Publikationen

1. Paczulla A.M., Rothfelder K., Raffel S., Konantz M., Steinbacher J., Wang H., Tandler C., Mbarga M., Schaefer T., Falcone M., Nievergall E., Dörfel D., Hanns P., Passweg J.R., Lutz Ch., Schwaller J., Zeiser R., Blazar B.R., Caligiuri M.A.,  Dirnhofer S., Lundberg P., Kanz L., Quintanille-Martinez L., Steinle A., Trumpp A.*, Salih H.R.*, Lengerke C.* (2019). Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature. Jul 17 (Epub ahead of print).
   *: Joint senior authorship, Impact Factor: 41.577 (2017).
2. Thier M.C., Hommerding O., Panten J., Pinna R., García-González D., Berger T., Wörsdörfer P., Assenov Y., Scognamiglio R., Przybylla A., Kaschutnig P., Becker L., Milsom M.D., Jauch A., Utikal J., Herrmann C., Monyer H., Edenhofer F. und Trumpp A. (2019). Identification of Embryonic Neural Plate Border Stem Cells and their generation by direct reprogramming from adult human blood cells. Cell Stem Cell. Jan 3; 24(1), 166-182.
   Impact Factor: 23.290 (2017). Citations: 1 (too new)
3. Bahr C., Paleske L.v., Uslu V.V., Remeseiro S., Takayama N., Ng S.W., Murison A., Langenfeld, K., Petretich M., Scognamiglio R., Zeisberger P., Benk A., Amit I., Zandstra P.W., Lupien M., Dick J.E., Trumpp A.* and Spitz F.* (2018). A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies. Nature Jan 25; 553(7689), 515-520 . *joint last and corresponding authors
   Impact Factor: 41.577 (2017). Citations: 29 (too new)
4. Raffel S., Falcone M., Kneisel N., Hansson J., Wang W., Lutz Ch., Bullinger L., Poschet G., Nonnenmacher Y., Barnert A., Bahr C., Zeisberger P., Przybylla A., Sohn M., Tönjes M., Erez A., Adler L., Jensen P., Scholl C., Fröhling S., Cocciardi S., Wuchter P., Thiede Ch., Flörcken A., Westermann J., Ehninger G., Lichter P., Hiller K., Hell R., Herrmann C., Ho A.D., Krijgsveld J., Radlwimmer B. and Trumpp A. (2017). BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Nature Nov 16; 551(7680), 384-388 (Epub 2017 Nov 8).
   The paper was highlighted in Cancer Discovery (0.1158/2159-8290.CD-RW2017-216)
   Impact Factor: 41.577 (2017). Citations: 28 (too new)
5. Cabezas-Wallscheid N., Buettner F., Klimmeck D., Sommerkamp P., Ladel L., Thalheimer F.B., Pastor-Flores D., Roma L.P., Renders S., Zeisberger P., Przybylla A., Schönberger K., Scognamiglio R., Altamura S., Florian C.M., Fawaz M., Vonficht D., Collier P., Pavlinik D., Geiger H., Schroeder T., Benes V., Dick T.P., Rieger M.A., Stegle O. and Trumpp A. (2017). Vitamin A / Retinoic Acid Signaling Regulates the Dormancy State of Hematopoietic Stem Cells. Cell May 18; 169(5), 807-823 (Epub 2017 May 4).
   The paper was highlighted in a Preview article in Cell Stem Cell by Cornelius Pronk (July 6, 2017).
   Impact Factor: 31.398 (2017). Citations: 66 (too new)
6. Velten L., Haas S.F., Raffel S., Blaszkiewicz S., Islam S., Henning B.P., Hirche Ch., Lutz Ch., Buss E.C., Nowak D., Boch T., Hofmann W.-K., Ho A.D., Huber W., Trumpp A.*, Essers M.A.G.*, Steinmetz L.M.* (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nature Cell Biology Apr 19; 19(4), 271-281 (Epub  2017 Mar 20). * joint last and corresponding authors
   Impact Factor: 19.064 (2017). Citations: 162
7. Scognamiglio R., Cabezas-Wallscheid N., Thier M.C., Altamura S., Reyes A., Prendergast Á.M., Baumgärtner D., Carnevalli L.S., Atzberger A., Haas S., von Paleske L., Boroviak T., Wörsdörfer P., Essers M.A.G., Kloz U., Eisenman R.N., Edenhofer F., Bertone P., Huber W., van der Hoeven F., Smith A. and Trumpp A. (2016). Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell Feb 11; 164(4), 668-680.
   The paper was selected as the Cover article of the of the Feb. 2016 issue of Cell andwas highlighted in a News & Views article in EMBO Journal by Sinya Yamanaka (March 10, 2016).
   Impact Factor: 31.398 (2017). Citations: 83
8. Noll E.M., Eisen C., Stenzinger A., Espinet E., Muckenhuber A., Klein C., Vogel V., Klaus B., Nadler W., Rösli C., Lutz C., Kulke M., Engelhardt J., Zickgraf F.M., Epsinosa O., Schlesner M., Jiang X., Kopp-Schneider A., Neuhaus P., Bahra M., Sinn B.V., Eils R., Giese N.A., Hackert T., Strobel O., Werner J., Büchler M.W., Weichert W., Trumpp A.* and Sprick M.R.* (2016). CYP3A5 mediates resistance to small molecule inhibitors in pancreatic cancer. Nature Medicine Mar; 22(3), 278-287. (Epub 2016 Feb 8). * joint last and corresponding authors.
   The paper was highlighted by previews in Cancer Discovery (April 1, 2016 6; OF14) and Nature Reviews Gastroenterology and Hepatology (13,188 (2016)).
   Impact Factor: 32.621 (2017). Citations: 75
9. Cabezas-Wallscheid N., Klimmeck D., Hansson J., Lipka D.B., Reyes A., et al., Huber W.*, Milsom M.D.*, Plass C.*, Krijgsveld J.* and Trumpp A.* (2014). Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome and DNA methylome analysis. Cell Stem Cell Oct 2; 15(4), 507-522.
   The paper was selected as the Cover article of the October issue of Cell Stem Cell.
   The paper was highlighted in a Preview by Demetrios Kalaitzidis and David Scadden in the EMBO Journal. Deep diving in the blood stem cell-ome. DOI 10.15252/embj.201489778.
   Impact Factor: 23.290 (2017). Citations: 208
10. Medyouf H., Mossner M., Jann J.C., Nolte F., Raffel S., Herrmann C., Lier A., Eisen C., Nowak V., Zens B., Müdder K., Klein C., Obländer J., Fey S., Vogler J., Fabarius A., Riedl E., Roehl H., Kohlmann A., Staller M., Haferlach C., Müller N., John T., Platzbecker U., Metzgeroth G., Hofmann WK., Trumpp A.*, Nowak D.* (2014). Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. Cell Stem Cell Jun 5; 14(6), 824-837.
    *joint last author and A.T. is corresponding author. This article was highlighted in a “preview in CELL Stem Cell by Marc H.G.P. Raaijmakers: Disease Progression in Myelodysplastic Syndromes: Do Mesenchymal Cells Pave the Way?
    Impact Factor: 23.290 (2017). Citations: 204
11. Baccelli I., Schneeweiss A., Riethdorf S., Stenzinger A., Schillert A., Vogel V., Klein C., Saini M., Bäuerle T., Wallwiener M., Holland-Letz T., Höfner T., Sprick M., Scharpff M., Marmé F., Sinn H.P., Pantel K., Weichert W. and Trumpp A. (2013). Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nature Biotechnology Jun; 31(6), 539-544. Epub 2013 Apr 21.
    This article was highlighted in: “Identifying the metastatic seeds of breast cancer”, Nature Biotechnology - NEWS AND VIEWS by Angera H. Kuo and Michael F. Clarke (Volume 31, Number 6, June 2013)
    Impact Factor: 35.724 (2017). Citations: 618
12. Essers M.A., Offner S., Blanco-Bose W.E., Waibler Z., Kalinke U., Duchosal M.A. and Trumpp A. (2009). IFNalpha activates dormant HSCs in vivo. Nature Apr 16; 458(7240), 904-908.
    This article was highlighted in: “The New England Journal of Medicine” (Sipkins DA. Rendering the leukemia cell susceptible to attack. N Engl J Med. 2009 Sep 24;361(13):1307-9).
    „Nature Medicine” (Passegue and Ernst, IFN-alpha wakes up sleeping hematopoietic stem cells. Nat Med. 2009, 15:612-613).
    “EMBO Molecular Medicine” (Viale and Pelicci. Awaking stem cells from dormancy: growing old and fighting cancer. EMBO Mol. Med. 2009, 1:88-91).
    It was picked by two “Faculty of 1000 Biology” members and has received the combined score of 8.0). In addition it was picked and evaluated by three “Faculty of 1000 Medicine” members and has received a combined F1000 Score of 9.8 (>9.0 is exceptional) and was for some time one of the highest rated papers in the F1000 Medicine section and was a member of the Top 10 list.
    Impact Factor: 41.577 (2017). Citations: 897
13. Wilson A., Laurenti E., Oser G., van der Wath R.C., Blanco-Bose W., Dunant C.F., Bockamp E., Liò P., Macdonald H.R. and Trumpp A. (2008). Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell Dec 12; 135(6), 1118-1129.
    The paper was highlighted with a Preview by David Scadden in Cell.
    This article was picked and evaluated by one “Faculty of 1000 Medicine” member and has received a score of 3.0. In addition it was picked and evaluated by three “Faculty of 1000 Biology” members and has received a combined F1000 Score of 9.8 (>9.0 is exceptional) and is currently one of the highest rated papers in the F1000 Biology section and was a member of the current Top 10 list. It was on position 5 of the most read/downloaded papers in Cell.
    Impact factor: 31.398 (2017). Citations: 1369
14. Laurenti  E., Varnum-Finney B., Wilson A., Ferrero I., Blanco-Bose W.E., Ehninger A., Knoepfler P.S., Cheng P.F., MacDonald H.R., Eisenman R.N., Bernstein I.D. and Trumpp A. (2008). Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell Dec 4; 3(6), 611-624.
    The paper was highlighted with a Preview by Guy Sauvageau in Cell Stem Cell. This paper was on position 13 of the most read/downloaded papers in Cell Stem Cell.
    Impact factor: 23.290 (2017). Citations: 242
15. Wilson A., Murphy M.J., Oskarsson T., Kaloulis K., Bettess M.D., Oser G.M., Pasche A.C., Knabenhans C., Macdonald H.R. and Trumpp A. (2004). c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. Nov 15; 18(22), 2747-2763.
    This article was picked and evaluated by one “Faculty of 1000” member and has received a F1000 Score of 3.0 (Recommended).
    Impact factor: 9.462 (2017) Citations: 689
16. Trumpp A. (corresponding author), Refaeli Y., Oskarsson T., Gasser S., Murphy M., Martin G.R. & Bishop J.M. (2001). c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature Dec 13; 414(6865), 768-773.
    This article was picked and evaluated by three “Faculty of 1000” members and has received a F1000 Score of 6.5 (>6 = Must read).
    Impact factor: 41.577 (2017). Citations: 425

