Sebastian Kruse
← Back to Team - Former Lab Members
Scientific CV
| Jan 2019 - Dec 2019 | Postdoctoral scientist, Immunotherapy and Immunoprevention, DKFZ, Heidelberg |
| 2015 - 2019 | PhD student, Junior Research Group Immunotherapy and Immunoprevention, DKFZ, Heidelberg |
| 2012 - 2015 | MSc Biological Sciences, Focus Disease Biology, University of Konstanz |
| Jan 2014 - Jun 2014 | ERASMUS exchange term, “Tumor Immunology”, La Sapienza University, Rome, Italy |
| Sep 2013 - Nov 2013 | Research Internship, “Tumor Immunology & Cancer Stem Cells”, University Hospital Bern, Bern, Switzerland |
| 2009 - 2012 | BSc Biological Sciences, University of Konstanz |
Research Project
Development of an optimal vaccination approach for minimal epitope-based therapeutic vaccines against HPV-induced malignancies in a humanized mouse model
In this project, we used HPV16 epitopes that were confirmed by mass spectrometry to be presented to the immune system on human cancer cells. These epitopes were used in several vaccine formulations to induce high numbers of specific cytotoxic T cells in a mouse model that was humanized for major histocompatibility complex (MHC) class I and class II molecules. In addition, a suitable tumor model for these mice was developed in this project. The final goal was to compare the tested vaccine formulations for mediating anti-tumor effects. Testing human epitopes in a humanized model system is expected to increase the translatability of the findings to the clinical setting.
Resulting Publications
Therapeutic vaccination using minimal HPV16 epitopes in a novel MHC-humanized murine HPV tumor model
Kruse S, Büchler M, Uhl P, Sauter M, Scherer P, Lan TCT, Zottnick S, Klevenz A, Yang R, Rösl F, Mier W, Riemer AB