Recent Publications

Selection of recent publications (for a complete list see https://pubmed.ncbi.nlm.nih.gov/?term=bartenschlager-r)

• Neufeldt C, Cerikan B, Cortese M, Frankish J, Lee JY, Plociennikowska A, Heigwer F, Prasad V, Joecks S, Burkart S, Zander D, Subramanian B, Gimi R, Padmanabhan S, Iyer R, Gendarme M, El Debs B, Halama N, Merle U, Boutros M, Binder M, Bartenschlager R. 2022. SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB. Communication Biology.
• Tabata, K., Prasad, V., Paul, D. et al. 2021. Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun 12, 7276.
• Twu WI, Lee JY, Kim H, Prasad V, Cerikan B, Haselmann U, Tabata K, Bartenschlager R. 2021. Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation. Cell Rep. 37(8):110049.
• Plociennikowska A, Frankish J, Moraes T, Del Prete D, Kahnt F, Acuna C, Slezak M, Binder M, Bartenschlager R. 2021. TLR3 activation by Zika virus stimulates inflammatory cytokine production which dampens the antiviral response induced by RIG-I-like receptors. J Virol. 95(10):e01050-20.
• Lee J-Y, Cortese M, Haselmann U, Tabata K, Romero-Brey I, Funaya C, Schieber N, Qiang Y, Bartenschlager M, Kallis S, Ritter C, Rohr K, Schwab Y, Ruggieri A, Bartenschlager R. 2019. Spatio-temporal coupling of the hepatitis C virus replication cycle by creation of a lipid droplet proximal membranous replication compartment. Cell Reports, 27(12):3602-3617.

• Tabata K, Prasad V, Paul D, Lee JY, Pham MT, Twu WI, Neufeldt CJ, Cortese M, Cerikan B, Stahl Y, Joecks S, Tran CS, Lüchtenborg C, V'kovski P, Hörmann K, Müller AC, Zitzmann C, Haselmann U, Beneke J, Kaderali L, Erfle H, Thiel V, Lohmann V, Superti-Furga G, Brügger B, Bartenschlager R. 2021. Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nat Commun. 12(1):7276.
• Zhang Z, Filzmayer C, Ni Y, Sültmann H, Mutz P, Hiet MS, Vondran FWR, Bartenschlager R, Urban S. 2018. Hepatitis D Virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes. Journal of Hepatology Jul;69(1):25-35.
• Lauber C, Seitz S, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs J and Bartenschlager R. 2017. Deciphering the origin and evolution of hepatitis B viruses by means of a family of nonenveloped fish viruses. Cell Host & Microbe, 22(3):387-399.
• Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt C, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R. 2016. Dengue virus perturbs mitochondrial morphodynamics to dampen innate immune responses. Cell Host & Microbe, 20(3):342-56. (Cover story)
• Seitz S, Iancu C, Volz T, Mier W, Dandri M, Urban S, Bartenschlager R. 2016. A slow maturation process renders hepatitis B virus infectious. Cell Host & Microbe 20(1):25-35.
• Romero-Brey I, Berger C, Kallis S, Kolovou A, Paul D, Lohmann V, Bartenschlager R. 2015. NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication. MBio. 6. pii: e00759-15.
• Poenisch M, Metz P, Blankenburg H, Ruggieri A, Lee JY, Rupp D, Rebhan I, Diederich K, Kaderali L, Domingues FS, Albrecht M, Lohmann V, Erfle H, Bartenschlager R. 2015. Identification of HNRNPK as regulator of hepatitis C virus particle production. PLoS Pathogens11:e1004573.
• Madan V, Paul D, Lohmann V, Bartenschlager R. 2014. Inhibition of HCV Replication by Cyclophilin Antagonists is Linked to Replication Fitness and Occurs by Inhibition of Membranous Web Formation. Gastroenterology. 146:1361-72
• Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R. 2014. Daclatasvir-like Inhibitors of NS5A Block Early Biogenesis of HCV-induced Membranous Replication Factories, Independent of RNA Replication. Gastroenterology. 147:1094-110
• Paul D, Hoppe S, Saher G, Krijnse-Locker J, Bartenschlager R. 2013 Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. Journal of Virology 87:10612-27. (Cover image, selected as Spotlight)
• Romero-Brey I, Merz A, Chiramel A, Lee JY, Chlanda P, Haselman U, Santarella-Mellwig R, Habermann A, Hoppe S, Kallis S, Walther P, Antony C, Krijnse-Locker J, Bartenschlager R. 2012. Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication. PLoS Pathog. 8(12):e1003056. (Editor pick)
• Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G. 2012. Viral immune modulators perturb the human molecular network by common and unique strategies. Nature. 487:486-90.
• Bauhofer O, Ruggieri A, Schmid B, Schirmacher P, Bartenschlager R. 2012. Persistance of HCV in Quiescent Hepatic Cells during an Interferon-Induced Antiviral Response. Gastroenterology. 143:429-38
• Metz P, Dazert E, Ruggieri A, Mazur J, Kaderali L, Kaul A, Zeuge U, Trippler M, Lohmann V, Binder M, Frese M, Bartenschlager R. 2012. Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology. 56:2082-93
• Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R. 2012. Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host & Microbe. 12:71-85. (selected as one out of ten papers of the year)
• Long G, Hiet MS, Windisch MP, Lee JY, Lohmann V, Bartenschlager R. 2011. Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology 141:1057-66.
• Jirasko V, Montserret R, Lee JY, Gouttenoire J, Moradpour D, Penin F, Bartenschlager R. 2010. Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathogens 6:e1001233
• Kaul A, Stauffer S, Berger C, Pertel T, Schmitt J, Kallis S, Lopez MZ, Lohmann V, Luban J, Bartenschlager R. 2009. Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathogens 5: e1000546.
• Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R. 2009. Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe. 5:365-75. Cover image
• Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R*, Thimme R*. 2009. Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest. 119:376-86. *co-corresponding authors
• Pietschmann T, Zayas M, Meuleman P, Long G, Appel N, Koutsoudakis G, Kallis S, Leroux-Roels G, Lohmann V, Bartenschlager R. 2009. Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathogens 5:e1000475
• Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, Kallis S, Engel U, Bartenschlager R. 2008. Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog. 28; 4(3). e1000035
• Miyanari, Y., K. Atsuzawa, U. Nobuteru, K. Watashi, T. Hishiki, M. Zayas, R. Bartenschlager, T. Wakita, M. Hijikata, K. Shimotohno. 2007. The Lipid droplet is an organelle important for Hepatitis C virus production. Nature Cell Biology 9:1089-97.
• Pietschmann T, A. Kaul, G. Koutsoudakis, A. Shavinskaya, S. Kallis, E. Steinmann, K. Abid, F. Negro, M. Dreux F.L. Cosset, and R. Bartenschlager. 2006. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proceedings of the National Academy of Sciences USA 103:7408-7413
• Wakita, T.*, T. Pietschmann*, T. Kato, T. Date, M. Miyamoto, Z. Zhao, K. Murthy, A. Habermann, H.-G. Kräusslich, M. Mizokami, R. Bartenschlager*, and T.J. Liang. 2005. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nature Medicine, 11:791-796. * Equal contribution.
• Lohmann, V., F. Körner, J.O. Koch, U. Herian, L. Theilmann and R. Bartenschlager. 1999. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science, 285:110-113.
• Lohmann, V., H. Overton and R. Bartenschlager. 1999. Selective Stimulation of Hepatitis C Virus and Pestivirus NS5B RNA Polymerase Activity by GTP. Journal of Biological Chemistry, 274:10807-10815.
• Lohmann, V., F. Körner, U. Herian and R. Bartenschlager. 1997. Biochemical properties of hepatitis C virus RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. Journal of Virology 71:8416-8428.
• Bartenschlager, R., V. Lohmann, T. Wilkinson and J. O. Koch. 1995. Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation. Journal of Virology 69:7519-7528.
• Bartenschlager, R., L. Ahlborn-Laake, K. Yasargil, J. Mous, and H. Jacobsen. 1995. Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase. Journal of Virology 69:198-205.
• Bartenschlager, R., L. Ahlborn-Laake, J. Mous, and H. Jacobsen. 1994. Kinetic and structural analyses of hepatitis C virus polyprotein processing. Journal of Virology 68:5045-5055.
• Bartenschlager, R., L. Ahlborn-Laake, J. Mous, and H. Jacobsen. 1993. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. Journal of Virology 67:3835-3844.
• Bartenschlager, R. and H. Schaller. 1992. Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome. EMBO Journal 11:3413-3420.
• Bartenschlager, R. and H. Schaller. 1988. The amino-terminal domain of the hepadnaviral P-gene encodes the terminal protein (genome-linked protein) believed to prime reverse transcription. EMBO Journal 7:4185-4192.

