Original- und Übersichtsarbeiten im Jahr 2021 und im Druck

Peter, R. S., Jaensch, A., Mons, U., Schoettker, B., Schmucker, R., Koenig, W., . . . , Rothenbacher, D. Prognostic value of long-term trajectories of depression for incident diabetes mellitus in patients with stable coronary heart disease. Cardiovascular Diabetology 2021; 20: 8.

Jaensch, A., Schoettker, B., Schmucker, R., Koenig, W., Brenner, H., Rothenbacher, D. Prevalence and Prognostic Value of Psychological Stress Events in Patients with First Myocardial Infarction-Long-Term Follow-Up Study. Journal of Clinical Medicine 2021; 10: 7.

Rehm, M., Buchele, G., Brenner, R. E., Gunther, K. P., Brenner, H., Koenig, W., Rothenbacher, D. Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis. Biomolecules 2021; 11: 12.

Matias-Garcia, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., . . . , Waldenberger, M. DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function. Clinical Epigenetics 2021; 13: 16.

Stocker, H., Perna, L., Weigl, K., Mollers, T., Schottker, B., Thomsen, H., . . . , Brenner, H. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular Psychiatry 2021; 26: 5812-5822.

Stocker, H., Nabers, A., Perna, L., Mollers, T., Rujescu, D., Hartmann, A. M., . . . , Brenner, H. Genetic predisposition, A beta misfolding in blood plasma, and Alzheimer's disease. Translational Psychiatry 2021; 11: 11.

Deutelmoser, H., Scherer, D., Brenner, H., Waldenberger, M., Suhre, K., Kastenmuller, G., . . . , Study, I. Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data. Briefings in Bioinformatics 2021; 22: 12.

Nguyen, T. N. M., Laetsch, D. C., Chen, L. J., Holleczek, B., Meid, A. D., Brenner, H., Schottker, B. Comparison of Five Lists to Identify Potentially Inappropriate Use of Non-Steroidal Anti-Inflammatory Drugs in Older Adults. Pain Medicine 2021; 22: 1962-1969.

Finke, I., Behrens, G., Maier, W., Schwettmann, L., Pritzkuleit, R., Holleczek, B., . . . , German Canc, S. Small-area analysis on socioeconomic inequalities in cancer survival for 25 cancer sites in Germany. International Journal of Cancer 2021; 149: 561-572.

Guo, F., Chen, C., Holleczek, B., Schottker, B., Hoffmeister, M., Brenner, H. Strong Reduction of Colorectal Cancer Incidence and Mortality After Screening Colonoscopy: Prospective Cohort Study From Germany. American Journal of Gastroenterology 2021; 116: 967-975.

Raut, J. R., Schottker, B., Holleczek, B., Guo, F., Bhardwaj, M., Miah, K., . . . , Brenner, H. A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction. Nature Communications 2021; 12: 9.

Mollers, T., Stocker, H., Perna, L., Nabers, A., Rujescu, D., Hartmann, A. M., . . . , Brenner, H. A beta misfolding in blood plasma is inversely associated with body mass index even in middle adulthood. Alzheimers Research & Therapy 2021; 13: 9.

Zhu, A. N., Kuznia, S., Niedermaier, T., Holleczek, B., Schoettker, B., Brenner, H. Distribution and Determinants of Vitamin D-Binding Protein, Total, "Non-Bioavailable", Bioavailable, and Free 25-Hydroxyvitamin D Concentrations among Older Adults. Nutrients 2021; 13: 14.

Deutelmoser, H., Scherer, D., Brenner, H., Waldenberger, M., Study, I., Suhre, K., . . . , Lorenzo, B. J. Robust Huber-LASSO Improves Prediction of Protein, Metabolite and Gene Expression Levels from Individual Genotype Data. Human Heredity 2021; 85: 75-75.

Jansen, L., Kanbach, J., Finke, I., Arndt, V., Emrich, K., Holleczek, B., . . . , Grp German Canc Survival, W. Estimation of the Potentially Avoidable Excess Deaths Associated with Socioeconomic Inequalities in Cancer Survival in Germany. Cancers 2021; 13: 14.

Sinning, C., Makarova, N., Volzke, H., Schnabel, R. B., Ojeda, F., Dorr, M., . . . , Thorand, B. Association of glycated hemoglobin A(1c) levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium. Cardiovascular Diabetology 2021; 20: 13.