(1) Wilson A. and Trumpp A. (2006). Bone marrow hematopoietic-stem-cell niches. Nature Reviews Immunology Feb; 6(2), 93-106. Impact factor: 39.932 (2016) Citations: 1341.

(2) Trumpp A., Essers M. and Wilson A. (2010). Awakening dormant haematopoietic stem cells. Nature Reviews Immunology Mar; 10(3), 201-209. Impact factor: 39.932 (2016) Citations: 288.

(3) Baccelli I. and Trumpp A. (2012). The evolving concept of cancer and metastasis stem cells. J Cell Biol. Aug 6; 198(3), 281-293. Impact factor: 7.955 (2016) Citations: 276.

(1) Feix G., Schwall M., Haaß M., Maier U., Quale T., Schmitz L. and Trumpp A. (1990). Regulatory elements of maize storage protein genes. In: Genetic Engineering of Crop Plants, eds. C.P. Grierson, G. Lycett. Butterworth and Heinemann, Oxford, pp159-170.

(2) Blundell P.A., de la Pompa J.L., Meijers J.H.C., Trumpp A. and Zeller R. (1991). The limb deformity gene encodes evolutionarily highly conserved proteins. In: Developmental Patterning of the Vertebrate Limb, ed. Hinchliffe J.R. et al. Plenum Press, New York, pp 25-30.

(3) Trumpp A. (1992). Das limb deformity Gen kodiert neuartige Kernproteine, welche während der embryonalen Determinierung und Differenzierung exprimiert sind. Ph.D Thesis, University of Freiburg, Germany.

(4) Trumpp A., Blundell P.A., de la Pompa J.L. and Zeller R. (1992). The limb deformity (ld) gene encodes nuclear proteins involved in embryonic development. Biol. Chem. Hoppe-Seyler; 297, 831.

(5) Trumpp, A. Blundell P.A., de la Pompa J.L. and Zeller R. (1992). The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis. Genes & Development Jan;  6(1), 14-28.

(6) Bates B., Trumpp A., Rios M., Chen C., Fan G., Bishop J.M. and Jaenisch R. (1999). Neurotrophin-3 is required for proper cerebellar development. Nature Neuroscience Feb; 2(2), 115-117.

(7) Trumpp A., Depew M.J., Rubenstein J.L., Bishop J.M. and Martin G.R. (1999). Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes & Development Dec 1; 13(23), 3136-3148.

(8) Buchholz F., Refaeli Y., Trumpp A. and Bishop J.M. (2000). Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP mediated recombination in the mouse. EMBO Reports Aug; 1(2), 133-139.

(9) Fan G., Beard C., Chen R.Z., Csankovszki G., Sun Y., Siniaia M., Biniszkiewicz D., Bates B., Lee PP., Kuhn R., Trumpp A., Poon C.S., Wilson C.B. and Jaenisch R. (2001). DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci Feb 1; 21(3), 788-797.

(10) Groszer M., Erickson R., Scripture-Adams D.D., Lesche R., Trumpp A., Zack J.A., Kornblum H.I., Wu H. and Liu X. (2001). Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in Vivo. Science Dec 7; 294(5549), 2186-2189.
This article was picked and evaluated by three “Faculty of 1000” members and has received a F1000 Score of 8.1.

(11) Trumpp A.*, Refaeli Y., Oskarsson T., Gasser S., Murphy M., Gail R. Martin and Bishop J.M. (2001). c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature Dec 13; 414(6865), 768-773.
* corresponding author
This article was picked and evaluated by three “Faculty of 1000” members and has received a F1000 Score of 6.5.

(12) Delacour A., Nepote V., Trumpp A. and Herrera P.L. (2003) Nestin expression in pancreatic exocrine cell lineages. Mech Dev. Jan; 121(1), 3-14.

(13) Crone S.A., Negro A., Trumpp A., Giovannini M. and Lee K.F. (2003). Colonic Epithelial Expression of ErbB2 Is Required for Postnatal Maintenance of the Enteric Nervous System. Neuron Jan 9; 37(1), 29-40.

(14) MacPherson D., Sage J., Crowley D., Trumpp A., Bronson R.T. and Jacks T. (2003). Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol. Cell. Biol. Feb; 23(3), 1044-1053.

