Scientific Core Facilities and Services - German Cancer Research Center

News from our Core Facilities

LMCF CrossTalks Seminar and Workshop
24 February 2025, 13:00 - 14:00
German Cancer Research Center (DKFZ), A0.106 (ATV, Ground Floor)

Extract more convincing high quality data from 3 D samples by applying THUNDER to your spinning disk confocal images While spinning disk alone provides powerful optical sectioning, applying THUNDER eliminates residual out of focus light for greater contrast and resolution, unlocking even more details Get more statistically
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The THUNDER Imager Cell Spinning Disk demo device will be available at the LMCF from February 25-27. Please contact us to make an appointment.

Below, the DKFZ Core Facilities are listed according to their area of specialty.

Genome, Transcriptome & Epigenome

The NGS Core Facility offers state-of-the-art DNA, RNA and bisulfite sequencing using Illumina MiSeq, NextSeq and NovaSeq technologies as well as Oxford Nanopore technologies.

More info about the Next Generation Sequencing Core Facility

The Microarray Core Facility provides state-of-the-art microarray technologies for Expression Profiling, Methylation Analysis, Genotyping/Copy-Number-Variation(CNV). High-throughput protein analysis utilizing cutting-edge Olink® technology, kinase activity profiling as well as assisted access to ddPCR and qPCR instruments and Ingenuity are also part of our service portfolio.

More info about the Microarray Core Facility

The Single-cell Open Lab provides an infrastructure for processing cells, preparing libraries for single-cell sequencing as well as spatial omics.

More info about the Single-cell Open Lab

Proteome

The unit provides mass spectrometry based Proteomics. State-of-the-art hardware in combination with specialized workflows allows most sensitive and in-depth Proteome analysis.

More info about the Proteomics Core Facility

The Single-cell Open Lab provides an infrastructure for processing cells, preparing libraries for single-cell sequencing as well as spatial omics.

More info about the Single-cell Open Lab

The Microarray Core Facility provides state-of-the-art microarray technologies for Expression Profiling, Methylation Analysis, Genotyping/Copy-Number-Variation(CNV). High-throughput protein analysis utilizing cutting-edge Olink® technology, kinase activity profiling as well as assisted access to ddPCR and qPCR instruments and Ingenuity are also part of our service portfolio.

More info about the Microarray Core Facility

The Antibodies Core Facility offers the production of monoclonal (mouse/rat) antibodies using the hybridoma technology and the production of polyclonal (guinea pig) ABs. In addition the Antibodies Core Facility offers antibody sequencing, engineering and recombinant expression.

More info about the Antibodies Core Facility

Metabolome

The Metabolomics Core Technology Platform (MCTP) is a core facility of Heidelberg University and officially collaborates with DKFZ. It is localized within the Centre for Organismal Studies. We offer a broad range of qualitative and quantitative metabolomics services from diverse sample matrices to all DKFZ groups as internal users.

More info about the Metabolomics Core Technology Platform

Cellular and Preclinical Imaging

The Electron Microscopy Core Facility performs experiments in full service for ultrastructural studies by TEM as well as SEM.

More info about the Electron Microscopy Core Facility

The Light Microscopy Core Facility offers a variety of advanced imaging-related services at several locations on the campus. We provide consultation, hands-on training, technical support and open access (24/7) to cutting-edge instrumentation and a broad range of applications.

More info about the Microscopy Core Facility

The Small Animal Imaging Center supports users in the application of numerous radiological methods such as ultrasound, optical imaging, µPET, µCT, µSPECT and MRT measurements to collect and quantify morphological and functional data in vivo.

More info about the Small Animal Imaging Core Facility

The service Unit for Radiopharmaceuticals and Preclinical Studies provides consultation and support in imaging and irradiation design/irradiation for preclinical studies as well as in experimental design for animal studies.

More info about the Service Unit for Radiopharmaceuticals and Preclinical Studies

Cytometry and Screening

The Immune Monitoring Unit supports oncology studies (IITs or industry-sponsored studies) of all phases using various state-of-the-art immunological analysis techniques.

More info about the Immune Monitoring Unit

The Flow Cytometry Core Facility advises and supports scientists in the planning, execution and evaluation of flow cytometry analyses and cell sorting. Modern instruments (analytical instruments and cell sorters) as well as various software are available for this purpose.

