, Raguz S, Martin N, Dhamarlingam G, Carroll T,González Meljem JM, Deswal S, Martínez-Barbera JP, García-Escudero R, Zuber J, Zender L, Gil J. SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. Genes Dev. (2016) Oct 1;30(19):2187-2198.
13. Tasdemir N*, Banito A*, Roe JS*, Alonso-Curbelo D*, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen C, Fennell M, Chicas A, Vakoc C, Lowe SW. BRD4 connects enhancer remodelling to senescence immune surveillance. Cancer Discov. (2016) June; 6(6): 612-29.*equal contribution.
14. Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol. (2015) Sep;17(9):1205-17.
15. Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell. (2014) Jul 31;158(3):579-92.
16. Acosta JC*, Banito A*, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. (2013) Aug;15(8):978-90 .*equal contribution.
17. Marqués-Torrejón MÁ, Porlan E, Banito A, Gómez-Ibarlucea E, Lopez-Contreras AJ, Fernández-Capetillo O, Vidal A, Gil J, Torres J, Fariñas I. Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression. Cell Stem Cell. (2013) Jan 3;12(1):88-100.
18. O'Loghlen A, Muñoz-Cabello AM, Gaspar-Maia A, Wu HA, Banito A, Kunowska N, Racek T, Pemberton HN, Beolchi P, Vermeulen M, Carroll T, Graumann J, Heard E, Dillon N, Azuara V, Snijders AP, Peters G, Bernstein E, Gil J. (2012) MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell. (2012) Jan 6;10(1):33-46.
19. Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG. ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell. (2010) Jun 4,547-556.
20. Pita JM, Banito A, Cavaco BM, and Leite V. Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas. Br J Cancer (2009) 101, 1782-1791.
21. Banito A, Rashid ST, Acosta JC, Li S, Pereira CF, Geti I, Pinho S, Silva JC, Azuara V, Walsh M, Vallier L, Gil J. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 23, 2134-2139.
22. Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenfuhr M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. (2009) 23, 1177-1182.
23. Cavaco BM, Batista PF, Martins C, Banito A, do Rosario F, Limbert E, Sobrinho LG, and Leite, V. Familial non-medullary thyroid carcinoma (FNMTC): analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations. Endocr Relat Cancer (2008) 15, 207-215.
24. Pinto AE, Silva G, Banito A, Leite V, Soares J. Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma. Oncol Rep (2008) 20, 913-919.
25. Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. (2008). Chemokine signalling via the CXCR2 receptor reinforces senescence. Cell. (2008) 133, 1006-1018.
26. Banito A, Pinto AE, Espadinha C, Marques AR, and Leite V. Aneuploidy and RAS mutations are mutually exclusive events in the development of well-differentiated thyroid follicular tumours. Clin Endocrinol (Oxf) (2007) 67, 706-711.
Review articles
1. Imle R, Kommoss FKF, Banito A*. Preclinical In Vivo Modeling of Pediatric Sarcoma-Promises and Limitations. J. Clin. Med. (2021), 10(8), 1578.
2. Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, et al. Sarcoma treatment in the era of molecular medicine. EMBO Mol Med (2020) Oct;13, e11131.
3. Jones DTW, Banito A, Grünewald TGP, Haber M, Jäger N, Kool M, Milde T, Molenaar JJ, Nabbi A, Pugh TJ, Schleiermacher G, Smith MA, Westermann F, Pfister SM. Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours. Nat Rev Cancer. (2019) Aug;19 (8):420-438.
4. Lujambio A and Banito A. Functional screening to identify senescence regulators in cancer. Curr Opin Genet Dev. (2019) Feb;54:17-24.
5. Banito A and Lowe SW (2013). A new development in senescence. Cell. (2013) Nov 21; 155 (5):977-8.
6. Banito A and Gil, J. Enhancing reprogramming to pluripotency by controlling senescence. Tumor Dormancy, Quiescence and Senescence. (2013) Vol 1, 195-205.
7. Banito A and Gil J. Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep (2010) 11, 353-359.
8. Acosta JC, O'Loghlen A, Banito A, Raguz, S, and Gil J. Control of senescence by CXCR2 and its ligands. Cell Cycle. (2008) 7, 2956-2959.