(15) Wilson A., Murphy M.J., Kaloulis K., Bettess M.D., Pasche A.C., Macdonald H.R. and Trumpp A. (2004). c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. Nov 15; 18(22), 2747-2763. This article was picked and evaluated by one “Faculty of 1000” member and has received a F1000 Score of 3.0.

(16) Murphy M.J., Wilson A., Trumpp A. (2005). More than just proliferation: Myc function in stem cells. Trends Cell Biol. Mar; 15(3), 128-137.

(17) Oskarsson T., Trumpp A. (2005). The Myc trilogy: lord of RNA polymerases. Nat Cell Biol. Mar; 7(3), 215-217.

(18) Refaeli Y., Field K.A., Turner B.C., Trumpp A. and Bishop J.M. (2005). The Protooncogene MYC can break B cell tolerance. Proc Natl Acad Sci USA Mar 15; 102(11), 4097-4102.

(19) Ackermann J., Frutschi M., Kaloulis K., McKee T., Trumpp A. and Beermann F. (2005). Metastasizing melanoma formation caused by expression of activated N-rasQ61K on an INK4a-deficient background. Cancer Research May 15; 65(10), 4005-4011.

(20) Bettess M.D., Murphy M.J., Dubey C., Dubois N., Roger C., Robine S. and Trumpp A. (2005). c-Myc is required for the formation of intestinal crypts, but dispensable for homeostasis of the adult intestinal epithelium. Molecular and Cellular Biology Sep; 25(17), 7868-7878.

(21) Riggi N., Cironi P.P., Suva M.-L., Kaloulis K., Garcia-Echeveria C., Hoffmann F., Trumpp A. and Stamenkovic I. (2005). Development of Ewing’s Sarcoma from Primary Bone Marrow-Derived Mesenchymal Progenitor Cells. Cancer Research Dec 15; 65 (24), 11459-11468.

(22) Trumpp A. (2006). c-Myc and activated Ras during skin tumorigenesis: cooperation at the cancer stem cell level? Ernst Schering Found Symp Proc.; 5, 13-26.

(23) Beermann F., Kaloulis K., Hofmann D., Murisier F., Bucher P. and Trumpp A. (2006). Identification of evolutionarily conserved regulatory elements in the mouse Fgf8 locus. Genesis Jan; 44(1),1-6.

(24) Wilson A. and Trumpp A. (2006). Bone marrow hematopoietic-stem-cell niches. Nature Reviews Immunology Feb; 6(2), 93-106.

(25) Prathapam T., Tegen S., Oskarsson T., Trumpp A. and Martin G.S. (2006). Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition. Proc Natl Acad Sci USA Feb 21; 103(8), 2695-2700.

(26) Bianchi T., Gasser S., Trumpp A. and Macdonald H.R. (2006). c-Myc acts downstream of IL-15 in the regulation of memory CD8 T cell homeostasis. Blood May 15; 107(10), 3992-3999.

(27) Sclafani A.M., Skidmore J.M., Ramaprakash H., Trumpp A., Gage P.J. and Martin D.M. (2006). Nestin-Cre mediated deletion of Pitx2 in the mouse. Genesis Jul; 44(7), 336-344.

(28) Oskarsson T., Essers M.A., Dubois D., Dubey C., Roger C., Metzger D., Chambon P., Hummler E., Beard P. and Trumpp A. (2006). Skin epidermis lacking the c-myc gene is resistant to Ras driven tumorigenesis but can re-acquire sensitivity upon additional loss of the p21CIP1 gene. GenesDev Aug 1; 20(15), 2024-2029.
This article was picked and evaluated by one “Faculty of 1000” member and has received a F1000 Score of 3.0.

(29) Dubois N.C., Hofmann D., Kaloulis K., Bishop J.M. and Trumpp A. (2006). The Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney and somite derived tissues. Genesis Aug; 44(8), 355-360.

(30) Wilson A., Oser G.M., Jaworski M., Blanco-Bose W.E., Laurenti E., Adolphe C., Essers M.A., Macdonald H.R. and Trumpp A. (2007). Dormant and self-renewing hematopoietic stem cells and their niches. Ann. N.Y. Acad. Sci. Jun; 1106, 64-75. Epub 2007 Apr 18.

(31) Ju, Z., Jiang H., Jaworski M., Gompf A., Rathinam C.3, Klein C., Trumpp A. and Rudolph K.L. (2007). Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med. Jun; 13(6), 742-747.

(32) Strom A., Bonal C., Ashery-Padan R., Hashimoto N., Campos M.L., Trumpp A., Noda T., Kido Y., Real F.X., Thorel F. and Herrera P.L. (2007). Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development Aug; 134(15), 2719-2725. Epub 2007 June 27.

(33) Bonal C., Thorel F., Ait-Lounis A., Reith W., Trumpp A. and Herrera P.L. (2008). Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transfifferentiates Acinar Cells into Adipocytes in Mice. Gastroenterology Jan; 136 (1), 309-319. Epub 2008 Oct 9.

(34) Trumpp A., Wiestler O.D. (2008). Mechanisms of Disease: cancer stem cells - targeting the evil twin. Nat Clin Pract Oncol. Jun; 5(6), 337-347.

(35) Dubois N., Adolphe C., Ehninger A., Robertson E.J., Wang R. and Trumpp A. (2008). Placental rescue reveals a sole requirement for c-Myc in erythroblast survival and hematopoietic stem cell function. Development Aug; 135(14), 2455-2465. Epub 2008, June 11.

(36) He C., Hu H., Fong S.Y., Trumpp A., Carlson T.R., Braren R., and Wang R.A. (2008). C-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development Aug; 135(14), 2467-2477. Epub 2008 June 11.

(37) Blanco-Bose W.E.*, Murphy M.J.*, Ehninger A., Offner S., Dubey C., Huang W., Moore D.D. and Trumpp A. (2008). c-Myc and its target FoxM1 are critical downstream effectors of TCPOBOP-CAR induced direct liver hyperplasia. Hepatology Oct; 48(4), 1302-1311.

(38) Marsh V., Winton D., Williams G.T., Dubois N., Trumpp A., Sansom O.J. and Clarke A.R. (2008). Epithelial Pten is dispensable for intestinal homeostasis, but suppresses adenoma development and progression following Apc mutation. Nature Genetics Dec; 40(12), 1436-1444.

(39) Laurenti  E., Varnum-Finney B., Wilson A., Ferrero I., Blanco-Bose W.E., Ehninger A., Knoepfler P.S., Cheng P.F., MacDonald H.R., Eisenman R.N., Bernstein I.D. and Trumpp A. (2008). Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell Dec 4; 3(6), 611-624.

(40) Wilson A., Laurenti E., Oser G., van der Wath R.C., Blanco-Bose W.E., Dunant C.F, Bockamp E., Liò P., Macdonald H.R. and Trumpp A. (2008). Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell Dec 12; 135(6), 1118-1129. Published online Dec 4, 2008.

(41) Nagao M., Campell K., Burns K., Kuan C-Y., Trumpp A. and Nakafuku M. (2008). Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway. J. Cell Biol. Dec 29; 183(7), 1243-1257.

(42) Essers M.A., Offner S., Blanco-Bose W.E., Waibler Z., Kalinke U., Duchosal M.A. and Trumpp A. (2009). IFNα activates dormant HSCs in vivo. Nature  Apr 16; 458(7240), 904-908. Epub 2009 Feb 11.

(43) Barde I., Laurenti E., Verp S., Groner A.C., Towne C., Padrun V., Aebischer P., Trumpp A. and Trono D. (2009). Regulation of episomal gene expression by KRAB/KAP1-mediated histone modifications. Journal of Virology Jun; 83(11), 5574-5580. Epub 2009 Mar 11.

