Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Molecular Neurobiology
- Mechanisms Regulating Gene Expression
- Molecular Biology of Centrosomes and Cilia
- Dermato-Oncology
- Pediatric Leukemia
- Tumour Metabolism and Microenvironment
- Personalized Medical Oncology
- Molecular Hematology - Oncology
- Cancer Progression and Metastasis
- Translational Surgical Oncology
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Cell Fate Engineering and Disease Modeling
- Cancer Drug Development
- Cell Morphogenesis and Signal Transduction
- Functional and Structural Genomics
- Molecular Genome Analysis
- Molecular Genetics
- Pediatric Neurooncology
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
- Areas of Interest
- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
- Group Members
- Publications
- Open Positions
- Funding
- Teaching
- Areas of Interest
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Applied Functional Genomics
- Applied Bioinformatics
- Translational Medical Oncology
- Metabolic crosstalk in cancer
- Pediatric Glioma Research
- Cancer Epigenomics
- Translational Pediatric Sarcoma Research
- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
- Neuropathology
- Pediatric Oncology
- Neurooncology
- Somatic Evolution and Early Detection
- Translational Control and Metabolism
- Soft-Tissue Sarcoma
- Precision Sarcoma Research
- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
- Brain Tumor Translational Targets
- Translational Functional Cancer Genomics
- Regulatory Genomics and Cancer Evolution
- SPRINT
- Cancer Risk Factors and Prevention
- Cancer Epidemiology
- Biostatistics
- Clinical Epidemiology and Aging Research
- Health Economics
- Physical Activity, Prevention and Cancer
- Preventive Oncology
- Personalized Early Detection of Prostate Cancer
- Digital prevention, diagnostics and therapy guidance
- Tumorigenesis and molecular cancer prevention
- Genomic Epidemiology
- Cancer Survivorship
- Immunology, Infection and Cancer
- Structural Biology of Infection and Immunity
- Cellular Immunology
- B Cell Immunology
- Immune Diversity
- Immunoproteomics
- Personalized Immunotherapy
- mRNA Cancer Immunotherapies
- Tumor Immunology and Tumor Immunotherapy
- Infections and Cancer Epidemiology
- Pathogenesis of Virus-Associated Tumors
- Immunotherapy and Immunoprevention
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Microbiome and Cancer
- Molecular Oncology of Gastrointestinal Tumors
- Applied Tumor Immunity
- Neuroimmunology and Brain Tumor Immunology
- Applied Tumor Biology
- Virotherapy
- Adaptive Immunity and Lymphoma
- Dermal Oncoimmunology
- Immune Regulation in Cancer
- Systems Immunology and Single Cell Biology
- Pediatric Immuno-Oncology
- Epithelium Microbiome lnteractions
- Experimental Hepatology, Inflammation and Cancer
- GMP & T Cell Therapy
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immune Monitoring
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- Imaging and Radiooncology
- Radiology
- Research
- Computational Radiology Research Group
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Dual- and Multienergy CT
- Radiomics Research Group
- Prostate Research Group
- Bone marrow
- Musculoskeletal Imaging
- Microstructural Imaging Research Group
- Staff
- Patients
- Research
- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Federated Information Systems
- Translational Molecular Imaging
- Medical Physics in Radiation Oncology
- Biomedical Physics in Radiation Oncology
- Intelligent Medical Systems
- Medical Image Computing
- Radiooncology - Radiobiology
- Smart Technologies for Tumor Therapy
- Team
- Research
- Microrobots and Miniaturize Devices for Minimally-invasive Surgery
- Magnetic localization and sensing for biomedical devices
- Nanorobots for Targeted Delivery in Deep Biological Tissues
- 3D Additive Manufacturing of Soft Materials as In Vitro Tumor Models
- Surgical Simulation on Cyber-physical Organ Models
- News
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- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Translational Radiotheranostics
- Interactive Machine Learning
- Intelligent Systems and Robotics in Urology
- Multiparametric methods for early detection of prostate cancer
- Translational Molecular Imaging in Oncologic Therapy Monitoring
- Radiology
- Cell Biology and Tumor Biology
- Research Groups A-Z
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- List of Core Facilities
- Antibodies
- Cellular Tools
- Center for Preclinical Research
- Central Library
- Chemical Biology
- Dieter Morszeck Biorepository
- Electron Microscopy
- Flow Cytometry
- Information Technology ITCF
- Light Microscopy
- Metabolomics
- Microarray
- Microbiological Diagnostics
- Next Generation Sequencing
- Omics IT and Data Management
- Proteomics
- Radiopharmaceuticals and Preclinical Trials
- Single-cell Open Lab
- Small Animal Imaging
- Transgenic Service
- Tumor Models
- OMERO@DKFZ
- List of Technologies
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- Enabling Technology
- Data Science @ DKFZ
- INFORM
- Baden-Württemberg Cancer Registry
- Cooperations & Networks
- National Cooperations
- International Cooperations
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Program
- Members of the Program Committee
- Call
- Publication Database
- German-Israeli Cancer Research Schools
- Archive
- Heidelberg - Israel, Science and Culture
- Symposium 40 Years of German-Israeli Cooperation
- 35th Anniversary Symposium
- 34th Meeting of the DKFZ-MOST Program
- 40th Anniversary Publication
- 30th Anniversary Publication
- 20th Anniversary Publication
- Flyer - The Cancer Cooperation Program
- List Publications 1976-2004
- Highlight-Projects
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Cooperations with industrial companies
- DKFZ PostDoc Network
- Cross Program Topic RNA@DKFZ
- Cross Program Topic Epigenetics@dkfz
- Cross Program Topic Single Cell Sequencing
- WHO Collaborating Centers
- DKFZ Site Dresden
- Health + Life Science Alliance Heidelberg Mannheim
Publications in 2020
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Hayes, P. ; Fergus, C. ; Ghanim, M. ; Cirzi, C. ; Burtnyak, L. ; McGrenaghan, C. J. ; Tuorto, F. ; Nolan, D. P. ; Kelly, V. P.
Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.
Nutrients 12(3), 871 (2020) [10.3390/nu12030871]2020
Fulltext by Pubmed Central
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Guerrero-Martínez, J. A. ; Ceballos-Chávez, M. ; Koehler, F. ; Peiró, S. ; Reyes, J. C.
TGF? promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
Nature Communications 11(1), 6196 (2020) [10.1038/s41467-020-19877-5]2020
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Coutinho Carneiro, V. (First author) ; de Abreu da Silva, I. C. ; Amaral, M. S. ; Pereira, A. S. A. ; Silveira, G. O. ; Pires, D. d. S. ; Verjovski-Almeida, S. ; Dekker, F. J. ; Rotili, D. ; Mai, A. ; Lopes-Torres, E. J. ; Robaa, D. ; Sippl, W. ; Pierce, R. J. ; Borrello, M. T. ; Ganesan, A. ; Lancelot, J. ; Thiengo, S. ; Fernandez, M. A. ; Vicentino, A. R. R. ; Mourão, M. M. ; Coelho, F. S. ; Fantappié, M. R.
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni
PLoS neglected tropical diseases 14(7), e0008332 - (2020) [10.1371/journal.pntd.0008332]2020
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Volcic, M. ; Sparrer, K. M. J. ; Koepke, L. ; Hotter, D. ; Sauter, D. ; Stürzel, C. M. ; Scherer, M. ; Stamminger, T. ; Hofmann, T. ; Arhel, N. J. ; Wiesmüller, L. ; Kirchhoff, F.
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
Nature microbiology 5(10), 1247-1261 (2020) [10.1038/s41564-020-0753-6]2020
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Köhler, F. (First author) ; Bormann, F. ; Raddatz, G. ; Gutekunst, J. ; Corless, S. ; Musch, T. ; Lonsdorf, A. S. ; Erhardt, S. ; Lyko, F. ; Rodríguez-Paredes, M. (Last author)
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome.
Genome medicine 12(1), 46 (2020) [10.1186/s13073-020-00749-y]2020
Fulltext by Pubmed Central
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Carneiro, V. C. (First author) ; Lyko, F. (Last author)
Rapid epigenetic adaptation in animals and its role in invasiveness.
Integrative and comparative biology 60(2), 267-274 (2020) [10.1093/icb/icaa023]2020
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Solé-Boldo, L. (First author) ; Raddatz, G. ; Schütz, S. ; Mallm, J.-P. ; Rippe, K. ; Lonsdorf, A. S. ; Rodríguez-Paredes, M. ; Lyko, F. (Last author)
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming.
Communications biology 3(1), 188 (2020) [10.1038/s42003-020-0922-4]2020
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Andriantsoa, R. (First author) ; Jones, J. P. G. ; Achimescu, V. ; Randrianarison, H. ; Raselimanana, M. ; Andriatsitohaina, M. ; Rasamy, J. ; Lyko, F. (Last author)
Perceived socio-economic impacts of the marbled crayfish invasion in Madagascar.
PLOS ONE 15(4), e0231773 - (2020) [10.1371/journal.pone.0231773]2020
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Ansari, I. ; Raddatz, G. ; Gutekunst, J. ; Ridnik, M. ; Cohen, D. ; Abu-Remaileh, M. ; Tuganbaev, T. ; Shapiro, H. ; Pikarsky, E. ; Elinav, E. ; Lyko, F. (Last author) ; Bergman, Y.
The microbiota programs DNA methylation to control intestinal homeostasis and inflammation.
Nature microbiology 5(4), 610-619 (2020) [10.1038/s41564-019-0659-3]2020
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Legrand, C. (First author) ; Tuorto, F. (Last author)
RiboVIEW: a computational framework for visualization, quality control and statistical analysis of ribosome profiling data.
Nucleic acids research 48(2), e7 (2020) [10.1093/nar/gkz1074]2020
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Köhler, F. (First author) ; Rodríguez-Paredes, M. (Last author)
DNA Methylation in Epidermal Differentiation, Aging, and Cancer.
The journal of investigative dermatology 140(1), 38-47 (2020) [10.1016/j.jid.2019.05.011]2020
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