Publications of E050 in 2021
Journal Article
Screening and Psycho-Oncological Support for Patients With Head and Neck Cancer and Brain Malignancies Before Radiotherapy With Mask Fixation: Results of a Feasibility Study.
Frontiers in psychology 12, 760024 (2021) [10.3389/fpsyg.2021.760024]
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Journal Article
Treatment outcomes of elderly salivary gland cancer patients undergoing radiotherapy - results from a large multicenter analysis.
Radiotherapy and oncology 156, 266-274 (2021) [10.1016/j.radonc.2020.12.024]
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Journal Article
How can scanned proton beam treatment planning for low-grade glioma cope with increased distal RBE and locally increased radiosensitivity for late MR-detected brain lesions?
Medical physics 48(4), 1497-1507 (2021) [10.1002/mp.14739]
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Journal Article
DCE-MRI detected vascular permeability changes in the rat spinal cord do not explain shorter latency times for paresis after carbon ions relative to photons.
Radiotherapy and oncology 165, 126-134 (2021) [10.1016/j.radonc.2021.09.035]
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Journal Article
Joint optimization of photon - carbon ion treatments for Glioblastoma.
International journal of radiation oncology, biology, physics 111(2), 559-572 (2021) [10.1016/j.ijrobp.2021.05.126]
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Journal Article
Knowledge bases and software support for variant interpretation in precision oncology.
Briefings in bioinformatics 22(6), bbab134 (2021) [10.1093/bib/bbab134]
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Journal Article
Comparative Analyses of Two Established Scores to Assess the Stability of Spinal Bone Metastases Before and After Palliative Radiotherapy.
Frontiers in oncology 11, 753768 (2021) [10.3389/fonc.2021.753768]
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Journal Article
ESTRO-ACROP recommendations on the clinical implementation of hybrid MR-linac systems in radiation oncology.
Radiotherapy and oncology 159, 146-154 (2021) [10.1016/j.radonc.2021.03.025]
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Book/Proceedings
Continuous-Time Deep Glioma Growth Models
10.1007/978-3-030-87199-4_8, StraßburgStraßburg, France, 27 Sep 2021 - 1 Oct 2021
Lecture Notes in Computer Science 12903, (2021) [10.1007/978-3-030-87199-4_8]
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Journal Article
68Ga-FAPI-PET/CT in patients with various gynecological malignancies.
European journal of nuclear medicine and molecular imaging 48(12), 4089-4100 (2021) [10.1007/s00259-021-05378-0]
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Journal Article
Carbon Ion FLASH Dose-Rate Radiotherapy: First Investigation in Human Brain Organoids.
International journal of radiation oncology, biology, physics 111(3S), e231 (2021) [10.1016/j.ijrobp.2021.07.791]
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Journal Article (Review Article)
Physics and biomedical challenges of cancer therapy with accelerated heavy ions
Nature reviews 3(12), 777-790 (2021) [10.1038/s42254-021-00368-5]
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Journal Article
Severe skin toxicity during whole-brain radiotherapy, targeted therapy, and additional drug intake including St. John's wort skin oil.
Strahlentherapie und Onkologie 197(7), 644-649 (2021) [10.1007/s00066-020-01739-0]
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Journal Article (Editorial)
Carbon Ion Radiation Therapy: One Decade of Research and Clinical Experience at Heidelberg Ion Beam Therapy Center.
International journal of radiation oncology, biology, physics 111(3), 597 - 609 (2021) [10.1016/j.ijrobp.2021.05.131]
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Journal Article
Effectiveness and Toxicity of Fractionated Proton Beam Radiotherapy for Cranial Nerve Schwannoma Unsuitable for Stereotactic Radiosurgery.
Frontiers in oncology 11, 772831 (2021) [10.3389/fonc.2021.772831]
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Journal Article
Effect of timing, technique and molecular features on brain control with local therapies in oncogene-driven lung cancer.
ESMO open 6(3), 100161 (2021) [10.1016/j.esmoop.2021.100161]
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Journal Article
High-sensitivity cardiac troponin T determines all-cause mortality in cancer patients: a single-centre cohort study.
ESC heart failure 8(5), 3709-3719 (2021) [10.1002/ehf2.13515]
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Journal Article
Head-to-head intra-individual comparison of biodistribution and tumor uptake of 68Ga-FAPI and 18F-FDG PET/CT in cancer patients.