(44) Mycko M.P., Ferrero I., Wilson A., Jiang W., Bianchi T., Trumpp A. and Macdonald H.R. (2009). Selective Requirement for c-Myc at an Early Stage of Va14i NKT Cell Development. Journal of Immunology Apr 15; 182(8), 4641-4648.

(45) van der Wath R.C., Wilson A., Laurenti E., Trumpp A. and Liò P. (2009). Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics. PLoS One Sep 22; 4(9), e6972.

(46) Stoelzle T., Schwarb P., Trumpp A. and Hynes N.E. (2009). c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland. BMC Biol. Sep 28; 7, 63.
This article was highlighted with a Minireview in the same issue by Nicole Sodir and Gerard Evan.

(47) Bockamp E., Antunes C., Liebner S., Schmitt S., Cabezas-Wallscheid N., Heck R., Ohnngemach S., Bartlomowicz O., Rickert C., Sanchez M.J., Hengstler J., Kaina B., Wilson A., Trumpp A. and Eshkind L. (2009). In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice. Mech Dev. Oct; 126(10), 863-872. Epub 2009 Jul 23. 

(48) Loizou J.I., Oser G., Shukla V., Sawan C., Murr R., Wang Z.Q., Trumpp A. and Herceg Z. (2009). Histone acetyltransferase cofactor Trrap is essential for maintaining the hematopoietic stem/progenitor cell pool. J Immunol. Nov 15; 183(10), 6422-6431; Epub 2009 Oct 30.

(49) Tesio M., Golan K., Corso S., Giordano S., Schajnovitz A., Vagima Y., Shivtiel S., Kalinkovich A., Caione L., Gammaitoni L., Laurenti E., Buss E.C., Shezen E., Itkin T., Kollet O., Petit I., Trumpp A., Christensen J., Aglietta M., Piacibello W. and Lapidot T. (2010). Enhanced c-Met activity promotes G-CSF induced mobilization of hematopoietic progenitor cells via ROS signaling. Blood Jan 13; 117(2), 419-428. Epub 2010 Jun 28.

(50) Jiang W., Ferrero I., Laurenti E., Trumpp A. and Macdonald H.R. (2010). c-Myc controls the development of CD8aa TCRab intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival. Blood Jun 3; 115(22), 4431-4438. Epub 2010 Mar 22.

(51) Laurenti E., Barde I., Verp S., Offner S., Wilson A., Quenneville S., Wiznerowicz M., Macdonald H.R., Trono, D. and Trumpp A. (2010). Inducible gene and shRNA expression in resident hematopoietic stem cells in vivo. Stem Cells Aug; 28(8), 1390-1398.

(52) Di Maggio N., Piccinini E., Jaworski M., Trumpp A., Wendt D.J. and Martin I. (2011). Toward modeling the bone marrow niche using scaffold-based 3D culture systems. Biomaterials Jan; 32(2), 321-329.

(53) Perna D., Fagà G., Verrecchia A., Gorski M.M., Barozzi I., Narang V., Khng J., Lim K.C., Sung W.K., Sanges R., Stupka E., Oskarsson T., Trumpp A., Wei C.L., Müller H. and Amati B. (2011). Genome-wide mapping of Myc binding and gene-regulation in serum-stimulated fibroblasts. Oncogene Mar 29; 31(13), 1695-1709.

(54) Domínguez-Frutos E., López-Hernández I., Vendrell V., Neves J., Gallozzi M., Gutsche K., Quintana L., Sharpe J., Knoepfler P.S., Eisenman R.N., Trumpp A., Giráldez F. and Schimmang T. (2011). N-myc Controls Proliferation, Morphogenesis, and Patterning of the Inner Ear. J Neurosci May 11; 31(19),  7178-7189.

(55) Medyouf H., Gusscott S., Wang H., Wai C., Nemirovsky O., Trumpp A., Pflumio F., Carboni J., Gottardis M., Pollak M., Aster J.C., Holzenberger M., and Weng A.P. (2011). High level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med. Aug 29; 208(9), 1809-1822. Epub 2011 Aug 1.

(56) Barde I., Laurenti E., Verp S., Wiznerowicz M., Offner S., Viornery A., Galy A., Trumpp A. and Trono D. (2011). Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease. Gene Ther. Nov; 18(11), 1087-1097. Epub 2011 May 5.

(57) Wallwiener M., Hartkopf A.D., Baccelli I., Riethdorf S., Schott S., Pantel K., Marmé F., Sohn C., Trumpp A., Rack B., Aktas B., Solomayer E.F., Müller V., Janni W., Schneeweiss A. and Fehm T.N. (2012). The prognostic impact of circulating tumor cells in subtypes of metastatic breast cancer. Breast Cancer Res Treat Jan; 137(2), 503-510. Epub 2012 Dec 28.

(58) Lander A.D., Kimble J., Clevens H., Fuchs E., Montarras D., Buckingham M., Calof A.L., Trumpp A., Oskarsson T. (2012). What does the concept of the stem cell niche really mean today? BMC Biol. Mar 9; 10-19.

(59) Schemionek M., Spieker T., Kerstiens L., Elling C., Essers M., Trumpp A., Berdel W.E., Müller-Tidow C. and Koschmieder S. (2012). Leukemic spleen cells are more potent than bone marrow-derived cells in a transgenic mouse model of CML. Leukemia May; 26(5), 1030-1037. Epub 2011 Dec 23.

(60) Pshenichnaya I., Schouwey K. Armaro M., Larue L., Knoepfler P.S., Eisenmann R.N., Trumpp A., Delmas V. and Beermann, F. (2012). Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc. Pigment Cell Melanoma Res. May; 25(3), 312-325.

(61) Glauche I., Horn K., Horn M., Thielecke L., Essers M.A., Trumpp A., Roeder I. (2012). Therapy of chronic myeloid leukemia can benefit the activation of stem cells: simulation studies of different treatment combinations. Br J Cancer May 22; 106(11); 1742-1752.

(62) Klimmeck D., Hansson J., Raffel S., Vakhrushev S.Y., Trumpp A.* and Krijgsveld J.* (2012). Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells. Mol Cell Proteomics Aug; 11(8), 286-302. Epub 2012 Mar 27.
*joint last authorship.

(63) Bruns I., Cadeddu R.P., Brueckmann I., Fröbel J., Geyh S., Büst S., Fischer J.C., Roels F., Wilk C.M., Schildberg F.A., Hünerlitürkoglu A.N., Zilkens C., Jäger M., Steidl U., Zohren F., Fenk R., Kobbe G., Brors B., Czibere A., Schroeder T., Trumpp A. and Haas R. (2012). Multiple myeloma-related deregulation of bone marrow-derived CD34+ hematopoietic stem and progenitor cells. Blood Sep 27; 120(13), 2620-2630. Epub 2012 Apr 18.

(64) Madhavan D., Zucknick M., Wallwiener M., Cuk K., Modugno C., Scharpff M., Schott S., Heil J., Turchinovich A., Yang R., Benner A., Riethdorf S., Trumpp A., Sohn C., Pantel K., Schneeweiss A. and Burwinkel B. (2012). Circulating microRNAs as Surrogate Markers for circulating tumour cells and prognostic markers in metastatic breast cancer. Clin Cancer Res. Nov 1; 18(21), 5972-5982. Epub 2012 Sep 4.

(65) Baccelli I., Schneeweiss A., Riethdorf S., Stenzinger A., Schillert A., Vogel V., Klein C., Saini M., Bäuerle T., Wallwiener M., Holland-Letz T., Höfner T., Sprick M., Scharpff M., Marmé F., Sinn H.P., Pantel K., Weichert W. and Trumpp A. (2013). Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nature Biotechnology Jun; 31(6), 539-544. Epub 2013 Apr 21.

