Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

ERC Starting Grant for Chong Sun

No. 66 | 22/11/2022

With its "Starting Grants", the European Research Council (ERC) aims to pave the way for excellent young scientists to pursue independent careers. This year, immunologist Chong Sun from the German Cancer Research Center (DKFZ) will receive the prestigious funding: He plans to investigate why therapeutic T cells often fail to infiltrate a tumor and thus develop their full efficacy against cancer cells.

Chong Sun
© Jung/ DKFZ

The funding provided by the European Research Council (ERC) is regarded as an accolade for scientists at all career stages. With its ERC Starting Grants, the European Research Council (ERC) supports talented young scientists. The funds of 1.5 million euros for up to five years are intended to support the establishment of an own research group at a recognized research institution in the EU.

Scientists are working intensively on the development of cellular cancer immunotherapies. For this form of therapy, they take immune cells, mostly T cells, from cancer patients, modify them in the culture dish, and then inject them back into the patients' bloodstream. But despite some success stories, for example in certain forms of blood cancer, these therapies often fall short of expectations.

Evidence has shown that one major reason for the often disappointing efficacy of this treatment is that the therapeutic T cells are unable to infiltrate the solid tumor. With the help of the ERC grant, Chong Sun now wants to elucidate the reasons for this failure. On the one hand, the researcher is focusing on the tumor microenvironment, more specifically the special messenger substances, called chemokines, produced by the cells in the tumor. How cancer hijacks their production? And how to modulate the chemokine production to "attract" or "repel" the migration of immune cells into the tumor?

On the other hand, Chong is putting T cells themselves to the test: Are there built-in mechanisms in T cells that promote and facilitate migration into a tumor? Finally, he wants to find out whether factors that promote or impede T-cell infiltration can be influenced by drugs or gene editing. His goal is to potentially improve the efficacy of T-cell immunotherapies in this way.

Chong Sun first began his studies in biotechnology in 2003 at Nanjing University of Science and Technology, China, and graduated with a master's degree in pharmaceutical science from Utrecht University, Netherlands, in 2010. He then conducted research as a PhD student and later as a postdoctoral fellow at the Netherland Cancer Institute until 2019. Since November 2019, Chong Sun has been leading the Immune Regulation in Cancer junior research group at the German Cancer Research Center.

With more than 3,000 employees, the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) is Germany’s largest biomedical research institute. DKFZ scientists identify cancer risk factors, investigate how cancer progresses and develop new cancer prevention strategies. They are also developing new methods to diagnose tumors more precisely and treat cancer patients more successfully. The DKFZ's Cancer Information Service (KID) provides patients, interested citizens and experts with individual answers to questions relating to cancer.

To transfer promising approaches from cancer research to the clinic and thus improve the prognosis of cancer patients, the DKFZ cooperates with excellent research institutions and university hospitals throughout Germany:

  • National Center for Tumor Diseases (NCT, 6 sites)
  • German Cancer Consortium (DKTK, 8 sites)
  • Hopp Children's Cancer Center (KiTZ) Heidelberg
  • Helmholtz Institute for Translational Oncology (HI-TRON Mainz) - A Helmholtz Institute of the DKFZ
  • DKFZ-Hector Cancer Institute at the University Medical Center Mannheim
  • National Cancer Prevention Center (jointly with German Cancer Aid)
The DKFZ is 90 percent financed by the Federal Ministry of Education and Research and 10 percent by the state of Baden-Württemberg. The DKFZ is a member of the Helmholtz Association of German Research Centers.

RSS-Feed

Subscribe to our RSS-Feed.

to top
powered by webEdition CMS