European journal of nuclear medicine and molecular imaging 48(13), 4377-4385 (2021) [10.1007/s00259-021-05307-1]
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Journal Article
FAPI-74 PET/CT Using Either 18 F-AlF or Cold-Kit 68 Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients
Journal of nuclear medicine 62(2), 201 - 207 (2021) [10.2967/jnumed.120.245084]
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Journal Article
Effectiveness of fractionated carbon ion treatments in three rat prostate tumors differing in growth rate, differentiation and hypoxia.
Radiotherapy and oncology 158, 131-137 (2021) [10.1016/j.radonc.2021.01.038]
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Journal Article
ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy.
The pharmacogenomics journal 21(1), 37-46 (2021) [10.1038/s41397-020-0174-1]
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Journal Article (Erratum/Correction)
Correction: ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy.
The pharmacogenomics journal 21(2), 273 (2021) [10.1038/s41397-020-00193-6]
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Journal Article
3D-printed individualized tooth-borne tissue retraction devices compared to conventional dental splints for head and neck cancer radiotherapy: a randomized controlled trial
Radiation oncology 16(1), 75 (2021) [10.1186/s13014-021-01803-8]
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Journal Article
Individualized 3D-Printed Tissue Retraction Devices for Head and Neck Radiotherapy.
Frontiers in oncology 11, 628743 (2021) [10.3389/fonc.2021.628743]
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Journal Article (Review Article)
Magnetic-resonance-guided radiotherapy : The beginning of a new era in radiation oncology?[Magnetresonanzgeführte Strahlentherapie : Beginn einer neuen Ära in der Radioonkologie?]
Der Radiologe 61(1), 13-20 (2021) [10.1007/s00117-020-00761-8]
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Journal Article
Intensity-modulated radiotherapy (IMRT) with simultaneously integrated boost shortens treatment time and is non-inferior to conventional radiotherapy followed by sequential boost in adjuvant breast cancer treatment: results of a large randomized phase III trial (IMRT-MC2 trial).
International journal of radiation oncology, biology, physics 109(5), 1311-1324 (2021) [10.1016/j.ijrobp.2020.12.005]
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Journal Article (Review Article)
MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy?
Frontiers in oncology 10, 615697 (2021) [10.3389/fonc.2020.615697]
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Journal Article
A practical implementation of risk management for the clinical introduction of online adaptive Magnetic Resonance-guided radiotherapy
Physics & Imaging in Radiation Oncology 17, 53 - 57 (2021) [10.1016/j.phro.2020.12.005]
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Journal Article
Sarcoma classification by DNA methylation profiling.
Nature Communications 12(1), 498 (2021) [10.1038/s41467-020-20603-4]
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Journal Article
Clinical outcome of PSMA-guided radiotherapy for patients with oligorecurrent prostate cancer.
European journal of nuclear medicine and molecular imaging 48(1), 143-151 (2021) [10.1007/s00259-020-04777-z]
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Journal Article
Predicting the Risk of Metastases by PSMA-PET/CT-Evaluation of 335 Men with Treatment-Naïve Prostate Carcinoma.
Cancers 13(7), 1508 (2021) [10.3390/cancers13071508]
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Journal Article
Novel FAP ligands enable improved imaging contrast in sarcoma patients due to FAPI-PET/CT.
European journal of nuclear medicine and molecular imaging 48(12), 3918-3924 (2021) [10.1007/s00259-021-05374-4]
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Journal Article
Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM).
Physica medica 81, 273-284 (2021) [10.1016/j.ejmp.2020.11.028]
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Dissertation / PhD Thesis
New Methods to Evaluate and Reduce Uncertainties in Particle Therapy: From LET Calculation to CICR Planning
Dissertation, Universität Heidelberg, 2021[10.11588/HEIDOK.00029703]
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Journal Article
Simultaneous targeting of TGF-?/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion.
Cancer cell 39(10), 1388-1403.e10 (2021) [10.1016/j.ccell.2021.08.008]
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Journal Article
Definitive radiotherapy for squamous cell carcinoma of the oral cavity: a single-institution experience.
Radiology and oncology 55(4), 467 - 473 (2021) [10.2478/raon-2021-0041]
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Journal Article
Impact of FAPI-PET/CT on Target Volume Definition in Radiation Therapy of Locally Recurrent Pancreatic Cancer
Cancers 13(4), 796 (2021) [10.3390/cancers13040796]
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Journal Article
Effectiveness of Carbon Ion Radiation in Locally Advanced Pancreatic Cancer.
