Research
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- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
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- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
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- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
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- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
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- Metabolic crosstalk in cancer
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- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
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- Translational Control and Metabolism
- Soft-Tissue Sarcoma
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- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
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Arunraj Dhamodaran
Arunraj Dhamodaran
Position:
Postdoctoral Researcher
Scientific CV
Since April 2024
Postdoctoral Researcher, Microbiome and Cancer, DKFZ, Heidelberg Germany
2019-2023
T-knife Therapeutics, Berlin Germany & San Francisco USA
Founding Scientist (2019-2020), Team Lead & Sr. Manager (2020-2023)
2013-2019
PhD Fellow, Max Delbrück Center for Molecular Medicine, Berlin Germany
2010-2012
M.Sc.: Cancer Biology, International Program by DKFZ & Uni-Heidelberg Germany
2006-2010
Bachelor of Tech.: Biotechnology, VIT University - Vellore Campus, India
Publications
Dhamodaran, A., Chen, X., Fellmer, N., Agrawal, D., Danner, E., Kühn, R., Blankenstein, T. Mice with a diverse human T cell receptor repertoire selected on a complete HLA class I haplotype. In preparation.
Welters, C., Welters, M-L., Stadler, S., Bullinger, L., Strobel, J., Hackstein, H., Dhamodaran, A., Blankenstein, T., Hansmann, L. HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation. Haematologica 10.3324, 283812 (2023).
Blanc, E., Holtgrewe, M., Dhamodaran, A. et al. Identification and ranking of recurrent neo-epitopes in cancer. BMC Med Genomics 12, 171 (2019).
Leliavski, A., Knackstedt, L., Oduro, J., Selck, C., Dhamodaran, A. et al. Generating optimal-affinity T cell receptors targeting the shared neoantigen KRAS G12V using the humanized TCR transgenic mouse platform HuTCR. Cancer Res 82, 5507 (2022).
T. Kalaivani, M. Sasirekha, Dhamodaran, Arunraj, et al. In Vitro evaluation of antibacterial activity of phytochemical extracts from aerial parts of Bacopa monnieri (L.) (Scorphulariaceae). Journal of Pharmacy Research 5(3),1636-1639 (2012).
IP/Patents
Patents on fully humanized HLA/TCR mouse model for TCR discovery.
A non-human mammal comprising in its genome at least two human leukocyte antigen (HLA) class I alleles, methods of making such mammal and uses thereof. Main inventor. MDC-Berlin & T-knife/2023-08-03. EPO Nr. EP4215042A1. PCT Nr. WO2023144087A1.
Patent on TCRs against KRAS neoantigen.
Antigen recognizing construct that binds specific peptide with determinable affinity and T cell receptor having antigenic specificity for KRAS as well as corresponding nucleic acid sequence, vector, host cell, pharmaceutical composition and kit. Co-inventor. T-knife/2023-07-27. PCT Nr. WO2023139257A1.
Connect with me - LinkedIn:
https://www.linkedin.com/in/arunraj-dhamodaran/