Publications 2007

Braun K., Brasch L.v., Pipkorn R., Ehemann V., Jenne J., Spring H., Debus J., Didinger B., Rittgen W., Waldeck W.: BioShuttle-mediated plasmid transfer. Int.J.Med.Sci. 4 (5) 267-277, 2007.

Bräuning A., Ittrich C., Köhle C., Buchmann A., Schwarz M.: Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomas. Drug Metab.Dispos. 35 (4) 503-507, 2007.

Buchholz E., Manegold C., Pilz L., Thatcher N., Drings P.: Standard versus dose-Intensified chemotherapy with sequential reinfusion of hematopoietic progenitor cells in small cell lung cancer patients with favorable prognosis. J.Thoracic Oncol. 2 (1) 51-58, 2007.

Eichinger M., Puderbach M., Smith H.J., Tetzlaff R., Kopp-Schneider A., Bock M., Biederer J., Kauczor H.U.: Magnetic resonance-compatible-spirometry: principle, technical evaluation and application. Eur.Respir.J. 30 (5) 972-979, 2007.

Groos J., Bannasch P., Schwarz M., Kopp-Schneider A.: Comparison of mode of action of four hepatocarcinogens: A model based approach. Toxicol.Sci. 99 (2) 446-454, 2007.

Heinzl H., Benner A., Ittrich C., Mittlböck M.: Proposals for sample size calculation programs. Meth.Inf.Med. 46 (6) 655-661, 2007.

Heinzl H., Mittlböck M., Edler L.: On the translation of uncertainty from toxicokinetic to toxicodynamic models - the TCDD example. Chemosphere 67 (9) 365-374, 2007.

Henrich K.O., Claas A., Praml C., Benner A., Mollenhauer J., Poustka A., Schwab M., Westermann F.: Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. Eur.J.Cancer 43 (3) 607-616, 2007.

Hensel M., Zoz M., Giesecke C., Benner A., Neben K., Jauch A., Stilgenbauer S., Ho A.D., Krämer A.: High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukemia. Int.J.Cancer 121 (5) 978-983, 2007.

Hillengass J., Wasser K., Delorme S., Kiessling F., Zechmann C., Benner A., Kauczor H.U., Ho A.D., Goldschmidt H., Möhler T.M.: Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma. Clin.Cancer Res. 13 (2) 475-481, 2007.

Hundemer M., Klein U., Hose D., Raab M.S., Cremer F.W., Jauch A., Benner A., Heiss C., Moos M., Ho A.D., Goldschmidt H.: Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14). Bone Marrow Transplant. 40 (11) 1033-1037, 2007.

Jakubowska A., Gronwald J., Menkiszak J., Gorski B., Huzarski T., Byrski T., Edler L., Lubinski J., Scott R.J., Hamann U.: The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers. Cancer Epidem.Biomark.Prevent. 16 (2) 270-275, 2007.

Jakubowska A., Gronwald J., Menkiszak J., Gorski B., Huzarski T., Byrski T., Edler L., Lubinski J., Scott R.J., Hamann U.: Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks. Breast Cancer Res.Treat. 104 (3) 299-308, 2007.

Jakubowska A., Gronwald J., Gorski B., Huzarski T., Byrski T., Benner A., Lubinski J., Scott R.J., Hamann U.: The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation. Breast Cancer Res.Treat. 104 (1) 67-74, 2007.

Jakubowska A., Gronwald J., Menkiszak J., Gorski B., Huzarski T., Byrski T., Edler L., Lubinski J., Scott R.J., Hamann U.: Integrin {beta}3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk. J.Med.Genet. 44 (6) 408-411, 2007.

Jaworski M., Ittrich C., Hailfinger S., Bonin M., Buchmann A., Schwarz M., Köhle C.: Global gene expression in Ha-ras and B-raf mutated mouse liver tumors. Int.J.Cancer 121 (6) 1382-1385, 2007.

Kenzelmann M., Märtens S., Hergenhahn M., Küffer S., Hotz-Wagenblatt A., Li L., Wang S., Ittrich C., Lemberger T., Arribas R., Jonnakuty S., Hollstein M.C., Schmid W., Gretz N., Gröne H.J., Schütz G.: Microarray analysis of newly synthesized RNA in cells and animals. PNAS 104 (15) 6164-6169, 2007.

Kienle D., Katzenberger T., Ott G., Saupe D., Benner A., Kohlhammer H., Barth T.F., Holler S., Kalla J., Rosenwald A., Müller-Hermelink H.K., Möller P., Lichter P., Döhner H., Stilgenbauer S.: Quantitative gene expression deregulation in mantle-cell lymphoma: correlation with clinical and biologic factors. J.Clin.Oncol. 25 (19) 2770-2777, 2007.