Frontiers in oncology 11, 708884 (2021) [10.3389/fonc.2021.708884]
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Journal Article
Deciphering time-dependent DNA damage complexity, repair and oxygen tension: a mechanistic model for FLASH-dose-rate radiotherapy.
International journal of radiation oncology, biology, physics 110(2), 574-586 (2021) [10.1016/j.ijrobp.2020.12.048]
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Journal Article (Other)
Combined DNA Damage Repair Inhibition and Ion Beam Therapy: Development, Benchmark and Clinical Implications of a Mechanistic Biological Model.
International journal of radiation oncology, biology, physics 111(3S), e247 - e248 (2021) [10.1016/j.ijrobp.2021.07.829]
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Journal Article
18F-labeled tracers targeting fibroblast activation protein.
EJNMMI radiopharmacy and chemistry 6(1), 26 (2021) [10.1186/s41181-021-00144-x]
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Journal Article
Development and Benchmarking of a Monte Carlo Dose Engine for Proton Radiation Therapy
Frontiers in physics 9, 741453 (2021) [10.3389/fphy.2021.741453]
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Journal Article
FLASH Dose-Rate Helium Ion Beams: First In Vitro Investigations.
International journal of radiation oncology, biology, physics 111(3S), S20 - S21 (2021) [10.1016/j.ijrobp.2021.07.076]
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Journal Article
Individual 3D-printed fixation masks for radiotherapy: first clinical experiences.
International journal of computer assisted radiology and surgery 16(6), 1043-1049 (2021) [10.1007/s11548-021-02393-2]
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Journal Article
Spot-Scanning Hadron Arc (SHArc) Therapy: A Study With Light and Heavy Ions.
Advances in radiation oncology 6(3), 100661 (2021) [10.1016/j.adro.2021.100661]
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Journal Article
Postoperative Radiotherapy for Endometrial Cancer in Elderly (?80 Years) Patients: Oncologic Outcomes, Toxicity, and Validation of Prognostic Scores.
Cancers 13(24), 6264 (2021) [10.3390/cancers13246264]
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Journal Article
Neck involvement and disease recurrence in adenoid cystic carcinoma of the minor salivary glands: the role of surgery in primary and progressive disease.
International journal of oral and maxillofacial surgery 50(4), 423-430 (2021) [10.1016/j.ijom.2020.07.034]
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Journal Article
Toward AI-Driven Proton Dose Calculation: Development and Evaluation of 3D and 2D Sequential Neural Network Design.
International journal of radiation oncology, biology, physics 111(3S), e116 (2021) [10.1016/j.ijrobp.2021.07.528]
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Journal Article
Biologically consistent dose accumulation using daily patient imaging.
Radiation oncology 16(1), 65 (2021) [10.1186/s13014-021-01789-3]
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Journal Article
Assessment of Sodium MRI at 7 Tesla as Predictor of Therapy Response and Survival in Glioblastoma Patients
Frontiers in neuroscience 15, 782516 (2021) [10.3389/fnins.2021.782516]
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Journal Article
Safety and Efficacy of Stereotactic Body Radiotherapy in Ultracentral Lung Tumors Using a Risk-optimized Fractionation Scheme
Clinical lung cancer 22(4), 332-340.e3 (2021) [10.1016/j.cllc.2020.11.003]
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Journal Article
Simultaneous integrated boost concepts in definitive radiation therapy for esophageal cancer: outcomes and toxicity.
Radiation oncology 16(1), 23 (2021) [10.1186/s13014-021-01749-x]
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Journal Article
Impact of 68 Ga-FAPI PET/CT Imaging on the Therapeutic Management of Primary and Recurrent Pancreatic Ductal Adenocarcinomas
Journal of nuclear medicine 62(6), 779 - 786 (2021) [10.2967/jnumed.120.253062]
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Journal Article
Spinal Stabilization Exercises for Cancer Patients with Spinal Metastases of High Fracture Risk: Feasibility of the DISPO-II Training Program.
Cancers 13(2), 201 (2021) [10.3390/cancers13020201]
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Journal Article
Improved risk stratification via integration of radiomics and dosiomics features in patients with recurrent high-grade glioma undergoing carbon ion radiotherapy (CIRT)
American journal of clinical oncology 2043(39), 15_suppl (2021) [10.1200/JCO.2021.39.15_suppl.2043]
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Journal Article
Intensity Modulated Radiotherapy with Carbon Ion Radiotherapy Boost for Acinic Cell Carcinoma of the Salivary Glands.