Liu, Z. Z., Thong, M. S. Y., Doege, D., Koch-Gallenkamp, L., Bertram, H., Eberle, A., . . . , Arndt, V. Prevalence of benefit finding and posttraumatic growth in long-term cancer survivors: results from a multi-regional population-based survey in Germany. British Journal of Cancer 2021; 125: 877-883.

Siziba, L. P., Brenner, H., Amitay, E. L., Koenig, W., Rothenbacher, D., Genuneit, J. Potential sex differences in human milk leptin and their association with asthma and wheeze phenotypes: Results of the Ulm Birth Cohorts. Pediatric Allergy and Immunology 2021; 32: 1663-1672.

Li, X. W., Zhang, Y., Gao, X., Holleczek, B., Schottker, B., Brenner, H. Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study. Ebiomedicine 2021; 74: 8.

Doege, D., Thong, M. S. Y., Weisser, L., Koch-Gallenkamp, L., Jansen, L., Bertram, H., . . . , Arndt, V. Health-Related Quality of Life in Very Long-Term Cancer Survivors 14-24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study. Cancers 2021; 13: 15.

Sinning, C., Makarova, N., Schnabel, R., Ojeda, F., Felix, S. B., Koenig, W., . . . , BiomarCaRe. Association of glycated haemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE consortium. European Heart Journal 2021; 42: 2624-2624.

Heisser, T., Cardoso, R., Guo, F., Moellers, T., Hoffmeister, M., Brenner, H. Strongly Divergent Impact of Adherence Patterns on Efficacy of Colorectal Cancer Screening: The Need to Refine Adherence Statistics. Clinical and Translational Gastroenterology 2021; 12: 9.

Heisser, T., Mollers, T., Cardoso, R., Niedermaier, T., Hoffmeister, M., Brenner, H. Earlier Screening Colonoscopy in Men: Additional Screening Is Needed at Older Ages. Deutsches Arzteblatt International 2021; 118: 691-692.

Brenner, H., Kuznia, S., Laetsch, C., Niedermaier, T., Schottker, B. Prevention of Advanced Cancer by Vitamin D-3 Supplementation: Interaction by Body Mass Index Revisited. Nutrients 2021; 13: 7.

Erben, V., Poschet, G., Schrotz-King, P., Brenner, H. Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms. Diagnostics 2021; 11: 13.

Li, H. J., Boakye, D., Chen, X. C., Hoffmeister, M., Brenner, H. Association of Body Mass Index With Risk of Early-Onset Colorectal Cancer: Systematic Review and Meta-Analysis. American Journal of Gastroenterology 2021; 116: 2173-2183.

Niedermaier, T., Gredner, T., Kuznia, S., Schottker, B., Mons, U., Brenner, H. Vitamin D supplementation to the older adult population in Germany has the cost-saving potential of preventing almost 30 000 cancer deaths per year. Molecular Oncology 2021; 15: 1986-1994.

Cardoso, R., Zhu, A. N., Guo, F., Heisser, T., Hoffmeister, M., Brenner, H. Incidence and Mortality of Proximal and Distal Colorectal Cancer in Germany Trends in the Era of Screening Colonoscopy. Deutsches Arzteblatt International 2021; 118: 281-+.

Erben, V., Carr, P. R., Guo, F., Weigl, K., Hoffmeister, M., Brenner, H. Individual and Joint Associations of Genetic Risk and Healthy Lifestyle Score with Colorectal Neoplasms Among Participants of Screening Colonoscopy. Cancer Prevention Research 2021; 14: 649-657.

Ahadova, A., Seppala, T. T., Engel, C., Gallon, R., Burn, J., Holinski-Feder, E., . . . , Kloor, M. The "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance. International Journal of Cancer 2021; 148: 800-811.

Scherer-Trame, S., Jansen, L., Arndt, V., Chang-Claude, J., Hoffmeister, M., Brenner, H. Inpatient rehabilitation therapy among colorectal cancer patients - utilization and association with prognosis: a cohort study. Acta Oncologica 2021; 60: 1000-1010.

Butt, J., Murugan, R., Hippchen, T., Olberg, S., van Straaten, M., Wardemann, H., . . . , Waterboer, T. From Multiplex Serology to Serolomics-A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome. Viruses-Basel 2021; 13: 17.

Niedermaier, T., Heisser, T., Gies, A., Guo, F., Amitay, E. L., Hoffmeister, M., Brenner, H. To what extent is male excess risk of advanced colorectal neoplasms explained by known risk factors? Results from a large German screening population. International Journal of Cancer 2021; 149: 1877-1886.

