Publications 2008

Ader A., Reimer P., Kam R., Kobinger S., Klopp M., Dienemann H., Edler L., Pfannschmidt J.: Feasibility of irrigation and instillation of antimicrobial or antibiotic solutions in patients with parapneumonic empyema. A prospective randomized study. Ind.J.Thorac.Cardiovasc.Surg. 24 (3) 184-190, 2008.

Baumann S., Fas S.C., Giaisi M., Müller W.W., Merling A., Gülow K., Edler L., Krammer P.H., Li-Weber M.: Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood 111 (4) 2354-2363, 2008.

Bochtler T., Hegenbart U., Heiss C., Benner A., Cremer F., Volkmann M., Ludwig J., Perz J., Ho A.D., Goldschmidt H., Schonland S.: Evaluation of the serum-free light chain test in untreated patients with AL amyloidosis. Haematologica 93 (3) 459-462, 2008.

Bochtler T., Hegenbart U., Cremer F., Heiss C., Benner A., Hose D., Moos M., Bila J., Bartram C.R., Ho A.D., Goldschmidt H., Jauch A., Schonland S.: Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared to monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability. Blood 111 (9) 4700-4705, 2008.

Combs S.E., Nagy M., Edler L., Rausch R., Bischof M., Welzel T., Debus J., Schulz-Ertner D.: Comparative evaluation of radiochemotherapy with temozolomide versus standard-of-care postoperative radiation alone in patients with WHO grade III astrocytic tumors. Radiother.Oncol. 88 (2) 177-182, 2008.

Combs S.E., Wagner J., Bischof M., Welzel T., Edler L., Rausch R., Wagner F., Zabel-du Bois A., Debus J., Schulz-Ertner D.: Radiochemotherapy in patients with primary glioblastoma comparing two Temozolomide dose regimens. Int.J.Radiat.Oncol.Biol.Phys. 71 (4) 999-1005, 2008.

Deubzer H.E., Ehemann V., Kulozik A., Westermann F., Savelyeva L., Kopp-Schneider A., Riester D., Schwab M., Witt O.: Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro. Cancer Lett. 264 (1) 21-28, 2008.

Dinkel J., Bartling S.H., Kuntz J., Grasruck M., Kopp-Schneider A., Iwasaki M., Dimmeler S., Gupta R., Semmler W., Kauczor H.U., Kiessling F.: Intrinsic gating for small-animal computed tomography. A robust ECG-less paradigm for deriving cardiac phase information and functional imaging. Circul.Cardiovasc.Imag. 1 (3) 235-243, 2008.

Edler L., Pilz L.R.: Datenerhebung und Datenmanagement mit Richtlinien, Erfahrungen, Warnungen und Empfehlungen. Onkol. 31 (S2) 7-13, 2008.

Edler L., Combs S.E.: In reply to dr. Jalali. Int.J.Radiat.Oncol.Biol.Phys. 72 (5) 1622-1623, 2008.

Fabel M., Tengg-Kobligk H.v., Giesel F.L., Bornemann L., Dicken V., Kopp-Schneider A., Moser C., Delorme S., Kauczor H.U.: Semi-automated volumetric analysis of lymph node metastases in patients with malignant melanoma stage III/IV-A feasibility study. Eur.Radiol. 18 (6) 1114-1122, 2008.

Görn M., Habermann C.R., Anige M., Thöm I., Schuch G., Andritzky B., Brandl S., Burkholder I., Edler L., Hossfeld D.K., Bokemeyer C., Laack E.: A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkol. 31 (4) 185-189, 2008.

Grund K., Ahmadi R., Jung F., Funke V., Gdynia G., Benner A., Sykora J., Walczak H., Joos S., Felsberg J., Reifenberger G., Wiestler O.D., Herold-Mende C., Roth W.: Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD. Cancer Biol.Therap. 7 (12) 1982-1990, 2008.

Halatsch M.E., Löw S., Hielscher T., Schmidt U., Unterberg A., Vougioukas V.I.: Epidermal growth factor receptor pathway gene expressions and biological response of glioblastoma multiforme cell lines to erlotinib. Anticanc.Res. 28 (6A) 3725-3728, 2008.

Heinzl H., Mittlböck M., Edler L.: Technical uncertainty in the back-calculation of occupational exposure to dioxins. Stat.Med. 27 (12) 2214-2233, 2008.

Hillengass J., Zechmann C.M., Nadler A., Hose D., Cremer F., Jauch A., Heiss C., Benner A., Ho A.D., Bartram C.R., Kauczor H.U., Delorme S., Goldschmidt H., Möhler T.: Gain of 1q21 and distinct adverse cytogenetic abnormalities correlate with increased microcirculation in multiple myeloma. Int.J.Cancer 122 (12) 2871-2875, 2008.

Hoffmann S., Edler L., Gardner I., Gribaldo L., Hartung T., Klein C., Liebsch M., Sauerland S., Schechtman L., Stammati A., Nikolaidis E.: Points of reference in the validation process. The report and recommendations of ECVAM Workshop 66. ATLA 36 (3) 343-352, 2008.

Hönsch H.P., Groh B., Edler L., Kirch W.: Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence. World J.Gastroenterol. 14 (14) 2187-2193, 2008.

Jakubowska A., Gronwald J., Menkiszak J., Gorski B., Huzarski T., Byrski T., Edler L., Lubinski J., Scott R.J., Hamann U.: The VEGF_936_C>T 3'UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women. Cancer Lett. 262 (1) 71-76, 2008.

