2019
- Costa B, Eisemann T, Strelau J, Spaan I, Korshunov A, Liu HK, Bugert P, Angel P, Peterziel H: Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells. Blood Adv. 2019; 3:1092-1102.
- Eisemann T, Costa B, Harter PN, Wick W, Mittelbronn M, Angel P, Peterziel H. Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma. Neuro Oncol. 2019; 21:326-336.
- Eisemann T, Costa B, Peterziel H, Angel P: Podoplanin positive myeloid cells promote glioma development by immune suppression. Front Oncol. 2019; 9:187. doi: 10.3389/fonc.2019.00187.
- Eisemann T, Costa B, Strelau J, Mittelbronn M, Angel P, Peterziel H: An advanced glioma cell invasion assay based on organotypic brain slice cultures. BMC Cancer. 2019; 18:103. doi: 10.1186/s12885-018-4007-4.
- Wu J, Ma S, Hotz-Wagenblatt A, Angel P, Mohr K, Schlimmbach T, M Schmitt M, Cui G: Regulatory t cells sense effector t-cell activation through synchronized junb expression. FEBS Lett. 2019; 593:1020-1029.
- Rusu P, Shao C, Neuerburg A, Acikgoz AA, Wu Y, Zou P, Phapale P, Shankar TS, Doring K, Dettling S, Korkel-Qu H, Bekki G, Costa B, Guo T, Friesen O, Schlotter M, Heikenwalder M, Tschaharganeh DF, Bukau B, Kramer G, Angel P, Herold-Mende C, Radlwimmer B, Liu HK. Gpd1 specifically marks dormant glioma stem cells with a distinct metabolic profile. Cell Stem Cell, 2019 25:241-257 e248.
- Schneller D, Angel P: Cellular origin of hepatocellular carcinoma. In: Tirnitz-Parker JEE, ed. Hepatocellular carcinoma. Brisbane (AU); 2019.
2018
- Hiebert P, Wietecha MS, Cangkrama M, Haertel E, Mavrogonatou E, Stumpe M, Steenbock H, Grossi S, Beer HD, Angel P, Brinckmann J, Kletsas D, Dengjel J, Werner S: Nrf2-mediated fibroblast reprogramming drives cellular senescence by targeting the matrisome. Dev Cell, 2018 46:145-161 e110.
- Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K: Junb defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin. Nat Commun. 2018; 9:3425.
- Wan S, Meyer AS, Weiler SME, Rupp C, Toth M, Sticht C, Singer S, Thomann S, Roessler S, Schorpp-Kistner M, Schmitt J, Gretz N, Angel P, Tschaharganeh DF, Marquardt J, Schirmacher P, Pinna F, Breuhahn K: Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness. Hepatology, 2018; 67:1842-1856.
2015
- Baars S, Bauer C, Szabowski S, Hartenstein B, Angel P: Epithelial deletion of podoplanin is dispensable for re-epithelialization of skin wounds. Exp Dermatol. 2015; 24:785-787.
- De Ponti A, Wiechert L, Schneller D, Pusterla T, Longerich T, Hogg N, Vogel A, Schirmacher P, Hess J, Angel P: A pro-tumorigenic function of s100a8/a9 in carcinogen-induced hepatocellular carcinoma. Cancer Lett. 2015 369:396-404.
- Kiesow K, Bennewitz K, Miranda LG, Stoll SJ, Hartenstein B, Angel P, Kroll J, Schorpp-Kistner M: Junb controls lymphatic vascular development in zebrafish via mir-182. Sci Rep. 2015; 5:15007.
- Merz C, Strecker A, Sykora J, Hill O, Fricke H, Angel P, Gieffers C, Peterziel H: Neutralization of the cd95 ligand by apg101 inhibits invasion of glioma cells in vitro. Anticancer Drugs, 2015 26:716-727.
- Funk S, Mark R, Bayo P, Flechtenmacher C, Grabe N, Angel P, Plinkert PK, Hess J: High S100A8 and S100A12 protein expression is a favorable prognostic factor for survival of oropharyngeal squamous cell carcinoma. Int J Cancer, 2015; 136:2037-46. doi: 10.1002/ijc.29262.
