Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Molecular Neurobiology
- Mechanisms Regulating Gene Expression
- Molecular Biology of Centrosomes and Cilia
- Dermato-Oncology
- Pediatric Leukemia
- Tumour Metabolism and Microenvironment
- Personalized Medical Oncology
- Molecular Hematology - Oncology
- Cancer Progression and Metastasis
- Translational Surgical Oncology
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Cell Fate Engineering and Disease Modeling
- Cancer Drug Development
- Cell Morphogenesis and Signal Transduction
- Functional and Structural Genomics
- Molecular Genome Analysis
- Molecular Genetics
- Pediatric Neurooncology
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
- Areas of Interest
- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
- Group Members
- Publications
- Open Positions
- Funding
- Teaching
- Areas of Interest
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Applied Functional Genomics
- Applied Bioinformatics
- Translational Medical Oncology
- Metabolic crosstalk in cancer
- Pediatric Glioma Research
- Cancer Epigenomics
- Translational Pediatric Sarcoma Research
- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
- Neuropathology
- Pediatric Oncology
- Neurooncology
- Somatic Evolution and Early Detection
- Translational Control and Metabolism
- Soft-Tissue Sarcoma
- Precision Sarcoma Research
- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
- Brain Tumor Translational Targets
- Translational Functional Cancer Genomics
- Regulatory Genomics and Cancer Evolution
- SPRINT
- Cancer Risk Factors and Prevention
- Cancer Epidemiology
- Biostatistics
- Clinical Epidemiology and Aging Research
- Health Economics
- Physical Activity, Prevention and Cancer
- Preventive Oncology
- Personalized Early Detection of Prostate Cancer
- Digital prevention, diagnostics and therapy guidance
- Tumorigenesis and molecular cancer prevention
- Genomic Epidemiology
- Cancer Survivorship
- Immunology, Infection and Cancer
- Structural Biology of Infection and Immunity
- Cellular Immunology
- B Cell Immunology
- Immune Diversity
- Immunoproteomics
- Personalized Immunotherapy
- mRNA Cancer Immunotherapies
- Tumor Immunology and Tumor Immunotherapy
- Infections and Cancer Epidemiology
- Pathogenesis of Virus-Associated Tumors
- Immunotherapy and Immunoprevention
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Microbiome and Cancer
- Molecular Oncology of Gastrointestinal Tumors
- Applied Tumor Immunity
- Neuroimmunology and Brain Tumor Immunology
- Applied Tumor Biology
- Virotherapy
- Adaptive Immunity and Lymphoma
- Dermal Oncoimmunology
- Immune Regulation in Cancer
- Systems Immunology and Single Cell Biology
- Pediatric Immuno-Oncology
- Epithelium Microbiome lnteractions
- Experimental Hepatology, Inflammation and Cancer
- GMP & T Cell Therapy
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immune Monitoring
- News
- Imaging and Radiooncology
- Radiology
- Research
- Computational Radiology Research Group
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Dual- and Multienergy CT
- Radiomics Research Group
- Prostate Research Group
- Bone marrow
- Musculoskeletal Imaging
- Microstructural Imaging Research Group
- Staff
- Patients
- Research
- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Federated Information Systems
- Translational Molecular Imaging
- Medical Physics in Radiation Oncology
- Biomedical Physics in Radiation Oncology
- Intelligent Medical Systems
- Medical Image Computing
- Radiooncology - Radiobiology
- Smart Technologies for Tumor Therapy
- Team
- Research
- Microrobots and Miniaturize Devices for Minimally-invasive Surgery
- Magnetic localization and sensing for biomedical devices
- Nanorobots for Targeted Delivery in Deep Biological Tissues
- 3D Additive Manufacturing of Soft Materials as In Vitro Tumor Models
- Surgical Simulation on Cyber-physical Organ Models
- News
- Vacancies
- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Translational Radiotheranostics
- Interactive Machine Learning
- Intelligent Systems and Robotics in Urology
- Multiparametric methods for early detection of prostate cancer
- Translational Molecular Imaging in Oncologic Therapy Monitoring
- Radiology
- Cell Biology and Tumor Biology
- Research Groups A-Z
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- List of Core Facilities
- Antibodies
- Cellular Tools
- Center for Preclinical Research
- Central Library
- Chemical Biology
- Dieter Morszeck Biorepository
- Electron Microscopy
- Flow Cytometry
- Information Technology ITCF
- Light Microscopy
- Metabolomics
- Microarray
- Microbiological Diagnostics
- Next Generation Sequencing
- Omics IT and Data Management
- Proteomics
- Radiopharmaceuticals and Preclinical Trials
- Single-cell Open Lab
- Small Animal Imaging
- Transgenic Service
- Tumor Models
- OMERO@DKFZ
- List of Technologies
- DKFZ Core Facilities Publication Policy
- Enabling Technology
- Data Science @ DKFZ
- INFORM
- Baden-Württemberg Cancer Registry
- Cooperations & Networks
- National Cooperations
- International Cooperations
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Program
- Members of the Program Committee
- Call
- Publication Database
- German-Israeli Cancer Research Schools
- Archive
- Heidelberg - Israel, Science and Culture
- Symposium 40 Years of German-Israeli Cooperation
- 35th Anniversary Symposium
- 34th Meeting of the DKFZ-MOST Program
- 40th Anniversary Publication
- 30th Anniversary Publication
- 20th Anniversary Publication
- Flyer - The Cancer Cooperation Program
- List Publications 1976-2004
- Highlight-Projects
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Cooperations with industrial companies
- DKFZ PostDoc Network
- Cross Program Topic RNA@DKFZ
- Cross Program Topic Epigenetics@dkfz
- Cross Program Topic Single Cell Sequencing
- WHO Collaborating Centers
- DKFZ Site Dresden
- Health + Life Science Alliance Heidelberg Mannheim
Publications in 2023
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Falckenhayn, C. ; Bienkowska, A. ; Söhle, J. ; Wegner, K. ; Raddatz, G. ; Kristof, B. ; Kuck, D. ; Siegner, R. ; Kaufmann, R. ; Korn, J. ; Baumann, S. ; Lange, D. ; Schepky, A. ; Völzke, H. ; Kaderali, L. ; Winnefeld, M. ; Lyko, F. ; Grönniger, E.
Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin.
Frontiers in aging 4, 1258184 (2023) [10.3389/fragi.2023.1258184]2023
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Bienkowska, A. ; Raddatz, G. ; Söhle, J. ; Kristof, B. ; Völzke, H. ; Gallinat, S. ; Lyko, F. ; Kaderali, L. ; Winnefeld, M. ; Grönniger, E. ; Falckenhayn, C.
Development of an epigenetic clock to predict visual age progression of human skin.
Frontiers in aging 4, 1258183 (2023) [10.3389/fragi.2023.1258183]2023
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Legrand, C. (First author) ; Andriantsoa, R. ; Lichter, P. ; Raddatz, G. ; Lyko, F. (Last author)
Time-resolved, integrated analysis of clonally evolving genomes.
PLoS Genetics 19(12), e1011085 - (2023) [10.1371/journal.pgen.1011085]2023
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Carneiro, V. ; Galil, B. ; Lyko, F. (Last author)
A voyage into the Levant: the first record of a marbled crayfish Procambarus virginalis (Lyko, 2017) population in Israel
BioInvasions Records 12(3), 829 - 836 (2023) [10.3391/bir.2023.12.3.18]2023
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Schütz, S. (First author) ; Solé-Boldo, L. ; Lucena-Porcel, C. ; Hoffmann, J. ; Brobeil, A. ; Lonsdorf, A. S. ; Rodríguez-Paredes, M. (Last author) ; Lyko, F. (Last author)
Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma.
Nature Communications 14(1), 5413 (2023) [10.1038/s41467-023-41141-9]2023
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Cirzi, C. (First author) ; Dyckow, J. ; Legrand, C. ; Schott, J. ; Guo, W. ; Perez Hernandez, D. ; Hisaoka, M. ; Parlato, R. ; Pitzer, C. ; van der Hoeven, F. ; Dittmar, G. ; Helm, M. ; Stoecklin, G. ; Schirmer, L. ; Lyko, F. ; Tuorto, F. (Last author)
Queuosine-tRNA promotes sex-dependent learning and memory formation by maintaining codon-biased translation elongation speed.
The EMBO journal 42(19), e112507 (2023) [10.15252/embj.2022112507]2023
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Koch, J. (First author) ; Neuberger, M. ; Schmidt-Dengler, M. ; Xu, J. ; Carneiro, V. C. ; Ellinger, J. ; Kriegmair, M. C. ; Nuhn, P. ; Erben, P. ; Michel, M. S. ; Helm, M. ; Rodríguez-Paredes, M. ; Nientiedt, M. ; Lyko, F. (Last author)
Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder.
iScience 26(8), 107300 (2023) [10.1016/j.isci.2023.107300]2023
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Ansari, I. ; Solé-Boldo, L. (First author) ; Ridnik, M. ; Gutekunst, J. ; Gilliam, O. R. ; Korshko, M. ; Liwinski, T. ; Jickeli, B. ; Weinberg-Corem, N. ; Shoshkes-Carmel, M. ; Pikarsky, E. ; Elinav, E. ; Lyko, F. ; Bergman, Y.
TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.
Nature Communications 14(1), 4005 (2023) [10.1038/s41467-023-39512-3]2023
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Lyko, F. (Last author)
Distal memory in wound healing and cancer
Nature cell biology 25(5), 631-632 (2023) [10.1038/s41556-023-01132-w]2023
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Venkatesh, G. (First author) ; Tönges, S. ; Hanna, K. ; Ng, Y. L. ; Whelan, R. ; Andriantsoa, R. ; Lingenberg, A. ; Roy, S. ; Nagarajan, S. ; Fong, S. ; Raddatz, G. ; Böhl, F. ; Lyko, F. (Last author)
Context-dependent DNA methylation signatures in animal livestock.
Environmental epigenetics 9(1), dvad001 (2023) [10.1093/eep/dvad001]2023
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