We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential enable/disable

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name	Webedition CMS
Purpose	This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name	econda
Purpose	Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

Statistics enable/disable

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name	econda
Purpose	Statistics

External media enable/disable

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name	YouTube
Purpose	Show YouTube content
Name	Twitter
Purpose	activate Twitter Feeds

Research

Influence of apple juice constituents on biomarkers of colon carcinogenesis in vitro and in vivo

The project is aimed at the characterization of low- and high-molecular weight cancer chemopreventive components in apple juice extracts, fecal water and fermentation supernatants of apple juice extracts by activity-guided fractionation, and to elucidate their mechanisms of action.

Based on the results of in vitro experiments, we will also investigate the influence of apple juice ingredients on intestinal carcinogenesis in the APCMin/+ mouse model to evaluate the relevance of our in vitro findings in vivo.

Further, we will analyze the potential of fecal water fractions to modulate biomarkers in in vitro test systems.

These investigations will help to better understand biological modifications which occur during colon carcinogenesis, to identify possibilities for their prevention, and to develop strategies for the transfer of the results to the human situation.

These studies are part of the BMBF-funded Nutrition Net:
Role of dietary components on the genesis of intestinal disorders and possibilities of their prevention by nutritional intervention