mRNA Cancer Immunotherapies

Our Research

Sunscreen - Lipid Nanoparticle Formulation device — Lipid nanoparticle formulation device

Our lab conducts research on "mRNA cancer immunotherapies", including antigen-specific immunotherapies using both antibody- and T-cell-based approaches. In addition to classical laboratory techniques, the focus is on sequencing techniques and bioinformatics methods. The aim is - in line with the philosophy of HI-TRON Mainz - to promote the rapid transfer of laboratory research into the clinic.

Team

Prof. Dr. Ugur Sahin
Dr. Alexandra Alves Duarte
Dr. Costanza Zanetti
Dr. Sakshi Singh
Dr. Jannis Wißfeld
Dr. Akhil Velluva
Dr. Thomas Kerzel-Gnaneswaran
Varad Kulkarni
Jule Dettweiler
Melike Aydin

Selected Publications

2024 - Cancer Cell

Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancershe publication

Beck JD, Diken M, Suchan M, Streuber M, Diken E, Kolb L, Vascotto F, Peters D, Beißert T, Türeci Ö, Kreiter S, Vormehr M, Sahin U.

2022 - Nature Biotechnology

Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens

Weber D, Ibn-Salem J, Sorn P, Suchan M, Holtsträter C, Lahrmann U, Vogler I, Schmoldt K, Lang F, Schrörs B, Löwer M, Sahin U.

2020 - Nature

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, Kranz LM, Diken M, Kreiter S, Haas H, Attig S, Rae R, Cuk K, Kemmer-Brück A, Breitkreuz A, Tolliver C, Caspar J, Quinkhardt J, Hebich L, Stein M, Hohberger A, Vogler I, Liebig I, Renken S, Sikorski J, Leierer M, Müller V, Mitzel-Rink H, Miederer M, Huber C, Grabbe S, Utikal J, Pinter A, Kaufmann R, Hassel JC, Loquai C, Türeci Ö.