• Tabata K, Neufeldt CJ, Bartenschlager R. 2019. Hepatitis C Virus Replication. Cold Spring Harb Perspect Med 2020;10:a037093.
• Bartenschlager R, Urban S, Protzer U. 2019. Towards curative therapy of chronic viral hepatitis. Z Gastroenterol. 57(1):61-73.
• Neufeldt CJ, Cortese M, Acosta EG, Bartenschlager R. 2018. Rewiring cellular networks by members of the Flaviviridae family. Nat Rev Microbiol. 16(3):125-142.
• Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T. 2018. Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies. Virus Res. 248:53-62.
• Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R. 2018. Host-directed therapies for bacterial and viral infections. Nat Rev Drug Discov 17, 35–56.
• Tu T, Bühler S, Bartenschlager R. 2017. Chronic viral hepatitis and its association with liver cancer. Biol Chem. 398(8):817-837.
• Bartenschlager RF, Rice CM, Sofia MJ. 2016. Hepatitis C Virus-From Discovery to Cure: The 2016 Lasker-DeBakey Clinical Medical Research Award. JAMA. 2016 Sep 27;316(12):1254-5.
• Urban S, Bartenschlager R, Kubitz R, Zoulim F. 2014. Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes. Gastroenterology. 147:48-64.
• Paul D, Madan V, Bartenschlager R. 2014. Hepatitis C Virus RNA Replication and Assembly: Living on the Fat of the Land. Cell Host & Microbe 16:569-579.
• Bartenschlager, R. (Editor) 2013. Hepatitis C Virus: From Molecular Virology to Antiviral Therapy. Series: Current Topics in Microbiology and Immunology, Vol. 369.
• Lohmann V, Bartenschlager R. 2013. On the History of Hepatitis C Virus Cell Culture Systems. J Med Chem. 57(5):1627-42.
• Bühler S, Bartenschlager R. 2012. Promotion of hepatocellular carcinoma by hepatitis C virus. Dig Dis. 2012;30(5):445-52.
• Bartenschlager, R. 2002. Hepatitis C virus replicons – potential role for drug development. 2002. Nature Reviews Drug Discovery, 1:911-916.