Synthesis Club

Total Synthesis of the Hexacyclic Sesterterpenoid Niduterpenoid B via Structural Reorganization Strategy

Xue, Y.; Hou, S.-H.; Zhang, X.; Zhang, F.-M.; Zhang, X.-M.; Tu, Y.-Q. J. Am. Chem. Soc. 2024, 146, 254454–25450.

Total Syntheses of Borolithochromes A, D and G

K. Kirita, H. Matsumoto, G. Endo, S. Hosokawa Angew. Chem. Int. Ed. 2024, 63, e202400586

Total Synthesis of the Euphorbia Diterpenoid Pepluacetal

Liu, M.; Wu, C.; Xie, X.; Li, H.; She, X. Angew. Chem. Int. Ed. 2024, e202400943.

Enantioselective Synthesis of Pactamycin, a Complex Antitumor Antibiotic

Justin T. Malinowki, Robert J. Sharpe, Jeffrey S. Johnson Science, 2013, 340, 180–182.

Concise Total Synthesis of Complanadine A

D. Ma, B. S. Martin, K. S. Gallagher, T. Saito, and M. Dai Synthesis 2024, 56, 107-117; J. Am. Chem. Soc. 2021, 143, 16383–16387.

A concise synthesis of tetrodotoxin

Konrad, D.B., Rühmann, K., Ando, H., Hetzler, B.E., Strassner, N., Houk, K.N., Matsuura, B.S., Trauner, D. Science, 2022, 377, 411–415.

Navigating Excess Complexity: Total Synthesis of Daphenylline

Wright, BB. A., Regni, A., Chaisan, N., Sarpong, R. J. Am. Chem. Soc. 2024, 146, 1813–1818.

Total Synthesis of Aleutianamine

Hao Yu, Zachary P. Sercel, Samir P. Rezgui, Jonathan Farhi, Scott C. Virgil, Brian M. Stoltz J. Am. Chem. Soc. 2023, 145, 25533–25537.

Total Synthesis of Metaphanine and Oxoepistephamiersine

Ya-Kui Sun, Jin-Bao Qiao, Yu-Meng Xin, Qin Zhou, Zhi-Hua Ma, Hui Shao, Yu-Ming Zhao Angew. Chem. Int. Ed. 2023, 62, e202310917.

Asymmetric Total Synthesis of Illisimonin A

Etling, C., Tedesco, G., Di Marco, A., Kalesse, M. J. Am. Chem. Soc. 2023, 145, 7021–7029.

A Convergent Total Synthesis of (+)-Ineleganolide

Gross, Benjamin M.; Han, Seo-Jung; Virgil, Scott C.;Stoltz, Brian M. J. Am. Chem. Soc. 2023, 145, 7763–7767.

Enantioselective total synthesis of sacrolide A

T. Mohri, Y. Ogura, R. Towada, S. Kuwahara Tetrahedrom Lett. 2017, 58, 4011-4013.

Enantioselective Total Synthesis of (−)-Caulamidine A

Zhouyang Zhu and Thomas J. Maimone J. Am. Chem. Soc. 2023, 145, 14215–14220.

Total Syntheses of (+)-Waixenicin A, (+)-9-Deacetoxy-14,15-deepoxyxeniculin, and (−)-Xeniafaraunol A

Steinborn, C., Huber, T., Lichtenegger, J., Plangger, I., Wurst, K., & Magauer, T. J. Am. Chem. Soc. 2023, 145, 11811–11817.

Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion

Johnson, T.C., Chin, M.R., Han, T., Shen, J.P., Rana, T., Siegel, D. J. Am. Chem. Soc. 2016, 138, 6068–6073

Enantioselective Total Synthesis of Lycopodine

Hua Yang, Rich G. Carter and Lev N. Zakharov J. Am. Chem. Soc. 2008, 130, 9238–9239.

Total Synthesis and Structure Assignment of (+)-Hexacyclinol

Porco, J.A., Jr.; Su, S.; Lei, X.; Bardhan, S.; Rychnovsky, S.D. Angew. Chem. Int. Ed.  2006, 45, 5790 – 5792.

Total Synthesis of Vilmoraconitine

Ji, J; Chen, J; Qin, S; Li, W; Zhao, J; Li, G; Song, H; Liu, X-Y; Qin, Y J. Am. Chem. Soc. 2023, 145, 3903–3908.

Total Synthesis of Yuzurine-type Alkaloid Daphgraciline

Li, L.-X.; Min, L.; Yao, T.-B.; Ji, S.-X.; Qiao, C.; Tian, P.-L.; Sun, J.; Li, C.-C. J. Am. Chem. Soc. 2022, 144, 18823 – 18828.

Scalable Total Synthesis of (–)-Vinigrol

Xuerong Yu, Lianghong Xiao, Zechun Wang, Tuoping Luo J. Am. Chem. Soc. 2019, 141, 3440–13443.

Second-generation synthesis of salvinorin A

H. Hagiwara, Y. Suka, T. Nojima, T. Hoshi, T. Suzuki Tetrahedron 2009, 65, 4820–4825.