Jakubowska A., Gronwald J., Menkiszak J., Gorski B., Huzarski T., Byrski T., Benner A., Lubinski J., Scott R.J., Hamann U.: Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. BMC Cancer 8 90, 2008.

Koch L., Linderkamp O., Ittrich C., Benner A., Pöschl J.: Gene expression profiles of adult peripheral and cord blood mononuclear cells altered by lipopolysaccharide. Neonatol. 93 (2) 87-100, 2008.

Korshunov A., Benner A., Remke M., Lichter P., Deimling A.v., Pfister S.: Accumulation of genomic aberrations during clinical progression of medulloblastoma. Acta Neuropathol. 116 (4) 383-390, 2008.

Löw S., Vougioukas V.I., Hielscher T., Schmidt U., Unterberg A., Halatsch M.E.: Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib. Anticanc.Res. 28 (6A) 3729-3732, 2008.

Michel S., Benner A., Tariverdian M., Wentzensen N., Höfler P., Pommerencke T., Grabe N., Knebel-Doeberitz M.v., Kloor M.: High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability. Br.J.Cancer 99 (11) 1867-1873, 2008.

Pfister S., Janzarik W.G., Remke M., Ernst A., Werft W., Becker N., Tödt G., Wittmann A., Kratz C., Olbrich H., Ahmadi R., Thieme B., Joos S., Radlwimmer B., Kulozik A., Pietsch T., Herold-Mende C., Gnekow A., Reifenberger G., Korshunov A., Scheurlen W., Omran H., Lichter P.: BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J.Clin.Invest. 118 (5) 1739-1749, 2008.

Pilz L.R.: Fortgeschrittenes nicht kleinzelliges Lungenkarzinom: In acht Wochen entscheidet sich die Überlebenschance (Kommentar). PneumoNews 3 23-24, 2008.

Sander S., Bullinger L., Leupolt E., Benner A., Kienle D., Katzenberger T., Kalla J., Ott G., Müller-Hermelink H.K., Barth T.F., Möller P., Döhner H., Stilgenbauer S.: Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations. Haematologica 93 (5) 680-687, 2008.

Sangrajrang S., Schmezer P., Burkholder I., Waas P., Boffetta P., Brennan P., Bartsch H., Wiangnon S., Popanda O.: Polymorphisms in three base excision repair genes and breast cancer risk in Thai women. Breast Cancer Res.Treat. 111 (2) 279-288, 2008.

Schaarschmidt F., Sill M., Hothorn L.: Poly-k-trend tests for survival adjusted analysis of tumor rates formulated as approximate multiple contrast test. J.Biopharm.Stat. 18 (5) 934-948, 2008.

Schaarschmidt F., Sill M., Hothorn L.: Approximate simultaneous confidence intervals for multiple contrasts of binomial proportions. Biometr.J. 50 (5) 782-792, 2008.

Schlenk R.F., Döhner K., Krauter J., Fröhling S., Corbacioglu A., Bullinger L., Habdank M., Späth D., Morgan M., Benner A., Schlegelberger B., Heil G., Ganser A., Döhner H., German Austrian AML Study Group: Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N.Engl.J.Med. 358 (18) 1909-1918, 2008.

Schwake L., Streit J.P., Edler L., Encke J., Stremmel W., Junghanss T.: Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study. Crit.Care 12 (1) R22, 2008.

Schwitalle Y., Kloor M., Eiermann S., Linnebacher M., Kienle P., Knäbel H.P., Tariverdian M., Benner A., Knebel-Doeberitz M.v.: Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. Gastroenterol. 134 (4) 988-997, 2008.

Sharma R., Zucknick M., London R., Kacevska M., Liddle C., Clarke S.J.: Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer. Clin.Colorect.Cancer 7 (5) 331-337, 2008.

Sharma R., Hoskins J.M., Rivory L.P., Zucknick M., London R., Liddle C., Clarke S.J.: Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients. Clin.Cancer Res. 14 (3) 817-825, 2008.

Tschuch C., Schulz A., Pscherer A., Werft W., Benner A., Hotz-Wagenblatt A., Barrionuevo L.S., Lichter P., Mertens D.: Off-target effects of siRNA specific for GFP. BMC Mol.Biol. 9 60, 2008.

Westermann F., Muth D., Benner A., Bauer T., Henrich K.O., Oberthür A., Brors B., Beissbarth T., Vandescompele J., Pattyn F., Hero B., König R., Fischer M., Schwab M.: Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol. 9 (10) R150, 2008.

Wittmann S., Wunder C., Zirn B., Furtwängler R., Wegert J., Graf N., Gessler M.: New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms Tumors. Genes, Chromosomes & Cancer 47 (5) 386-395, 2008.

Zenz T., Häbe S., Benner A., Kienle D., Döhner H., Stilgenbauer S.: The MDM2 -309 T/G promoter single nucleotide polymorphism does not alter disease characteristics in chronic lymphocytic leukemia. Haematologica 93 (7) 1111-1113, 2008.

Zenz T., Kröber A., Scherer K., Häbe S., Bühler A., Benner A., Denzel T., Winkler D., Edelmann J., Schwänen C., Döhner H., Stilgenbauer S.: Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 112 (8) 3322-3329, 2008.

Zenz T., Benner A., Döhner H., Stilgenbauer S.: Chronic lymphocytic leukemia and treatment resistance in cancer: The role of the p53 pathway. Cell Cycle 7 (24) 3810-3814, 2008.

Zucknick M., Richardson S., Stronach E.A.: Comparing the characteristics of gene expression profiles derived by univariate and multivariate classification methods. Stat.Appl.Genet.Mol.Biol. 7 (1 (Art. 7)) 1-22, 2008.