Publications of Pediatric Neurooncology 2023
The first-in-class ERK inhibitor ulixertinib shows promising activity in MAPK-driven pediatric low-grade glioma models.
Neuro-Oncology 25(3), 566-579 (2023) [10.1093/neuonc/noac183]
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BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.
Neuro-Oncology 25(4), 735-747 (2023) [10.1093/neuonc/noac199]
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Personal Comorbidities and their Subsequent Risks for Liver, Gallbladder and Bile Duct Cancers.
International journal of cancer 152(6), 1107-1114 (2023) [10.1002/ijc.34308]
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Rare embryonal and sarcomatous central nervous system tumours: State-of-the art and future directions.
European journal of medical genetics 66(1), 104660 (2023) [10.1016/j.ejmg.2022.104660]
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Clinical implementation of integrated molecular-morphologic risk prediction for meningioma.
Brain pathology 33(3), e13132 (2023) [10.1111/bpa.13132]
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Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
Acta neuropathologica 145(1), 49-69 (2023) [10.1007/s00401-022-02516-2]
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Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.
Acta neuropathologica 145(1), 97-112 (2023) [10.1007/s00401-022-02522-4]
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Reply to Evans and Woodward.
Journal of the National Cancer Institute 115(2), 231-232 (2023) [10.1093/jnci/djac224]
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Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry.
European journal of cancer 180, 71 - 84 (2023) [10.1016/j.ejca.2022.11.015]
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Long-term survival trends in solid cancers in the Nordic countries marking timing of improvements.
International journal of cancer 152(9), 1837-1846 (2023) [10.1002/ijc.34416]
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Revana: a comprehensive tool for regulatory variant analysis and visualization of cancer genomes.
Bioinformatics 39(1), btac831 (2023) [10.1093/bioinformatics/btac831]
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Investigation of Rare Non-Coding Variants in Familial Multiple Myeloma.
Cells 12(1), 96 (2023) [10.3390/cells12010096]
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Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses.
Acta Neuropathologica Communications 11(1), 7 (2023) [10.1186/s40478-023-01504-1]
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Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression.
Cancers 15(2), 479 (2023) [10.3390/cancers15020479]
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Author Correction: The evolutionary history of 2,658 cancers
Nature <London> 614(7948), p. E42 (2023) [10.1038/s41586-022-05601-4]
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Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Nature <London> 614(7948), p. E40 (2023) [10.1038/s41586-022-05599-9]
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Author Correction: Genomic basis for RNA alterations in cancer
Nature <London> 614(7948), p. E37 (2023) [10.1038/s41586-022-05596-y]
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Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
Nature cancer 4(2), 276-289 (2023) [10.1038/s43018-022-00509-4]
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The complementary roles of genome-wide approaches in identifying genes linked to an inherited risk of colorectal cancer.
Hereditary cancer in clinical practice 21(1), 1 (2023) [10.1186/s13053-023-00245-5]
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Autoimmune diseases as comorbidities for liver, gallbladder, and biliary duct cancers in Sweden.
Cancer nn, nn (2023) [10.1002/cncr.34663]
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Risk prediction in early childhood SHH medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than two subgroups.
Neuro-Oncology 25(8), 1518-1529 (2023) [10.1093/neuonc/noad027]
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Author Correction: The repertoire of mutational signatures in human cancer
Nature <London> 614, E41 (2023) [10.1038/s41586-022-05600-5]
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Author Correction: Patterns of somatic structural variation in human cancer genomes
Nature <London> 614, E38 (2023) [10.1038/s41586-022-05597-x]
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Author Correction: Pan-cancer analysis of whole genomes
Nature <London> 614, E39 (2023) [10.1038/s41586-022-05598-w]
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The significance of margins in pediatric Non-Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT).
Cancer medicine 12(10), 11719-11730 (2023) [10.1002/cam4.5671]
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Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability.
Nature Communications 14(1), 762 (2023) [10.1038/s41467-023-36400-8]
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Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.
Acta Neuropathologica Communications 11(1), 25 (2023) [10.1186/s40478-023-01514-z]
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Survival in Colon, Rectal and Small Intestinal Cancers in the Nordic Countries through a Half Century.
Cancers 15(3), 991 (2023) [10.3390/cancers15030991]
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Correction to: Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
Acta neuropathologica 145(4), 511-514 (2023) [10.1007/s00401-023-02538-4]
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CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population.
Acta Neuropathologica Communications 11(1), 26 (2023) [10.1186/s40478-023-01523-y]
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Survival in gastric and esophageal cancers in the Nordic countries through a half century.
Cancer medicine 12(9), 10212-10221 (2023) [10.1002/cam4.5748]
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Survival in hematological malignancies in the Nordic countries through a half century with correlation to treatment
Leukemia 37(4), 854-863 (2023) [10.1038/s41375-023-01852-w]
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Are population level familial risks and germline genetics meeting each other?
Hereditary cancer in clinical practice 21(1), 3 (2023) [10.1186/s13053-023-00247-3]
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CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability.
