Publications

Cancer Hallmarks: Piecing the Puzzle Together.Alcolea MP, Alonso-Curbelo D, Ambrogio C, Bullman S, Correia AL, Ernst A, Halbrook CJ, Kelly GL, Lund AW, Quail DF, Ruscetti M, Shema E, Stromnes IM, Tam WL. Cancer Discov. 2024 Apr 4;14(4):674-682.

Rausch T, Snajder R, Leger A, Simovic M, ... , Bonder MJ*, Ernst A*, Korbel JO*. Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures. Cell Genomics (2023) 3(4):100281

Comparative parallel multi-omics analysis during the induction of pluripotent and trophectoderm states. Jaber M, Radwan A, Loyfer N, Abdeen M, Sebban S, Khatib A, Yassen H, Kolb T, Zapatka M, Makedonski K, Ernst A, Kaplan T, Buganim Y. Nat Commun. 2022 Jun 17;13(1):3475.

Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis. Schreiber HS, Simovic M, Ernst A. Current Stem Cell Reports. 10 May 2022. Invited review.

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis. Khalid U, Simovic M, Hammann LA, Iskar M, Wong JKL, Kumar R, Jugold M, Sill M, Bolkestein M, Kolb T, Hergt M, Devens F, Ecker J, Kool M, Milde T, Westermann F, Benner A, Lewis J, Dietrich S, Pfister SM, Lichter P, Zapatka M, Ernst A. IJC. 2022 Aug 15;151(4):590-606.

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions. Dias D, Kalkitsas J, Kelahmetoglu Y, Estrada C, Tatarishvili J, Holl D, Jansson L, Banitalebi S, Amiry-Moghaddam M, Ernst A, Huttner H, Kokaia Z, Lindvall O, Brundin L, Frisen J, Goeritz C. Nat Commun. 2021 Sep 17;12(1):5501.

Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model. Simovic M, Bolkestein M, Moustafa M, Wong JKL, Körber V, Benedetto S, Khalid U, Schreiber HS, Jugold M, Korshunov A, Hübschmann D, Mack N, Brons S, Wei PC, Breckwoldt MO, Heiland S, Bendszus M, Jürgen D, Höfer T, Zapatka M, Kool M, Pfister SM, Abdollahi A, Ernst A. Neuro Oncol. 2021 May 28.

Cell-based model systems for genome instability: Dissecting the mechanistic basis of chromothripsis in cancer. Kolb T, Ernst A. Int J Cancer. 2021 May 1. Invited review.

The age of adult pilocytic astrocytoma cells. Voronina N*, Aichmueller C*, Kolb T*, Korshunov A, Ryzhova M, Barnholtz-Sloan J, Cioffi G, Sill M, von Deimling A, Pfister SM, Gronych J, Jones D, Frisen J, Zapatka J, Ernst A. Oncogene. 2021 Apr;40(16):2830-2841.

Chromothripsis, DNA repair and checkpoints defects. Simovic M, Ernst A. Semin Cell Dev Biol. 2021 Feb 12:S1084-9521(21)00025-2. Invited review.

Chromothripsis in human breast cancer. Bolkestein M, Wong JKL, Thewes V, Körber V, Hlevnjak M, Elgaafary S, Schulze M, Kommoss FKF, Sinn P, Anzeneder T, Hirsch S, Devens F, Schröter P, Höfer T, Schneeweiss A, Lichter P, Zapatka M, Ernst A. Cancer Research. 2020 Nov 15;80(22):4918-4931.

A versatile system to introduce clusters of genomic double-strand breaks in large cell populations. Kolb T, Khalid U, Simović M, Ratnaparkhe M, Wong J, Jauch A, Schmezer P, Rode A, Sebban S, Haag D, Hergt M, Devens F, Buganim Y, Zapatka M, Lichter P, Ernst A. Genes Chromosomes Cancer. 2020 Jul 31.

The landscape of chromothripsis across adult cancer types. Voronina N, Wong JKL, Hübschmann D, Hlevnjak M, Sebastian Uhrig S, Heilig CE, Horak P, Kreutzfeldt S, Mock A, Stenzinger A, Hutter B, Fröhlich M, Brors B, Jahn A, Klink B, Gieldon L, Sieverling L, Feuerbach L, Priya Chudasama P, Beck K, Kroiss M, Heining C, Möhrmann L, Fischer A, Schröck E, Glimm H, Zapatka M, Lichter P, Fröhling S, Ernst A. Nat Commun. 2020 May 8;11(1):2320.

Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response. Aichmüller CF, Iskar M, Jones DTW, Korshunov A, Radlwimmer B, Kool M, Ernst A, Pfister SM, Lichter P, Zapatka M. Neuro Oncol. 2020 Feb 13.

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors. Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A. Nat Commun. 2018 Nov 12;9(1):4760.

Nuclear envelope structure and proteasome function of micronuclei. Maass KK, Rosing F, Ronchi P, Willmund KV, Devens F, Hergt M, Herrmann H, Lichter P, Ernst A. Exp Cell Res. 2018 Oct 15;371(2):353-363.

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugières L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hernáiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon DA, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM. Lancet Oncol. 2018 Jun;19(6):785-798.

Evidence for a pre-malignant cell line in a skin biopsy from a patient with Nijmegen breakage syndrome. Habib R, Neitzel H, Ernst A, Wong JKL, Goryluk-Kozakiewicz B, Gerlach A, Demuth I, Sperling K, Chrzanowska K. Mol Cytogenet. 2018 Feb 7;11:17.