Kloor M., Michel S., Buckowitz B., Rüschoff J., Büttner R., Holinski-Feder E., Dippold W., Wagner R., Tariverdian M., Benner A., Schwitalle Y., Kuchenbuch B., Knebel-Doeberitz M.v.: Beta2-microglobulin mutations in microsatellite unstable colorectal tumors. Int.J.Cancer 121 (2) 454-458, 2007.

Kunitz A., Wolter M., van den Boom J., Felsberg J., Tews B., Hahn M., Benner A., Sabel M., Lichter P., Reifenberger G., Deimling A.v., Hartmann C.: DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in human gliomas. Brain Pathol. 17 (4) 363-370, 2007.

Laack E., Thöm I., Krüll A., Engel-Riedel W., Müller T., Meißner C., Dürk H., Fischer J., Gütz C., Kortsik C., Elbers M., Schuch G., Andritzky B., Görn M., Burkholder I., Edler L., Hossfeld D.K., Bokemeyer C.: A phase II study of irinotecan (CPT-11) and carboplatin in patients with limited disease small cell lung cancer (SCLC). Lung Cancer 57 (2) 181-186, 2007.

Luft T., Conzelmann M., Benner A., Rieger M., Hess M., Strohhäcker U., Görner M., Hegenbart U., Ho A.D., Dreger P.: Serum cytokeratin-18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft-versus-host disease. Blood 110 (13) 4535-4542, 2007.

Manegold C., Koschel G., Hruska D., Schott von Römer K., Mezger J., Pilz L.R.: Open, randomized, phase II study of single-agent gemcitabine and docetaxel as first- and second-line treatment in patients with advanced non-small-cell lung cancer. Clin.Lung Cancer 8 (4) 245-251, 2007.

Ochs B.G., Simank H.G., Kopp-Schneider A., Rupp R., Schablowski-Trautmann M.: Ganganalyse bei extremitätenerhaltender Tumorchirurgie - Vergleich der Bewegungsmuster nach Resektion primär maligner Tumoren im Bereich des Kniegelenkes (Gait analysis in limb-preserving tumour surgery - Kinematic gait patterns after resection of malignant bone tumours near the knee joint). Z.Orthop.Unfall. 145 (6) 763-771, 2007.

Paret C., Hildebrand D., Weitz J., Kopp-Schneider A., Kuhn A., Beer A., Hautmann R., Zöller M.: C4.4A as a candidate marker in the diagnosis of colorectal cancer. Br.J.Cancer 97 (8) 1146-1156, 2007.

Pfister S., Schläger C., Mendrzyk F., Wittmann A., Benner A., Kulozik A., Scheurlen W., Radlwimmer B., Lichter P.: Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma. Nucl.Acids Res. 35 (7) e51, 2007.

Pfister S., Remke M., Tödt G., Werft W., Benner A., Mendrzyk F., Wittmann A., Devens F., Hoff K.v., Rutkowski S., Kulozik A., Radlwimmer B., Scheurlen W., Lichter P., Korshunov A.: Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas. Genes, Chromosomes & Cancer 46 (9) 839-851, 2007.

Popanda O., Edler L., Waas P., Schattenberg T., Butkiewicz D., Muley T., Dienemann H., Risch A., Bartsch H., Schmezer P.: Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms. Lung Cancer 55 (1) 25-34, 2007.

Prowatke I., Devens F., Benner A., Grone E.F., Mertens D., Grone H.J., Lichter P., Joos S.: Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays. Br.J.Cancer 96 (1) 82-88, 2007.

Puderbach M., Eichinger M., Häselbarth J., Ley S., Kopp-Schneider A., Tüngerthal S., Schmähl A., Fink C., Plathow C., Wiebel M., Demirakca S., Müller F.M., Kauczor H.U.: Assessment of morphological MRI for pulmonary changes in cystic fibrosis (CF) patients: comparison to thin-section CT and chest X-ray. Invest.Radiol. 42 (10) 715-725, 2007.

Renner M., Bergmann G., Krebs I., End C., Lyer S., Hilberg F., Helmke B., Gassler N., Autschbach F., Bikker F., Strobel-Freidekind O., Gronert-Sum S., Benner A., Blaich S., Wittig R., Hudler M., Ligtenberg A.J., Madsen J., Holmskov U., Annese V., Latiano A., Schirmacher P., Amerongen A.V., D'Amato M., Kioschis P., Hafner M., Poustka A., Mollenhauer J.: DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterol. 133 (5) 1499-1509, 2007.

Ribeiro D., Veldwijk M.R., Benner A., Laufs S., Wenz F., Ho A.D., Frühauf S.: Differences in functional activity and antigen expression of granulocytes primed in vivo with filgrastim, lenograstim, or pegfilgrastim. Transfusion 47 (6) 969-980, 2007.

