Agnieszka K. Grabowska
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Scientific CV
| Since 2018 | Cooperation partner as responsible scientist of Silvacx (Bonn, Heidelberg) |
| 2010 - 2014 | Postdoctoral Scientist, Junior Research Group Immunotherapy and Immunoprevention, DKFZ, Heidelberg |
| 2009 - 2010 | Postdoctoral Scientist and Project Leader, Okairos / Ceinge - Biotecnologie Avanzate s.c. a r.l., Naples, Italy |
| 2007 | Visiting Scientist, Friedrich-Löffler Institute, Tübingen, Germany |
| 2002 - 2009 | PhD student at the Department of Molecular Virology at the Intercollegiate Faculty of Biotechnology, Gdansk, Poland |
| 1997 - 2002 | Studies of Biology at the University of Gdansk, Poland |
Research Project
Identification of promiscuous HLA class II-restricted human papillomavirus type 16 E2-, E5-, E6- and E7-derived CD4+ helper T cell epitopes for therapeutic vaccine design
Human papillomavirus (HPV)-specific CD4+ T cell responses were found to play a crucial role in the clearance of HPV-induced malignant lesions. Up to now, therapeutic anti-HPV vaccines have mostly been developed to elicit CD8+T cell responses. HPV T cell epitopes have mostly been determined by indirect methods and for the most prevalent HLA-type, HLA-A2. However, the exclusive targeting of HLA class I-restricted HPV epitopes might not be sufficient, since HLA class I alleles may be downregulated in HPV-induced lesions. Therefore, detailed knowledge about naturally processed HLA class II-restricted HPV epitopes could complement future vaccine design strategies.
Resulting Publications
Steinbach A, Winter J, Reuschenbach M, Blatnik R, Klevenz A, Bertrand M, Hoppe S, von Knebel Doeberitz M, Grabowska AK, Riemer AB.
Schumacher T, Bunse L, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, Keil M, Balß J, Rauschenbach K, Grabowska AK, Vogler I, Diekmann J, Trautwein N, Eichmüller SB, Okun J, Stevanović S, Riemer AB, Sahin U, Friese MA, Beckhove P, von Deimling A, Wick W, Platten M.
Grabowska AK, Kaufmann AM, Riemer AB.
Khallouf H, Grabowska AK, Riemer AB.
Grabowska AK, Riemer AB.