Brenner, H. Vitamin D Supplementation to Prevent COVID-19 Infections and Deaths-Accumulating Evidence from Epidemiological and Intervention Studies Calls for Immediate Action. Nutrients 2021; 13: 8.

Heisser, T., Hoffmeister, M., Brenner, H. Effects of screening for colorectal cancer: Development, documentation and validation of a multistate Markov model. International Journal of Cancer 2021; 148: 1973-1981.

Niedermaier, T., Gredner, T., Kuznia, S., Schottker, B., Mons, U., Brenner, H. Potential of Vitamin D Food Fortification in Prevention of Cancer Deaths-A Modeling Study. Nutrients 2021; 13: 15.

Chen, X. C., Jansen, L., Guo, F., Hoffmeister, M., Chang-Claude, J., Brenner, H. Smoking, Genetic Predisposition, and Colorectal Cancer Risk. Clinical and Translational Gastroenterology 2021; 12: 8.

Gies, A., Niedermaier, T., Alwers, E., Hielscher, T., Weigl, K., Heisser, T., . . . , Brenner, H. Consistent Major Differences in Sex- and Age-Specific Diagnostic Performance among Nine Faecal Immunochemical Tests Used for Colorectal Cancer Screening. Cancers 2021; 13: 13.

Gruner, L. F., Amitay, E. L., Heisser, T., Guo, F., Niedermaier, T., Gies, A., . . . , Brenner, H. The Effects of Different Invitation Schemes on the Use of Fecal Occult Blood Tests for Colorectal Cancer Screening: Systematic Review of Randomized Controlled Trials. Cancers 2021; 13: 14.

Niedermaier, T., Balavarca, Y., Brenner, H. Screening for Colorectal Cancer-A German Perspective. American Journal of Gastroenterology 2021; 116: 841-841.

Schottker, B., Salem, A. A., Schwenk, M., Gao, X., Jansen, E., Brenner, H. Relationship of Physical Activity at Older Age with Biomarkers of Oxidative Stress: A Large, Population-based Cohort Study. Medicine & Science in Sports & Exercise 2021; 53: 2528-2535.

Tin, A., Schlosser, P., Matias-Garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H. B., . . . , Genetics, D. N. A. M. C. Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. Nature Communications 2021; 12: 18.

Gies, A., Niedermaier, T., Gruner, L. F., Heisser, T., Schrotz-King, P., Brenner, H. Fecal Immunochemical Tests Detect Screening Participants with Multiple Advanced Adenomas Better than T1 Colorectal Cancers. Cancers 2021; 13: 15.

Gredner, T., Niedermaier, T., Brenner, H., Mons, U. Impact of reducing alcohol consumption through price-based policies on cancer incidence in Germany 2020-50-a simulation study. Addiction 2021; 116: 1677-1688.

Boakye, D., Jansen, L., Halama, N., Chang-Claude, J., Hoffmeister, M., Brenner, H. Early discontinuation and dose reduction of adjuvant chemotherapy in stage III colon cancer patients. Therapeutic Advances in Medical Oncology 2021; 13: 18.

Schottker, B., Gao, X., Jansen, E., Brenner, H. Associations of Human Colorectal Adenoma with Serum Biomarkers of Body Iron Stores, Inflammation and Antioxidant Protein Thiols. Antioxidants 2021; 10: 13.

Chen, X. C., Guo, F., Hoffmeister, M., Chang-Claude, J., Brenner, H. Non-steroidal anti-inflammatory drugs, polygenic risk score and colorectal cancer risk. Alimentary Pharmacology & Therapeutics 2021; 54: 167-175.

Chen, L. J., Trares, K., Laetsch, D. C., Nguyen, T. N. M., Brenner, H., Schottker, B. Systematic Review and Meta-Analysis on the Associations of Polypharmacy and Potentially Inappropriate Medication With Adverse Outcomes in Older Cancer Patients. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 2021; 76: 1044-1052.

Scherer, S., Jansen, L., Boakye, D., Hoffmeister, M., Brenner, H. Changes in health-related outcomes among colorectal cancer patients undergoing inpatient rehabilitation therapy: a systematic review of observational and interventional studies. Acta Oncologica 2021; 60: 124-134.

Boakye, D., Jansen, L., Schottker, B., Jansen, E., Halama, N., Maalmi, H., . . . , Brenner, H. The association of vitamin D with survival in colorectal cancer patients depends on antioxidant capacity. American Journal of Clinical Nutrition 2021; 113: 1458-1467.