Small Methods 7(6), e2201605 (2023) [10.1002/smtd.202201605]
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Secretogranin II influences the assembly and function of MHC class I in melanoma.
Experimental hematology & oncology 12(1), 29 (2023) [DOI: 10.1186/s40164-023-00387-1]
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Optimising biomarkers for accurate ependymoma diagnosis, prognostication and stratification within International Clinical Trials: A BIOMECA study.
Neuro-Oncology 25(10), 1871-1882 (2023) [10.1093/neuonc/noad055]
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Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology.
Nature medicine 29(4), 917-926 (2023) [10.1038/s41591-023-02255-1]
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Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.
Acta neuropathologica 145(5), 667-680 (2023) [10.1007/s00401-023-02558-0]
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Corrigendum to 'Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry' [Eur J Cancer 180 (2023) 71-84].
European journal of cancer 184, 200-201 (2023) [10.1016/j.ejca.2023.02.024]
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Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature.
npj precision oncology 7(1), 30 (2023) [10.1038/s41698-023-00372-1]
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Epigenetic Modification of Mesenchymal Stromal Cells Derived from Bone Marrow and Embryonal Tumors to Facilitate Immunotherapeutic Approaches in Pediatric Malignancies.
Current issues in molecular biology 45(3), 2121 - 2135 (2023) [10.3390/cimb45030136]
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Reply to Li and colleagues.
Journal of the National Cancer Institute 115(6), 760-761 (2023) [10.1093/jnci/djad057]
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Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.
Acta neuropathologica 145(5), 651-666 (2023) [10.1007/s00401-023-02566-0]
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Combination Early-Phase Trials of Anticancer Agents in Children and Adolescents.
Journal of clinical oncology 41(18), 3408-3422 (2023) [10.1200/JCO.22.02430]
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The potential of PARP as a therapeutic target across pediatric solid malignancies.
BMC cancer 23(1), 310 (2023) [10.1186/s12885-022-10319-7]
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Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.
Oncogene 42(20), 1661-1671 (2023) [10.1038/s41388-023-02681-y]
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Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication.
Nature Communications 14(1), 1739 (2023) [10.1038/s41467-023-37438-4]
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GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis.
International journal of molecular sciences 24(7), 6029 (2023) [10.3390/ijms24076029]
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Second-line treatment of pediatric patients with relapsed rhabdomyosarcoma adapted to initial risk stratification: Data of the European Soft Tissue Sarcoma Registry (SoTiSaR).
Pediatric blood & cancer 70(7), e30363 (2023) [10.1002/pbc.30363]
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Survival in melanoma in the nordic countries into the era of targeted and immunological therapies.
European journal of cancer 186, 133 - 141 (2023) [10.1016/j.ejca.2023.03.019]
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LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients.
Neuro-Oncology 25(11), 2087-2097 (2023) [10.1093/neuonc/noad078]
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3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma.
Nature Communications 14(1), 2300 (2023) [10.1038/s41467-023-38044-0]
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Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes.
Acta neuropathologica 145(6), 829-842 (2023) [10.1007/s00401-023-02575-z]
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Survival in Lung Cancer in the Nordic Countries Through A Half Century.
Clinical epidemiology 15, 503 - 510 (2023) [10.2147/CLEP.S406606]
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Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
Nature genetics 55, 1078 (2023) [10.1038/s41588-023-01317-x]
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Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?
International journal of molecular sciences 24(9), 8005 (2023) [10.3390/ijms24098005]
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Pediatric Intracranial Ependymoma - Recommendations for First-Line Treatment from the German HIT-MED study group.[Kinder und Jugendliche mit intrakraniellem Ependymom ? Empfehlungen der HIT-MED-Studiengruppe der GPOH zur Erstlinientherapie].
Klinische Pa?diatrie 235(3), 167 - 177 (2023) [10.1055/a-2070-7572]
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Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.
Journal of neuro-oncology 163(1), 143-158 (2023) [10.1007/s11060-023-04319-1]
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Clinical outcome following surgical resection and radiotherapy in adult patients with pleomorphic xanthoastrocytoma as defined by DNA methylation profiling.
Neuro-oncology practice 10(3), 307 - 314 (2023) [10.1093/nop/npad004]
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Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization.
International journal of molecular sciences 24(10), 8500 (2023) [10.3390/ijms24108500]
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Desorption Kinetics Evaluation for the Development of Validated Desorption Electrospray Ionization-Mass Spectrometric Assays for Drug Quantification in Tissue Sections.
International journal of molecular sciences 24(10), 8469 (2023) [10.3390/ijms24108469]
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Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: a multicenter study.
Neuro-Oncology 25(10), 1854-1867 (2023) [10.1093/neuonc/noad096]
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Group-specific cellular metabolism in Medulloblastoma.
Journal of translational medicine 21(1), 363 (2023) [10.1186/s12967-023-04211-6]
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Pediatric meningiomas: A literature review and diagnostic update.
