We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential enable/disable

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name	Webedition CMS
Purpose	This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name	econda
Purpose	Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

Statistics enable/disable

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name	econda
Purpose	Statistics

External media enable/disable

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name	YouTube
Purpose	Show YouTube content
Name	Twitter
Purpose	activate Twitter Feeds

Research

Hormonal factors and genetic modification of colorectal cancer risk

Women are less likely to develop colorectal cancer than men are which may in part be due to hormonal differences. The DACHS study and other studies have shown that use of menopausal hormone therapy is associated with a reduced colorectal cancer risk. It is possible that both endogenous and exogenous hormones influence the development of colorectal cancer.

To explore this association, we investigate variants in candidate hormone related genes, which may modify the association between menopausal hormone therapy with colorectal cancer. Additionally, we carry out genome-wide assessments of gene-environment interactions in relation to menopausal hormone therapy as well as a pathway analysis including among others hormone-metabolism pathways. These analyses are conducted in collaboration with the "Genetics and Epidemiology of Colorectal Cancer Consortium" GECCO

Cooperation:
Division of Clinical Epidemiology and Aging Research (DKFZ),
Division of Molecular Genetic Epidemiology (DKFZ),
Institute of Pathology Heidelberg,
Institute of Clinical Molecular Biology (Schleswig-Holstein University Hospital),
GECCO (Fred Hutchinson Cancer Research Center Seattle, Washington, USA),
Colon Cancer Genetics Group (MRC Human Genetics Unit, Western General Hospital, Edinburgh)

Funding:
German Federal Ministry of Education and Research (BMBF, grant number 01KH0404, 01GS08181), NIH (USA) grant to GECCO (grant numbers U01CA137088, U01CA164930, R01 CA201407)