Nanocarriers
Nanocarriers, which can accommodate a large number of hyperpolarized atoms in the tissue, will be combined with improvements in the production of hyperpolarized xenon and associated MR imaging techniques in this project to allow the imaging of previously MR-invisible target molecules.
By introducing xenon hosts, the sensitivity of the Hyper-CEST method could be increased around 100-fold. The liposomes can then be provided with components that selectively bind to certain markers such as cell surface glycans of tumors. These sugar structures were visualized with MRI for the first time using the techniques developed here.
