Molecular thoracic Oncology

Our research is focused on understanding the genetic and molecular basis of lung and breast cancers by studying various oncogenic drivers and specific genetic alterations that drive cancer progression. Using advanced genetically engineered mouse models, we examine how distinct gene expression profiles influence tumor aggressiveness and responsiveness to treatment. A key part of our research involves identifying biomarkers predictive of poor therapeutic outcomes, aiming to develop more precise cancer therapies.

Methods and technologies 
Our research leverage several cutting-edge technologies:

• Genetically engineered mouse models to closely mimic human cancer.
• CRISPR/Cas9 technology for precise genetic modifications to study the impact of specific genes on cancer.
• Lineage tracing, this technique traces the evolution and differentiation of cancer cells, offering insights into tumor development.
• Epigenome and single-cell transcriptome analysis, help us explore gene expression and regulatory changes at the single-cell level, enhancing our understanding of cancer cell behavior.
• 3D in vitro culture systems that allow us to study cancer growth in environments that closely mimic physiological conditions.

Goals and societal relevance 
The overarching goal of our research is to advance our understanding of cancer biology to discover new therapeutic targets and strategies. By dissecting the molecular mechanisms of tumor progression and genetic instability, we strive to develop more effective treatments. Our efforts support the German Cancer Research Centre’s mission to address major challenges in cancer research, particularly in identifying and overcoming resistance mechanisms to improve patient outcomes.