Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Molecular Neurobiology
- Mechanisms Regulating Gene Expression
- Molecular Biology of Centrosomes and Cilia
- Dermato-Oncology
- Pediatric Leukemia
- Tumour Metabolism and Microenvironment
- Personalized Medical Oncology
- Molecular Hematology - Oncology
- Cancer Progression and Metastasis
- Translational Surgical Oncology
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Cell Fate Engineering and Disease Modeling
- Cancer Drug Development
- Cell Morphogenesis and Signal Transduction
- Functional and Structural Genomics
- Molecular Genome Analysis
- Molecular Genetics
- Pediatric Neurooncology
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
- Areas of Interest
- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
- Group Members
- Publications
- Open Positions
- Funding
- Teaching
- Areas of Interest
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Applied Functional Genomics
- Applied Bioinformatics
- Translational Medical Oncology
- Metabolic crosstalk in cancer
- Pediatric Glioma Research
- Cancer Epigenomics
- Translational Pediatric Sarcoma Research
- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
- Neuropathology
- Pediatric Oncology
- Neurooncology
- Somatic Evolution and Early Detection
- Translational Control and Metabolism
- Soft-Tissue Sarcoma
- Precision Sarcoma Research
- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
- Brain Tumor Translational Targets
- Translational Functional Cancer Genomics
- Regulatory Genomics and Cancer Evolution
- SPRINT
- Cancer Risk Factors and Prevention
- Cancer Epidemiology
- Biostatistics
- Clinical Epidemiology and Aging Research
- Health Economics
- Physical Activity, Prevention and Cancer
- Preventive Oncology
- Personalized Early Detection of Prostate Cancer
- Digital prevention, diagnostics and therapy guidance
- Tumorigenesis and molecular cancer prevention
- Genomic Epidemiology
- Cancer Survivorship
- Immunology, Infection and Cancer
- Structural Biology of Infection and Immunity
- Cellular Immunology
- B Cell Immunology
- Immune Diversity
- Immunoproteomics
- Personalized Immunotherapy
- mRNA Cancer Immunotherapies
- Tumor Immunology and Tumor Immunotherapy
- Infections and Cancer Epidemiology
- Pathogenesis of Virus-Associated Tumors
- Immunotherapy and Immunoprevention
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Microbiome and Cancer
- Molecular Oncology of Gastrointestinal Tumors
- Applied Tumor Immunity
- Neuroimmunology and Brain Tumor Immunology
- Applied Tumor Biology
- Virotherapy
- Adaptive Immunity and Lymphoma
- Dermal Oncoimmunology
- Immune Regulation in Cancer
- Systems Immunology and Single Cell Biology
- Pediatric Immuno-Oncology
- Epithelium Microbiome lnteractions
- Experimental Hepatology, Inflammation and Cancer
- GMP & T Cell Therapy
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immune Monitoring
- News
- Imaging and Radiooncology
- Radiology
- Research
- Computational Radiology Research Group
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Dual- and Multienergy CT
- Radiomics Research Group
- Prostate Research Group
- Bone marrow
- Musculoskeletal Imaging
- Microstructural Imaging Research Group
- Staff
- Patients
- Research
- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Federated Information Systems
- Translational Molecular Imaging
- Medical Physics in Radiation Oncology
- Biomedical Physics in Radiation Oncology
- Intelligent Medical Systems
- Medical Image Computing
- Radiooncology - Radiobiology
- Smart Technologies for Tumor Therapy
- Team
- Research
- Microrobots and Miniaturize Devices for Minimally-invasive Surgery
- Magnetic localization and sensing for biomedical devices
- Nanorobots for Targeted Delivery in Deep Biological Tissues
- 3D Additive Manufacturing of Soft Materials as In Vitro Tumor Models
- Surgical Simulation on Cyber-physical Organ Models
- News
- Vacancies
- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Translational Radiotheranostics
- Interactive Machine Learning
- Intelligent Systems and Robotics in Urology
- Multiparametric methods for early detection of prostate cancer
- Translational Molecular Imaging in Oncologic Therapy Monitoring
- Radiology
- Cell Biology and Tumor Biology
- Research Groups A-Z