Chen, L. J., Nguyen, T. N. M., Chang-Claude, J., Hoffmeister, M., Brenner, H., Schottker, B. Association of Polypharmacy with Colorectal Cancer Survival Among Older Patients. Oncologist 2021; 26: E2170-E2180.

Huang, L., Jansen, L., Balavarca, Y., van der Geest, L., Lemmens, V., Koerkamp, B. G., . . . , Brenner, H. Significance of Examined Lymph Node Number in Accurate Staging and Long-term Survival in Resected Stage I-11 Pancreatic Cancer More is Better? A Large International Population-based Cohort Study. Annals of Surgery 2021; 274: E554-E563.

Bhardwaj, M., Terzer, T., Schrotz-King, P., Brenner, H. Comparison of Proteomic Technologies for Blood-Based Detection of Colorectal Cancer. International Journal of Molecular Sciences 2021; 22: 17.

Hoffmeister, M., Brenner, H., Amitay, E. L. Smoking Is Consistently Associated With Major Molecular Subtypes of Colorectal Cancer. American Journal of Gastroenterology 2021; 116: 1092-1093.

Gao, X., Zhang, Y., Li, X. W., Jansen, L., Alwers, E., Bewerunge-Hudler, M., . . . , Brenner, H. DNA Methylation-Based Estimates of Circulating Leukocyte Composition for Predicting Colorectal Cancer Survival: A Prospective Cohort Study. Cancers 2021; 13: 14.

Kiehl, L., Kuntz, S., Hohn, J., Jutzi, T., Krieghoff-Henning, E., Kather, J. N., . . . , Brinker, T. J. Deep learning can predict lymph node status directly from histology in colorectal cancer. European Journal of Cancer 2021; 157: 464-473.

Amitay, E. L., Niedermaier, T., Gies, A., Hoffmeister, M., Brenner, H. Risk Factors of Inadequate Bowel Preparation for Screening Colonoscopy. Journal of Clinical Medicine 2021; 10: 7.

Krilaviciute, A., Brenner, H. Low positive predictive value of computed tomography screening for lung cancer irrespective of commonly employed definitions of target population. International Journal of Cancer 2021; 149: 58-65.

Brenner, H. Add Vitamin D Supplementation. Deutsches Arzteblatt International 2021; 118: 376-376.

Siziba, L. P., Lorenz, L., Brenner, H., Carr, P., Stahl, B., Mank, M., . . . , Genuneit, J. Changes in human milk fatty acid composition and maternal lifestyle-related factors over a decade: a comparison between the two Ulm Birth Cohort Studies. British Journal of Nutrition 2021; 126: 228-235.

Alwers, E., Jansen, L., Kather, J., Amitay, E., Blaker, H., Kloor, M., . . . , Hoffmeister, M. Response to neoadjuvant treatment among rectal cancer patients in a population-based cohort. International Journal of Colorectal Disease 2021; 36: 177-185.

Jansen, L., Boakye, D., Alwers, E., Carr, P. R., Reissfelder, C., Schneider, M., . . . , Brenner, H. Uptake Rates of Novel Therapies and Survival Among Privately Insured Versus Publicly Insured Patients With Colorectal Cancer in Germany. Journal of the National Comprehensive Cancer Network 2021; 19: 411-+.

Schlosser, P., Tin, A., Matias-Garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H. B., . . . , Genetics, D. N. A. M. C. Meta-analyses identify DNA methylation associated with kidney function and damage. Nature Communications 2021; 12: 16.

Schottker, B., Kuznia, S., Brenner, H. Efficacy of vitamin D-3 supplementation on cancer mortality in the general population and the prognosis of patients with cancer: protocol of a systematic review and individual patient data meta-analysis of randomised controlled trials. Bmj Open 2021; 11: 9.

Xu, X., Kharazmi, E., Tian, Y., Mukama, T., Sundquist, K., Sundquist, J., . . . , Fallah, M. Risk of prostate cancer in relatives of prostate cancer patients in Sweden: A nationwide cohort study. Plos Medicine 2021; 18: 17.

Tian, Y., Kharazmi, E., Brenner, H., Xu, X., Sundquist, K., Sundquist, J., Fallah, M. Importance of Family History of Colorectal Carcinoma In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study. Journal of the National Comprehensive Cancer Network 2021; 19: 1252-+.