(66) King K.Y., Essers M., Trumpp A., Goodell M.A. Response to Interferon-gamma impairs proliferation of hematopoietic stem cells in mice in 2013. [e-Letter],Blood (http://bloodjournal.hematologylibrary.org/content/121/18/3578.abstract/reply#bloodjournal_el_8138). Published September 25, 2013.

(67) Tesio M., Oser G.M., Baccelli I., Blanco-Bose W., Wu H., Göthert J.R., Kogan S.C. and Trumpp A. (2013). Pten loss in the bone marrow leads to G-CSF mediated HSC mobilization. J Exp Med. Oct 21; 210(11), 2337-2349. Epub 2013 Oct 14.

(68) Jäger N., Schlesner M., Jones D.T.W., Raffel S., et al. Trumpp A., Rippe K., Lehmann I., Lichter P., Pfister Stefan M. and Eils R. (2013). Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell Oct 24; 155(3), 567-581. Epub 2013 Oct 17.

(69) Hofner T., Macher-Goeppinger S., Klein C., Rigo-Watermeier T., Eisen C., Pahernik S., Hohenfellner M., Trumpp A. and Sprick M.R. (2013). Development and characteristics of preclinical experimental models for the research of rare neuroendocrine bladder cancer. J Urol. Dec; 190(6), 2263-2270. Epub 2013 Jun 29.

(70) Cabezas-Wallscheid N., Eichwald V., de Graaf J., Löwer M., Lehr H.A., Kreft A., Eshkind L., Hildebrandt A., Abassi Y., Heck R., Dehof A.K., Ohngemach S., Sprengel R., Wörtge S., Schmitt S., Lotz J., Meyer C., Kindler T., Zhang D.E., Kaina B., Castle J.C., Trumpp A., Sahin U. and Bockamp E. (2013). Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model. EMBO Mol Med. Dec; 5(12), 1804-1820. Epub 2013 Oct 4.

(71) Carnevalli L.S., Scognamiglio R., Cabezas-Wallscheid N., Rahmig S., Laurenti E., Masuda K., Jöckel L., Kuck A., Sujer S., Polykratis A., Erlacher M., Pasparakis M., Essers M.A. and Trumpp A. (2014). Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med. May 5; 211(5), 769-779.

(72) Medyouf H., Mossner M., Jann J.C., Nolte F., Raffel S., Herrmann C., Lier A., Eisen C., Nowak V., Zens B., Müdder K., Klein C., Obländer J., Fey, S., Vogler J., Fabarius A., Riedl E., Roehl H., Kohlmann A., Staller M, Haferlach C., Müller N., John T., Platzbecker U., Metzgeroth G., Hofmann W.K., Trumpp A.* and Nowak D.*(2014). Myelodysplastic cells in patients re-program mesenchymal stromal cells to establish a transplantable stem cell-niche disease unit. Cell Stem Cell Jun 5; 14(6), 824-837. Epub 2014 Apr 3.
*Joint last authorship; A.T. is corresponding author. The paper was highlighted by a Preview by Marc Raiijmakers in the same issue of Cell stem cell.

(73) Ehninger A., Boch T., Uckelmann H., Essers M.A., Müdder K., Sleckman B.P. and Trumpp A. (2014). Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α induced stress response. Blood Jun19; 123(25), 3909-3913. Epub 2014 May 2.

(74) Ehninger A., Boch T., Medyouf H., Müdder K., Orend G. and Trumpp A. (2014). Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence. Blood Jun 26; 123(26), 4054-4063. Epub 2014 May 15.

(75) Wallwiener M., Riethdorf S., Hartkopf A.D., Modugno C., Nees J., Madhavan D., Sprick M.R., Schott S., Domschke C., Baccelli I., Schönfisch B., Burwinkel B., Marmé F., Heil J., Sohn C., Pantel K., Trumpp A.* and Schneeweiss A.* Joined last authorship. (2014). Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients. BMC Cancer. Jul 11; 14, 512. * Joint last authorship.

(76) Hofner T., Macher-Goeppinger S., Klein C., Schillert A., Eisen C., Wagner S., Rigo-Watermeier T., Baccelli I., Vogel V., Trumpp A. and Sprick M.R. (2014). Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy. Urol Oncol. Jul; 32(5), 678-686. Epub 2014 Mar 12.

(77) Madhavan D., Wallwiener M., Bents K., Zucknick M., Nees J., Schott S., Cuk K., Riethdorf S., Trumpp A., Pantel K., Sohn C., Schneeweiss A., Surowy H. and Burwinkel B. (2014). Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis. Breast Cancer Res Treat. Jul; 146(1), 163-174. Epub 2014 May 17.

(78) Baccelli I., Stenzinger A., Vogel V., Pfitzner B.M., Klein C., Wallwiener M., Scharpff M., Massimo S., Holland-Letz T., Sinn H.-P., Schneeweiss A., Denkert C., Weichert W. and Trumpp A. (2014). Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients. Oncotarget. Sep 30; 5(18), 8147-8160.

(79) Cabezas-Wallscheid N., Klimmeck D., Hansson J., Lipka D.B., Reyes A., Wang Q., Weichenhan D., Lier A., von Paleske L., Renders S., Wünsche P., Brocks D., Gu L., Herrmann C., Haas S., Essers M., Brors B., Eils R., Huber W., Milsom M.D., Plass C., Krijgsveld J. and Trumpp A. (2014). Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome and DNA methylome analysis. Cell Stem Cell. Oct 2; 15(4), 507-522. Epub 2014 Aug 21. COVER STORY
* the paper was selected as the Cover article of the October issue of Cell Stem Cell
* the paper was ranked number 1 of the most downloaded papers of Cell Stem Cell
* The paper was highlighted with a Preview by Demetrios Kalaitzidis and David Scadden in the EMBO Journal. Deep diving in the blood stem cell-ome. DOI 10.15252/embj.201489778

(80) Klimmeck D., Cabezas-Wallscheid N., Reyes A., von Paleske L., Renders S., Hansson J., Krijgsveld J., Huber W. and Trumpp A. (2014). Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment. Stem Cell Reports. Nov 11; 3(5), 858-875. Epub 2014 Sep 25.

(81) Lipka D.B, Wang Q., Cabezas-Wallscheid N., Klimmeck D., Weichenhan D., Herrmann C., Lier A., Brocks D., von Paleske L., Renders S., Wünsche P., Zeisberger P., Gu L., Haas S., Essers M.A., Brors B., Eils R., Trumpp A., Milsom M.D. and Plass C. (2014). Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing. Cell Cycle. Nov 15; 13(22), 3476-3487.

(82) Höfner T., Zeier M., Hatiboglu G., Eisen C., Schönberg G., Hadaschik B., Teber D., Duensing S., Trumpp A., Hohenfellner M. and Pahernik S. (2014). The impact of type 2 diabetes on the outcome of localized renal cell carcinoma. World J Urol. Dec; 32(6), 1537-1542. Epub 2013 Dec 27.

(83) Höfner T., Eisen C., Klein C., Rigo-Watermeier T., Goeppinger S.M., Jauch A., Schoell B., Vogel V., Noll E., Weichert  W., Baccelli I., Schillert A., Wagner S.,  Pahernik S., Sprick M.R. and Trumpp A. (2015). Defined Conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin. Stem Cell Reports Mar 10; 4(3), 503-518. Epub 2015 Feb 19.

(84) Vick B., Rothenberg M., Sandhöfer N., Carlet M., Finkenzeller C., Krupka C., Grunert M., Trumpp A., Corbacioglu S., Ebinger M., André MC., Hiddemann W., Schneider S., Subklewe M., Metzeler KH., Spiekermann K. and Jeremias I. (2015). An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging. PLoS One Mar 20; 10(3), e0120925.