Integrative genomic and transcriptomic analysis of leiomyosarcoma. Chudasama P, Mughal SS, Sanders MA, Hübschmann D, Chung I, Deeg KI, Wong SH, Rabe S, Hlevnjak M, Zapatka M, Ernst A, Kleinheinz K, Schlesner M, Sieverling L, Klink B, Schröck E, Hoogenboezem RM, Kasper B, Heilig CE, Egerer G, Wolf S, von Kalle C, Eils R, Stenzinger A, Weichert W, Glimm H, Gröschel S, Kopp HG, Omlor G, Lehner B, Bauer S, Schimmack S, Ulrich A, Mechtersheimer G, Rippe K, Brors B, Hutter B, Renner M, Hohenberger P, Scholl C, Fröhling S. Nat Commun. 2018 Jan 10;9(1):144.

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype. Rücker FG, Dolnik A, Blätte TJ, Teleanu V, Ernst A, Thol F, Heuser M, Ganser A, Döhner H, Döhner K, Bullinger L. Haematologica. 2018 Jan;103(1):e17-e20.

Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis. Ratnaparkhe M, Hlevnjak M, Kolb T, Jauch A, Maass KK, Devens F, Rode A, Hovestadt V, Korshunov A, Pastorczak A, Mlynarski W, Sungalee S, Korbel J, Hoell J, Fischer U, Milde T, Kramm C, Nathrath M, Chrzanowska K, Tausch E, Takagi M, Taga T, Constantini S, Loeffen J, Meijerink J, Zielen S, Gohring G, Schlegelberger B, Maass E, Siebert R, Kunz J, Kulozik AE, Worst B, Jones DT, Pfister SM, Zapatka M, Lichter P, Ernst A. Leukemia. 2017 Oct;31(10):2048-2056.

Telomere dysfunction and chromothripsis. Ernst A, Jones DT, Maass KK, Rode A, Deeg KI, Jebaraj BM, Korshunov A, Hovestadt V, Tainsky MA, Pajtler KW, Bender S, Brabetz S, Gröbner S, Kool M, Devens F, Edelmann J, Zhang C, Castelo-Branco P, Tabori U, Malkin D, Rippe K, Stilgenbauer S, Pfister SM, Zapatka M, Lichter P. Int J Cancer. 2016 Jun 15;138(12):2905-14.

Chromothripsis in cancer cells: An update. Rode A*, Maass KK*, Willmund KV, Lichter P, Ernst A. Int J Cancer. 2016 May 15;138(10):2322-33.

Adult neurogenesis in humans- common and unique traits in mammals. Ernst A, Frisén J. PLoS Biol. 2015 Jan 26;13(1):e1002045.

Neurogenesis in the striatum of the adult human brain. Ernst A, Alkass K, Bernard S, Salehpour M, Perl S, Tisdale J, Possnert G, Druid H, Frisén J. Cell. 2014 Feb 27;156(5):1072-83.

Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation. Kees T, Lohr J, Noack J, Mora R, Gdynia G, Tödt G, Ernst A, Radlwimmer B, Falk CS, Herold-Mende C, Régnier-Vigouroux A. Neuro Oncol. 2012 Jan;14(1):64-78.

A gene signature distinguishing CD133hi from CD133- colorectal cancer cells: essential role for EGR1 and downstream factors. Ernst A, Aigner M, Nakata S, Engel F, Schlotter M, Kloor M, Brand K, Schmitt S, Steinert G, Rahbari N, Koch M, Radlwimmer B, Weitz J, Lichter P. Pathology. 2011 Apr;43(3):220-7.

An in vitro model for Pelger-Huët anomaly: stable knockdown of lamin B receptor in HL-60 cells. Olins AL, Ernst A, Zwerger M, Herrmann H, Olins DE. Nucleus. 2010 Nov-Dec;1(6):506-12.

Differentiation therapy exerts antitumor effects on stem-like glioma cells. Campos B, Wan F, Farhadi M, Ernst A, Zeppernick F, Tagscherer KE, Ahmadi R, Lohr J, Dictus C, Gdynia G, Combs SE, Goidts V, Helmke BM, Eckstein V, Roth W, Beckhove P, Lichter P, Unterberg A, Radlwimmer B, Herold-Mende C. Clin Cancer Res. 2010 May 15;16(10):2715-28.

De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures. Ernst A, Campos B, Meier J, Devens F, Liesenberg F, Wolter M, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B. Oncogene. 2010 Jun 10;29(23):3411-22.

Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival. Ernst A, Hofmann S, Ahmadi R, Becker N, Korshunov A, Engel F, Hartmann C, Felsberg J, Sabel M, Peterziel H, Durchdewald M, Hess J, Barbus S, Campos B, Starzinski-Powitz A, Unterberg A, Reifenberger G, Lichter P, Herold-Mende C, Radlwimmer B. Clin Cancer Res. 2009 Nov 1;15(21):6541-50. Oct 27.

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma. Milde T, Pfister S, Korshunov A, Deubzer HE, Oehme I, Ernst A, Starzinski-Powitz A, Seitz A, Lichter P, von Deimling A, Witt O. Genes Chromosomes Cancer. 2009 Mar;48(3):229-38.

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. Pfister S, Janzarik WG, Remke M, Ernst A, Werft W, Becker N, Toedt G, Wittmann A, Kratz C, Olbrich H, Ahmadi R, Thieme B, Joos S, Radlwimmer B, Kulozik A, Pietsch T, Herold-Mende C, Gnekow A, Reifenberger G, Korshunov A, Scheurlen W, Omran H, Lichter P. J Clin Invest. 2008 May;118(5):1739-49.