2014
- Braun J, Strittmatter K, Nubel T, Komljenovic D, Sator-Schmitt M, Bauerle T, Angel P, Schorpp-Kistner M. Loss of stromal JUNB does not affect tumor growth and angiogenesis. International journal of cancer. Journal international du cancer 2014;134:1511-6.
- De Ponti A, Wiechert L, Stojanovic A, Longerich T, Marhenke S, Hogg N, Vogel A, Cerwenka A, Schirmacher P, Hess J, Angel P. Chronic liver inflammation and hepatocellular carcinogenesis are independent of S100A9. International journal of cancer. Journal international du cancer 2015;136:2458-63.
- Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E: Human and mouse vegfa-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discov. 2014; 4:730-743.
- Meides A, Gutschalk CM, Devel L, Beau F, Czarny B, Hensler S, Neugebauer J, Dive V, Angel P, Mueller MM: Effects of selective mmp-13 inhibition in squamous cell carcinoma depend on estrogen. Int J Cancer, 2014; 135:2749-2759.
2013
- Pusterla T, Nèmeth J, Stein I, Wiechert L, Knigin D, Marhenke S, Longerich T, Kumar V, Arnold B, , Vogel A, Bierhaus A, Pikarsky E, Hess J, Angel P: Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice. Hepatology 58 (1), 363-373, 2013.
- Schumacher M, Schuster C, Rogon ZM, Bauer T, Caushaj N, Baars S, Szabowski S, Bauer C, Schorpp-Kistner M, Hess J, Holland-Cunz S, Wagner EF, Eils R, Angel P, Hartenstein B: Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts. J Invest Dermatol. 2014; 134:1332-1341. doi: 10.1038/jid.2013.535. Epub 2013 Nov 16.
- Leibold JS, Riehl A, Hettinger J, Durben M, Hess J, Angel P: Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo. J Invest Dermatol. 2013; 133:2400-2406. doi: 10.1038/jid.2013.185. Epub 2013.
- Singh A, Rajasekaran N, Hartenstein B, Szabowski S, Gajda M, Angel P, Bräuer R, Illges H: Collagenase-3 (MMP-13) deficiency protects C57BL/6 mice from antibody-induced arthritis. Arthritis Res Ther. 2013; 15:R222.
- Leibold JS, Riehl A, Hettinger J, Durben M, Hess J, Angel P: Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo. J Invest Dermatol. 2013; 133:2400-2406. doi: 10.1038/jid.2013.185. Epub 2013
2012
- Brockschmidt, A., Trost, D., Peterziel, H., Zimmermann, K., Ehrler, M., Grassmann, H., Pfenning, P.-N., Waha, A., Stabenow, D., Brockschmidt, F.F, Jugold, M., Hoischen, A., Kalla, C, Waha, A., Seifert, G., Knolle, P.A., Latz, E., Hans, V-H., Wick, W., Pfeifer, A., Angel, P, Weber, R.G.: KIAA1797/FOCAD encodes a novel focal adhesion protein with tumor suppressor function in gliomas. Brain 135 (Pt 4), 1027-1041, 2012.
- Wiechert,L., Nemeth, J., Pusterla,C, Bauer, C., de Ponti, A., Manthey, S., Marhenke, S., Vogel, A., Klingmueller, U., Hess, J., Angel, P.: Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment. Cell Communication and Signaling 10 (1), Art. Nr. 40, 2012.
- Peterziel, H., Mueller, J., Danner, A., Barbus, S., Liu, H.-K., Radlwimmer, B., Pietsch, T., Lichter, P., Schuetz, G., Hess, J., Angel, P.: Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation. Neuro-Oncology 14 (4), 426-439, 2012.
2011
- Krenzer, S., Peterziel, H., Mauch, C., Blaber, S. I., Blaber, M., Angel, P., Hess, J.: Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. Journal of Investigative Dermatology 131 (11), 2281-2288, 2011.
- Treiber N, Maity P, Singh K, Kohn M, Keist AF, Ferchiu F, Sante L, Frese S, Bloch W, Kreppel F, Kochanek S, Sindrilaru A, Iben S, Hoegel J, Ohnmacht M, Claes LE, Ignatius A, Chung JH, Lee MJ, Kamenisch Y, Berneburg M, Nikolaus T, Braunstein K, Sperfeld AD, Ludolph AC, Briviba K, Wlaschek M, Florin L, Angel P, Scharffetter-Kochanek K.: Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue. Aging Cell 10 (2), 239-245, 2011.