Huang, L., Jansen, L., Verhoeven, R. H. A., Ruurda, J. P., Van Eycken, L., De Schutter, H., . . . , Brenner, H. Largely varying patterns and trends of primary cancer-directed resection for gastric carcinoma with synchronous distant metastasis in Europe and the US: a population-based study calling for further standardization of care. Therapeutic Advances in Medical Oncology 2021; 13: 14.

Thong, M. S. Y., Jansen, L., Chang-Claude, J., Hofmeister, M., Brenner, H., Arndt, V. Association of laparoscopic colectomy versus open colectomy on the long-term health-related quality of life of colon cancer survivors (vol 34, pg 5593, 2020). Surgical Endoscopy and Other Interventional Techniques 2021; 35: 4900-4900.

Kuntz, S., Krieghoff-Henning, E., Kather, J. N., Jutzi, T., Hohn, J., Kiehl, L., . . . , Brinker, T. J. Gastrointestinal cancer classification and prognostication from histology using deep learning: Systematic review. European Journal of Cancer 2021; 155: 200-215.

Brenner, H., Hoffmeister, M. Striving to optimize colorectal cancer prevention. Nature Reviews Gastroenterology & Hepatology 2021; 18: 677-678.

Finke, I., Seppa, K., Malila, N., Jansen, L., Brenner, H., Pitkaniemi, J. Educational inequalities and regional variation in colorectal cancer survival in Finland. Cancer Epidemiology 2021; 70: 7.

Park, H. A., Neumeyer, S., Michailidou, K., Bolla, M. K., Wang, Q., Dennis, J., . . . , Investigators, K. C. Mendelian randomisation study of smoking exposure in relation to breast cancer risk. British Journal of Cancer 2021; 125: 1135-1145.

Gorski, M., Jung, B., Li, Y., Matias-Garcia, P. R., Wuttke, M., Coassin, S., . . . , Regeneron Genetics, C. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline. Kidney International 2021; 99: 926-939.

Karabegovic, I., Portilla-Fernandez, E., Li, Y., Ma, J. T., Maas, S. C. E., Sun, D. K., . . . , Ghanbari, M. Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Nature Communications 2021; 12: 13.

Brenner, H., Cross, A. J. Merits, Challenges, and Limitations of Randomized Trials on Colorectal Cancer Screening Effectiveness. Gastroenterology 2021; 160: 1009-1011.

Schundeln, M. M., Lange, T., Knoll, M., Spix, C., Brenner, H., Bozorgmehr, K., Stock, C. Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study. Cancer Epidemiology 2021; 70: 9.

Park, H. A., Canzian, F., Harrison, T. A., Hua, X. W., Shi, Q., Goldberg, R. M., . . . , Chang-Claude, J. Genome-wide Association Study of Predictive Genetic Polymorphisms for Oxaliplatin Treatment Efficacy in Colorectal Cancer. Genetic Epidemiology 2021; 45: 779-780.

Koole, J. L., Bours, M. J. L., Geijsen, A., Gigic, B., Ulvik, A., Kok, D. E., . . . , Weijenberg, M. P. Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium. American Journal of Clinical Nutrition 2021; 113: 1468-1481.

Galeotti, A. A., Gentiluomo, M., Rizzato, C., Obazee, O., Neoptolemos, J. P., Pasquali, C., . . . , Campa, D. Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction. Journal of Medical Genetics 2021; 58: 369-377.

Morra, A., Escala-Garcia, M., Beesley, J., Keeman, R., Canisius, S., Ahearn, T. U., . . . , Investigators, K. C. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment. Breast Cancer Research 2021; 23: 18.

Ponce, C. B., Scherer, D., Brinster, R., Boekstegers, F., Marcelain, K., Garate-Calderon, V., . . . , Bermejo, J. L. Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data. Hepatology 2021; 73: 1783-1796.

Kapoor, P. M., Mavaddat, N., Choudhury, P. P., Wilcox, A. N., Lindstrom, S., Behrens, S., . . . , Chang-Claude, J. Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk. Jnci-Journal of the National Cancer Institute 2021; 113: 329-337.

Sainz, J., Garcia-Verdejo, F. J., Martinez-Bueno, M., Kumar, A., Sanchez-Maldonado, J. M., Diez-Villanueva, A., . . . , Forsti, A. Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts. Cancers 2021; 13: 16.

Culliford, R., Cornish, A. J., Law, P. J., Farrington, S. M., Palin, K., Jenkins, M. A., . . . , Houlston, R. S. Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis. British Journal of Cancer 2021; 124: 1169-1174.

