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Forschungsprojekt
Investigation of vaccination platforms for the induction of an efficient anti-HPV16 T cell response at mucosal tumor sites
To investigate new vaccination platforms for their induction of an efficient anti-HPV16 CD8+ T cell response at mucosal tumor sites, the Riemer lab has recently developed orthotopic, HPV-dependent tumor models in MHC-humanized mice that mimic HPV-driven cervical as well as head and neck cancer. This project explores a Clostridium Assisted Drug Delivery platform (CADD), developed by an industrial collaboration partner, and other therapeutic HPV vaccine platforms. Using imunopeptidomics, we assess the potential of vaccine candidates to induce a specific immune response based on the epitope presentation on antigen-presenting cells. Promising vaccine candidates are subsequently tested for the induction of systemic as well as mucosal immune responses by means of spectral flow cytometry, and anti-tumor effects in our orthotopic tumor models will be monitored.
Wissenschaftlicher Lebenslauf
Since Oct 2023
PhD student, Immunotherapy and Immunoprevention, DKFZ, Heidelberg
2020 - 2023
MSc Immunobiology, University of Bonn
2017 - 2020
BSc Molecular Biomedicine, University of Bonn
2016 - 2017
BSc program Molecular Life Sciences, Radboud University Nijmegen, Netherlands