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Research

GECCO - Genetics and Epidemiology of Colorectal Cancer Consortium

The Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) is a consortium made up of scientists from North America, Australia, Asia and Europe with the goal of identifying genetic variants for colorectal cancer risk and prognosis also by molecular subtypes, and investigating how these variants interact with environmental factors. The coordinating center at the Fred Hutchinson Cancer Research Center harmonizes data from 70 epidemiological studies on colorectal cancer, comprising in total over 130,000 participants.

The DACHS study participates in this consortium by providing clinical and epidemiologic data as well as DNA samples for genotyping. Using the rich data source made available by GECCO, our group leads several studies that mainly focus on the interplay between menopausal hormone therapy and genetic susceptibility in relation to risk of colorectal cancer. Both conventional and functionally-informed genome-wide analyses of gene-environment interactions with menopausal hormone therapy will be carried out as well as a pathway analysis of hormone-metabolism pathways.

Funding:
National Cancer Institute, NIH, U.S. Department of Health and Human Services (U01 CA137088, R01CA201407)