Morra, A., Jung, A. Y., Behrens, S., Keeman, R., Ahearn, T. U., Anton-Culver, H., . . . , Chang-Claude, J. Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium. Cancer Epidemiology Biomarkers & Prevention 2021; 30: 623-642.

Johnson, N., Maguire, S., Morra, A., Kapoor, P. M., Tomczyk, K., Jones, M. E., . . . , kConFab, I. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. British Journal of Cancer 2021; 124: 842-854.

Escala-Garcia, M., Canisius, S., Keeman, R., Beesley, J., Anton-Culver, H., Arndt, V., . . . , Investigators, K. A. Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis. Scientific Reports 2021; 11: 11.

Peduzzi, G., Gentiluomo, M., Tavano, F., Arcidiacono, P. G., Ermini, S., Vodicka, P., . . . , Campa, D. Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk. Cancer Epidemiology Biomarkers & Prevention 2021; 30: 2342-2345.

Corradi, C., Gentiluomo, M., Gajdan, L., Cavestro, G. M., Kreivenaite, E., Di Franco, G., . . . , Campa, D. Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. International Journal of Cancer 2021; 148: 2779-2788.

Lu, Y., Corradi, C., Gentiluomo, M., de Maturana, E. L., Theodoropoulos, G. E., Roth, S., . . . , Canzian, F. Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk. Frontiers in Genetics 2021; 12: 11.

Lu, Y., Gentiluomo, M., Macauda, A., Gioffreda, D., Gazouli, M., Petrone, M. C., . . . , Canzian, F. Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk. Frontiers in Oncology 2021; 11: 10.

Brenner, H., Hoffmeister, M., Heisser, T., Zhu, A. Falling Mortality Thanks to Improved Treatment for Colorectal Cancer Reply. Deutsches Arzteblatt International 2021; 118: 664-664.

Amadou, A., Freisling, H., Jenab, M., Tsilidis, K. K., Trichopoulou, A., Boffetta, P., . . . , Romieu, I. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium. British Journal of Cancer 2021; 124: 1882-1890.

Pistoni, L., Gentiluomo, M., Lu, Y., de Maturana, E. L., Hlavac, V., Vanella, G., . . . , Lovecek, M. Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma. Carcinogenesis 2021; 42: 1037-1045.

Lin, H. Y., Wang, X. N., Tseng, T. S., Kao, Y. H., Fang, Z. D., Molina, P. E., . . . , Consortium, P. Alcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness. Journal of Clinical Medicine 2021; 10: 14.

Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., . . . , Relton, C. L. A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer. Cancer Epidemiology Biomarkers & Prevention 2021; 30: 564-575.

Lin, H. Y., Huang, P. Y., Cheng, C. H., Tung, H. Y., Fang, Z. D., Berglund, A. E., . . . , Consortium, P. KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness. Scientific Reports 2021; 11: 15.

Cardoso, R., Guo, F., Heisser, T., Hackl, M., Ihle, P., De Schutter, H., . . . , Brenner, H. Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study. Lancet Oncology 2021; 22: 1002-1013.

Dimou, N., Yarmolinsky, J., Bouras, E., Tsilidis, K. K., Martin, R. M., Lewis, S. J., . . . , Murphy, N. Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study. Cancer Epidemiology Biomarkers & Prevention 2021; 30: 953-964.

Jiang, M., Fares, A. F., Shepshelovich, D., Yang, P., Christiani, D., Zhang, J., . . . , Liu, G. The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients. Lung Cancer 2021; 152: 58-65.

Gottlieb, J., Worth, H., Volk, T., Fuhner, T., Brenner, H. Oxygen Treatment in COVID-19. Deutsches Arzteblatt International 2021; 118: 375-376.

Hua, X. W., Dai, J. Y., Lindstrom, S., Harrison, T. A., Lin, Y., Alberts, S. R., . . . , Newcomb, P. A. Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study. Cancer Epidemiology Biomarkers & Prevention 2021; 30: 1349-1358.

Baxter, J. S., Johnson, N., Tomczyk, K., Gillespie, A., Maguire, S., Brough, R., . . . , Investigators, A. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element. American Journal of Human Genetics 2021; 108: 1190-1203.

Conti, D. V., Darst, B. F., Moss, L. C., Saunders, E. J., Sheng, X., Chou, A., . . . , Haiman, C. A. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nature Genetics 2021; 53: 11-15.

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