2010
- Flechsig P, Hartenstein B, Teurich S, Dadrich M, Hauser K, Abdollahi A, Gröne HJ, Angel P, Huber PE. Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 2010 Jun 1;77(2):582-90
- Hildenbrand M, Rhiemeier V, Hartenstein B, Lahrmann B, Grabe N, Angel P, Hess J. Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice. J Invest Dermatol. 2010 Jul;130(7):1922-30.
- Hildenbrand, M., Rhiemeier, V., Hartenstein, B., Lahrmann, B., Grabe, N., Angel, P., Hess, J.: Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice. Journal of Investigative Dermatology 130 (7), 1922-1930, 2010.
- Riehl, A., Bauer, T., Brors, B., Busch, H., Mark, R., Nemeth, J., Gebhardt, C., Bierhaus, A., Nawroth, P., Eils, R., Koenig, R., Angel, P., Hess, J.: Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation. BMC Genomics 11 (1), 537, 2010.
- Licht, A.H., Nuebel, T., Feldner, A., Jurisch-Yaksi, N., Marcello, M, Demicheva, E., Hu, J.H., Hartenstein, B., Augustin, H.G., Hecker, M., Angel, P., Korff, T., Schorpp-Kistner, M.: Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. Journal of Clinical Investigation 120 (7), 2307-2318, 2010.
2008
- Durchdewald M, Guinea-Viniegra J , Haag D, Riehl A, Lichter P, Hahn M, Wagner EF, Angel P, Hess J. Podoplanin is a novel Fos target gene in skin carcinogenesis. Cancer Res. 2008 Sep 1;68(17):6877-83
- Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K. AP-1-Controlled Hepatocyte Growth Factor Activation Promotes Keratinocyte Migration via CEACAM1 and Urokinase Plasminogen Activator/Urokinase Plasminogen Receptor. J Invest Dermatol. 2008 Nov 20.
- Busch H, Camacho-Trullio D, Rogon Z, Breuhahn K, Angel P, Eils R, Szabowski A. Gene network dynamics controlling keratinocyte migration. Mol Syst Biol. 2008;4:199. Epub 2008 Jul 1.
- Gebhardt C, Riehl A, Durchdewald M, Németh J, Fürstenberger G, Müller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P. RAGE signaling sustains inflammation and promotes tumor development. J Exp Med. 2008 Feb 18; 205(2):275-285.
- Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K. AP-1-Controlled Hepatocyte Growth Factor Activation Promotes Keratinocyte Migration via CEACAM1 and Urokinase Plasminogen Activator/Urokinase Plasminogen Receptor. J Invest Dermatol. 2008 Nov 20. [Epub ahead of print]
2007
- Textor B, Licht AH, Tuckermann JP, Jessberger R, Razin E, Angel P, Schorpp-Kistner M, Hartenstein B. JunB is required for IgE-mediated degranulation and cytokine release of mast cells. J Immunol. 2007 Nov 15;179(10):6873-80.
- Klucky B, Mueller R, Vogt I, Teurich S, Hartenstein B, Breuhahn K, Flechtenmacher C, Angel P, Hess J. Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion. Cancer Res. 2007 Sep 1;67(17):8198-206.
- Textor B, Sator-Schmitt M, Richter KH, Angel P, Schorpp-Kistner M. c-Jun and JunB are essential for hypoglycemia-mediated VEGF induction. Ann N Y Acad Sci. 2006 Dec;1091:310-8.
- Vogel J, Weigand MA, Behrens A, Wagner EF, Schorpp-Kistner M, Zimmermann M, Schenkel J. Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action. Brain Res. 2007 Jun 2;1151:12-9. Epub 2007 Mar 13.
- Ott RG, Simma O, Kollmann K, Weisz E, Zebedin EM, Schorpp-Kistner M, Heller G, Zochbauer S, Wagner EF, Freissmuth M, Sexl V. Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action. Brain Res. 2007 Jun 2;1151:12-9. Epub 2007 Mar 13.