(85) Tesio M., Tang Y., Müdder K., Saini M., von Paleske L., Macintyre E., Pasparakis M., Waisman A. and Trumpp A. (2015). Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway. J Exp Med. Apr 6; 212(4), 525-538. Epub 2015 Mar 30.

(86) Walter D., Lier A., Geiselhart A., Thalheimer F.B., Huntscha S., Sobotta M.C., Moehrle B., Brocks D., Bayindir I., Kaschutnig P., Müdder K., Klein C., Jauch A., Schroeder T., Geiger H., Dick T.P., Holland-Letz T., Schmezer P., Lane S.W., Rieger M.A., Essers M.A.G., Williams D., Trumpp A. and Milsom M.D. (2015). Exit from dormancy provokes DNA damage-induced attrition in haematopoietic stem cells. Nature Apr 23; 520(7548), 549-552. Epub 2015 Feb 18.

(87) Werner S., Brors B., Eick J., Marques E., Pogenberg V., Parret A., Kemming D., Wood A.W., Edgren H., Neubauer H., Streichert T., Riethdorf S., Bedi U., Baccelli I., Jucker M., Eils R., Fehm T., Trumpp A., Johnsen S.A., Klefstrom J., Wilmanns M., Muller V., Pantel K. and Wikman H. (2015). Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid induced 2. Cancer Discovery May; 5(5), 506-519. Epub 2015 Feb 25.

(88) Wallwiener M., Hartkopf A.D., Riethdorf S., Nees J., Sprick M.R., Schönfisch B., Taran F.A., Heil J., Sohn C., Pantel K., Trumpp A. and Schneeweis A. (2015). The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a retrospective study in 107 patients. BMC Cancer May 14; 15(1), 403.

(89) Teodorczyk M., Kleber S., Wollny D., Sefrin J.P., Aykut B., Mateos A., Herhaus P., Sancho-Martinez I., Hill O., Gieffers C., Sykora J., Weichert W., Eisen C., Trumpp A., Sprick M.R, Bergmann F., Welsch T. and Martin-Villalba A. (2015). CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma. Cell Death Differ Jul; 22(7), 1192-1202. Epub 2015 Jan 23.

(90) Dietlein F., Kalb B., Jokic M., Noll E., Strong A., Tharun L., Ozretić L., Künstlinger H., Kambartel K., Randerath W.J., Jüngst C., Schmitt A., Torgovnick A., Richters A., Rauh D., Siedek F., Persigehl T., Mauch C, Bartkova J., Bradley A., Sprick M., Trumpp A., Rad R., Saur D., Bartek J., Wolf J., Büttner R., Thomas R.K. and Reinhardt H.C. (2015). A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Cell Jul 2; 162(1), 146-159.

(91) Hoang V.T., Buss E.C., Wang W., Hoffmann I., Raffel S., Zepeda-Moreno A., Baran N., Wuchter P., Eckstein V., Trumpp A., Jauch A., Ho A.D. and Lutz C. (2015). The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients. Int J Cancer Aug 1; 137(3), 525-536. Epub 2015 Jan 14.

(92) Haas S., Hansson J., Klimmeck D., Loeffler D., Velten L., Uckelmann H., Wurzer S., Prendergast A.M., Schnell A., Hexel K., Santarella-Mellwig R., Blaszkiewicz S., Kuck A., Geiger H., Milsom M.D., Steinmetz L.M., Schroeder T., Trumppp A., Krijgsveld J., Essers M.A.G. (2015). Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors. Cell Stem Cell Oct 1; 17(4), 422-434. Epub 2015 Aug 20.

(93) Stockklausner C., Raffel S., Klermund J., Bandapalli O.R., Beier F., Brümmendorf T.H., Bürger F., Sauer S.W., Hoffmann G.F., Lorenz H., Tagliaferri L., Nowak D., Hofmann W.K., Buergermeister R., Kerber C., Rausch T., Korbel J.O., Luke B., Trumpp A., Kulozik A.E. (2015). A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging (Albany NY) Nov; 7(11), 911-927.

(94) Aloia A., Petrova E., Tomiuk S., Bissels U., Deas O., Saini M., Zickgraf F.M., Wagner S., Spaich S., Sütterlin M., Schneeweiss A., Reitberger M., Rüberg S., Gerstmayer B., Agorku D., Knöbel S., Terranegra A., Falleni M., Soldati L., Sprick M.R., Trumpp A., Judde J.-G., Bosio A., Cairo S., Hardt O. (2015). The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy resistant breast cancer cells with mesenchymal features. Breast Cancer Research Nov 25; 17(1), 146.

(95) Paul F., Arkin Y., Jaitin D.A., Gilad A., Kenigsberg E., Keren-Shaul H., Winter D., Lara-Astiaso D.,  Gury M., Weiner A., David E., Cohen N., Haas S., Lauridsen F.K.B., Mildner A., Jung S., Trumpp A., Porse B.T., Tanay A., Amit I. (2015). Transcriptional heterogeneity and lineage commitment in myeloid progenitors. Cell Dec 17; 163(7), 1663-1677. (Epub 2015 Nov 25)

(96) Höfner T., Klein C., Eisen C., Rigo-Watermeier T., Haferkamp A., Trumpp A., Sprick M.R. (2016). The influence of prostatic anatomy and neurotrophins on basal prostate epithelial progenitor cells. Prostate Jan; 76(1), 114-121. Epub 2015 Oct 7.

(97) Alexandrova S., Kalkan T., Humphreys P., Riddell A., Scognamiglio R., Trumpp A. and Nichols J. (2016). Selection and dynamics of embryonic stem cell integration into early mouse embryos. Development Jan 1; 143(1), 24-34. (Epub 2015 Nov 19)

(98) Morrison G., Scognamiglio R., Trumpp A. and Smith A. (2015). Convergence of cMyc and -catenin on Tcf7I1 enables endoderm specificaiton. The EMBO Journal Feb 1; 35(3), 356-368. (Epub 2015 Dec 16)

(99) Scognamiglio R., Cabezas-Wallscheid N., Thier M.C., Altamura S., Reyes A., Prendergast Á.M., Baumgärtner D., Carnevalli L.S., Atzberger A., Haas S., von Paleske L., Boroviak T., Wörsdörfer P., Essers M.A.G., Kloz U., Eisenman R.N., Edenhofer F., Bertone P., Huber W., van der Hoeven F., Smith A. and Trumpp A. (2016). Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell Feb 11; 164(4), 668-680.

(100) Noll E.M., Eisen C., Stenzinger A., Espinet E., Muckenhuber A., Klein C., Vogel V., Klaus B., Nadler W., Rösli C., Lutz C., Kulke M., Engelhardt J., Zickgraf F.M., Epsinosa O., Schlesner M., Jiang X., Kopp-Schneider A., Neuhaus P., Bahra M., Sinn B.V., Eils R., Giese N.A., Hackert T., Strobel O., Werner J., Büchler M.W., Weichert W., Trumpp A.* and Sprick M.R. (2016). CYP3A5 mediates resistance to small molecule inhibitors in pancreatic cancer. Nature Medicine Mar; 22(3), 278-287. (Epub 2016 Feb 8).
* joint last authorship, A.T. is corresppinding author

(101) Nadler W., Berg R., Walch P., Hanke S., Baalmann M., Kerner A., Trumpp A., Roesli C. (2016). Ion source-dependent performance of 4-vinylpyridine, iodoacetamide, and N-maleoyl derivatives for the detection of cysteine-containing peptides in complex proteomics. Anal Bioanal Chem. Mar; 408(8), 2005-2067. (Epub 2015 Oct 22)

(102) Madhavan D., Peng C., Wallwiender M., Zucknick M., Nees J., Schott S., Rudolph A., Riethdorf S., Trumpp A., Pantel K., Sohn C., Chang-Claude J., Schneeweiss A., Burwinkel B. (2016). Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis. Carcinogenesis May; 37(5), 461-470. (Epub 2016 Jan 19)

