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Immunoproteomics

  • HI-TRON Mainz
  • Immunology, Infection and Cancer
Prof. Dr. Stefan Tenzer

Prof. Dr. Stefan Tenzer

The Tenzer research group focuses on the development, optimization and application of mass spectrometry (MS)-based workflows for quantitative immunoproteomics to facilitate a detailed understanding of the interplay between tumor antigenicity, tumor microenvironment and the anti-tumor immune response.

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Our Research

Currently, the research group harbours several high-resolution mass spectrometry instrument platforms, including three timsTOF Pro-2, one timsTOF SCP (Bruker) and two Orbitraps Exploris 480 (Thermo Scientific). With these high-performance instruments, the Tenzer research group investigates the contribution of proteases involved in MHC-I-restricted antigen processing and develops high sensitivity methods and workflows for the in-depth characterization of the immunopeptidome. This will enable high-throughput immuno-phenotyping of quantity-limited clinical samples to define biomarkers and neoantigen targets for individualized immunotherapies.

Team

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    Prof. Dr. Stefan Tenzer

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    Dr. Mohammad Abukhalaf

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    Julian Beyrle

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    Dr. Yannic Chen

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    Anke Ries

Get in touch with us

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Prof. Dr. Stefan Tenzer
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