- Haase D, Meister M, Muley T, Hess J, Teurich S, Schnabel P, Hartenstein B, Angel P. FRMD3, a novel putative tumour suppressor in NSCLC. Oncogene. 2007 Jun 28;26(30):4464-8. Epub 2007 Jan 29.
- Fries F, Nazarenko I, Hess J, Claas A, Angel P, Zoller M. CEBPbeta, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene. Int J Cancer. 2007 May 15;120(10):2135-47.
- Hock TD, Liby K, Wright MM, McConnell S, Schorpp-Kistner M, Ryan TM, Agarwal A. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J Biol Chem. 2007 Mar 2;282(9):6875-86. Epub 2007 Jan 3.
- Schmidt D, Textor B, Pein OT, Licht AH, Andrecht S, Sator-Schmitt M, Fusenig NE, Angel P, Schorpp-Kistner M. Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis. EMBO J. 2007 Feb 7;26(3):710-9. Epub 2007 Jan 25.
2006
- Licht AH, Pein OT, Florin L, Hartenstein B, Reuter H, Arnold B, Lichter P, Angel P, Schorpp-Kistner M. JunB is required for endothelial cell morphogenesis by regulating core-binding factor {beta}. J Cell Biol. 2006 Dec; 175(6):981-91
- Textor B, Sator-Schmitt M, Richter KH, Angel P, Schorpp-Kistner M. c-Jun and JunB are Essential for hypoglycemia-mediated VEGF induction. Ann N Y Acad Sci. 2006 Dec;1091:310-8.
- Gebhardt C, Nemeth J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 2006 Nov;72(11):1622-31.
- Rhiemeier V, Breitenbach U, Richter KH, Gebhardt C, Vogt I, Hartenstein B, Fürstenberger G, Mauch C, Hess J, Angel P. A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. Am J Pathol. 2006 Apr;168(4):1354-64.
- Florin L, Knebel J, Zigrino P, Vonderstrass B, Mauch C, Schorpp-Kistner M, Szabowski A, Angel P. Delayed Wound Healing and Epidermal Hyperproliferation in Mice Lacking JunB in the Skin. J Invest Dermatol. 2006 Apr;126(4):902-11.
- Bourcier C, Jacquel A, Hess J, Peyrottes I, Angel P, Hofman P, Auberger P, Pouyssegur J, Pages G. p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res. 2006 Mar 1;66(5):2700-7.
- Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. J Invest Dermatol. 2006 Feb;126(2):486-96.
- Nausch N, Florin L, Hartenstein B, Angel P, Schorpp-Kistner M, Cerwenka A. Cutting Edge: The AP-1 Subunit JunB Determines NK Cell-Mediated Target Cell Killing by Regulation of the NKG2D-Ligand RAE-1{epsilon}. J Immunol. 2006 Jan 1;176(1):7-11.
2005
- Liao Y, Abel U, Grobholz R, Hermani A, Trojan L, Angel P, Mayer D. Up-regulation of insulin-like growth factor axis components in human primary prostate cancer correlates with tumor grade. Hum Pathol. 2005 Nov;36(11):1186-96. Epub 2005 Oct 7.
- Gack S, Marme A, Marme F, Wrobel G, Vonderstrass B, Bastert G, Lichter P, Angel P, Schorpp-Kistner M. Preeclampsia: increased expression of soluble ADAM 12. J Mol Med. 2005 Oct 25; [Epub ahead of print]
- Hummerich L, Muller R, Hess J, Kokocinski F, Hahn M, Furstenberger G, Mauch C, Lichter P, Angel P. Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. Oncogene. 2005 Oct 17; [Epub ahead of print]
- Zenz R, Eferl R, Kenner L, Florin L, Hummerich L, Mehic D, Scheuch H, Angel P, Tschachler E, Wagner EF. Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature. 2005 Sep 15;437(7057):369-75.
- Hermani A, Hess J, De Servi B, Medunjanin S, Grobholz R, Trojan L, Angel P, Mayer D. Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer. Clin Cancer Res. 2005 Jul 15;11(14):5146-52.
- Gebhardt C, Breitenbach U, Richter KH, Furstenberger G, Mauch C, Angel P, Hess J. c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis. Am J Pathol. 2005 Jul;167(1):243-53.