- Junior Research Groups
- Core Facilities
- News
- List of Core Facilities
- Antibodies
- Cellular Tools
- Center for Preclinical Research
- Central Library
- Chemical Biology
- Dieter Morszeck Biorepository
- Electron Microscopy
- Flow Cytometry
- Information Technology ITCF
- Light Microscopy
- Metabolomics
- Microarray
- Microbiological Diagnostics
- Next Generation Sequencing
- Omics IT and Data Management
- Proteomics
- Radiopharmaceuticals and Preclinical Trials
- Single-cell Open Lab
- Small Animal Imaging
- Transgenic Service
- Tumor Models
- OMERO@DKFZ
- List of Technologies
- DKFZ Core Facilities Publication Policy
- Enabling Technology
- Data Science @ DKFZ
- INFORM
- Baden-Württemberg Cancer Registry
- Cooperations & Networks
- National Cooperations
- International Cooperations
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Program
- Members of the Program Committee
- Call
- Publication Database
- German-Israeli Cancer Research Schools
- Archive
- Heidelberg - Israel, Science and Culture
- Symposium 40 Years of German-Israeli Cooperation
- 35th Anniversary Symposium
- 34th Meeting of the DKFZ-MOST Program
- 40th Anniversary Publication
- 30th Anniversary Publication
- 20th Anniversary Publication
- Flyer - The Cancer Cooperation Program
- List Publications 1976-2004
- Highlight-Projects
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Cooperations with industrial companies
- DKFZ PostDoc Network
- Cross Program Topic RNA@DKFZ
- Cross Program Topic Epigenetics@dkfz
- Cross Program Topic Single Cell Sequencing
- WHO Collaborating Centers
- DKFZ Site Dresden
- Health + Life Science Alliance Heidelberg Mannheim
Publications in 2018
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Tuorto, F. (First author) ; Legrand, C. ; Cirzi, C. ; Federico, G. ; Liebers, R. ; Müller, M. ; Ehrenhofer-Murray, A. E. ; Dittmar, G. ; Gröne, H.-J. ; Lyko, F. (Last author)
Queuosine-modified tRNAs confer nutritional control of protein translation.
The EMBO journal 37(18), e99777 - (2018) [10.15252/embj.201899777]2018
Fulltext by Pubmed Central
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Avgustinova, A. ; Symeonidi, A. ; Castellanos, A. ; Urdiroz-Urricelqui, U. ; Solé-Boldo, L. ; Martín, M. ; Pérez-Rodríguez, I. ; Prats, N. ; Lehner, B. ; Supek, F. ; Benitah, S. A.
Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours.
Nature cell biology 20(12), 1400 - 1409 (2018) [10.1038/s41556-018-0233-x]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Pervolaraki, K. (First author) ; Rastgou Talemi, S. ; Albrecht, D. ; Bormann, F. ; Bamford, C. ; Mendoza, J. L. ; Garcia, K. C. ; McLauchlan, J. ; Höfer, T. ; Stanifer, M. L. ; Boulant, S. (Last author)
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance.
PLoS pathogens 14(11), e1007420 - (2018) [10.1371/journal.ppat.1007420]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Schulz, N. K. E. ; Wagner, C. I. ; Ebeling, J. ; Raddatz, G. ; Diddens-de Buhr, M. F. ; Lyko, F. ; Kurtz, J.
Dnmt1 has an essential function despite the absence of CpG DNA methylation in the red flour beetle Tribolium castaneum.
Scientific reports 8(1), 16462 (2018) [10.1038/s41598-018-34701-3]2018
Fulltext by Pubmed Central
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Gatzmann, F. (First author) ; Falckenhayn, C. ; Gutekunst, J. ; Hanna, K. ; Raddatz, G. ; Carneiro, V. C. ; Lyko, F. (Last author)
The methylome of the marbled crayfish links gene body methylation to stable expression of poorly accessible genes.
Epigenetics & chromatin 11(1), 57 (2018) [10.1186/s13072-018-0229-6]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Geyh, S. ; Rodríguez-Paredes, M. (First author) ; Jäger, P. ; Koch, A. ; Bormann, F. ; Gutekunst, J. ; Zilkens, C. ; Germing, U. ; Kobbe, G. ; Lyko, F. ; Haas, R. ; Schroeder, T.
Transforming growth factor ?1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia.
Haematologica 103(9), 1462 - 1471 (2018) [10.3324/haematol.2017.186734]2018
Fulltext by Pubmed Central
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Bormann, F. (First author) ; Rodríguez-Paredes, M. ; Lasitschka, F. ; Edelmann, D. ; Musch, T. ; Benner, A. ; Bergman, Y. ; Dieter, S. ; Ball, C. ; Glimm, H. ; Linhart, H. G. ; Lyko, F. (Last author)
Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis.