(103) Peng C., Wallwiener M., Rudolph A., Cuk K., Eilber U., Celik M., Modugno C., Trumpp A., Heil J., Marme F., Madhavan D., Nees J., Riethdorf S., Schott S., Sohn C., Pantel K., Schneeweiss A., Chang-Claude J., Yang R. and Burwinkel B. (2016). Plasma Hyaluronic Acid Level as a Prognostic and Monitoring Marker of Metastatic Breast Cancer. International Journal of Cancer May 15; 138(10), 2499-2509. (Epub 2016 Feb 16)

(104) Peng C., Chen H., Wallwiender M., Modugno C., Cuk K., Madhavan D., Trumpp A., Heil J., Marmé F., Nees J., Riethdorf S., Schott S., Sohn C., Pantel K., Schneeweiss A., Yang R., Burwinkel B. (2016). Plasma S100P level as a novel prognostic marker of metastatic breast cancer. Breast Cancer Res Treat. Jun; 157(2), 329-338. (Epub 2016 May 4)

(105) Hanke S., Kerner A., Nadler W.M., Trumpp A., Zhang Yixin, Rösli Ch.P. (2016). The pivotal role of reactivity in the design of novel biotinylation reagents for the chemical-proteomics-based identification of vascular accessible biomarkers. The Journal of Proteomics June 1; 141, 57-66.

(106) Mossner M., Jann J.C., Wittig J., Nolte F., Fey S., Nowak V., Obländer J., Pressler J., Palme I., Xanthopoulos C., Boch T., Metzgeroth G., Röhl H., Witt S.H., Dukal H., Klein C., Schmitt S., Gelß P., Platzbecker U., Balaian E., Fabarius A., Blum H., Schulze T.J., Meggendorfer M., Haferlach C., Trumpp A., Hofmann W.K., Medyouf H., Nowak D. (2016). Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure. Blood Sept 1; 128(9), 1246-1259. (Epub 2016 Jun 6)

(107) Poschke I., Faryna M., Bergmann F., Flossdorf M., Lauenstein C., Hermes J., Hinz U., Hank T., Ehrenberg R., Volkmar M., Loewer M., Glimm H., Hackert T., Sprick M.R., Höfer T., Trumpp A., Halama N., Hassel J.C., Strobel O., Büchler M., Sahin U., Offringa R. (2016). Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma. Oncoimmunology Oct 7; 5(12), e1240859

(108) Deutsch T.M., Riethdorf S., Nees J., Hartkopf A.D., Schönfisch B., Domschke C., Sprick M.R., Schütz F. Brucker S.Y., Stefanovic S., Sohn C., Pantel K., Trumpp A., Schneeweiss A., Wallwiener M. (2016). Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer. Breast Cancer Res Treat. Nov; 160(02), 277-290. (Epub 2016 Oct 1)

(109) Kanatsu-Shinohara M., Tanaka T., Ogonuki N., Ogura A., Morimoto H., Cheng P.F., Eisenmann R.N., Trumpp A. and Shinohara T. (2016). Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal. Genes & Development Dec 1; 30(23), 2637-2648.

(110) Kuhlman L., Nadler W.M., Kerner A., Hanke S.A., Noll E.M., Eisen C., Espinet E., Vogel V., Trumpp A., Sprick M.R., Roesli C.P. (2017). Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma. Pancreas Mar; 46(3), 311-322. (Epub ahead of print)

(111) Magnani L., Frigè G., Gadaleta R.M., Corleone G., Fabris S., Kempe H., Verschure P.J., Barozzi I., Vircillo V., Hong S.P., Perone Y., Saini M., Trumpp A., Viale G., Neri A. Ali S., Colleoni M.A., Pruneri G., Minucci S. (2017). Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer. Nat Genet. Mar; 49(3), 444-450. (Epub 2017 Jan 23)

(112) Nadler W., Waidelich, D., Kerner A., Hanke S., Berg R., Trumpp A., Roesli Ch. (2017).MALDI versus ESI – the impact of the ion source on peptide identification. The Journal of Proteome Research Mar 3; 16(3), 1207-1215.

(113) Wieland E., Rodriguez-Vita J., Liebler S.S., Mogler C., Moll I., Herberich S.E., Espinet E., Herpel E., Menuchin A., Chang-Claude J., Hoffmeister M., Gebhardt Ch., Brenner H., Trumpp A., Siebel Ch.W., Hecker M., Utikal J., Sprinzak D., Fischer A. (2017). Endothelial Notch1 activity facilitates metastasis. Cancer Cell Mar 13; 31(3), 355-367. (Epub 2017 Feb 23)

(114) Velten L., Haas S.F., Raffel S., Blaszkiewicz S., Islam S., Henning B.P., Hirche Ch., Lutz Ch., Buss E.C., Nowak D., Boch T., Hofmann W.-K., Ho A.D., Huber W., Trumpp A.*, Essers M.A.G.*, Steinmetz L.M.* (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nature Cell Biology Apr 19; 19(4), 271-281 (Epub  2017 Mar 20). * joint last and corresponding authors

(115) Berger A.K., Singh H.M., Werft W., Muckenhuber A., Sprick M.R., Trumpp A., Weichert W., Jäger D., Springfeld C. (2017). High prevalence of incidental and symptomatic venous thromboembolic events in patients with advanced pancreatic cancer under palliative chermotherapy: A retrospective cohort study. Pancreatology Apr 22; S1424-3903(17), 30078-30079 (Epub ahead of print)

(116) Cabezas-Wallscheid N., Buettner F., Sommerkamp P., Klimmeck D., Ladel L., Thalheimer F.B., Pastor-Flores D., Roma L.P., Renders S., Zeisberger P., Przybylla A., Schönberger K., Scognamiglio R., Altamura S., Florian C.M., Fawaz M., Vonficht D., Tesio M., Collier P., Pavlinic D., Geiger H., Schroeder T., Benes V., Dick T.P., Rieger M.A., Stegle O., Trumpp A. (2017). Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell, http://dx.doi.org/10.1016/j.cell.2017.04.018
Video Abstract

(117) Hirche C., Frenz T., Haas S.F., Döring M., Borst K., Tegtmeyer P.K., Brizic I., Jordan S., Keyser K., Chhatbar C., Pronk E., Lin S., Messerle M., Jonjic S., Falk C.S, Trumpp A., Essers M.A.G., Kalinke U. (2017). Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo. Cell Rep. June 13; 19(11), 2345-2356.

(118) Wang W., Stiehl T., Raffel S., Hoang V.T., Hoffmann I., Poisa-Beiro L., Saeed B.R., Blume R., Manta L., Eckstein V., Bochtler T., Wuchter P., Essers M., Jauch S., Trumpp A., Marciniak-Czochra A., Ho A.D., Lutz C. (2017). Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia. Haematologica Sep; 102(9),1567-1577 (Epub 2017 May 26).

(119) Bahr C., Paleske L.v., Uslu V.V., Remeseiro S., Takayama N., Ng S.W., Murison A., Langenfeld, K., Petretich M., Scognamiglio R., Zeisberger P., Benk A., Amit I., Zandstra P.W., Lupien M., Dick J.E., Trumpp A.* and Spitz F.* (2017). A cluster of distal Myc enhancers regulates normal and leukaemic haematopoietic stem cell hierarchies. Nature October(in press). * joint last and corresponding authors

(120) Muzumdar M.D., Chen P.Y., Dorans K.J., Chung K.M., Bhutkar A., Hong E., Noll E.M., Sprick M.R., Trumpp A., Jacks T. (2017). Survival of pancreatic cancer cells lacking KRAS function. Nat. Commun. Oct 23; 8(1), 1090.

