Virus-induced pathology originates from molecular and cellular interactions, which are initiated by the virus in the host tissue. Here we combine the virus & proteomics expertise of the Pichlmair laboratory (TUM) with the single cell genomics and lung pathology expertise of the Schiller and Theis laboratories (HMGU) in order to generate pipelines that characterize virus-host interactions in complex tissues.
This data-driven approach will identify key regulators of antiviral immunity and immunopathology, which will be functionally evaluated. We anticipate that this approach will pinpoint options for antiviral therapies.