- Baudendistel N, Muller G, Waldeck W, Angel P, Langowski J. Two-hybrid fluorescence cross-correlation spectroscopy detects protein-protein interactions in vivo. Chemphyschem. 2005 May;6(5):984-90.
- Fei JW, Wei QX, Angel P, de Villiers EM. Differential enhancement of a cutaneous HPV promoter by DeltaNP63alpha, Jun and mutant p53. Cell Cycle. 2005 May;4(5):689-96.
- Florin L, Maas-Szabowski N, Werner S, Szabowski A, Angel P. Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts. J Cell Sci. 2005 May 1;118(Pt 9):1981-9.
- Loffek S, Zigrino P, Angel P, Anwald B, Krieg T, Mauch C. High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1alpha and basic fibroblast growth factor-mediated mechanisms. J Invest Dermatol. 2005 Mar;124(3):638-43.
2004
- Hess J, Angel P, Schorpp-Kistner M. AP-1 subunits: quarrel and harmony among siblings. J Cell Sci. 2004 Dec 1;117(Pt 25):5965-73. Review.
- Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, Fosang AJ, Schorpp-Kistner M, Angel P, Werb Z. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development. 2004 Dec;13 (23):5883-95.
- Lee YN, Tuckerman J, Nechushtan H, Schutz G, Razin E, Angel P. c-Fos as a regulator of degranulation and cytokine production in FcepsilonRI-activated mast cells. J Immunol. 2004 Aug 15;173(4):2571-7.
- Florin L, Hummerich L, Dittrich BT, Kokocinski F, Wrobel G, Gack S, Schorpp-Kistner M, Werner S, Hahn M, Lichter P, Szabowski A, Angel P. Identification of novel AP-1 target genes in fibroblasts regulated during cutaneous wound healing. Oncogene. 2004 Sep 16;23(42):7005-17.
- Florin L, Alter H, Grone HJ, Szabowski A, Schutz G, Angel P. Cre recombinase-mediated gene targeting of mesenchymal cells. Genesis. 2004 Mar;38(3):139-44.
- Bierbaum H, Baumann S, Herr I, Tuckermann JP, Hess J, Schorpp-Kistner M, Angel P. Early activation and induction of apoptosis in T cells is independent of c-Fos. Ann N Y Acad Sci. 2003 Dec;1010:225-31.
- Kenner L, Hoebertz A, Beil T, Keon N, Karreth F, Eferl R, Scheuch H, Szremska A, Amling M, Schorpp-Kistner M, Angel P, Wagner EF. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol. 2004 Feb 16;164(4):613-23.
- Fieber C, Baumann P, Vallon R, Termeer C, Simon JC, Hofmann M, Angel P, Herrlich P, Sleeman JP. Hyaluronan-oligosaccharide-induced transcription of metalloproteases. J Cell Sci. 2004 Jan 15;117(Pt 2):359-67.
2003
- Bierbaum H, Baumann S, Herr I, Tuckermann JP, Hess J, Schorpp-Kistner M, Angel P. Early activation and induction of apoptosis in T cells is independent of c-Fos. Ann N Y Acad Sci. 2003 Dec;1010:225-31.
- Hess J, Hartenstein B, Teurich S, Schmidt D, Schorpp-Kistner M, Angel P. Defective endochondral ossification in mice with strongly compromised expression of JunB. J Cell Sci. (2003) Nov 15;116(Pt 22):4587-96.
- Liao Y, Grobholz R, Abel U, Trojan L, Michel MS, Angel P, Mayer D. Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer. Int J Cancer. 2003 Nov 20;107(4):676-80.
- Munz C, Psichari E, Mandilis D, Lavigne AC, Spiliotaki M, Oehler T, Davidson I, Tora L, Angel P, Pintzas A. TAF7 (TAFII55) plays a role in the transcription activation by c-Jun. J Biol Chem. (2003) Jun 13;278(24):21510-6.
- Schlingemann J, Hess J, Wrobel G, Breitenbach U, Gebhardt C, Steinlein P, Kramer H, Furstenberger G, Hahn M, Angel P, Lichter P.Profile of gene expression induced by the tumour promotor TPA in murine epithelial cells.