(121) Muckenhuber A., Berger A.K., Schlitter A.M., Steiger K., Konukiewitz B., Trumpp A., Eils R., Werner J., Friess H., Esposito I., Klöppel G., Ceyhan G., Jesinghaus M., Denkert C., Bahra M., Stenzinger A., Sprick M., Jäger D., Springfeld Ch., Weichert, W. (2017). Pancreatic Ductal Adenocarcinoma Subtyping using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response. Clinical Cancer Research Nov 3; pii: clincanres.2180.2017 (Epub ahead of print).

(122) Raffel S., Falcone M., Kneisel N., Hansson J., Wang W., Lutz Ch., Bullinger L., Poschet G., Nonnenmacher Y., Barnert A., Bahr C., Zeisberger P., Przybylla A., Sohn M., Tönjes M., Erez A., Adler L., Jensen P., Scholl C., Fröhling S., Cocciardi S., Wuchter P., Thiede Ch., Flörcken A., Westermann J., Ehninger G., Lichter P., Hiller K., Hell R., Herrmann C., Ho A.D., Krijgsveld J., Radlwimmer B. and Trumpp A. (2017). BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation. Nature Nov 16; 551(7680), 384-388 (Epub 2017 Nov 8).

(123) Neugebauer J., Zickgraf F.M., Park J., Jiang X., Wagner S., Spaich S., Sütterlin M., Schlesner M., Trumpp A., Sprick M., Eils R., Conrad Ch. (2017). Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. Molecular Systems Biology, Nov 27; 13(11), 955.

(1) Trumpp A. (1999). Inhibitors in Control. Trends in Cell Biology March; 9(3), 122.
Impact factor: 11.532 (2015).

(2) Trumpp A. (2002). After 25 years of research into the proto-oncogene c-myc, there is light at the end of the tunnel. Bull Suisse Cancer; 22(1), 34-37.
Impact factor: 0.604 (2015).

(3) Trumpp A. and Kalman D. (2004). Article “Science, Society and the Nobel Prize”. Book Review: J.M. Bishop: How to win the Nobel Prize. Nat Cell Biol.; 6(3), 173.
Impact factor: 20.060 (2016).

(4) Murphy M.J., Wilson A. and Trumpp A. (2005). More than proliferation: Myc functions in stem cells. Trends in Cell Biology; 15(3), 128-137.
Impact factor: 11.532 (2015). Citations: 176.

(5) Oskarsson T. and Trumpp A. (2005). The Myc trilogy: Lord of RNA Polymerases. Nat Cell Biol. Mar; 7(3), 215-217.
Impact factor: 20.060 (2016). Citations: 121.

(6) Trumpp A. (2006). C-Myc and activated Ras during skin tujorigenesis: cooperation at the cancer stem cell level? Ernst Schering Found Symp Proc.; 5, 13-26.
Impact factor: -- . Citations: 6.

(7) Wilson A. and Trumpp A. (2006). Bone marrow hematopoietic stem cell niches. Nature Reviews Immunology Feb; 6(2) 93-106.
Impact factor: 39.932 (2016). Citations: 1341.

(8) Wilson A., Oser G.M., Jaworski M., Blanco-Bose W.E., Laurenti E., Adolphe C., Essers M.A., Macdonald H.R. and Trumpp A. (2007). Dormant and self-renewing hematopoietic stem cells and their niches. Ann. N.Y. Acad. Sci. Jun; 1106, 64-75. Epub 2007 Apr 18.
Impact factor: 4.706 (2016). Citations: 226.

(9) Trumpp A. and Wiestler O.D. (2008). Mechanisms of Disease: cancer stem cells - targeting the evil twin. Nature Clinical Practice Oncology Jun; 5(6), 337-347.
Impact factor: 18.786 (2015). Citations: 164.

(10) Wilson A., Laurenti E., Trumpp A. (2009). Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev. Oct; 19(5), 461-468. Epub 2009 Oct 5.
Impact factor: 5.784 (2015). Citations: 142.

(11) Laurenti E., Wilson A., Trumpp A. (2009). Myc's other life: stem cells and beyond. Curr Opin Cell Biol. Dec; 21(6), 844-854; Epub 2009 Oct 14.
Impact factor: 9.937 (2016). Citations: 82.

(12) Trumpp A., Essers M.A.G. and Wilson A. (2010). Awakening dormant haematopoietic stem cells. Nature Rev Immunol. Mar; 10(3), 201-209.
Impact factor: 39.932 (2016). Citations: 288.

(13) Essers M.A.G. and Trumpp A. (2010). Targeting leukemic stem cells by breaking their dormancy. Molecular Oncology Oct; 4(5), 443-450.
Impact factor: 5.314 (2016). Citations: 142.

(14) Carnevalli L.S. and Trumpp A. (2010). Tuning mTORC1 activity for balanced self-renewal and differentiation. Dev Cell. Aug 17; 19(2), 187-188.
Impact factor: 9.174 (2016). Citations: 6.

(15) Milsom M.D. and Trumpp A. (2011). Bridging the information gap. Nat Immunol. May; 12(5), 377-379.
Impact factor: 21.506 (2016). Citations: 6.

(16) Ehninger A. and Trumpp A. (2011). The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J Exp Med. Mar 14; 208(3), 421-428.
Impact factor: 11.991 (2016). Citations: 420.

(17) Tesio M. and Trumpp A. (2011). Breaking the cell cycle of HSCs by p57 and friends. Cell Stem Cell Sep 2; 9(3), 187-192.
Impact factor: 23.394 (2016). Citations: 47.

(18) Lander A.D., Kimble J., Clevers H., Fuchs E., Montarras D., Buckingham M., Calof A.L., Trumpp A. and Oskarsson T. (2012). What does the concept of the stem cell niche really mean today? BMC Biol. Mar 9; 10,19.
Impact factor: 6.779 (2016). Citations: 122.

(19) Baccelli I. and Trumpp A. (2012). The evolving concept of cancer and metastasis stem cells. Journal of Cell Biology Aug 6; 198(3), 281-293.
Impact factor: 7.955 (2016). Citations: 276.

(20) Schillert A., Trumpp A., Sprick M.R. (2013). Label retaining cells in cancer – the dormant root of evil? Cancer Lett. Nov 28; 341(1), 73-79.
Impact factor: 6.375 (2016). Citations: 12.

(21) Cabezas-Wallscheid N. and Trumpp A. (2016). STEM CELLS. Potency finds its niches. Science Jan 8; 351(6269), 126-127.
Impact factor: 37.205 (2016). Citations: 3 (too new).

(22) Raffel S. and Trumpp A. (2016). miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells. Cancer Cell Feb 8; 29(2), 133-135.
Impact factor: 27.407 (2016). Citations: 9 (too new).

(23) Sommerkamp P. and Trumpp A. (2016). Metabolic cues for hematopoietic stem cells. Science Dec 2; 354(6316), 1103-1104.
Impact factor: 37.205 (2016). Citations: -- (too new).

(24) Bahr C., Correia N., Trumpp A. (2017). Stem cells make leukemia grow again. The EMBO Journal Sep 15; 36(18), 2667-2669.
Impact factor: 9.792 (2016). Citations: -- (too new).

(1) Trumpp A. (2007) c-Myc and Activated Ras during Skin Tumorigenesis: Cooperation at the Cancer Stem Cell Level? In: Wiestler/Mumberg (eds) Cancer Stem Cells. (Ernst Schering Foundation Symposium ) Springer, Berlin Heidelberg 2006/5

(2) Wilson A. and Trumpp A. (2009). Hematopoietic Stem Cell Niches in: Molecular Mechanisms of Hematopoiesis edited by Amittha Wickrema and Barbara Kee. Springer publishing.