Cancers 13(1), 124 (2021) [10.3390/cancers13010124]
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Journal Article
Prognostic Value of microRNA-221/2 and 17-92 Families in Primary Glioblastoma Patients Treated with Postoperative Radiotherapy
International journal of molecular sciences 22(6), 2960 (2021) [10.3390/ijms22062960]
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Journal Article
Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study.
Cancer epidemiology 70, 101873 (2021) [10.1016/j.canep.2020.101873]
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Journal Article
Methods of spatial cluster detection in rare childhood cancers: Benchmarking data and results from a simulation study on nephroblastoma
Data in Brief 34, 106683 (2021) [10.1016/j.dib.2020.106683]
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Journal Article
The role of combined ion-beam radiotherapy (CIBRT) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma.
Radiotherapy and oncology 159, 8-16 (2021) [10.1016/j.radonc.2021.01.029]
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Journal Article
Neoadjuvant irradiation of retroperitoneal soft tissue sarcoma with ions (Retro-Ion): study protocol for a randomized phase II pilot trial.
Trials 22(1), 134 (2021) [10.1186/s13063-021-05069-z]
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Journal Article
Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma.
Radiotherapy and oncology 155, 293-303 (2021) [10.1016/j.radonc.2020.10.024]
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Journal Article
PD-L1-R: A MR based surrogate for PD-L1 expression in Glioblastoma multiforme.
Journal of clinical oncology 39(15_suppl), 2041 - 2041 (2021) [10.1200/JCO.2021.39.15_suppl.2041]
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Journal Article
Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.
Neuro-Oncology 23(12), 2028-2041 (2021) [10.1093/neuonc/noab127]
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Journal Article (Review Article)
MR-guided radiotherapy of moving targets [MR-gestützte Strahlentherapie beweglicher Zielobjekte].
Der Radiologe 61(Suppl 1), 39-48 (2021) [10.1007/s00117-020-00781-4]
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Journal Article (Review Article)
Models for Translational Proton Radiobiology-From Bench to Bedside and Back.
Cancers 13(16), 4216 (2021) [10.3390/cancers13164216]
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Journal Article
FLASH dose-rate helium ion beams: first in vitro investigations.
International journal of radiation oncology, biology, physics 111(4), 1011-1022 (2021) [10.1016/j.ijrobp.2021.07.1703]
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Journal Article
Quality of life after simultaneously integrated boost with intensity-modulated versus conventional radiotherapy with sequential boost for adjuvant treatment of breast cancer: 2-year results of the multicenter randomized IMRT-MC2 trial.
Radiotherapy and oncology 163, 165-176 (2021) [10.1016/j.radonc.2021.08.019]
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Journal Article
Longitudinal MRI study after carbon ion and photon irradiation: shorter latency time for myelopathy is not associated with differential morphological changes.
Radiation oncology 16(1), 63 (2021) [10.1186/s13014-021-01792-8]
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Journal Article
Neurocognitive Outcomes in Pediatric Patients Following Brain Irradiation.
Cancers 13(14), 3538 (2021) [10.3390/cancers13143538]
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Journal Article
Magnetic Resonance-Guided Stereotactic Body Radiotherapy of Liver Tumors: Initial Clinical Experience and Patient-Reported Outcomes.
Frontiers in oncology 11, 610637 (2021) [10.3389/fonc.2021.610637]
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Journal Article (Review Article)
Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review.
EJNMMI Research 11(1), 18 (2021) [10.1186/s13550-021-00761-2]
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Journal Article (Erratum/Correction)
Carbon Ion and Proton Beam Irradiation of a Normal Human TK6 Lymphoblastoid Cell Line Within a Magnetic Field of 1.0 Tesla [Corrigendum]
Cancer management and research Volume 13, 4763 - 4764 (2021) [10.2147/CMAR.S323335]
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Journal Article
In Vivo Evaluation of Combined CK2 Inhibition and Irradiation in Human WiDr Tumours.
In vivo 35(1), 111 - 117 (2021) [10.21873/invivo.12238]
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Journal Article
Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge.
Anticancer research 41(4), 1909 - 1920 (2021) [10.21873/anticanres.14957]
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