Spin hyperpolarization

In close proximity to the NMR magnet, hyperpolarized xenon is produced in a polarizer optimized for hyper-CEST measurements using spin exchange optical pumping (SEOP). A narrow-band IR laser with 180 W cw power is used for this purpose.

A modern laboratory space filled with various scientific equipment, including large tanks, a control panel with screens, and a workstation. The room is well-lit and organized, designed for research and experimentation. Key safety signage is visible on some equipment.
Diagram illustrating the processes involved in spin hyperpolarization, featuring atomic transitions and collisional mixing of rubidium (Rb) atoms. It includes representations of thermal polarization, spin exchange, and hyperpolarization, supported by labeled energy levels and transitions. The focus is on quantum state interactions.

The D1 transition of rubidium vapor in a glass cell is pumped with a diode laser emitting at 795 nm. Together with a static magnetic field of approx. 20 G, this enables a high electron spin polarization to be achieved in accordance with the selection rules. Xenon gas flowing through the pump cell picks up this polarization through the Fermi contact interaction effect between the Rb electron and the Xe nucleus.

Graph depicting the normalized ^129Xe signal over various images, illustrating delivery stability with a 3.1% standard deviation. Data points for center regions of interest are highlighted in red, while noise is indicated with open circles. An inset shows a circular image with resolution details.

LEIPNIX can deliver hyperpolarized Xe with high stability continuously over several hours, enabling the acquisition of Xe MRI data that can detect even the smallest amounts of biosensors.

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