Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Study Confirms Safety of Colonoscopy

No. 13 | 27/02/2013 | by Koh

March’s Colon Cancer Awareness Month is about encouraging more people to get tested for colorectal cancer. Colonoscopy is the most reliable screening test. A current study from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) confirms that, contrary to what some critics say, it is also very safe. If more people made use of screening tests, about half of all new colorectal cancer cases and deaths from this cancer could be avoided in Germany every year.

© dkfz.de

Colon cancer develops slowly. Precancerous lesions usually need many years to turn into a dangerous carcinoma. They are well detectable in an endoscopic examination of the colon called colonoscopy and can be removed during the same examination. Therefore, regular screening can prevent colon cancer much better than other types of cancer. Since 2002, colonoscopy is part of the national statutory cancer screening program in Germany for all insured persons aged 55 or older.

However, only one fifth of those eligible actually make use of the screening program. The reasons for this are manifold including fear of a frightening diagnosis and fear of a potentially unpleasant examination which can also lead to complications.

“For an examination offered to large portions of the population, the question of safety is of central importance. Therefore, it is equally important that physicians and public health experts are very well informed about the risks of complications,” says Professor Hermann Brenner of DKFZ. “Only then can they profoundly evaluate chances and risks of a colonoscopy with their patients.” Brenner, a prevention expert, analyzed the actual incidence of serious side effects during colonoscopy examinations in Germany.

In the study now published, intestinal bleeding requiring hospitalization occurred after no more than about five in 10,000 colonoscopies. Injuries to the intestinal wall were also very rare, with an incidence of less than one case in 1,000 exams. Deaths and non-local complications such as strokes or myocardial infarctions were not more frequent in the colonoscopy group than in the control group.

Thus, the complication rate is in a range which the prevention experts expected and consider being justifiable in view of the much greater benefit of screening. “The rare serious local complications usually only occur when a large polyp is detected and removed during a colonoscopy,” says Hermann Brenner. “But these are the cases where patients profit most from colonoscopy, which may have saved their lives.”

Christian Stock, first author of the study, and his colleagues from Brenner’s team evaluated the data of over 30,000 individuals insured with the German statutory health insurance AOK who had undergone outpatient colonoscopy between 2001 and 2008 either for screening purposes or because of medical indications. The control group of the same size consisted of insured persons who had not had a screening test. The researchers analyzed the incidence of serious adverse events such as intestinal wall injuries, intestinal bleeding requiring hospitalization, myocardial infarction and stroke as well as mortality. They looked at a time period of 30 days following the colonoscopy in order to also include possible late effects.

In Germany, approximately 65,000 people are newly diagnosed with colorectal cancer every year; 26,000 people succumbed to the disease in 2010. Colon cancer is the second most common cancer in both men and women and the second most common cause of cancer-related death. Hermann Brenner concludes: “If more people made use of colorectal cancer screening tests, half of these new cases and deaths could be avoided.”

Christian Stock, Peter Ihle, Andreas Sieg, Ingrid Schubert, Michael Hoffmeister and Hermann Brenner: Adverse Events requiring hospitalization within 30 days after outpatient screening and nonscreening colonoscopies. Gastrointestinal Endoscopy 2013, DOI: 10.1016/j.gie.2012.10.028

With more than 3,000 employees, the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) is Germany’s largest biomedical research institute. DKFZ scientists identify cancer risk factors, investigate how cancer progresses and develop new cancer prevention strategies. They are also developing new methods to diagnose tumors more precisely and treat cancer patients more successfully. The DKFZ's Cancer Information Service (KID) provides patients, interested citizens and experts with individual answers to questions relating to cancer.

To transfer promising approaches from cancer research to the clinic and thus improve the prognosis of cancer patients, the DKFZ cooperates with excellent research institutions and university hospitals throughout Germany:

  • National Center for Tumor Diseases (NCT, 6 sites)
  • German Cancer Consortium (DKTK, 8 sites)
  • Hopp Children's Cancer Center (KiTZ) Heidelberg
  • Helmholtz Institute for Translational Oncology (HI-TRON Mainz) - A Helmholtz Institute of the DKFZ
  • DKFZ-Hector Cancer Institute at the University Medical Center Mannheim
  • National Cancer Prevention Center (jointly with German Cancer Aid)
The DKFZ is 90 percent financed by the Federal Ministry of Education and Research and 10 percent by the state of Baden-Württemberg. The DKFZ is a member of the Helmholtz Association of German Research Centers.

RSS-Feed

Subscribe to our RSS-Feed.

to top
powered by webEdition CMS