More info about the Flow Cytometry Core Facility

The Chemical Biology Core Facility is a collaboration between DKFZ and the European Molecular Biology Laboratory (EMBL) in Heidelberg, and is located at EMBL. The aim of this core facility is to provide researchers with inhibitory molecules against their target of interest and enable them to answer essential questions in their research.

More info about the Chemical Biology Core Facility

Whole Tissue Analysis

The Immune Monitoring Unit supports oncology studies (IITs or industry-sponsored studies) of all phases using various state-of-the-art immunological analysis techniques.

More info about the Immune Monitoring Unit

The Light Microscopy Core Facility offers a variety of advanced imaging-related services at several locations on the campus. We provide consultation, hands-on training, technical support and open access (24/7) to cutting-edge instrumentation and a broad range of applications.

More info about the Microscopy Core Facility

The Single-cell Open Lab provides an infrastructure for processing cells, preparing libraries for single-cell sequencing as well as spatial omics.

More info about the Single-cell Open Lab

Reagents and Resources for Cancer Research

The Antibodies Core Facility offers the production of monoclonal (mouse/rat) antibodies using the hybridoma technology and the production of polyclonal (guinea pig) ABs. In addition the Antibodies Core Facility offers antibody sequencing, engineering and recombinant expression.

More info about the Antibodies Core Facility

The Cellular Tools Core Facility offers standardized vector and clone resources as well as modular services for cell-based gain- and loss-of-function technologies.

More info about the Cellular Tools Core Facility

The Dieter Morszeck Biorepository is a fully automated cold storage facility in which valuable liquid biospecimens can be stored.

More info about the Dieter Morszeck Biorepository

The service Unit for Radiopharmaceuticals and Preclinical Studies provides consultation and support in imaging and irradiation design/irradiation for preclinical studies as well as in experimental design for animal studies.

More info about the Service Unit for Radiopharmaceuticals and Preclinical Studies

Animal Services

The Center for Preclinical Research (ZPF) advises and assists researchers in the design and realization of their animal experiments. It consists of four subdivisions: Central Animal Laboratory, Tumor Models, Microbiological Diagnostics and Transgene Service.

More info about the Center for Preclinial Research

Research Data Management

The Omics IT and Data Management Core Facility (ODCF) provides high-throughput computing, data management and basic bioinformatics services to groups at the DKFZ and their collaborating partners.

More info about the Omics IT and Data Management Core Facility

Library and IT Services

The Information Technology Core Facility (ITCF) is responsible for optimum usage of IT at DKFZ, for supporting staff of all departments in matters of choosing IT tools for their special needs as well as for providing central IT Services and support which are essential for everyone at DKFZ.

More info about the Information Technology Core Facility

The Library provides among other things scientific literature and information needed by the scientists of the German Cancer Research Center.

More info about the Library

Enabling Technology Department

The Enabling Technology Department is headed by the Chief Enabling Technology Officer Prof. Elisa May. She oversees the following Core Facilities: Antibodies, Cellular Tools, Chemical Biology (with EMBL), Dieter Morszeck Biorepository, Electron Microscopy, Flow Cytometry, Light Microscopy, Microarray, Next Generation Sequencing, Proteomics, Single Cell OpenLab, Small Animal Imaging, and the Scullery. The Department is also involved in two projects on biomage data management: the DFG project "Information Infrastructure for BioImage Data Management – I3D:bio", and the consortium "NFDI4BioImage" in the National Research Data Infrastructure NFDI, where Prof. May serves as a Co-Speaker.

Prof. Dr. Elisa May

Chief Enabling Technology Officer
+49 6221 42 2682

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Sigrid Ruder

CETO Assistant and Secretariat
+49 6221 42 2017

Contact form: Message to Sigrid Ruder

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Dr. Laura Pelz

Core Facility Coordinator and CETO Assistant
+49 6221 42 2014

Contact form: Message to Dr. Laura Pelz

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Dr. Christian Schmidt

Scientific Project Manager Research Data Management Microscopy
+49 6221 42 2657

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List of Technologies

Here you can find a searchable database of our equipment and service portfolio.

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