Ritsou E., Breitkreutz R., Benner A., Böhler T., Weigand M.A., Walczak H., Gougeon M.L., Krammer P.H.: CD4/CXCR4-mediated cell death in AIDS (Letter to the editor). Cell Death Diff. 14 (3) 634-636, 2007.

Sangrajrang S., Schmezer P., Burkholder I., Boffetta P., Brennan P., Wölfelschneider A., Bartsch H., Wiangnon S., Cheisilpa A., Popanda O.: The XRCC3 Thr241Met polymorphism and breast cancer risk: a case-control study in a Thai population. Biomarkers 12 (5) 523-532, 2007.

Schulz-Ertner D., Nikoghosyan A., Hof A., Didinger B., Combs S.E., Jakel O., Karger C.P., Edler L., Debus J.: Carbon ion radiotherapy of skull base chondrosarcomas. Int.J.Radiat.Oncol.Biol.Phys. 67 (1) 171-177, 2007.

Schulz-Ertner D., Karger C.P., Feuerhake A., Nikoghosyan A., Combs S.E., Jäkel O., Edler L., Scholz M., Debus J.: Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int.J.Radiat.Oncol.Biol.Phys. 68 (2) 449-457, 2007.

Schulze A., Mons U., Edler L., Pötschke-Langer M.: Smoke-free class competition: A reply to the initiators of the program (vol 43, pg 151, 2006). Prev.Med. 44 (2) 183, 2007.

Steinbild S., Mross K., Frost A., Morant R., Gillessen S., Dittrich C., Strumberg D., Hochhaus A., Hanauske A., Edler L., Burkholder I., Scheulen M.E.: A clinical phase II study with sorafenib in patients with progressive hormone-refractory prostate cancer: a study of the CESAR Central European Society for Anticancer Drug Research-EWIV. Br.J.Cancer 97 1480-1485, 2007.

Stilgenbauer S., Sander S., Bullinger L., Benner A., Leupolt E., Winkler D., Kröber A., Kienle D., Lichter P., Döhner H.: Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival. Haematologica 92 (9) 1242-1245, 2007.

Tews B., Rörig P., Hartmann C., Hahn M., Felsberg J., Blaschke B., Sabel M., Kunitz A., Tödt G., Neben K., Benner A., Deimling A.V., Reifenberger G., Lichter P.: Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. Oncogene 26 (34) 5010-5016, 2007.

Thöm I., Schult-Kronefeld O., Burkholder I., Görn M., Andritzky B., Blonski K., Kugler C., Edler L., Bokemeyer C., Schumacher U., Laack E.: Lectin histochemistry of metastatic adenocarcinomas of the lung. Lung Cancer 56 (3) 391-397, 2007.

Ugurel S., Thirumaran R.K., Blöthner S., Gast A., Sucker A., Müller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R., Schadendorf D.: B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis. PLoS_ONE Genetics & Genomics 2 (2) e236 (13p.)-doi:10.1371/journal.pone.0000236, 2007.

Villiers E.M., Bulajic M., Nitsch C., Kecmanovic D., Pavlov M., Kopp-Schneider A., Löhr M.: TTV infection in colorectal cancer tissues and normal mucosa (Letter to the editor). Int.J.Cancer 121 (9) 2109-2112, 2007.

Weber M.A., Kinscherf R., Krakowski-Roosen H., Aulmann M., Renk H., Kunkele A., Edler L., Kauczor H.U., Hildebrandt W.: Myoglobin plasma level related to muscle mass and fiber composition - a clincal marker of muscle wasting ? J.Mol.Med. 85 (8) 887-896, 2007.

Westermann F., Henrich K.O., Wei J.S., Lutz W., Fischer M., König R., Wiedemeyer R., Ehemann V., Brors B., Ernestus K., Leuschner T., Benner A., Khan J., Schwab M.: High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status. Clin.Cancer Res. 13 (16) 4695-4703, 2007.

Witzens-Harig M., Heilmann C., Hensel M., Kornacker M., Benner A., Hass R., Frühauf S.: Long-term follow-up of patients with non-Hodgkin lymphoma following myeloablative therapy and autologous transplantation of CD34+-selected peripheral blood progenitor cells. Stem Cells 25 (1) 228-235, 2007.

Zhang C., Wenger T., Mattern J., Ilea S., Frey C., Gutwein P., Altevogt P., Bodenmüller W., Gassler N., Schnabel P.A., Dienemann H., Marme A., Hohenfellner M., Haferkamp A., Pfitzenmaier J., Gröne H.J., Kolb A., Büchler P., Büchler M.W., Friess H., Rittgen W., Edler L., Debatin K.M., Krammer P.H., Rutz H.P., Herr I.: Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors. Cancer Biol.Therap. 6 (2) 278-287, 2007.