Prof. Henri-Jacques Delecluse, MD, PhD
Prof. Henri-Jacques Delecluse, MD, PhD
Position:
Group leader
Contact:
Phone 1:
+49 6221 424870 (Office 1)
Phone 2:
+49 6221 424852 (Office 2)
Fax:
+49 6221 424852
Building:
ATV
Room:
1.101
Curriculum Vitae
Education
1987 Medical degree. Faculty of Medicine, Lille, France
1988 Residency in Pathology, Lyon, France
1991 M.D. Faculty of Medicine, Lyon, France
1993 Diploma in Histo and Cytopathology. Full specialist registration
1995 Ph.D. Molecular Biology, University of Lyon, France
Additional qualifications: B.Sc. in Pure Mathematics (Paris, Besancon), M.Sc. in Genetics, Differentiation, Immunology (Lyon)
Professional experience
Since 2012 Director of Inserm-DKFZ Unit U1074
Since 2011 Member of the German Centre for Infection Research (DZIF)
2005-2011 Speaker of the department ‘Infections and Cancer’, DKFZ
Since 2003 Full (C4) professor at the University of Heidelberg, Head of the “Pathogenesis of Virus-associated Tumours” division.
2000-2003 Professor of Molecular Pathology (personal chair), University of Birmingham, UK. Pathology reporting (Hematopathology, Molecular Pathology)
1996-2000 Group leader, Institute for Clinical Molecular Biology, Gene Vectors Department, GSF, Munich, Germany
1995-1996 Lecturer in Pathology, University Hospital B. Franklin, Free University of Berlin, Germany. Pathology reporting (Hematopathology, Molecular Pathology)
1993-1995 Lecturer in Pathology, University Hospital E. Herriot, France. Pathology reporting (Hematopathology, Molecular Pathology)
10 selected publications (2002-2016)
Neuhierl B, Feederle R, Hammerschmidt H & Delecluse HJ. Glycoprotein gp110 of Epstein-Barr virus determines viral tropism and efficiency of infection.PNAS 2002, 99; 15036–15041
TimmsJM, BellA, FlavellJ, MurrayP, RickinsonA, Traverse-GlehenA, BergerF & Delecluse HJ. Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma Lancet 2003, 361; 217-23
Shannon-Lowe CD, Neuhierl B, Baldwin G, Rickinson AB, Delecluse HJ. Resting B cells as a transfer vehicle for Epstein-Barr Virus infection of epithelial cells. PNAS 2006,103; 7065-7070
Hutzinger R, Feederle R, Mrazek J, Schiefermeier N, Balwierz PJ, Zavolan M, Polacek N, Delecluse HJ*, Hüttenhofer A*. Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome.
PLoS Pathog. 2009 Aug;5(8):e1000547. *Corresponding authors
Feederle R, Linnstaedt SD, Bannert H, Lips H, Bencun M, Cullen BR, Delecluse HJ. A Viral microRNA cluster strongly potentiates the transforming properties of a Human Herpesvirus. PLoS Pathogens, 2011 PLoS Pathog 7(2): e1001294
Tsai MH, Raykova A, Klinke O, Bernhardt K, Gärtner K, Leung CS, Geletneky K, Sertel S, Münz C, Feederle R, Delecluse HJ. Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas. Cell Rep. 2013 Oct;5(2):458-70
Yu X, Ilecka M, Bartlett EJ, Schneidt V, Bhat R, Mautner J, Feederle R, Delecluse HJ. Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells. Blood. 2015 Mar 5;125(10):1601-10.
Lin X., Tsai MH., Shumilov A., Poirey R., Bannert H., Middeldorp JM., Feederle R., Delecluse HJ:: The Epstein-Barr virus BART miRNA cluster of the M81 strain modulates multiple functions in primary B cells. PloS Pathogens 2015.
Bernhardt K, Haar J, Tsai MH, Poirey R, Feederle R, Delecluse HJ. A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog. PLoS Pathog. 2016 Jan 22;12(1):e1005405. doi: 10.1371/journal.ppat.1005405. eCollection 2016 Jan.
Shumilov A, Tsai MH, Schlosser YT, KratzAS, BernhardtK, Fink S, MizaniT, LinX JauchA, MautnerJ, Kopp-SchneiderA, FeederleR, HoffmannI & Delecluse HJ Epstein-Barr virus particles induce centrosome amplification and chromosomal instability. Nature communications 2016, in press