- Baumann S, Hess J, Eichhorst ST, Krueger A, Angel P, Krammer PH, Kirchhoff S. An unexpected role for FosB in activation-induced cell death of T cells. Oncogene. 2003 Mar 6;22(9):1333-9.
2002
- Hartenstein B, Teurich S, Hess J, Schenkel J, Schorpp-Kistner M, Angel P. Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB. EMBO J. (2002) Dec 2;21(23):6321-9.
- Angel P, Szabowski A. Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin. (2002) Biochem Pharmacol. 64:949-56.
- Andrecht S, Kolbus A, Hartenstein B, Angel P, Schorpp-Kistner M. (2002) Cell Cycle Promoting Activity of JunB through Cyclin A Activation. J Biol Chem. 277:35961-8.
- Gebhardt C, Breitenbach U, Tuckermann JP, Dittrich BT, Richter KH, Angel P. (2002) Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis. Oncogene 21:4266-76.
- Doggett TA, Swarthout JT, Jefcoat SC Jr, Wilhelm D, Dieckmann A, Angel P, Partridge NC. Parathyroid hormone inhibits c-Jun N-terminal kinase activity in rat osteoblastic cells by a protein kinase A-dependent pathway. Endocrinology. 2002 May;143(5):1880-8.
2001
- Tuckermann JP, Vallon R, Gack S, Grigoriadis AE, Porte D, Lutz A, Wagner EF, Schmidt J, Angel P. Expression of collagenase-3 (MMP-13) in c-fos-induced osteosarcomas and chondrosarcomas is restricted to a subset of cells of the osteo-/chondrogenic lineage. Differentiation. 2001 Dec;69(1):49-57.
- Reichardt HM, Tuckermann JP, Gottlicher M, Vujic M, Weih F, Angel P, Herrlich P, Schutz G. Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J. 2001 Dec 17;20(24):7168-73.
- Breitenbach U, Tuckermann JP, Gebhardt C, Richter KH, Furstenberger G, Christofori G, Angel P. Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis. J Invest Dermatol. 2001 Sep;117(3):634-40.
- Angel, P., Szabowski, A., and Schorpp-Kistner, M. (2001). Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 20, 2413-23.
- Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Manes S, Bruckner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martinez C, Klein R. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001 May;2(5):446-52.
- Maas-Szabowski, N., Szabowski, A., Stark, H. J., Andrecht, S., Kolbus, A., Schorpp-Kistner, M., Angel, P., and Fusenig, N. E. (2001). Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation. J Invest Dermatol 116, 816-20.
- Passegue, E., Jochum, W., Schorpp-Kistner, M., Mohle-Steinlein, U., and Wagner, E. F. (2001). Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage. Cell 104, 21 32.
- Verrecchia, F., Tacheau, C., Schorpp-Kistner, M., Angel, P., and Mauviel, A. (2001). Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activation. Oncogene 20, 2205-11.
- Hess, J., Porte, D., Munz, C., and Angel, P. (2001). AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone- dependent MMP13 expression in osteoblasts through a new osteoblast- specific element 2/AP-1 composite element. J Biol Chem 276, 20029-38.
2000
- Szabowski, A., Maas-Szabowski, N., Andrecht, S., Kolbus, A., Schorpp-Kistner, M., Fusenig, N. E., and Angel, P. (2000). c-Jun and JunB antagonistically control cytokine-regulated mesenchymal- epidermal interaction in skin. Cell 103, 745-55.
- Tuckermann JP, Pittois K, Partridge NC, Merregaert J, Angel P. Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J Bone Miner Res. 2000 Jul;15(7):1257-65.
- Kolbus, A., Herr, I., Schreiber, M., Debatin, K. M., Wagner, E. F., and Angel, P. (2000). c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol 20, 575-82.
- Eichhorst, S. T., Muller, M., Li-Weber, M., Schulze-Bergkamen, H., Angel, P., and Krammer, P. H. (2000). A Novel AP-1 Element in the CD95 Ligand Promoter Is Required for Induction of Apoptosis in Hepatocellular Carcinoma Cells upon Treatment with Anticancer Drugs. Mol Cell Biol 20, 7826-7837.
before 2000
- Porte D, Tuckermann J, Becker M, Baumann B, Teurich S, Higgins T, Owen MJ, Schorpp-Kistner M, Angel P. Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene. 1999 Jan 21;18(3):667-78.
- Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF. JunB is essential for mammalian placentation. EMBO J. 1999 Feb 15;18(4):934-48.
- Schreiber M, Kolbus A, Piu F, Szabowski A, Mohle-Steinlein U, Tian J, Karin M, Angel P, Wagner EF. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 1999 Mar 1;13(5):607-19.
- Tuckermann JP, Reichardt HM, Arribas R, Richter KH, Schutz G, Angel P. The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J Cell Biol. 1999 Dec 27;147(7):1365-70.
- van Dam, H., Huguier, S., Kooistra, K., Baguet, J., Vial, E., van der Eb, A. J., Herrlich, P., Angel, P., and Castellazzi, M. (1998). Autocrine growth and anchorage independence: two complementing Jun- controlled genetic programs of cellular transformation. Genes Dev 12, 1227-39.
- Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., and Schutz, G. (1998). DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93, 531-41.
- Vallon, R., Muller, R., Moosmayer, D., Gerlach, E., and Angel, P. (1997). The catalytic domain of activated collagenase I (MMP-1) is absolutely required for interaction with its specific inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1). Eur J Biochem 244, 81-8.
- Zwilling, S., Dieckmann, A., Pfisterer, P., Angel, P., and Wirth, T. (1997). Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science 277, 221-5.
- Herr, I., Wilhelm, D., Bohler, T., Angel, P., and Debatin, K. M. (1997). Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J 16, 6200-8.
- Wilhelm, D., Bender, K., Knebel, A., and Angel, P. (1997). The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol Cell Biol 17, 4792-800.
- Schorpp, M., Jager, R., Schellander, K., Schenkel, J., Wagner, E. F., Weiher, H., and Angel, P. (1996). The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res 24, 1787-8.
- Schorpp, M., Mattei, M. G., Herr, I., Gack, S., Schaper, J., and Angel, P. (1995). Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J 308, 211-7.
- van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P., and Angel, P. (1995). ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J 14, 1798-811.
- Gack, S., Vallon, R., Schmidt, J., Grigoriadis, A., Tuckermann, J., Schenkel, J., Weiher, H., Wagner, E. F., and Angel, P. (1995). Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ 6, 759-67.
- Schreiber, M., Baumann, B., Cotten, M., Angel, P., and Wagner, E. F. (1995). Fos is an essential component of the mammalian UV response. EMBO J 14, 5338-49.
- Bannister, A. J., Oehler, T., Wilhelm, D., Angel, P., and Kouzarides, T. (1995). Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11, 2509-14.
- Gack, S., Vallon, R., Schaper, J., Ruther, U., and Angel, P. (1994). Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem 269, 10363-9.
- Oehler, T., Pintzas, A., Stumm, S., Darling, A., Gillespie, D., and Angel, P. (1993). Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP1-dependent genes by v-Jun. Oncogene 8, 1141-7.
- Hagmeyer, B. M., Konig, H., Herr, I., Offringa, R., Zantema, A., van der Eb, A., Herrlich, P., and Angel, P. (1993). Adenovirus E1A negatively and positively modulates transcription of AP- 1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun. EMBO J 12, 3559-72.
- Stein, B., Baldwin, A. S., Jr., Ballard, D. W., Greene, W. C., Angel, P., and Herrlich, P. (1993). Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 12, 3879-91.
- Oehler, T., and Angel, P. (1992). A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins. Mol Cell Biol 12, 5508-15.
- Angel, P., and Karin, M. (1991). The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072, 129-57.
- Chiu, R., Angel, P., and Karin, M. (1989). Jun-B differs in its biological properties from, and is a negative regulator of c-Jun. Cell 59, 979-86.
- Angel, P., Allegretto, E. A., Okino, S. T., Hattori, K., Boyle, W. J., Hunter, T., and Karin, M. (1988). Oncogene jun encodes a sequence-specific trans-activator similar to AP- 1. Nature 332, 166-71.
- Angel, P., Hattori, K., Smeal, T., and Karin, M. (1988). The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55, 875-85.
- Angel, P., Imagawa, M., Chiu, R., Stein, B., Imbra, R. J., Rahmsdorf, H. J., Jonat, C., Herrlich, P., and Karin, M. (1987). Phorbolester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49, 729-39.