Human heparanase – a promising target for the development of therapeutic strategies in cancer
Number of publications: 16
Israeli Partner: I. Vlodavsky, Cancer and Vascular Biology Res. Center
German Partner: P. Beckhove (div. of V. Schirrmacher), DKFZ
Publications
| Publication |
|---|
| Publication |
|
Abboud-Jarrous, G., Atzmon, R., Peretz, T., Palermo, C., Gadea, B. B., Joyce, J. A., Vlodavsky, I.
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment 283 (26), J Biol Chem, 18167-76, 2008 |
|
Barash, U., Cohen-Kaplan, V., Arvatz, G., Gingis-Velitski, S., Levy-Adam, F., Nativ, O., Shemesh, R., Ayalon-Sofer, M., Ilan, N., Vlodavsky, I.
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics 24 (4), Faseb j, 1239-48, 2010 |
|
Ben-Zaken, O., Shafat, I., Gingis-Velitski, S., Bangio, H., Kelson, I. K., Alergand, T., Amor, Y., Maya, R. B., Vlodavsky, I., Ilan, N.
Low and high affinity receptors mediate cellular uptake of heparanase 40 (3), Int J Biochem Cell Biol, 530-42, 2008 |
|
Bonertz, A., Weitz, J., Pietsch, D. H., Rahbari, N. N., Schlude, C., Ge, Y., Juenger, S., Vlodavsky, I., Khazaie, K., Jaeger, D., Reissfelder, C., Antolovic, D., Aigner, M., Koch, M., Beckhove, P.
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma 119 (11), J Clin Invest, 3311-21, 2009 |
|
Casu, B., Vlodavsky, I., Sanderson, R. D.
Non-anticoagulant heparins and inhibition of cancer 36 (3), Pathophysiol Haemost Thromb, 195-203, 2008 |
|
Cohen, E., Doweck, I., Naroditsky, I., Ben-Izhak, O., Kremer, R., Best, L. A., Vlodavsky, I., Ilan, N.
Heparanase is overexpressed in lung cancer and correlates inversely with patient survival 113 (5), Cancer, 1004-11, 2008 |
|
Cohen-Kaplan, V., Doweck, I., Naroditsky, I., Vlodavsky, I., Ilan, N.
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression 68 (24), Cancer Res, 10077-85, 2008 |
|
Cohen-Kaplan, V., Naroditsky, I., Zetser, A., Ilan, N., Vlodavsky, I., Doweck, I.
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis 123 (11), Int J Cancer, 2566-73, 2008 |
|
Domschke, C., Schuetz, F., Ge, Y., Seibel, T., Falk, C., Brors, B., Vlodavsky, I., Sommerfeldt, N., Sinn, H. P., Kuhnle, M. C., Schneeweiss, A., Scharf, A., Sohn, C., Schirrmacher, V., Moldenhauer, G., Momburg, F., Beckhove, P.
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis 69 (21), Cancer Res, 8420-8, 2009 |
|
Fux, L., Feibish, N., Cohen-Kaplan, V., Gingis-Velitski, S., Feld, S., Geffen, C., Vlodavsky, I., Ilan, N.
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling 69 (5), Cancer Res, 1758-67, 2009 |
|
Lerner, I., Baraz, L., Pikarsky, E., Meirovitz, A., Edovitsky, E., Peretz, T., Vlodavsky, I., Elkin, M.
Function of heparanase in prostate tumorigenesis: potential for therapy 14 (3), Clin Cancer Res, 668-76, 2008 |
|
Pusterla, T., Nemeth, J., Stein, I., Wiechert, L., Knigin, D., Marhenke, S., Longerich, T., Kumar, V., Arnold, B., Vogel, A., Bierhaus, A., Pikarsky, E., Hess, J., Angel, P.
Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice 58 (1), Hepatology, 363-73, 2013 |
|
Schuetz, F., Ehlert, K., Ge, Y., Schneeweiss, A., Rom, J., Inzkirweli, N., Sohn, C., Schirrmacher, V., Beckhove, P.
Treatment of advanced metastasized breast cancer with bone marrow-derived tumour-reactive memory T cells: a pilot clinical study 58 (6), Cancer Immunol Immunother, 887-900, 2009 |
|
Shafat, I., Barak, A. B., Postovsky, S., Elhasid, R., Ilan, N., Vlodavsky, I., Arush, M. W.
Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatment 9 (11), Neoplasia, 909-16, 2007 |
|
Shafat, I., Pode, D., Peretz, T., Ilan, N., Vlodavsky, I., Nisman, B.
Clinical significance of urine heparanase in bladder cancer progression 10 (2), Neoplasia, 125-30, 2008 |
|
Zcharia, E., Jia, J., Zhang, X., Baraz, L., Lindahl, U., Peretz, T., Vlodavsky, I., Li, J. P.
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases 4 (4), PLoS One, e5181, 2009 |