Cell reports 23(11), 3407 - 3418 (2018) [10.1016/j.celrep.2018.05.045]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Alupei, M. C. ; Maity, P. ; Esser, P. R. ; Krikki, I. ; Tuorto, F. ; Parlato, R. ; Penzo, M. ; Schelling, A. ; Laugel, V. ; Montanaro, L. ; Scharffetter-Kochanek, K. ; Iben, S.
Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome.
Cell reports 23(6), 1612 - 1619 (2018) [10.1016/j.celrep.2018.04.041]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Zhang, Y. ; Zhang, X. ; Shi, J. ; Tuorto, F. ; Li, X. ; Liu, Y. ; Liebers, R. ; Zhang, L. ; Qu, Y. ; Qian, J. ; Pahima, M. ; Liu, Y. ; Yan, M. ; Cao, Z. ; Lei, X. ; Cao, Y. ; Peng, H. ; Liu, S. ; Wang, Y. ; Zheng, H. ; Woolsey, R. ; Quilici, D. ; Zhai, Q. ; Li, L. ; Zhou, T. ; Yan, W. ; Lyko, F. ; Zhang, Y. ; Zhou, Q. ; Duan, E. ; Chen, Q.
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
Nature cell biology 20(5), 535 - 540 (2018) [10.1038/s41556-018-0087-2]2018
Fulltext by Pubmed Central
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Jantsch, M. ; Quattrone, A. ; O'Connell, M. ; et al
Positioning Europe for the EPITRANSCRIPTOMICS challenge.
RNA biology 15(6), 829-831 (2018) [10.1080/15476286.2018.1460996]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Gutekunst, J. (First author) ; Andriantsoa, R. ; Falckenhayn, C. ; Hanna, K. ; Stein, W. ; Rasamy, J. ; Lyko, F. (Last author)
Clonal genome evolution and rapid invasive spread of the marbled crayfish.
Nature ecology & evolution 2(3), 567 - 573 (2018) [10.1038/s41559-018-0467-9]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
González-Vallinas, M. (First author) ; Rodríguez-Paredes, M. ; Albrecht, M. ; Sticht, C. ; Stichel, D. ; Gutekunst, J. ; Pitea, A. ; Sass, S. ; Sánchez-Rivera, F. J. ; Lorenzo-Bermejo, J. ; Schmitt, J. ; De La Torre, C. ; Warth, A. ; Theis, F. J. ; Müller, N. S. ; Gretz, N. ; Muley, T. ; Meister, M. ; Tschaharganeh, D. F. ; Schirmacher, P. ; Matthäus, F. ; Breuhahn, K.
Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.
Molecular cancer research 16(3), 390 - 402 (2018) [10.1158/1541-7786.MCR-17-0334]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Genenncher, B. ; Durdevic, Z. (First author) ; Hanna, K. ; Zinkl, D. ; Mobin, M. B. ; Senturk, N. ; Da Silva, B. ; Legrand, C. ; Carré, C. ; Lyko, F. ; Schaefer, M.
Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats.
Cell reports 22(7), 1861 - 1874 (2018) [10.1016/j.celrep.2018.01.061]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Rodríguez-Paredes, M. (First author) ; Bormann, F. ; Raddatz, G. ; Gutekunst, J. ; Lucena-Porcel, C. ; Köhler, F. ; Wurzer, E. ; Schmidt, K. ; Gallinat, S. ; Wenck, H. ; Röwert-Huber, J. ; Denisova, E. ; Feuerbach, L. ; Park, J. ; Brors, B. ; Herpel, E. ; Nindl, I. ; Hofmann, T. ; Winnefeld, M. ; Lyko, F. (Last author)
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin.
Nature Communications 9(1), 577 (2018) [10.1038/s41467-018-03025-1]2018
Fulltext by Pubmed Central
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Molina-Pinelo, S. ; Salinas, A. ; Moreno-Mata, N. ; Ferrer, I. ; Suarez, R. ; Andrés-León, E. ; Rodríguez-Paredes, M. ; Gutekunst, J. ; Jantus-Lewintre, E. ; Camps, C. ; Carnero, A. ; Paz-Ares, L.
Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer
OncoTarget 9(4), 4395 - 4410 (2018) [10.18632/oncotarget.10611]2018
BibTeX |
EndNote:
XML,
Text |
RIS
http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
Lyko, F. (Last author)
The DNA methyltransferase family: a versatile toolkit for epigenetic regulation.
Nature reviews / Genetics 19(2), 81 - 92 (2018) [10.1038/nrg.2017.80]2018
BibTeX |
EndNote:
XML,
Text |
RIS