Neuro-oncology advances 5(Suppl 1), 105-111 (2023) [10.1093/noajnl/vdac165]
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Analysis of recurrence probability following radiotherapy in patients with CNS WHO grade 2 meningioma using integrated molecular-morphologic classification.
Neuro-oncology advances 5(1), vdad059 (2023) [10.1093/noajnl/vdad059]
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A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma.
Neuro-oncology advances 5(1), vdad057 (2023) [10.1093/noajnl/vdad057]
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Survival in Kidney and Bladder Cancers in Four Nordic Countries through a Half Century
Cancers 15(10), 2782 (2023) [10.3390/cancers15102782]
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Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development.
Acta pharmaceutica 73(2), 243 - 256 (2023) [10.2478/acph-2023-0019]
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Outcome of Children and Adolescents With Relapsed/Refractory/Progressive Malignancies Treated With Molecularly Informed Targeted Drugs in the Pediatric Precision Oncology Registry INFORM.
JCO precision oncology 7(7), e2300015 (2023) [10.1200/PO.23.00015]
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Population-Attributable Fractions of Personal Comorbidities for Liver, Gallbladder, and Bile Duct Cancers.
Cancers 15(12), 3092 (2023) [10.3390/cancers15123092]
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Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome.
Neuro-Oncology 25(12), 2273-2286 (2023) [10.1093/neuonc/noad114]
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BRCA1/2 potential founder variants in the Jordanian population: an opportunity for a customized screening panel.
Hereditary cancer in clinical practice 21(1), 11 (2023) [10.1186/s13053-023-00256-2]
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Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics.
Acta neuropathologica 146(3), 527-541 (2023) [10.1007/s00401-023-02608-7]
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Survival, Incidence, and Mortality Trends in Female Cancers in the Nordic Countries.
Obstetrics and gynecology international 2023, 1 - 9 (2023) [10.1155/2023/6909414]
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Mitochondrial DNA mutations in Medulloblastoma.
Acta Neuropathologica Communications 11(1), 124 (2023) [10.1186/s40478-023-01602-0]
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MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.
Nature Communications 14(1), 4533 (2023) [10.1038/s41467-023-40235-8]
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Implementation of DNA methylation array profiling in pediatric central nervous system tumors - the AIM BRAIN Project: an Australian and New Zealand Children's Haematology and Oncology (ANZCHOG) Group study.
The journal of molecular diagnostics 25(10), 709-728 (2023) [10.1016/j.jmoldx.2023.06.013]
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Mapping pediatric brain tumors to their origins in the developing cerebellum.
Neuro-Oncology 25(10), 1895-1909 (2023) [10.1093/neuonc/noad124]
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Conditional survival in breast cancer up to 10 years in the Nordic countries.
Cancer medicine 12(17), 17945-17951 (2023) [10.1002/cam4.6436]
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Conditional Survival in Prostate Cancer in the Nordic Countries Elucidates the Timing of Improvements.
Cancers 15(16), 4132 (2023) [10.3390/cancers15164132]
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Early mortality critically impedes improvements in thyroid cancer survival through a half century.
European journal of endocrinology 189(3), 355 - 362 (2023) [10.1093/ejendo/lvad117]
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Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours.
Genome medicine 15(1), 67 (2023) [10.1186/s13073-023-01219-x]
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Long-Term Periodic and Conditional Survival Trends in Prostate, Testicular, and Penile Cancers in the Nordic Countries, Marking Timing of Improvements.
Cancers 15(17), 4261 (2023) [10.3390/cancers15174261]
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Identification of novel genetic loci for risk of multiple myeloma by functional annotation.
Leukemia 37(11), 2326-2329 (2023) [10.1038/s41375-023-02022-8]
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The Site of Origin of Medulloblastoma: Surgical Observations Correlated to Molecular Groups.
Cancers 15(19), 4877 (2023) [10.3390/cancers15194877]
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Inflammatory Myofibroblastic Tumor With ROS1 Gene Fusions in Children and Young Adolescents.
JCO precision oncology 7(7), e2300323 (2023) [10.1200/PO.23.00323]
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Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas.
Cell reports / Medicine 4(11), 101249 (2023) [10.1016/j.xcrm.2023.101249]
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Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen: A Nonrandomized Controlled Trial.
JAMA oncology 9(12), 1688-1695 (2023) [10.1001/jamaoncol.2023.4437]
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Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Acta Neuropathologica Communications 11(1), 176 (2023) [10.1186/s40478-023-01669-9]
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Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.
Nature Communications 14(1), 7717 (2023) [10.1038/s41467-023-43564-w]
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Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.
Journal of neuro-oncology 165(3), 467-478 (2023) [10.1007/s11060-023-04500-6]
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Reference on copy number variations in pleomorphic xanthoastrocytoma: Implications for diagnostic approach.
Free Neuropathology 4, 4-19 (2023) [10.17879/FREENEUROPATHOLOGY-2023-5156]
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Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments.
EMBO molecular medicine 15(12), e18199 (2023) [10.15252/emmm.202318199]
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